scholarly journals CORRELATION BETWEEN SERUM CREATININE & URINE ALBUMIN IN DIABETIC NEPHROPATHY PATIENTS: A STUDY IN A TERTIARY LEVEL HOSPITAL OF BANGLADESH

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Sanyal M ◽  
Khan A
Keyword(s):  
Diabetic Nephropathy ◽  
Serum Creatinine ◽  
Serum Creatinine Level ◽  
Creatinine Level ◽  
Total Protein ◽  
Medical College Hospital ◽  
Diabetic Patients ◽  
College Hospital ◽  
Medical College ◽  
Urine Albumin

Serum creatinine is a very common tool of renal assessment in diabetic nephropathy. Specially due to its availably and cost-effectiveness, serum creatinine has been a popular choice among the clinicians even in rural areas. Also, the staging of diabetic nephropathy is done on the basis of eGFR which is calculated mainly with serum creatinine level. Sometimes, clinicians , even overlook the other investigations ,such as urine routine examinations or ultra sonogram of kidney, when the serum creatinine level is within normal limit. This study aims at observation of existing correlation between serum creatinine and urine albumin in diabetic nephropathy patients. This cross sectional observational study has been conducted on 50 patients in a period of 6 months in the medicine department of Dhaka Medical College Hospital. 50 diabetic patients admitted to Dhaka Medical College Hospital were enrolled in this study after fulfilling inclusion and exclusion criteria. Among the total 50 patients, 34 patients were diagnosed on the basis of microalbuminuria and the rest had raised urinary total protein. No correlation was found between serum creatinine and urine albumin or urine total protein. Staging of the kidney disease was done according to eGFR (calculated by MDRD equation).  Only 41.37% of the patients with microalbuminuria, showed eGFR consistent with its staging while 31.5% of the patients with proteinuria showed respective expected eGFR. The rest of the patient’s eGFR was inconsistent with the staging. And the difference between the mean serum creatinine in two groups was insignificant. This study has shown that, the serum creatinine has no linear correlation with urinary albumin in diabetic nephropathy patients. So, commonly used serum creatinine based formula to calculate the eGFR can misinterpret the staging of the disease which can delay the appropriate treatment thereafter. Keywords: Diabetic Nephropathy, Proteinuria, Microalbuminuria, Serum Creatinine

scholarly journals Correlation Between Serum Creatinine & Urine Albumin in Diabetic Nephropathy Patients

2020 ◽  
Vol 27 (2) ◽  
pp. 141-147
Author(s):  
Mousumi Sanyal ◽  
Mohammad Zaid Hossain ◽  
Md Arif Uddin Khan ◽  
Farzana Rahman ◽  
Md Haider Ali
Keyword(s):  
Diabetic Nephropathy ◽  
Serum Creatinine ◽  
Blood Sugar ◽  
Total Protein ◽  
Complete Blood Count ◽  
Diabetic Patients ◽  
College Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Urine Albumin

Diabetic nephropathy has some distinct stages and each of the stages are individually defined according to different amount of albumin excreted through urine. Serum creatinine is a very common tool of renal assessment in diabetic nephropathy. This study aims at observation of existing correlation between serum creatinine and urine albumin in diabetic nephropathy patients. This cross sectional observational study has been conducted on 50 diabetic patients admitted to medicine department of Dhaka Medical College Hospital. Patients were included in this study after fulfilling inclusion and exclusion criteria in a period January 2018 to June 2018. After selection, data were collected by structured questionnaire. Then 24 hour urinary total protein, urine for microalbumin, complete blood count, fasting blood sugar, two hours postprandial blood sugar, HbA1C, serum creatinine report were collected and analyzed it with the help of SPSS 16.0 MS excel. Among total 50 patients, 34 patients were diagnosed on the basis of microalbuminuria and the rest were found to have raised urinary total protein. The male patients were 54 percent of the total population. Most of the patients were in between the age of 57 to 67 years. The r value is insignificant in two graphs where serum creatinine was compared with urine microalbumin and serum creatinine respectively, which suggests absence of linear or any other correlation between these two components. The estimated Glomerular Filtration Rate (eGFR) was calculated by MDRD equation individually. Staging was done on the base of eGFR. Only 41.37% of the patients with microalbuminuria, showed eGFR consistent with its staging while only 31.5% of the patients with proteinuria showed respective expected eGFR. And the difference between the mean serum creatinine in two groups was insignificant. This study has shown that, the serum creatinine has no linear correlation with urinary albumin in diabetic nephropathy patients. So, commonly used serum creatinine based formula to calculate the estimated GFR cannot reflect the amount of urinary protein excretion all the time. So it can misinterpret the staging of the disease which can delay the appropriate treatment of the patient. J Dhaka Medical College, Vol. 27, No.2, October, 2018, Page 141-147

scholarly journals Clinical profile and management outcome of Parathyroid Adenoma - A 7 years retrospective study

2015 ◽  
Vol 20 (1) ◽  
pp. 27-34
Author(s):  
Md Arif Hossain Bhuyan ◽  
Abu Yusuf Fakir ◽  
Md Nurullah ◽  
Md Abdullah Hil Kafi ◽  
Sk Nurul Fattah Rumi ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Serum Creatinine ◽  
Serum Creatinine Level ◽  
Parathyroid Adenoma ◽  
Creatinine Level ◽  
Medical College Hospital ◽  
Clinical Profile ◽  
Emission Computed Tomography ◽  
College Hospital ◽  
Medical College

The study aims to present the clinical profile and management outcomes of parathyroid adenoma patients in our institutions. This retrospective study included ten patients with parathyroid adenoma presented to Department of Otolaryngology and Head-Neck Surgery at Dhaka Medical College Hospital and Ibn Sina Medical College Hospital, Dhaka from January 2004 to January 2011.Out of 10 patients, 8 were female. Average age of presentation was 50 years. 6 patients were symptomatic and 4 were asymptomatic. In 8 patients, serum creatinine level was within normal limits and 2 patients had elevated serum creatinine level. All 10 patients had hypercalcaemia and increase parathormone level, from mild to severe. CT guided fine needle aspiration cytology diagnosed 2 cases preoperatively. 6 patients diagnosed with 99mTc Sestamibi scan and 3 patients diagnosed by single photon emission computed tomography (SPECTCT) dual isotope (I-123/99mTc-MIBI) substraction for imaging parathyroid adenoma. All the patients underwent parathyroidectomy except for 1 patient in whom hemithyroidectomy was done. Postoperative period was not without complications but has been managed with strong monitoring. Long term follow up was done up to 1 year with 100% cure rate. DOI: http://dx.doi.org/10.3329/bjo.v20i1.22014 Bangladesh J Otorhinolaryngol; April 2014; 20(1): 27-34

STUDY OF OUTCOME OF CHRONIC KIDNEY DISEASE IN DIABETIC PATIENTS IN THANJAVUR MEDICAL COLLEGE HOSPITAL

2021 ◽  
pp. 17-20
Author(s):  
S.Hema Akilandeswari ◽  
K. Rajkanth ◽  
S. Janani
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Glycemic Control ◽  
Medical College Hospital ◽  
Diabetic Patients ◽  
Type I ◽  
Strong Positive Correlation ◽  
College Hospital ◽  
Medical College

Background: Diabetes Mellitus is one of the common causes of Chronic Kidney Disease which usually leads to end-stage kidney disease. Thus this study was planned to nd out the outcome of CKD in DM, disease progression, appropriate management and the complications. Methods: A cross sectional study among Diabetes Mellitus patients with Chronic Kidney Disease attending the Department of Nephrology and Department of Medicine in Thanjavur Medical College Hospital during the period of July and August 2018. The duration of study period was 2 months. All patients who attended the outpatient department (OPD) and in-patients departments with Type I and Type II diabetes mellitus associated with chronic kidney disease, on any line of management were included in this study. A total of 101 patients were included. Statistical Package for Social Sciences (SPSS for Windows V20) was used for data analysis. Results: Poor glycemic control, albuminuria, hypertriglyceridemia (greater than 150), increase in LDLlevels (greater than 100), BMI (greater than or equal to 25), poor BP control and a longer duration of diabetes mellitus had a strong positive correlation with decrease in eGFR less than 60 ml/min. Glycemic control, weight reduction and adequate BPcontrol retard the progression of CKD. Conclusion: Albuminuria and decline in eGFR both are independent risk factors for diabetic CKD and are strong predictors of morbidity and mortality from a major vascular event, especially cardiovascular complications and stroke.

Clinical Evaluation of the Effect of Daio (Rhei Rhizoma) on the Progression of Diabetic Nephropathy with Overt Proteinuria

2003 ◽  
Vol 31 (02) ◽  
pp. 267-275 ◽  
Author(s):  
Hirozo Goto ◽  
Yutaka Shimada ◽  
Kiyoaki Tanikawa ◽  
Shigehiko Sato ◽  
Hiroaki Hikiami ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Serum Creatinine ◽  
Serum Creatinine Level ◽  
Creatinine Level ◽  
Herbal Medicines ◽  
Control Group ◽  
Dialysis Treatment ◽  
Rhei Rhizoma ◽  
The Mean ◽  
Overt Proteinuria

We studied the effect of traditional herbal medicines containing Daio (Rhei Rhizoma) on the long-term progression of diabetic nephropathy with overt proteinuria in eight patients [mean age 60 (45–73) years; duration of diabetes 18 (7–36) years]. At the beginning of the study, mean HbA1c was 8.2% and mean serum creatinine was 1.0 ± 0.3 mg/dl. Every patient had diabetic neuropathy and retinopathy. Three of the patients had hypertension and four had ischemic heart disease. After 107 ± 25 months, the mean serum creatinine level had significantly increased to 4.8 ± 2.6 mg/dl. The mean serum creatinine levels of five patients not advancing to dialysis treatment increased from 1.2 ± 0.3 to 3.2 ± 1.0 mg/dl, and the three patients requiring dialysis increased from 0.8 ± 0.1 to 7.5 ± 2.1 mg/dl. In the control group, treated without traditional herbal medicines, the mean serum creatinine level had significantly increased from 1.0 ± 0.3 to 9.5 ± 1.9 mg/dl after 71 ± 12 months. All of the control group required dialysis treatment. Diabetic nephropathy with overt proteinuria is reported to develop into renal failure after 6–7 years. In this retrospective study, traditional herbal medicines with Daio were considered to be effective in prolonging the pre-dialysis period of diabetic nephropathy.

scholarly journals Lifestyle Pattern and Knowledge about Diabetes Mellitus

2019 ◽  
Vol 31 (2) ◽  
pp. 102-104
Author(s):  
Kartick Chanda Shaha ◽  
Shima Akhter Khatun ◽  
Nafisa Mustafa ◽  
Farzana Ahmed ◽  
Mohammed Asaduzzaman Khan
Keyword(s):  
Diabetes Mellitus ◽  
Medical College Hospital ◽  
High Rate ◽  
Outpatient Department ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
College Hospital ◽  
Medical College ◽  
Adherence To Diet

Introduction:The aim of the present study was to assess the pattern of lifestyle and knowledge about diabetes mellitus among type 2 diabetic patients at two tertiary level hospitals in Mymensingh Materials and Methods: A descriptive, cross sectional study was conducted from July 2015 to December 2015 among 300 patients attending at Medicine outpatient department of the Community Based Medical College Hospital and Endocrine outpatient department of the Mymensingh Medical College Hospital after obtaining requisite consent from the patients. Data were collected through the interviewing of the patients. The collected data were entered into the computer and analyzed by using SPSS version 20.1. The study was approved by the institutional ethical committee. Results: In a pool of 300 type 2 diabetics, Most of the patients (57.3%) belonged to the middle age group 41-60 years. More than half of the respondents were female (n=223, 74.3%). 97% patients were found to have knowledge about timing of dose regimen. Majority of patient’s (35.7%) knowledge about hypoglycemia was poor. The rate of adherence to diet was 51%. The rate of adherence to exercise was 68.3%. Conclusion: Majority of type 2 DM patients displayed optimal level of diabetes knowledge. There was a high rate of non adherence to diet and exercise recommendations by patients suffering from type 2 diabetes mellitus. So continuous patient education and awareness program are required. Medicine Today 2019 Vol.31(2): 102-104

scholarly journals Dietary Diversity and Associated Health Status of Newly Diagnosed Type 2 Diabetic Patients in Jashore Region of Bangladesh

2020 ◽  
pp. 438-453
Author(s):  
Sharmin Sultana ◽  
Nazia Nawshad Lina ◽  
Md. Tarek Hasan ◽  
Md. Jannatul Ferdaus ◽  
Biplab Kumar Dash ◽  
...  
Keyword(s):  
Health Status ◽  
Serum Creatinine ◽  
Serum Creatinine Level ◽  
Creatinine Level ◽  
Glucose Level ◽  
Dietary Diversity ◽  
Leafy Vegetables ◽  
Diabetic Patients ◽  
Newly Diagnosed

Lack of adequate dietary diversity may contribute to the deterioration of health and nutritional status of newly diagnosed type 2 diabetes mellitus (T2DM) patients. This cross-sectional study was designed to assess the dietary diversity and related health status of 110 newly diagnosed T2DM patients. The diabetes history of the subjects was collected from the hospital’s e-database. IDDS (individual dietary diversity score) was measured based on the FFQ (food frequency questionnaire) according to the FAO guidelines for measuring household and individual dietary diversity. BMI (body mass index), FBG (fasting blood glucose) level, 2h-PG (two-hour plasma glucose) level, serum creatinine level, and any signs of macro and microvascular diseases were recorded. The mean±SD of IDDS was moderate, 5.74±0.85. About half of the newly diagnosed diabetic patients consumed foods with high diversity. All respondents consumed starchy foods and about half of them did not consume any green leafy vegetables. Younger patients had a lower tendency to take high IDDS diets than the older. About half of individuals were overweight or obese. Higher IDDS and lower BMI, hypertension, serum creatinine, FBG, and 2-HPG were found among males than that of the females. Approximately 35% and 20% patients had microvascular and macrovascular complications respectively.The BMI and serum creatinine level of newly diagnosed diabetic patients were negatively affected by the IDDS. Dietary diversity and varied socio-demographic determinants were found to be related to the health status of diabetics.

scholarly journals Comparative effectiveness of sitagliptin and vildagliptin in the management of patients with type 2 diabetes mellitus undergoing haemodialysis: an Indian rural tertiary care centre experience

2018 ◽  
Vol 7 (7) ◽  
pp. 1268
Author(s):  
Suthakaran C. ◽  
Bhaskaran S.
Keyword(s):  
Diabetic Nephropathy ◽  
Glycaemic Control ◽  
Serum Creatinine ◽  
Insulin Glargine ◽  
Tertiary Care ◽  
Glycated Haemoglobin ◽  
Routine Care ◽  
Diabetic Patients ◽  
Urine Albumin

Background: The prevalence of chronic kidney disease is increasing with diabetic nephropathy as the common underlying cause. Although numerous drugs are being used to improve glycaemic control, evidence in patients with diabetic nephropathy is sparse. The aim of the present was to evaluate the effectiveness of sitagliptin or vildagliptin addition on glycaemic control in patients with T2DM undergoing haemodialysis as part of their routine care in a rural tertiary care setting.Methods: Type 2 diabetic patients on maintenance haemodialysis as part of routine care and whose glycaemia was not controlled adequately and prescribed one of the oral gliptins once daily in addition to existing therapy for a period of 24 weeks were included in the present study. Effectiveness was assessed in terms of glycaemic control as measured by the change over time in glycated haemoglobin. Data analysis included glycated haemoglobin, body weight, serum creatinine, urine albumin creatinine ratio and the occurrence of hypoglycaemia.Results: Significant reduction in glycated haemoglobin values were noted after 24 weeks of therapy with gliptins similar to insulin glargine with a small weight loss. There was an insignificant decrease in the serum creatinine and urine albumin excretion levels after treatment with vildagliptin with Vildagliptin producing a slightly higher decrease but there was no correlation with changes in A1c levels. The overall incidence of adverse experiences was low and generally mild in both groups.Conclusions: In a group of Asian Indian patients with diabetic nephropathy due to T2DM undergoing haemodialysis in whom glycaemia was not controlled adequately, addition of gliptins helped to achieve glycaemic control to a similar extent as insulin glargine but with a marginal weight advantage.

scholarly journals A COMPARATIVE ASSESSMENT OF SERUM CREATININE AND CYSTATIN C AS A SIGNIFICANCE OF NEPHROPATHY IN DIABETIC PATIENTS

2020 ◽  
Vol 20 (3) ◽  
pp. 189-194
Author(s):  
Maytham Salim Al-Nasrawii ◽  
Balqees Sadoon Jasim ◽  
Salim Hussein Hassan
Keyword(s):  
Diabetic Nephropathy ◽  
Serum Creatinine ◽  
Creatinine Level ◽  
Cystatin C ◽  
Vascular Complications ◽  
Diabetic Patients ◽  
Serum Cystatin C ◽  
Early Evaluation ◽  
Type2 Diabetes ◽  
Cystatine C

The critical micro-vascular complications of diabetes ultimately result in renal dysfunction known as diabetic nephropathy (DN). Measurement of glomerular filtration rate (GFR) is considered to be an important parameter in renal function assessment, evaluating GFR by Creatinine level. Recently, Cystatin C is used as a substitute indicator in several studies to assess diabetic nephropathy. This work was conceived to determine whether serum cystatinC would replace serum creatinine (Scr) in patients with type2 diabetes for early evaluation of nephropathy. A Case-Control Study was enrolled on 30 Patients with diabetic and 30 apparently healthy as control, aged between 25 - 83 years. Levels of serum cystatine C and serum Creatinine were calculated for both groups. Serum Creatinine, as well as serum cystatin C levels, was significant relationship with diabetic pt. in compared to non-diabetic individuals. ROC analysis noted the cystatinC was more predict indicator in diagnosed Diabetic Nephropathy (DNP) from Serum Creatinine level. In Type 2 diabetics, CystatinC is a good marker for uncontrolled diabetic nephropathy relative to serum creatinine.

Sign in / Sign up

Export Citation Format

Share Document