scholarly journals Chemical constituents of the lichen Roccella sinensis growing in Binh Thuan province

2019 ◽  
Vol 2 (5) ◽  
pp. 63-67
Author(s):  
Huy Thuc Duong ◽  
Hao Xuan Bui
Keyword(s):  
Spectroscopic Analysis ◽  
Chemical Constituents ◽  
Human Lung Cancer ◽  
Cytotoxic Activities ◽  
Human Breast ◽  
Nmr Data ◽  
Liver Hepatocellular Carcinoma ◽  
First Time ◽  
Layer Chromatography ◽  
Mcf 7

The lichen Roccella sinensis has not been studied chemically. This research described the isolation and elucidation of compounds isolated from the lichen Roccella sinensis collected in Binh Thuan. Phytochemistry investigation of this lichen was carried out by using normal phase silica gel column chromatography and thin-layer chromatography. Six compounds was isolated. Their structures were established by extensively spectroscopic analysis as well as comparison with NMR data in the literatures. They are (+)-D-montagnetol (1), (+)-D-erythrin (2), lecanorin (3), 1-acetylerythritol (4), (E)-nostodione A (5), and 2,4-dihydroxyphthalide (6). This is the first time compounds 3 6 were found in the Roccella genus. Compounds 1, 2, and 6 were evaluated for their cytotoxic activities against HepG2 (liver hepatocellular carcinoma), NCI-H460 (human lung cancer), MCF-7 (human breast cancer), and HeLa (human epithelial cancer) and all of them showed no activity.

scholarly journals SOME TRITERPENOIDS AND STEROIDS FROM THE LICHEN LOBARIA ORIENTALIS, LOBARIACEAE.

2018 ◽  
Vol 54 (2C) ◽  
pp. 313
Author(s):  
Nguyen Thi My Dung
Keyword(s):  
Spectroscopic Data ◽  
Human Lung ◽  
Ethyl Acetate Extract ◽  
Cancer Cell Line ◽  
Human Lung Cancer ◽  
Cytotoxic Activities ◽  
Ic50 Value ◽  
Liver Hepatocellular Carcinoma ◽  
First Time ◽  
Mcf 7

Chemical investigation of the ethyl acetate extract of the lichen Lobaria orientalis,Lobariaceae, collected in Vietnam, afforded six known compounds, including four triterpenoids,zeorin (1), 16β-acetoxyhopane-6α,22-diol (2), retigeric acid A (3), retigeric acid B (4), togetherwith two steroids, ergosterol-5α,8α-peroxide (5) and cerevisterol (6). Their chemical structureswere elucidated by spectroscopic data analysis and comparison with those reported in theliterature. The cytotoxic activities of some compounds against liver hepatocellular carcinoma(HepG2), human lung cancer (NCI-H460), human epithelial carcinoma (HeLa) and humanbreast cancer (MCF-7) cell lines were evaluated. Compound 2 exhibited good cytotoxicityagainst MCF-7 cancer cell line with IC50 value of 21.10 μg/mL. This is the first time compounds(1), (2), (6) are reported in the Lobaria genus.

scholarly journals Chemical constituents of the lichen Dendriscosticta platyphylloides, Lobariaceae

2019 ◽  
Vol 22 (1) ◽  
pp. 165-172
Author(s):  
Dung Thi My Nguyen ◽  
Lien Thi My Do ◽  
Huynh Thi Ngoc Tuyet ◽  
Minh Ky Quang Ho ◽  
Hai Tuan Nguyen ◽  
...  
Keyword(s):  
Cell Lines ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Human Lung Cancer ◽  
Cytotoxic Activities ◽  
Tropical Regions ◽  
Sulforhodamine B ◽  
The Family ◽  
Liver Hepatocellular Carcinoma ◽  
First Time

Introduction: Dendriscosticta is a new genus belong the Sticta wrightii group of the family Lobariaceae. This genus of foliose lichen is widely distributed in tropical regions worldwide. The lichen Dendriscosticta platyphylloides is very abundant in Bidoup forest, Lam Dong province, Vietnam. Methods: The structure of these compounds was elucidated through the interpretation of their 1D and 2D-NMR and HR-MS data. The cytotoxic activities of these compounds against liver hepatocellular carcinoma (HepG2), human lung cancer (NCI-H460), human epithelial carcinoma (HeLa) and human breast cancer (MCF-7) cell lines was performed at the concentration of 100 mg/mL using the sulforhodamine B (SRB) assay. Results: In this paper, we reported the isolation of six known compounds, including (1) 15a-acetoxyhopan-22-ol (2) hopane-15a,22-diol, (3) zeorin, (4) cerevisterol, (5) salvigenin, and (6) 5-hydroxy-3',4',7-trimethoxyflavone. Conclusion: This is the first time that these compounds are isolated from Dendriscosticta genus. These compounds showed no cytotoxic activity against four cell lines.  

scholarly journals Chemical constituents of Euphorbia tirucalli L.

2019 ◽  
Vol 2 (5) ◽  
pp. 76-82
Author(s):  
Dung Thi Kim Le ◽  
Hao Xuan Bui ◽  
Tuyet Thi Anh Nguyen ◽  
Tuyen Nguyen Kim Pham ◽  
Huy Thuc Duong
Keyword(s):  
Thin Layer ◽  
Gallic Acid ◽  
Spectroscopic Analysis ◽  
Chemical Constituents ◽  
Normal Phase ◽  
Chemical Structures ◽  
Euphorbia Tirucalli ◽  
Arjunolic Acid ◽  
First Time ◽  
Layer Chromatography

Euphorbia tirucalli has not been chemically studied much in Vietnam. This research described the isolation and elucidation of compounds isolated from the plant collected in Binh Thuan. Multiple chromatographic methods were applied, including normal phase silica gel column chromatography and thin-layer chromatography. Seven compounds were isolated and their chemical structures were elucidated by spectroscopic analysis as well as comparing their data with the ones in the literature. They are arjunolic acid (1), eriodictyol (2), quercitrin (3), afzelin (4), scopoletin (5), 3,3′,4- trimethylellagic acid (6), and gallic acid (7). Among them, compound 1 a major component was isolated for the first time in Euphorbia genus, while three compounds 2, 4, and 5 were isolated from this species for the first time.

scholarly journals Nine Unique Iridoids and Iridoid Glycosides From Patrinia scabiosaefolia

2021 ◽  
Vol 9 ◽  
Author(s):  
Zhenhua Liu ◽  
Yun Niu ◽  
Li Zhou ◽  
Lijun Meng ◽  
Sitan Chen ◽  
...  
Keyword(s):  
Spectroscopic Analysis ◽  
Chemical Constituents ◽  
Iridoid Glycosides ◽  
Chinese Herb ◽  
2D Nmr ◽  
Iridoid Glycoside ◽  
Cytotoxic Activities ◽  
Medicinal Value ◽  
Patrinia Scabiosaefolia ◽  
Mcf 7

Patrinia scabiosaefolia is a medical and edible Chinese herb with high nutritional and medicinal value. The continuing study of its chemical constituents led to the discovery of nine unique iridoids and iridoid glycosides, including three new iridoids (1-3) and six previously unknown irioid glycosides (5-10), and one known compound (4). Among them, compound 1 was a deformed iridoid, while compounds 3, 5-7, and 10 formed a new ring in their skeletons which was uncommon in this genus. For compound 3, the new ring existed between C-3 and C-10, while a 1,3-dioxane appeared between C-7 and C-10 in compounds 5-7 and 10. Moreover, compound 10 was a bis-iridoid glycoside, which was the first reported in P. scabiosaefolia. And the sugar of irioid glycosides (5-10) was glucose at C-11, except in 9 which had a 5-deoxyglucose moiety. All their structures were confirmed based on the extensive spectroscopic analysis, including IR, UV, HR-ESI-MS, ECD, and 1D- and 2D-NMR experiments. Their cytotoxic activities against HL-60, A-549, SMMC-7721, MCF-7, SW480 were also tested.

scholarly journals A further investigation on the chemical constituents from Euphorbia tirucalli growing in Binh Thuan province

2019 ◽  
Vol 22 (2) ◽  
Author(s):  
Huy Thuc Duong
Keyword(s):  
Chemical Constituents ◽  
Normal Phase ◽  
Gel Chromatography ◽  
Asian Countries ◽  
Euphorbia Tirucalli ◽  
Ergosterol Peroxide ◽  
Nmr Data ◽  
Phenolic Components ◽  
First Time ◽  
Layer Chromatography

Introduction: Euphorbia tirucalli L. is a medicinal plant popularly distributed in Asian countries. In Vietnam, only one study on the polar extract the plant Euphorbia tirucalli growing in Binh Thuan province, Vietnam was reported, revealing several phenolic components. As of 2019, no chemical reports on the non-polar extract from the Vietnamese plant were found. This research described the isolation and elucidation of compounds isolated from the non-polar extract of E. tirucalli growing in Binh Thuan province. Method: The n-hexane extract of this plant was carried out by using normal phase silica gel column chromatography, thin-layer chromatography, and gel chromatography (Sephadex LH-20). Analysis of spectroscopic data and a comparison of the NMR data with that in the literature led to the structural elucidation of isolated compounds. Results: Three terpenoid compounds, euphol (1), lupenone (2), and vomifoliol (3), along with ergosterol peroxide (4), ferulic acid (5), and vanillic acid (6) were isolated and elucidated. Conclusions: Among them, compound 3 and 4 were reported in the first time from E. tirucalli.  

scholarly journals Chemical constituents of the leave of Gnetum gnemon L.

2020 ◽  
Vol 3 (3) ◽  
pp. 188-194
Author(s):  
Tho Huu Le ◽  
Hai Xuan Nguyen ◽  
Truong Nhat Van Do ◽  
Trinh Cong Pham ◽  
Truc Thien Lam ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Comprehensive Overview ◽  
Chromatography Method ◽  
Nmr Data ◽  
The Family ◽  
Pure Compounds ◽  
Gnetum Gnemon ◽  
Solvent Systems ◽  
First Time ◽  
Layer Chromatography

(Vietnamese name; L.), which belongs to the family, is an evergreen and perennial tree that is widely cultivated in Southeast Asia. In Vietnam, leaves of the species are used as an ordinary vegetable in many regions. The aim of this research is to investigate the chemical constituents of G. leaves collected from Lam Dong province, Vietnam. The fresh leaves were collected, dried, cut into small species, and extracted with ethanol to the extract. By using the column chromatography method together with thin layer chromatography on a normal phase silica gel with different solvent systems on the extract of the dried leaves of G. L., we isolated five pure compounds. The structures of 1-5 were elucidated by analyzing nuclear magnetic resonance (NMR) data. The result was confirmed by comparison with publish data including (1), acid (2), acid (3), (4), and (5). To the best of our knowledge, compounds 1-3were isolated from this plant for the first time. This study is to provide a comprehensive overview of of G. , and possibly make recommendations for further research.

scholarly journals Cytotoxic Activities of Flavonoids fromCentaurea scoparia

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Sayed A. Ahmed ◽  
Emadeldin M. Kamel
Keyword(s):  
Hepatocellular Carcinoma ◽  
Ethanolic Extract ◽  
2D Nmr ◽  
Cytotoxic Activities ◽  
Human Breast ◽  
Oroxylin A ◽  
Aerial Parts ◽  
Phytochemical Studies ◽  
First Time ◽  
Mcf 7

Phytochemical studies on the ethanolic extract of the aerial parts ofCentaurea scoparialed to the isolation of two new flavonoids, 3′,4′-dihydroxy-(3′′,4′′-dihydro-3′′-hydroxy-4′′-acetoxy)-2′′,2′′-dimethylpyrano-(5′′,6′′:7,8)-flavone-3-O-β-D-glucopyranoside (1) and 3,3′,4′-trihydroxy-(3′′,4′′-dihydro-3′′,4′′-dihydroxy)-2′′,2′′-dimethylpyrano-(5′′,6′′:7,8)-flavone (2), along with eight known flavonoids isolated for the first time from this plant, cynaroside (3), Apigetrin (4), centaureidin (5), oroxylin A (6), 5,7-dihydroxy-3′,4′,5′-trimethoxyflavone (7), atalantoflavone (8), 5-hydroxy-3′,4′,8-trimethoxy-2′′,2′′-dimethylpyrano (5′′,6′′:6,7)-flavone (9), and 3′,4′,5,8-tetramethoxy-2′′,2′′-dimethylpyrano (5′′,6′′:6,7)-flavone (10). The structures of the isolated compounds were elucidated by means of spectroscopic tools including 1D and 2D NMR, UV, IR, and mass spectroscopy. Cytotoxic activities of the isolated compounds were evaluated against human cervical carcinoma HeLa, human hepatocellular carcinoma HepG2, and human breast carcinoma MCF-7. Compound2was the most potent cytotoxic agent against HeLa cells with an IC500.079 μM.

scholarly journals Chemical Constituents of the Marine Sponge Aaptos aaptos (Schmidt, 1864) and Their Cytotoxic Activity

2021 ◽  
Vol 16 (2) ◽  
pp. 1934578X2199334
Author(s):  
Do Thi Trang ◽  
Bui Huu Tai ◽  
Dan Thuy Hang ◽  
Pham Hai Yen ◽  
Phan Thi Thanh Huong ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Spectral Data ◽  
Absolute Configuration ◽  
Marine Sponge ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Extensive Analysis ◽  
First Time ◽  
Tddft Method ◽  
Mcf 7

Seven compounds (1-7) were isolated from the marine sponge Aaptos aaptos living in the Vietnamese sea. Their structures were determined as 2 hours, 5 H,7 H,9 H-9 S-hydroxy-imidazo[1,5- α]pyridine-1,3-dione (1), 3-([9-methylhexadecyl]oxy)propane-1,2-diol 2, 2,3-dihydro-2,3-dioxoaaptamine (3), indol-3-aldehyde (4), methyl indole-3-carboxylate (5) 4-hydroxy-5-(indole-3-yl)−5-oxo-pentan-2-one (6), and thymidine (7) by extensive analysis of HR-ESI-MS, 1D, and 2D NMR spectral data, as well as by comparison of the spectral data with those reported in the literature. In addition, the absolute configuration of 1 was determined from the experimental ECD spectrum and comparison of this with the theoretical ECD calculations using the TDDFT method. Compounds 1 and 2 were isolated from nature for the first time. Compound 3 induced cytotoxic activity against SK-LU-1, MCF-7, HepG2, and SK-Mel-2 cell lines with IC50 values of 41.27 ± 2.63, 40.70 ± 2.65, 34.31 ± 3.43, and 36.63 ± 1.40 µM, respectively.

scholarly journals Chemical Constituents and Derivatization of Melodorinol from the Roots of Melodorum fruticosum

2015 ◽  
Vol 10 (4) ◽  
pp. 1934578X1501000
Author(s):  
Siriwat Hongnak ◽  
Jongkolnee Jongaramruong ◽  
Suttira Khumkratok ◽  
Pongpun Siriphong ◽  
Santi Tip-pyang
Keyword(s):  
Cell Lines ◽  
Spectroscopic Data ◽  
Chemical Constituents ◽  
Chemical Investigation ◽  
Crude Extracts ◽  
First Time ◽  
Mcf 7

Chemical investigation of the CH2Cl2 and MeOH crude extracts of the roots of Melodorum fruticosum Lour. led to the isolation of 15 known compounds, of which 5, 10, and 12-15 are reported for the first time from this plant. In addition, melodorinol (7) was derivatized to afford six new (7a-7d and 7f-7g) analogues and one known compound (7e). Their structures were identified on the basic of spectroscopic data. Most of them were evaluated for their cytotoxicity against KB, HeLa, MCF-7 and HepG-2 cell lines. Compounds 4 and 7b were the most potent to all cell lines.

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