The effect of hydroalcoholic extract of Mentha Pulegium on anxiety in male rats

Introduction: The number of neurons in the hippocampus can have a direct effect on its function. The plant Brazembel from the mint family may have antioxidant properties. The aim of the present study was to investigate the effects of stress and Brazmble extract on neuronal density of CA1, CA2 in male rats. Methods: In this experimental study, Wistar rats were divided into 6 groups (n=5), including control, and negative control under stress, also experimental group,including stress and get Brazmbl doses of the extract mL 50, mL 75 and mL 100. Limiting stress for 21 days, the rats were exposed in 2 hours. Groups receiving the extract for 21 days, to get inside limiting extracts were gavaged. After removal of the brain by perfusion, the hippocampus was excised and stained, and the neuronal density was calculated by dissector and metasteriology. The results were analyzed by Minitab 16 software with t-test and ANOVA at a significant level (P <0.05). Results: Statistical analysis of the data showed that the mean neuronal density in the stress group compared to the control in CA1 and CA2 had a significant decrease (p <0.01). The mean neuronal density of CA1 region between the stress group (29 ± 3) and hydroalcoholic treatment at 50 mg / kg (25 ± 3) showed a significant increase. In addition, the mean neuronal density in the stress group with 75 mg / kg extract (27±3) and in the group treated with hydroalcoholic extract was 100 mg / kg (25 ± 3). Mean neuronal density of CA2 region between the stress (21 ± 3) and hydroalcoholic treatment at 50 mg / kg (28 ± 3) groups showed a significant increase (p <0.01). The mean neuronal density in the stress group with 75 mg / kg extract was 27 ± 3 and in the hydroalcoholic extract treatment group was 100 mg / kg (22 ± 3), which increased significantly compared to the stress group (p <0.01). Conclusion: The results of the current study show that the hydroalcoholic extract of plant Bromzebel probably increases the neuronal density of the brain hippocampus due to its polyphenolic substances such as flavonoids, which is due to its high antioxidant properties.

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Feeding hydroalcoholic extract powder ofLepidium meyenii(maca) increases serum testosterone concentration and enhances steroidogenic ability of Leydig cells in male rats

Andrologia ◽

10.1111/and.12453 ◽

2015 ◽

Vol 48 (3) ◽

pp. 347-354 ◽

Cited By ~ 12

Author(s):

Y. Ohta ◽

K. Yoshida ◽

S. Kamiya ◽

N. Kawate ◽

M. Takahashi ◽

...

Keyword(s):

Leydig Cells ◽

Serum Testosterone ◽

Male Rats ◽

Hydroalcoholic Extract ◽

Testosterone Concentration

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Evaluation of Antidiabetic and Antihyperlipidemic Effects of Peganum harmala Seeds in Diabetic Rats

Cholesterol ◽

10.1155/2016/7389864 ◽

2016 ◽

Vol 2016 ◽

pp. 1-6 ◽

Cited By ~ 3

Author(s):

Gholamreza Komeili ◽

Mohammad Hashemi ◽

Mohsen Bameri-Niafar

Keyword(s):

Total Cholesterol ◽

Glycosylated Hemoglobin ◽

Diabetic Rats ◽

Male Rats ◽

Peganum Harmala ◽

Hydroalcoholic Extract ◽

End Of Treatment ◽

Total Antioxidant ◽

Treatment Of Diabetes ◽

Different Doses

The present study was carried out to investigate the antidiabetic and antihyperlipidemic properties of hydroalcoholic extract of Peganum harmala in streptozotocin-induced diabetic male rats. In an experimental study, 64 normal Wistar albino male rats (200–230 g) were randomly divided into 8 groups. Control and diabetic rats were treated with normal saline and three different doses (30, 60, and 120 mg/kg) of hydroalcoholic extract of Peganum harmala seeds for 4 weeks orally. At the end of treatment, blood samples were taken and glucose, triglycerides, total cholesterol, LDL-c, HDL-c, malondialdehyde (MDA), total antioxidant capacity (TCA), ALT, AST, GGT, bilirubin, and glycosylated hemoglobin (HbA1C) were determined. STZ-induced diabetic rats showed significant changes in the values of glucose, triglycerides, total cholesterol, LDL-c, MDA, TAC, ALT, AST, GGT, bilirubin, and HbA1C in comparison with normal rats. Administration of the extract to diabetic rats resulted in a remarkable decrease in glucose, lipid profiles, MDA, ALT, AST, GGT, bilirubin, and HbA1C levels and increase in TAC relative to diabetic group. The results of this study indicated that hydroalcoholic extract of Peganum harmala seeds possesses antidiabetic and hypolipidemic activities and could be useful in treatment of diabetes.

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Effect of Hydroalcoholic Extract of Truffle (Terfezia Boudieri) on Serum Level of Thyroid Hormones in Male Rats

Journal of Arak University of Medical Sciences ◽

10.32598/jams.22.6.2949.2 ◽

2019 ◽

pp. 182-191

Author(s):

Eslam Zabihi ◽

Seyed Eqbal Motavallibashi ◽

Hamdollah Panahpour ◽

Hamid Sheikhkanloui Milan

Keyword(s):

Serum Level ◽

Thyroid Hormones ◽

Male Rats ◽

Hydroalcoholic Extract ◽

Terfezia Boudieri

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The Dynamics of Subcutaneous Tissue Response to Microorganisms Associated with the Extract of Araçá (Psidium cattleianum): An Edemogenic and Microscopic Analysis

Brazilian Dental Science ◽

10.14295/bds.2017.v20i2.1408 ◽

2017 ◽

Vol 20 (2) ◽

pp. 93 ◽

Cited By ~ 1

Author(s):

Alessandra Cury Machado ◽

Denise Belucio Ruviere ◽

Renata Zoccal Novais ◽

Carlos Roberto Emerenciano Bueno ◽

Elerson Gaetti Jardim Jr ◽

...

Keyword(s):

Subcutaneous Tissue ◽

Tissue Response ◽

Male Rats ◽

Saline Control ◽

Control Group ◽

Dorsal Region ◽

Hydroalcoholic Extract ◽

Psidium Cattleianum ◽

Significant Difference

Objective: To evaluate in vivo tissue reaction to the extract of araçá (Psidium cattleianum) associated with inactivated microorganisms. Material and Methods: A 0.1 mL suspension was used containing Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, Enterococcus faecalis, Peptostreptococcus micros, and Porphyromonas endodontalis, which were inactivated by heat and mixed into a 1.0 mL saline (control group), an aqueous solution, or a hydroalcoholic extract of araçá. Eighteen male rats (Rattus norvegiccus) under general anesthesia received 0.2 mL of 1% intravenous Evans blue. Thirty minutes later, 0.1 mL of one of the associations was injected into the animals’ dorsal region. The animals were euthanized after 3 and 6 hours, and the materials obtained were placed in formamide for 72 hours then analyzed in a spectrophotometer (λ=630 hm). For the morphological analysis, 30 rats received polyethylene tubes implants with the extracts or the saline with the associations in the dorsal region and euthanized after 7 and 30 days to be analyzed according to an inflammation cell score. Results: No significant difference (p>0.05) was observed in the edema among groups. The optical microscopy results showed a repair in the 30-day-period, which was higher when compared to the 7-day-period (p<0.0001). Nevertheless, in the 7-day-period, the hydroalcoholic extract presented a significant response compared to the aqueous extract (p=0.05) and a trend for better results than the control group. Conclusion: The aqueous and hydroalcoholic araçá extracts associated with inactivated microorganisms showed similar responses to control, indicating no interference on the toxic effects of the bacterial components in tissue repair.KeywordsAnaerobic bacteria; Edema; Inflammation; Plant extracts; Psidium.

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Efficacy of Eggplant Hydroalcoholic Extract on Blood Lipid Indice in Streptozotocin-Induced Diabetic Male Rats

journal of ilam university of medical sciences ◽

10.29252/sjimu.26.2.180 ◽

2018 ◽

Vol 26 (2) ◽

pp. 180-188

Author(s):

Zohre Nikbakht ◽

Saeed Valipour-Chahardahcharic ◽

Hosein Sazegar ◽

◽

...

Keyword(s):

Blood Lipid ◽

Male Rats ◽

Hydroalcoholic Extract

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Investigating the effect of Crocus sativus L. petal hydroalcoholic extract on inflammatory and enzymatic indices resulting from alcohol use in kidney and liver of male rats

Journal of Inflammation Research ◽

10.2147/jir.s216125 ◽

2019 ◽

Vol Volume 12 ◽

pp. 269-283 ◽

Cited By ~ 1

Author(s):

Monireh Azizi ◽

Naser Abbasi ◽

Mojtaba Mohamadpour ◽

Salar Bakhtiyari ◽

Sirous Asadi ◽

...

Keyword(s):

Alcohol Use ◽

Crocus Sativus ◽

Male Rats ◽

Hydroalcoholic Extract

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Evaluation of Wound Healing Activity of Sea Cucumber Holothuria parva Hydroalcoholic Extract in Rat

The International Journal of Lower Extremity Wounds ◽

10.1177/15347346211059331 ◽

2021 ◽

pp. 153473462110593

Author(s):

Associate professor Elnaz Bazmakdar ◽

Professor Eskandar Moghimipour ◽

Associate professor Neda Sistani Karampour ◽

Annahita Rezaie ◽

Professor Seyed Mohammad Bagher Nabavi

Keyword(s):

Wound Healing ◽

Granulation Tissue ◽

Sea Cucumber ◽

Positive Control ◽

Negative Control ◽

Male Rats ◽

Hydroalcoholic Extract ◽

Treatment Groups ◽

Accelerate Wound Healing ◽

Good Potential

A significant challenge in biomedicine is the development of Biomaterials with the potential to accelerate wound healing. The aim of this study was to investigate the effect of the gel prepared from sea cucumber on wound healing in rats. Full-thickness wounds were created in male rats divided into five experimental groups, negative control (NC), positive control (PC), and treatments. The NC and PC groups received respectively gel base and phenytoin cream 1%. Treatment groups were treated topically by gels of 1%, 3%, and 5% Holothuria parva extract (HPE) in the gel base. The rats were sacrificed on days 7, 14, and 21. Pathological reports revealed the proliferation of keratinocytes in the borders of the wound in treatment groups and controls. Formation of granulation tissue was seen on day 7 in treatment groups, collagen fibers in granulation tissue were randomly organized, and the rate of fibroblast decreased. Results showed that there were statistically significant differences in wound contraction between all groups in comparison to the NC group ( P < .05) on day 8. It was concluded that the 1% HPE gel has a good potential for promoting wound healing. [Formula: see text]

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