scholarly journals Coriocarcinoma Primário de Ovário: Relato de um Caso em Paciente de 10 Anos de Idade

2009 ◽  
Vol 55 (1) ◽  
pp. 49-53
Author(s):  
Daniela Moreira Santos ◽  
Fernanda Lazzarine Peruchi ◽  
João Nestor Rodrigues Miranda ◽  
Luciene Lage da Motta ◽  
Antônio Chambô Filho
Keyword(s):  
Ca 125 ◽  
Beta Hcg

O coriocarcinoma primário de ovário é um tumor raro que se origina de células germinativas, apresentando-se, na maioria das vezes, associado a outros tumores também de origem de células germinativas. Será descrito um caso de coriocarcinoma primário de ovário em uma menina de 10 anos que apresentava um quadro de sangramento vaginal e distensão abdominal. Após serem dosados os marcadores tumorais, que mostraram níveis de beta-HCG (gonadotrofina coriônica humana) e CA-125 altos, e alfafetoproteína normal, e ser realizado ultrassonografia abdominal, a paciente foi submetida a tratamento cirúrgico. O exame histopatológico da peça cirúrgica e a imunohistoquímica foram compatíveis com diagnóstico de coriocarcinoma primário de ovário. Depois da cirurgia, a paciente evoluiu mal, indo a óbito no primeiro dia de pós-operatório devido a uma embolia tumoral pulmonar. Concluiu-se, então, que essa neoplasia é bastante agressiva, causando metástase precoce na maioria dos casos e apresentando prognóstico desfavorável, principalmente em jovens abaixo de 20 anos de idade.

scholarly journals Large Solitary Luteinized Follicle Cyst of Pregnancy and Puerperium: a Rare Post-partum Clinical Presentation

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S31-S31
Author(s):  
A Singh ◽  
L Yoxtheimer ◽  
S N Bajestani ◽  
J L Harbert
Keyword(s):  
Frozen Section ◽  
Post Partum ◽  
Obstructive Uropathy ◽  
Pap Test ◽  
Pelvic Mass ◽  
Mass Effect ◽  
Ca 125 ◽  
Mitotic Figure ◽  
First Case ◽  
Beta Hcg

Abstract Introduction/Objective In literature, all large solitary luteinized follicular cysts of pregnancy and puerperium (LSLFCPP) recognized were removed before or during delivery. This would be the first case in literature describing the clinical behavior of the LSLFCPP in the post-partum period. Methods We herein report a rare case of 21-year-old G2P2 female who underwent a full-term uneventful spontaneous vaginal delivery (39w0d, APGARS 9,9) without removal of the undiagnosed LSLFCPP, which nearly doubled in size post-partum. Her past medical history was significant for treated syphilis and normal Pap Test of the cervix. Three months after delivery, the patient presented with LSLFCPP exhibiting mass effect (retroverted uterus, mild right-sided obstructive uropathy, compressed bladder and intermittent pain). The antepartum ultrasound showed 14 cm pelvic mass that had grown to 30 cm on CT scan, in largest dimension. Beta-hCG levels returned to pre- pregnancy levels. Treponema pallidum antibody, FTA-ABS and RPR were reactive. Alpha-fetoprotein, inhibin B, CA- 125, CEA, and CA 19-9 screen were unremarkable. The patient underwent exploratory laparotomy cyst removal with right salpingo-oophorectomy. Results Grossly, the tumor weighed 22 lbs with a diameter of 28 cm; excrescences were not noted. Intraoperative consultation revealed a unilocular benign cyst. Histologically, the cyst was not only lined by luteinized cells but nests of luteinized cells infiltrated the fibrous wall. These cells were positive for Inhibin A and calretinin. A rare mitotic figure was noted. A diagnosis of LSLFCPP was rendered. Conclusion High levels of gonadotropin in pregnancy are implicated in the pathogenesis of LSLFCPP; however, in our case, the cyst doubled in size three months after delivery with undetectable beta-hCG levels. This indicates that the pathogenesis of this cyst relies on more than beta-hCG stimulation. LSLFCPP is important to recognize because it can mimic a malignant proliferation on frozen section and can potentially compromise fetal viability with mass effect.

scholarly journals Đặc điểm nồng độ CA-125, beta-hCG và progesterone huyết thanh trong thai lạc chỗ

2022 ◽  
Vol 19 (3) ◽  
pp. 26-30
Author(s):  
Thị Ngọc Bích Trần ◽  
Ngọc Thành Cao
Keyword(s):  
Ca 125 ◽  
Beta Hcg ◽  
Β Hcg

Mục tiêu: Khảo sát giá trị CA-125, β-hCG và progesterone huyết thanh trong các trường hợp thai lạc chỗ. Đối tượng và phương pháp nghiên cứu: Nghiên cứu bệnh chứng trên 42 trường hợp thai lạc và 42 trường hợp thai trong tử cung được quản lý tại Bệnh viện Trường Đại học Y - Dược Huế từ 05/2019 đến 05/2020. Chẩn đoán xác định thai lạc chỗ dựa vào kết quả phẫu thuật và giải phẫu bệnh. Nhóm chứng là các trường hợp đơn thai phát triển bình thường trong tử cung, tương đồng tuổi thai. Nồng độ CA-125 và β-hCG, progesterone huyết thanh khảo sát theo các nhóm tuổi thai, < 6 tuần, 6 - 7 tuần, và ≥ 8 tuần. Kết quả: Nồng độ CA-125 ở nhóm thai lạc chổ là 23,8 U/ml (11,6 - 59,4), thấp hơn nhóm thai trong tử cung 70,1 U/ml (35,0 - 146,0), p < 0,001. Nồng độ β-hCG và progesterone ở nhóm thai lạc chỗ thứ tự là 2570,0 mUI/ml (42,8 - 94579,0) và 9,1 ng/ml (0,7 - 29,8), các giá trị này đều thấp hơn so với nhóm thai trong tử cung, tương ứng là 18357,5 mIU/ml (4622,0 - 157985,0) và 26,7 ng/ml (20,4 - 37,1), p < 0,001. Ở nhóm thai lạc chổ, nồng độ CA-125 không có sự khác biệt có ý nghĩa thống kê theo tuổi thai, ở nhóm < 6 tuần, 6 - 7 tuần và nhóm ≥ 8 tuần tương ứng là 23,2 U/ml (11,6 - 59,4), 23,6 U/ml (15,9 - 48,9) và 23,3 U/ml (20,5 - 32,8), p = 0,08. Trong khi đó, ở nhóm thai phát triển trong tử cung, nồng độ CA-125 tăng dần theo tuổi thai, nhóm < 6 tuần, 6 - 7 tuần và nhóm ≥ 8 tuần tương ứng 59,1 U/ml (35,0 - 83,3), 81,4 U/ml (75,7 - 90,1) và 101,1 U/ml (91,4 - 146,0), p = 0,02. Kết luận: Nồng độ CA-125 và β-hCG, progesterone thấp hơn trong thai lạc chỗ so với thai trong tử cung. Giá trị CA-125 thay đổi không đáng kể theo tuổi thai trong nhóm thai lạc chỗ.

TO DETERMINE THE ROLE OF CA125 IN THE DIAGNOSIS OF ACUTE APPENDICITIS

2020 ◽  
Vol 4 (7) ◽  
Author(s):  
Vinod Kumar ◽  
Bhupen Songra ◽  
Richa Jain ◽  
Deeksha Mehta
Keyword(s):  
Acute Appendicitis ◽  
Clinical Diagnosis ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Ca 125 ◽  
Care Hospital ◽  
Serum Samples ◽  
Roc Curve Analysis ◽  
Surgery Department

Background: the present study was under taken to determine the role of CA-125 in the diagnosis of acute appendicitis (AA), to prevent its complications and also in preventing negative appendicectomies in tertiary care hospital. Methods: The study was conducted at a tertiary care and research center between 01/03/2018 to 30/06/2019. Patients admitted to the surgery department with diagnosis of AA were considered for the study. After informed consent, a, standardized history was obtained as a case Performa. Serum samples from all the cases with clinical diagnosis of AA were obtained and stored. Only the cases with histopathologically approved AA were included in the study. Cases operated for clinical diagnosis of AA, but not histopathologically proven AA was not included in the study. CA125 levels in cases with definitive diagnosis of AA were measured. Results: In present study, ROC curve analysis revealed the sensitivity of 87.27 % and specificity of 90.91 % when the CA 125 cut-off value of > 16.8 was taken to diagnose acute appendicitis. AUC was 0.911 with a standard error of 0.0292. Conclusion: In this study we have observed that CA125 showed a positive correlation with acute appendicitis, that was statistically not significant (P>0.05). We didn’t evaluate the correlation with the disease severity. We consider that CA125 can be used as a marker in acute appendicitis cases although further research is still needed. Keywords: CA125, Acute Appendicitis, Surgery.

Primary Peritoneal Serous Psammocarcinoma: a Case Report

2015 ◽  
Vol 24 (2) ◽  
pp. 253-256 ◽  
Author(s):  
Răzvan Dan Togănel ◽  
Ioan Şimon ◽  
Adriana Zolog ◽  
Răzvan Simescu ◽  
Angela Cozma ◽  
...  
Keyword(s):  
Adjuvant Chemotherapy ◽  
Posterior Wall ◽  
Ca 125 ◽  
Low Grade ◽  
Abdominal Girth ◽  
Treatment Protocols ◽  
Standardized Treatment ◽  
Pelvic Peritonectomy ◽  
Optimal Debulking ◽  
Douglas Pouch

Background: Psammocarcinomas (PCas) are rare epithelial tumors, usually originating in the ovaries or the peritoneum. These tumors are morphologically characterized by extensive psammomatous calcifications, invasiveness and low-grade cytological features.Case report: We present the case of a 54-year-old woman who was referred to our department with an umbilical tumor and increasing abdominal girth. The patient had had an umbilical hernia for more than 20 years. The CA 125 level was normal. The CT scan showed small peritoneal nodules at the level of the Douglas pouch, including the posterior wall of the uterus, and the entire colon, as well as large nodules located on the caecum and the sigmoid colon. We performed partial enterectomy, total colectomy with ileo-rectal anastomosis, omentectomy, total histerectomy and bilateral adnexectomy, pelvic peritonectomy of the Douglas pouch. Pathology findings were consistent with F.I.G.O. stage IIIC peritoneal PCa. The patient received adjuvant chemotherapy with Taxol and Carboplatin. To date, twelve months after surgery, the follow-up shows no evidence of disease.Conclusion: Standardized treatment protocols are hindered by the rarity of the PCas. However, literature concludes that optimal debulking is mandatory, whereas the efficacy of adjuvant chemotherapy remains to be elucidated.

Cystic struma ovarii, a rare form of ovarian tumor – a case report, and review of the literature

2007 ◽  
Vol 148 (48) ◽  
pp. 2285-2287 ◽  
Author(s):  
Gabriella Östör ◽  
Ildikó Tóth ◽  
Zsuzsanna Hrubyné Tóth ◽  
Sándor Bazsa
Keyword(s):  
Case Report ◽  
Ovarian Tumor ◽  
Ca 125 ◽  
Struma Ovarii ◽  
Review Of The Literature ◽  
Rare Form

Az ovarialis strumák a petefészek-teratomák kevesebb mint 3%-át adják. Megjelenhet bennük a pajzsmirigy szinte minden betegsége, és előfordulhat malignitás is. A szerzők esetében egy 31 éves nő bal oldali petefészekcisztáját távolították el, amely az ovariumcarcinoma klinikai tüneteit mutatta, úgymint nagy hasi térfoglalás, ascites, emelkedett szérum-CA 125-szint. A szövettani diagnózis benignus struma ovarii volt. A posztoperatív pajzsmirigyműködés normális maradt.

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