scholarly journals The Effect of Discontinuation of Angiotensin-II Receptor Blocker on Therapeutic Effect of Synthetic Erythropoietin on Anemia Modification in Hemodialysis Patients

2019 ◽  
Vol 25 (3) ◽  
pp. 230-254
Author(s):  
Farid Reza Ejlali ◽  
◽  
Mahmood Reza Khazaei ◽  
Zahra Mostafavian ◽  
Jalil Moshari ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Hemodialysis Patients ◽  
Hemoglobin Level ◽  
Maintenance Hemodialysis ◽  
Angiotensin Ii Receptor Blocker ◽  
Angiotensin Ii Receptor ◽  
Before And After ◽  
In The Beginning

Aims The aim of this study was to evaluate the effect of discontinuation of losartan in response to synthetic erythropoietin therapy on hemoglobin level in patients on maintenance hemodialysis. Methods & Materials This study was a pre-and post-interventional clinical trial. The population of the study was hemodialysis patients with chronic renal failure. In the beginning of the study, and three months after removal of losartan, the patients’ hemoglobin changes were compared. Findings Hemoglobin was significantly increased at the end of the study in all patients (from 10.90±1.66 at the beginning of the study to 11.37±1.42g/dl at the end of 3 months, P=0.046). No significant changes were seen in the hemoglobin level before and after intervention between patients according age, sex, and duration of the disease. Conclusion There was a significant increase in hemoglobin level at the end of study after losartan discontinuation. But this increase did not have a significant relationship with patient’s age, sex as well as the duration of the disease.

Contribution of dialysis to endogenous oxalate production in patients with chronic renal failure

1994 ◽  
Vol 40 (8) ◽  
pp. 1544-1548 ◽  
Author(s):  
N C France ◽  
P T Holland ◽  
M R Wallace
Keyword(s):  
Renal Failure ◽  
Peritoneal Dialysis ◽  
Chronic Renal Failure ◽  
Isotope Dilution Mass Spectrometry ◽  
Product Inhibition ◽  
Maintenance Hemodialysis ◽  
Production Rates ◽  
Stable Isotope Dilution ◽  
Before And After ◽  
Buffering Agent

Abstract We tested the possibility that the buffering agents in dialysis bath fluid might contribute to increased endogenous oxalate production in dialyzed patients. Using stable isotope dilution mass spectrometry, we obtained oxalate production rates and pool sizes directly for 10 patients in chronic renal failure, 5 of whom were undergoing continuous ambulatory peritoneal dialysis (lactate-buffered fluid). All peritoneal dialysis patients had either increased oxalate production rates or expanded oxalate pools when compared with undialyzed patients in renal failure. From a further four patients receiving maintenance hemodialysis we took blood samples immediately before and after three consecutive dialysis sessions in which the bath-fluid buffering agent (bicarbonate or acetate) was alternated; we analyzed these samples for oxalate and key precursors by capillary gas chromatography. Plasma glycine and serine concentrations remained within the physiological range. Glycolate and oxalate concentrations decreased, but the oxalate remained above normal after dialysis. All changes were independent of the bath-fluid buffering agent. We suggest that dialysis might stimulate the formation of oxalate by removing product inhibition of a late catabolic step.

scholarly journals Thyroid Functions Before and After Maintenance Hemodialysis in Patients with Chronic Renal Failure.

1988 ◽  
Vol 35 (6) ◽  
pp. 865-876 ◽  
Author(s):  
SHINICHI SAKURAI ◽  
YOSHIHITO HARA ◽  
SHIRO MIURA ◽  
MICHIYUKI URABE ◽  
KENICHI INOUE ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Maintenance Hemodialysis ◽  
Before And After

scholarly journals Effect of Cool Dialysate on Depression in Patients with Chronic Renal Failure Treated with Hemodialysis: A Randomized Clinical Trial

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Maryam Farhadi ◽  
Zahra Mirhosseini ◽  
Sedigheh Rastaghi ◽  
Mostafa Rad
Keyword(s):  
Clinical Trial ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Hemodialysis Patients ◽  
Depression Severity ◽  
Control Groups ◽  
P Values ◽  
Severity Of Depression ◽  
The Mean ◽  
And Control

Background: Depression is one of the most common psychiatric problems in hemodialysis patients. Objectives: This study aimed to evaluate the effect of cool dialysate on depression in patients with chronic renal failure treated with hemodialysis. Methods: This randomized clinical trial was performed on 66 hemodialysis patients suffering from depression. Patients were selected by a convenience sampling method and divided equally into intervention and control groups randomly by permuted block allocation, each group containing 33 patients. Data were acquired with the Beck Depression inventory-I. The intervention and control groups underwent one month of treatment with cool dialysate at 35.5 and 37°C, respectively. The severity of depression for each group was measured at the end of each treatment stage and two weeks after the intervention. Data were analyzed using R version 25 software with a confidence level of 95%. Results: There was no statistically significant difference between the control and intervention groups before and after the intervention (P-values more than 0.05). While the mean of depression severity for the control group decreased from 26.15 ± 1.46 to 22.24 ± 2.00 (P-values < 0.01), the mean of depression severity for the intervention group decreased from 25.56 ± 1.28 to 22.41 ± 1.65 by the intervention (P-value > 0.05). Conclusions: The application of cool dialysate as a non-pharmacological method did not significantly reduce the severity of depression in patients undergoing hemodialysis. Therefore, it is advised to perform further studies that include more research units from different geographical locations, considering a longer intervening duration.

scholarly journals Evaluation of the cognitive and affective status in hemodialysis patients with chronic renal failure

2018 ◽  
Vol 71 (7-8) ◽  
pp. 222-226
Author(s):  
Aleksandra Jakovljevic ◽  
Vojkan Nestorovic ◽  
Mirjana Dejanovic ◽  
Zoran Bukumiric ◽  
Aleksandar Jakovljevic ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Reaction Time ◽  
Beck Depression Inventory ◽  
Simple Reaction Time ◽  
Hemodialysis Patients ◽  
Cognitive Status ◽  
Control Group ◽  
Simple Reaction ◽  
Before And After

Introduction. Hemodialysis patients with chronic renal failure, suffer from affective dysfunction to a variable extent. The aim of our study was to evaluate the cognitive and affective status in patients before and after hemodialysis. Apart from this, the goal of the study was to examine and compare the cognitive status of patients on dialysis in relation to the control group, but also in relation to laboratory parameters. Material and Methods. This research was a prospective study including 30 hemodialysis patients with chronic renal failure treated at the Department of Nephrology of the Health Center in Kosovska Mitrovica. The cognitive status of the subjects was evalueted by determining the simple reaction time to auditory and visual stimuli before and after hemodialysis sessions and using the Mini Mental Status Examination, while the affective status was evalueted by using the Beck Depression Inventory. Results. The analysis of the obtained results showed a statistically significantly lower auditory and visual simple reaction times (p = 0.014) after dialysis (p = 0.023). The results have confirmed a statistically significantly decreased simple reaction time to visual stimuli (p = 0.001), while a statistical significance (p = 0.137) was not obtained for the auditory stimuli when compared to the control group. The Mini Mental Status Examination and the Beck Depression Inventory did not indicate a significant cognitive status damage or presence of depression. Conclusion. The importance of hemodialysis in the improvement of cognitive function is clearly evident, even though the general state of cognitive status in patients on hemodialysis is lower compared to the healthy population. Evaluation of the cognitive and affective status using simple reaction time, Folstein?s Mini Mental State Examination and the Beck Depression Inventory, should be used on daily basis in hemodialysis patients.

scholarly journals The Effect Of Mind-Body-Spirit Therapy On Mood Score In Patients With Chronic Renal Failure With Hemodialysis

2018 ◽  
Vol 2 (1) ◽  
pp. 42-50
Author(s):  
Errick Endra Cita ◽  
Dian Miftahul Mizan
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Hemodialysis Patients ◽  
Wilcoxon Test ◽  
Early Screening ◽  
Wide Range ◽  
Before And After ◽  
Post Test ◽  
Mood Score ◽  
Life Threatening

Background: The number of new chronic renal failure patients with hemodialysis therapy continues to increase from year to year in Indonesia. When people learn they need to begin dialysis, they typically experience a flurry of emotions. The stress is caused by chronic illness accounts for a wide range of feelings and moods. This includes general irritability, anger and frustration over the problems caused by the illness, and feelings of being hopeless and helpless when faced with a life-threatening disease. Mind-body-spirit therapy (Concepts of Islam) focuses on the ability to manage the mindset and psychic that will affect the physical, attitudes and behavior of individuals in addressing their lives. Purpose : Giving mind-body-spirit therapy to hemodialysis patients to improve quality of life, given for 4 weeks with the frequency twice a week. Methods : Pre-experimental study with one group pre-test post-test. The sample of 23 patients with hemodialysis therapy taken by purposive sampling. The FACES test is a visual analog scale representation of mood was used in this study. Early screening on mood was taken in 23 patients (13 men and 10 women, mean age 51.5 years). Mind-body-spirit therapy (Islamic concept) consisted of Tausiyah (cognitive reconstruction), prayer, dhikr and drinking zam-zam water. The mood score was evaluated at week 4 after 4 weeks of treatments. Wilcoxon test results, obtained a significance value of 0,000 (p <0,05). This suggests "there are significant differences in mood conditions before and after the Mind Body Spirit therapy intervention (Islamic Concept). Result : After the treatments, there is an increase in the mood score of hemodialysis patients. Conclusion : A mind-body-spirit therapy of 4 weeks is effective for improving the mood of patients with chronic renal failure with hemodialysis therapy

Propranolol-Associated Hypoglycemia in Patients on Maintenance Hemodialysis

1981 ◽  
Vol 4 (3) ◽  
pp. 130-134 ◽  
Author(s):  
A. Zarate ◽  
M. Gelfand ◽  
A. Novello ◽  
J. Knepshield ◽  
H.G. Preuss
Keyword(s):  
Renal Failure ◽  
Cardiac Arrest ◽  
Chronic Renal Failure ◽  
Severe Hypoglycemia ◽  
Signs And Symptoms ◽  
Hemodialysis Patients ◽  
Maintenance Hemodialysis ◽  
Life Threatening ◽  
Insulin Use

Propranolol is widely employed in hemodialysis patients for the control of renin-dependent hypertension. Infrequent reports have linked hypoglycemia and propranolol, especially in complex situations such as malnutrition, anesthesia, and excessive insulin use. Three patients on maintenance hemodialysis taking propranolol developed severe hypoglycemia resulting in cardiac arrest. The life-threatening hypoglycemia occurred without apparent precipitating cause and unaccompanied by the classical signs and symptoms of hypoglycemia. These three cases suggest that propranolol in a setting of chronic renal failure and dialysis may bring about severe hypoglycemia, a complication previously unsuspected.

Incidence and oncologic outcome of renal cell carcinoma in hemodialysis patients detected by annual computed tomography (CT) screening.

2012 ◽  
Vol 30 (5_suppl) ◽  
pp. 426-426
Author(s):  
Shingo Hatakeyama ◽  
Hayato Yamamoto ◽  
Takahiro Yoneyama ◽  
Yasuhiro Hashimoto ◽  
Takuya Koie ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Renal Dysfunction ◽  
Hemodialysis Patients ◽  
Maintenance Hemodialysis ◽  
Normal Kidney ◽  
Cancer Specific Survival ◽  
Annual Screening ◽  
Function Group

426 Background: Patients with maintenance hemodialysis (HD) have been recognized as a high risk group for cancer. The aim of this study was to verify the incidence and oncological outcomes of patients on maintenance hemodialysis with renal cell carcinoma (RCC) compared with RCC patients without renal dysfunction. Methods: We have been carried out annual screening for renal mass for the hemodialysis patients.The oncological outcome of pT1N0M0 RCC detected by annual screening of CT imaging were retrospectively reviewed in 1217 patients with HD between January 2002 and December 2010 at Oyokyo kidney Research Institute and Hirosaki University Hospital, Hirosaki, Japan. Overall and cancer specific survival was compared with age matched 106 of pT1N0M0 RCC patients without renal dysfunction who performed radical nephrectomy at the same periods. Results: Among the hemodialysis patients, 14 RCCs were incidentally detected by screening CT examinations and RCC detection rate in HD patients was 0.27% per year. Total 119 pT1N0M0 RCC patients (13 with HD group, 106 normal kidney function group) were incidentally detected by regular abdominal CT imaging without symptoms. There were no significant differences on age and gender between HD and normal kidney function group. Cancer specific survival after tumor diagnosis was not different, but overall survivals were significantly superior in patients without renal dysfunction compared to those with chronic renal failure (P < 0.0001). Cancer specific and Overall 5-year survival was 95% and 96% in patients without renal dysfunction, 92% and 54% in those with chronic renal failure. Conclusions: There was no significant difference in cancer specific survival of pT1 RCC between the two groups. However, overall survival was significantly worse in HD patients. Oncological effectiveness of annual CT screening for the HD patients was not evident in the present retrospective study.

Cation-exchange chromatography of guanidine derivatives in plasma of patients with chronic renal failure.

1976 ◽  
Vol 22 (2) ◽  
pp. 240-242 ◽  
Author(s):  
G Perez ◽  
A Rey ◽  
M Micklus ◽  
I Stein
Keyword(s):  
Renal Failure ◽  
Liquid Chromatography ◽  
Chronic Renal Failure ◽  
Accurate Method ◽  
Hemodialysis Patients ◽  
Exchange Chromatography ◽  
Maintenance Hemodialysis ◽  
Healthy Controls ◽  
Cation Exchange Chromatography ◽  
Guanidine Derivatives

Abstract Guanidine derivatives are suspected of contributing to the toxic manifestations of uremia. We describe a method for measurement of guanidine derivatives in 5-ml samples of plasma by liquid chromatography. Concentrations of guanidinosuccinate and guanidinobutyrate in plasma were significantly increased both in undialyzed patients with chronic renal failure (5.54 +/- 0.94 and 17.5 +/- 4.07 mg/liter) and those undergoing maintenance hemodialysis (2.35 +/- 0.41 and 19.4 +/- 3.99 mg/liter) when compared to healthy controls (less than 0.4 and 1.0 +/- 0.3 mg/liter, respectively). Creatine and guanidinoacetate concentrations tended to be higher in hemodialysis patients and lower in the undialyzed group of patients with chronic renal failure. This procedure provides a rapid, sensitive, and accurate method for the study of guanidine metabolism in persons with uremia.

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