scholarly journals A further investigation on the chemical constituents from Euphorbia tirucalli growing in Binh Thuan province

2019 ◽  
Vol 22 (2) ◽  
Author(s):  
Huy Thuc Duong
Keyword(s):  
Chemical Constituents ◽  
Normal Phase ◽  
Gel Chromatography ◽  
Asian Countries ◽  
Euphorbia Tirucalli ◽  
Ergosterol Peroxide ◽  
Nmr Data ◽  
Phenolic Components ◽  
First Time ◽  
Layer Chromatography

Introduction: Euphorbia tirucalli L. is a medicinal plant popularly distributed in Asian countries. In Vietnam, only one study on the polar extract the plant Euphorbia tirucalli growing in Binh Thuan province, Vietnam was reported, revealing several phenolic components. As of 2019, no chemical reports on the non-polar extract from the Vietnamese plant were found. This research described the isolation and elucidation of compounds isolated from the non-polar extract of E. tirucalli growing in Binh Thuan province. Method: The n-hexane extract of this plant was carried out by using normal phase silica gel column chromatography, thin-layer chromatography, and gel chromatography (Sephadex LH-20). Analysis of spectroscopic data and a comparison of the NMR data with that in the literature led to the structural elucidation of isolated compounds. Results: Three terpenoid compounds, euphol (1), lupenone (2), and vomifoliol (3), along with ergosterol peroxide (4), ferulic acid (5), and vanillic acid (6) were isolated and elucidated. Conclusions: Among them, compound 3 and 4 were reported in the first time from E. tirucalli.  

scholarly journals Chemical constituents of Euphorbia tirucalli L.

2019 ◽  
Vol 2 (5) ◽  
pp. 76-82
Author(s):  
Dung Thi Kim Le ◽  
Hao Xuan Bui ◽  
Tuyet Thi Anh Nguyen ◽  
Tuyen Nguyen Kim Pham ◽  
Huy Thuc Duong
Keyword(s):  
Thin Layer ◽  
Gallic Acid ◽  
Spectroscopic Analysis ◽  
Chemical Constituents ◽  
Normal Phase ◽  
Chemical Structures ◽  
Euphorbia Tirucalli ◽  
Arjunolic Acid ◽  
First Time ◽  
Layer Chromatography

Euphorbia tirucalli has not been chemically studied much in Vietnam. This research described the isolation and elucidation of compounds isolated from the plant collected in Binh Thuan. Multiple chromatographic methods were applied, including normal phase silica gel column chromatography and thin-layer chromatography. Seven compounds were isolated and their chemical structures were elucidated by spectroscopic analysis as well as comparing their data with the ones in the literature. They are arjunolic acid (1), eriodictyol (2), quercitrin (3), afzelin (4), scopoletin (5), 3,3′,4- trimethylellagic acid (6), and gallic acid (7). Among them, compound 1 a major component was isolated for the first time in Euphorbia genus, while three compounds 2, 4, and 5 were isolated from this species for the first time.

scholarly journals Chemical constituents of the lichen Roccella sinensis growing in Binh Thuan province

2019 ◽  
Vol 2 (5) ◽  
pp. 63-67
Author(s):  
Huy Thuc Duong ◽  
Hao Xuan Bui
Keyword(s):  
Spectroscopic Analysis ◽  
Chemical Constituents ◽  
Human Lung Cancer ◽  
Cytotoxic Activities ◽  
Human Breast ◽  
Nmr Data ◽  
Liver Hepatocellular Carcinoma ◽  
First Time ◽  
Layer Chromatography ◽  
Mcf 7

The lichen Roccella sinensis has not been studied chemically. This research described the isolation and elucidation of compounds isolated from the lichen Roccella sinensis collected in Binh Thuan. Phytochemistry investigation of this lichen was carried out by using normal phase silica gel column chromatography and thin-layer chromatography. Six compounds was isolated. Their structures were established by extensively spectroscopic analysis as well as comparison with NMR data in the literatures. They are (+)-D-montagnetol (1), (+)-D-erythrin (2), lecanorin (3), 1-acetylerythritol (4), (E)-nostodione A (5), and 2,4-dihydroxyphthalide (6). This is the first time compounds 3 6 were found in the Roccella genus. Compounds 1, 2, and 6 were evaluated for their cytotoxic activities against HepG2 (liver hepatocellular carcinoma), NCI-H460 (human lung cancer), MCF-7 (human breast cancer), and HeLa (human epithelial cancer) and all of them showed no activity.

scholarly journals Four flavonols from the seed of Hibiscus sabdariffa. Linn. growing in Binh Thuan Province

2019 ◽  
Vol 22 (4) ◽  
pp. 348-351
Author(s):  
Pham Nguyen Kim Tuyen ◽  
Truong Van Tien ◽  
Tran The Anh Huy ◽  
Nguyen Thi Hoa ◽  
Huynh Bui Linh Chi ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
2D Nmr ◽  
Hibiscus Sabdariffa ◽  
Asian Countries ◽  
Chromatography Analysis ◽  
Liquid Liquid Extraction ◽  
Nmr Data ◽  
First Time ◽  
Layer Chromatography

Introduction: Hibiscus sabdariffa Linn. (Malvaceae) is a medicinal plant popularly distributed in Asian countries. As of 2019, no chemical investigations from the Vietnamese plant were found. This paper reported the isolation and elucidation of compounds isolated from the seeds of Hibiscus sabdariffa Linn. (Malvaceae) growing in Binh Thuan province. Method: The maceration was applied to the seeds of the plant to afford the crude extract which was then fractionated by liquid-liquid extraction to obtain the ethyl acetate extract. The extract was carried out by using normal phase silica gel column chromatography and thin-layer chromatography. Analysis of spectroscopic data including HR-ESI-MS, 1D and 2D-NMR and a comparison of the NMR data with that in the literature led to the structural elucidation of isolated compounds. Results: Four flavonols comprising quercetin 3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (1), quercetin 3-O-β-D-glucopyranoside (2), quercetin (3) and kaempferol (4) were isolated from the ethyl acetate extract. Conclusions: This is the first time the isolated compounds were found from the seeds of this plant.

scholarly journals Chemical constituents of the leave of Gnetum gnemon L.

2020 ◽  
Vol 3 (3) ◽  
pp. 188-194
Author(s):  
Tho Huu Le ◽  
Hai Xuan Nguyen ◽  
Truong Nhat Van Do ◽  
Trinh Cong Pham ◽  
Truc Thien Lam ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Comprehensive Overview ◽  
Chromatography Method ◽  
Nmr Data ◽  
The Family ◽  
Pure Compounds ◽  
Gnetum Gnemon ◽  
Solvent Systems ◽  
First Time ◽  
Layer Chromatography

(Vietnamese name; L.), which belongs to the family, is an evergreen and perennial tree that is widely cultivated in Southeast Asia. In Vietnam, leaves of the species are used as an ordinary vegetable in many regions. The aim of this research is to investigate the chemical constituents of G. leaves collected from Lam Dong province, Vietnam. The fresh leaves were collected, dried, cut into small species, and extracted with ethanol to the extract. By using the column chromatography method together with thin layer chromatography on a normal phase silica gel with different solvent systems on the extract of the dried leaves of G. L., we isolated five pure compounds. The structures of 1-5 were elucidated by analyzing nuclear magnetic resonance (NMR) data. The result was confirmed by comparison with publish data including (1), acid (2), acid (3), (4), and (5). To the best of our knowledge, compounds 1-3were isolated from this plant for the first time. This study is to provide a comprehensive overview of of G. , and possibly make recommendations for further research.

Chemical Constituents of the Aerial Parts of Scutellaria lateriflora and their α-Glucosidase Inhibitory Activities

2012 ◽  
Vol 7 (4) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Minpei Kuroda ◽  
Katsura Iwabuchi ◽  
Yoshihiro Mimaki
Keyword(s):  
Methyl Ester ◽  
Chemical Constituents ◽  
Meoh Extract ◽  
Aerial Parts ◽  
Screening Experiments ◽  
Data Analyses ◽  
Nmr Data ◽  
Scutellaria Lateriflora ◽  
Inhibitory Activities ◽  
First Time

MeOH extracts of 37 herbs were tested in screening experiments for rat intestinal α-glucosidase. The MeOH extract of the aerial parts of Scutellaria lateriflora L. (Lamiaceae) significantly inhibited sucrase and maltase activities, using sucrose and maltase as the substrates. Enzyme inhibition guided-fractionation of the MeOH extract of S lateriflora resulted in the isolation of a new diterpene glucoside, deacetylajugarin-IV 18- O-β-D-glucopyranoside (1), along with 20 known phenolics (2-21). The structures of 1-21 were elucidated on the basis of MS and NMR data analyses. Baicalein (4) and baicalin (10), a glycoside of 4, showed moderate sucrase inhibitory activities at IC50 values of 14.9 and 36.3 μM, respectively, whereas luteolin (3), acteoside (16), leucosceptoside A (18), and isoacteoside (20) showed weak inhibitory activities at IC50 values of 811, 522, 727, and 443 μM, respectively. This is the first report on mammalian α-glucosidase inhibitory activities of S lateriflora extract and identification of the constituents responsible for the activities. Apigenin (2), luteolin (3), 6-methoxyluteolin 4'-methyl ether (6), isoscutellarin 8- O-β-D-glucuronide (7), luteolin 7- O-β-D-glucuronide (9), wogonin 7- O-β-D-glucuronide methyl ester (12), eriodictyol (13), naringenin (14), naringenin 7- O-β-D-glucuronide (15), jionoside D (17), leucosceptoside A (18), and (+)-syringaresinol 4'- O-β-D-glucopyranoside (21) were isolated from this plant for the first time. The inhibitory properties of S lateriflora extract against α-glucosidase provide a prospect for its antidiabetic usage.

scholarly journals TRITERPENES FROM CERIOPS DECANDRA (GRIFF.) W. THEOB.

2017 ◽  
Vol 10 (11) ◽  
pp. 244
Author(s):  
Judy Perez ◽  
Chien-chang Shen ◽  
Consolacion Y Ragasa
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Literature Search ◽  
Chemical Constituents ◽  
Fatty Acid Esters ◽  
Gel Chromatography ◽  
Anticancer Properties ◽  
Nmr Data ◽  
Ceriops Decandra ◽  
Silica Gel Chromatography ◽  
Acid Esters

  Objective: To isolate and identify the chemical constituents of Ceriops decandra. Methods: The chemical constituents of C. decandra (Griff.) W. Theob. were isolated by silica gel chromatography. The structures of the isolated compounds were identified by nuclear magnetic resonance (NMR) spectroscopy.Results: Chemical investigation of the dichloromethane extracts of the leaves of C. decandra has led to the isolation of 3β-E-coumaroylbetulinic acid (1), lupeol fatty acid esters (2), betulonic acid (3), betulin (4), betulinic acid (5), lupeol (6), lupenone (7), and a mixture of 3β-E-feruloyllupeol (8) and 3β-Z-feruloyllupeol (9), and chlorophyll a (10). The structures of 1-10 were identified by comparison of their NMR data with literature data.Conclusion: To the best of our knowledge, this is the first report on the isolation of 1-3 from C. decandra. Literature search revealed that the triterpenes isolated from C. decandra exhibited anticancer properties.

scholarly journals (4S)-4,8-dihydroxy-1-tetralone and other chemical constituents from Pestalotiopsis sp. EJC07, endophytic fromBauhinia guianensis

2016 ◽  
Vol 88 (1) ◽  
pp. 29-33 ◽  
Author(s):  
Eleane M.C. de Souza ◽  
Ellon L. Da Silva ◽  
Andrey M.R. Marinho ◽  
Patrícia S.B. Marinho
Keyword(s):  
Spectral Methods ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Hydroxybenzoic Acid ◽  
Ergosterol Peroxide ◽  
First Time

The present work reports the isolation of eight compounds fromPestalotiopsis sp. EJC07 isolated as endophytic fromBauhinia guianensis, a tipical plant of the Amazon. The compounds (4S)-4,8-dihydroxy-1-tetralone (1), uracil (2), uridin (3), p-hydroxybenzoic acid (4), ergosterol (5), ergosterol peroxide (6), cerevisterol (7) and ducitol (8) were isolated by chromatographic procedures and identified by spectral methods of 1D and 2D NMR and MS. The compound 1 is being reported for the first time in the genusPestalotiopsis.

scholarly journals Triterpenoids from the wood of Willughbeia cochinchinensis

2018 ◽  
Vol 1 (T5) ◽  
pp. 137-142
Author(s):  
Linh Thi My Lam ◽  
Phu Hoang Dang ◽  
Hai Xuan Nguyen ◽  
Nhan Trung Nguyen ◽  
Mai Thi Thanh Nguyen
Keyword(s):  
Thin Layer ◽  
Ethyl Acetate ◽  
Thin Layer Chromatography ◽  
Silica Gel ◽  
Column Chromatography ◽  
Normal Phase ◽  
Reverse Phase ◽  
Chemical Structures ◽  
First Time ◽  
Layer Chromatography

From the wood of n-hexane extract of Willughbeia cochinchinensis, perform column chromatography on a normal phase silica gel with n-hexane: ethyl acetate obtained in 8 fractions. From GD-D and GD-F fractions, multiple column chromatography on silica gel was performed in combination with normal and reverse phase thin-layer chromatography, four triterpene compounds as epifriedelanol (1), taraxeryl acetate (2), ambolic acid (3) and α- amyrin (4) were isolated. Their chemical structures were determined by spectrocopic methods as well as comparing with data in the literature. These compounds were isolated for the first time from Willughbeia cochinchinensis.

scholarly journals CHEMICAL CONSTITUENTS FROM POLYGONATUM KINGIANUM COLL. ET HEMSL. OF VIETNAM

2020 ◽  
Vol 58 (5) ◽  
pp. 549
Author(s):  
Lê Minh Hà
Keyword(s):  
Spectral Data ◽  
Nmr Spectra ◽  
Chemical Constituents ◽  
Dienoic Acid ◽  
2D Nmr ◽  
Ergosterol Peroxide ◽  
2D Nmr Spectra ◽  
First Time

Seven compounds, including two homoisoflavanones 3-(2ʹ-hydroxy-4ʹ-methoxy-benzyl)-5,7-dihydroxy-8-methyl-chroman-4-one (1), disporopsin (2) along with 2-O-methyl-α-D-fructofuranose (3), (E,E)-9-oxooctadeca-10,12-dienoic acid (4), 1-palmitoylglycerol (5), 5α,8α-ergosterol  peroxide (6),  daucosterol (7) were isolated from the rhizomes of Polygonatum kingianum of Vietnam. Their structures were determined by 1D and 2D NMR spectra and by comparison with the reported spectral data. Compounds 3, 4 and 6 are first reported from the genus Polygonatum. Compound 1 and 5 are reported for the first time from Polygonatum kingianum.

scholarly journals Chemical Constituents of the Lichen Stereocaulon azoreum

1992 ◽  
Vol 47 (7-8) ◽  
pp. 503-507 ◽  
Author(s):  
Antonio G. González ◽  
Elsa M. Rodríguez Pérez ◽  
Consuelo E. Hernández Padrón ◽  
Jaime Bermejo Barrera
Keyword(s):  
Ursolic Acid ◽  
Column Chromatography ◽  
Chemical Constituents ◽  
Acetone Extract ◽  
Ergosterol Peroxide ◽  
First Time ◽  
Acetone Condensation

Column chromatography of the acetone extract of the lichen Stereocaulon azoreum afforded several substances identified by chemical and spectral means; α-amyrin, lupeol, taraxerol, ursolic acid, ergosterol peroxide, brassicasterol, cerevisterol, stictic acid and an acetone-condensation derivative, lobaric acid. Furthermore atranorin, methyl β-orsellinate, atranol and, for the first time from the genus Stereocaulon, cryptostictic acid and the dibenzofuran, strepsilin were isolated.

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