scholarly journals The Factors Associated With Olfactory Dysfunction in Patients with Multiple Sclerosis

2021 ◽  
Vol 12 (1) ◽  
pp. 89-94
Author(s):  
Mostafa Almasi ◽  
◽  
Mohammad Ali Sahraian ◽  
Fahimeh Haji Akhoundi ◽  
Hamid Reza Ezzati ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Disease Duration ◽  
Admission Rate ◽  
Cross Sectional Study ◽  
Olfactory Dysfunction ◽  
Olfactory Function ◽  
Older Age ◽  
Cross Sectional ◽  
Hospital Admission Rate ◽  
Secondary Progressive

Introduction: An impaired sense of smell has a remarkable impact on the quality of life. It is seen in a variety of neurodegenerative diseases such as Parkinson disease. In this study, we assessed the olfactory function in patients with Multiple Sclerosis (MS) by Sniff Magnitude Test (SMT). Methods: A cross-sectional study was conducted on 48 patients with MS. A questionnaire, including demographic and clinical variables, was completed for each patient. The SMT was used for the evaluation of olfactory function. Results: Olfactory dysfunction was found in 14.6% of patients (8.3% hyposmia and 6.3% anosmia). Older age, longer disease duration, higher hospital admission rate, lower mini-mental status examination score, and secondary progressive course of MS were significantly related to olfactory dysfunction. Conclusion: Secondary progressive MS and markers of advanced disease toward neurodegenerative phase (including older age, longer disease duration, and lower cognitive function) can be associated with olfactory dysfunction in MS patients.

Olfactory threshold is impaired in early, active multiple sclerosis

2011 ◽  
Vol 17 (8) ◽  
pp. 964-969 ◽  
Author(s):  
A Lutterotti ◽  
M Vedovello ◽  
M Reindl ◽  
R Ehling ◽  
F DiPauli ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Disease Duration ◽  
Demographic Data ◽  
Olfactory Function ◽  
Olfactory Threshold ◽  
Perception Threshold ◽  
Cross Sectional ◽  
Odour Perception

Background: Olfactory dysfunction has been reported in multiple sclerosis (MS). However, to date no data are available on different qualities of olfactory function, namely odour identification, odour discrimination and odour perception threshold. Objective: To assess different qualities of olfactory function in patients with MS and correlate these with demographic data, clinical data, depression, quality of life and cognitive functions. Methods: In this cross-sectional study, 50 patients with MS or clinically isolated syndrome and 30 healthy controls were included. Olfactory function was measured using the Sniffin’ Sticks test. Results: The scores for odour identification ( p = 0.001), odour perception threshold ( p = 0.037) and the combined score of odour identification, discrimination and perception threshold (TDI, p = 0.002) were significantly lower in MS. Hyposmia for identification ( p = 0.0017), threshold ( p = 0.017) and TDI score ( p = 0.0014) was more frequent in MS. Olfactory threshold was impaired in patients who were clinically active in the previous year ( p = 0.026) and in patients with a disease duration less than 2 years ( p = 0.0093). Identification score was negatively correlated with disease duration ( p = 0.0017). Olfactory function was not associated with disability, depression or quality of life. Conclusions: We report evidence for qualitatively distinct hyposmia in MS, with increased smell threshold in the early inflammatory phases of the disease and impaired identification with a more widespread chronic disease.

scholarly journals High prevalence of fatigue in contemporary patients with multiple sclerosis

2021 ◽  
Vol 7 (1) ◽  
pp. 205521732199982
Author(s):  
Line Broch ◽  
Cecilia Smith Simonsen ◽  
Heidi Øyen Flemmen ◽  
Pål Berg-Hansen ◽  
Åshild Skardhamar ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Disease Severity ◽  
Daytime Sleepiness ◽  
Disease Duration ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Disease Modifying Drugs ◽  
High Prevalence ◽  
The Mean ◽  
Anxiety Depression

Objective The prevalence of multiple sclerosis (MS)-related fatigue may have changed due to new diagnostic criteria and new disease modifying drugs. We aimed to assess the prevalence of fatigue in a contemporary MS cohort, and to explore associations between fatigue and clinical and demographic factors. Methods This is a cross-sectional study of the MS population in three Norwegian counties. Fatigue was assessed with the Fatigue Scale for Motor and Cognitive Functions (FSMC). We also assessed self-reported anxiety, depression and daytime sleepiness. Results The response rate was 64% (1599/2512). The mean age of the participants was 52 ± 13 years, median EDSS was 2.5 (IQR 1.5-3.0) and median disease duration from onset was 16 years (IQR 8-25). We found a prevalence of fatigue of 81%. Women had a higher prevalence of fatigue than men (83% vs 78%, p = 0.02). The prevalence increased with age (p < 0.001) and with increasing disease severity (p < 0.001), but in multivariate analyses, only sex and disease severity remained independent determinants of fatigue. Anxiety, depression, and daytime sleepiness were more prevalent in patients with fatigue than in those without fatigue (all p-values < 0.001). Conclusion The prevalence of fatigue is high in contemporary patients with MS. Fatigue is associated with female sex and level of disability, as well as with anxiety, depression and excessive daytime sleepiness.

scholarly journals Older patients' utilisation of emergency department resources: a cross-sectional study

2001 ◽  
Vol 24 (3) ◽  
pp. 44 ◽  
Author(s):  
Kevin Chu ◽  
Anthony Brown
Keyword(s):  
Emergency Department ◽  
Hospital Admission ◽  
Older Patients ◽  
Admission Rate ◽  
Cross Sectional Study ◽  
Resource Utilisation ◽  
Sectional Study ◽  
Cross Sectional ◽  
Hospital Admission Rate ◽  
After Hours

A cross-sectional study was conducted to investigate older patients' utilisation of emergency department resources.Patients aged >65 years, compared with adults <65 years, were more likely to be triaged to higher clinical urgency categories. They have a higher hospital admission rate and longer length-of-stay even after adjusting for triage category.Patients >80 years, compared with 65-79 years, were more likely to be triaged to higher urgency categories. These groups had similar hospital admission rates and lengths-of-stay. Patients �65 years presented in similar numbers during office-hours and after-hours, but after-hours attendances were more likely to be triaged to higher urgency categories. The greater emergency department resource utilisation by older people has implications for the provision of health services in an aging population.

scholarly journals Evaluation of Quality of Life among Patients with Multiple Sclerosis and voiding dysfunction: A Cross-Sectional Study

2019 ◽  
Author(s):  
Fatemeh Nazari ◽  
Vahid Shaygannejad ◽  
Mehrdad Mohammadi Sichani ◽  
Marjan Mansourian Gharaagozlou ◽  
Valiollah Hajhashemi
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Disease Duration ◽  
Voiding Dysfunction ◽  
Cross Sectional Study ◽  
Urinary Symptoms ◽  
Sectional Study ◽  
Cross Sectional ◽  
Urinary Problems

Abstract Background: Evaluating the usefulness of treatment requires a direct measurement of the health-related quality of life (QOL). Therefore, this study was carried out aiming to determine the QOL of patients with MS and voiding dysfunction . Materials and Methods: This cross-sectional study was carried out using multi-stage random cluster sampling method on 602 patients with MS in Isfahan, Iran. All data were collected through interviews using standard questionnaires including International Prostate Symptom Score (IPSS), and the Multiple Sclerosis Quality of Life-54 (MSQOL-54). Data were analyzed using descriptive and inferential statistical tests. Results: The prevalence rate of mixed, irritative, and obstructive urinary symptoms was 52.2%, 25.5%, and 6.5%, respectively. The mixed symptom had the highest prevalence among men and women with rates of 56.5% and 51.1%, respectively. The prevalence of irritative and obstructive symptoms was, respectively, higher and statistically significant among women alone and men alone (P < 0.05). The prevalence of irritative symptoms was higher among patients with MS, EDSS score ≤ 3, disease duration of less than 5 years, and with clinically isolated syndrome. In addition, the prevalence of mixed symptoms was higher among patients with MS of over 30 years of age with a Pre-high school degree, severe disability, disease duration of over 10 years, and progressive MS; the difference was statistically significant (P < 0.05). There was a difference in the combined dimensions of physical and mental health of QOL between the two groups with and without urinary symptoms (P < 0.05). Logistic regression analysis revealed that there was a higher probability of a urinary problems among patients with MS and high age [3.273 (1.083-9.860); P = 0.035]. Conclusions: Mixed urinary symptoms are highly prevalent among MS patients and affect QOL dimensions. In order to improve QOL, more attention and focus should be paid to urinary problems in MS patients. Keywords: Multiple sclerosis, urinary symptoms, quality of life

scholarly journals Functional and self-care capacity of people with multiple sclerosis

2019 ◽  
Vol 27 ◽  
Author(s):  
Ana Railka de Souza Oliveira-Kumakura ◽  
Larissa Maria Bezutti ◽  
Juliany Lino Gomes Silva ◽  
Renata Cristina Gasparino
Keyword(s):  
Multiple Sclerosis ◽  
Activities Of Daily Living ◽  
Daily Living ◽  
Disease Duration ◽  
Self Care ◽  
Cross Sectional Study ◽  
Strongly Correlated ◽  
Cross Sectional ◽  
Care Capacity

Objective: describe the self-care and functionality levels of patients with multiple sclerosis and determine whether sociodemographic, clinical and functional variables interfere with self-care and/or functionality. Method: correlational, cross-sectional study with a quantitative approach performed with individuals in outpatient follow-up. We collected sociodemographic and clinical data and applied the Appraisal of Self-care Agency Scale, the Barthel index, the Lawtton and Brody Scale, and the instrument to investigate the performance in Advanced Activities of Daily Living. We performed descriptive and inferential analysis. Results: most patients were classified as “having self-care” (82.14%); with moderate dependence (51.19%) for the basic activities of daily living, partial dependence for the instrumental activities of daily living (55.95%), and more active for the advanced activities of daily living (85.71%). Patients with longer disease duration had a higher number of disabilities and, in those with better socioeconomic and educational profile, the functionality was better. Conclusion: disease duration was strongly correlated with a higher number of disabilities and better socioeconomic and educational profiles showed to be protective factors for functionality. Care planning should consider the needs observed by the multidisciplinary team, stimulating the development of self-care, functionality and sociability.

scholarly journals Modeling of Cognitive Impairment by Disease Duration in Multiple Sclerosis: A Cross-Sectional Study

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e71058 ◽  
Author(s):  
Anat Achiron ◽  
Joab Chapman ◽  
David Magalashvili ◽  
Mark Dolev ◽  
Mor Lavie ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Disease Duration ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

Association between olfactory function and quality of life in patients with olfactory disorders: a multicenter study in over 760 participants

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
L-q. Zou ◽  
T. Hummel ◽  
M.S. Otte ◽  
T. Bitter ◽  
G. Besser ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Disease Duration ◽  
Olfactory Dysfunction ◽  
Olfactory Function ◽  
Self Assessment ◽  
Cross Sectional ◽  
Visual Analog Scales ◽  
Related Quality ◽  
The Individual

BACKGROUND: This cross-sectional, multi-centric study aimed to investigate the differences in quality of life among patients with olfactory dysfunction (OD) of different origin, and to identify factors associated with olfactory-related quality of life (QOL). METHODS: Seven hundred sixty-three adults were recruited from 8 Smell & Taste clinics in Germany, Switzerland, and Austria. Olfactory-related QOL was assessed by the Questionnaire of Olfactory Disorders (QOD). Olfactory function was assessed with the “Sniffin’ Sticks” test; self-assessment was performed with visual analog scales. RESULTS: Patients with post-infectious and post-traumatic OD showed poorer olfactory-related QOL than patients with sinonasal and idiopathic OD. The olfactory-related QOL was positively associated with the Sniffin’ Sticks test score, self-assessed olfactory function, disease duration, and age, with younger olfactory dysfunction patients showing lower QOL. Female patients presented with poorer olfactory-related QOL. In addition, the results showed that self-assessment of olfactory function explained more of the variance in olfactory-related QOL than olfactory function evaluated by the Sniffin’ Sticks test. CONCLUSIONS: In addition to the psychophysical testing results, several factors such as disease cause, disease duration, sex, or self- assessed olfactory dysfunction should be taken into account when assessing the individual severity of the smell loss.

Smelling multiple sclerosis: Different qualities of olfactory function reflect either inflammatory activity or neurodegeneration

2018 ◽  
Vol 26 (1) ◽  
pp. 57-68 ◽  
Author(s):  
Gabriel Bsteh ◽  
Klaus Berek ◽  
Harald Hegen ◽  
Barbara Teuchner ◽  
Michael Auer ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Function ◽  
Disease Duration ◽  
Olfactory Function ◽  
Odor Identification ◽  
Linear Regression Models ◽  
Olfactory Threshold ◽  
Short Term ◽  
Fiber Layer ◽  
Cross Sectional

Background: Peripapillary retinal nerve fiber layer (pRNFL) thickness and olfactory function are both emerging biomarkers in multiple sclerosis (MS). Impairment of odor identification and discrimination is an irreversible feature of more advanced MS suggested to be associated with neurodegeneration, while olfactory threshold is a transient feature of early, active MS possibly associated with short-term inflammatory disease activity. Objective: The aim of this study was to validate the association of olfactory (dys)function and parameters of MS disease course in a large cohort of MS patients and to correlate olfactory function with pRNFL thickness as a surrogate biomarker of neurodegeneration. Methods: In a cross-sectional design, olfactory function was assessed using the Sniffin’ Sticks test, which quantifies three different qualities of olfactory function (threshold, discrimination, and identification). pRNFL thickness was measured by spectral-domain optical coherence tomography (OCT). Results were correlated with age, sex, disease duration, relapses, Expanded Disability Status Scale (EDSS), cognitive function, depression, smoking, and pRNFL thickness by multivariable linear regression models. Results: We included 260 MS patients (mean age of 35.9 years, 68.7% female). Olfactory threshold correlated significantly with number of relapses in the year prior to assessment and shorter disease duration. Odor discrimination, identification, and their sum score were significantly correlated with longer disease duration, higher EDSS, and reduced cognitive function. pRNFL thickness was associated with identification and discrimination, but not with threshold. Conclusion: Olfactory threshold is a marker of short-term inflammatory relapse activity unrelated to parameters of neurodegeneration, while odor identification and discrimination are markers of neurodegeneration mostly independent of relapse activity. Assessment of olfactory function provides an opportunity to stratify MS patients with regard to inflammation and neurodegeneration.

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