Peran reseptor vascular endothelial growth factor (VEGF) pada konka hipertrofi disebabkan oleh rinitis alergi

Latar belakang: Konka hipertrofi walaupun tidak mengancam jiwa, namun dapat menyebabkan gangguan kualitas hidup akibat sumbatan hidung. Patogenesis terjadinya konka hipertrofi adalah akibat airway remodelling terutama pada konka nasal inferior. Vascular endothelial growth factor (VEGF) merupakan salah satu faktor angiogenik yang berperan dalam proses neovaskularisasi. Bagaimana peran angiogenik reseptor VEGF pada konka hipertrofi yang terjadi pada rinitis alergi, sampai saat ini belum jelas dan belum banyak diteliti. Tujuan: Mengetahui peran VEGF sebagai faktor angiogenesis pada konka hipertrofi yang terjadi pada rinitis alergi. Metode: Penelitian ini bersifat observasional analitik dengan rancangan case control pada sampel penelitian yang memenuhi kriteria inklusi. Reseptor VEGF diperiksa secara imunohistokimia, di mana nilainya terdiri dari nilai negatif dan positif. Hasil: Pada penelitian ini, didapati nilai odds ratio 0,11 dan 95% CI 0,013-0,982. Hal tersebut menunjukkan bahwa reseptor VEGF berperan sebagai faktor protektif pada konka hipertrofi yang terjadi pada rinitis alergi. Kesimpulan: Reseptor VEGF dianggap berperan sebagai faktor protektif terjadinya konka hipertrofi yang terjadi pada rinitis alergi.Kata kunci: Reseptor vascular endothelial growth factor, konka nasal hipertrofi, rinitis alergi, imunohistokimia ABSTRACT Background: Although hypertrophic turbinate is not life threatening, this condition often decreases quality of life, resulted from nasal obstruction. Pathogenesis of hypertrophic turbinate resulted from airway remodeling especially in inferior turbinate. Vascular endothelial growth factor (VEGF) is one of angiogenic factors which has a role in neovascularitation process. However, it is still unclear what is the role of VEGF receptor in angiogenic of allergic rhinitis, and until now there were very few studies about this matter. Purpose: To identify the role of VEGF as an angiogenic factor in hypertrophic turbinate caused by allergic rhinitis. Methods: This study was an analytical observation by case control method. VEGF receptors were examined by immunohistochemistry with negative and positive result. Result: This study found odds ratio 0.11 and 95% CI 0.013-0.982, which means that VEGF receptor was a protective factor in hypertrophic turbinate caused by allergic rhinitis. Conclusion: VEGF receptor was considered as a protective factor for the occurrence hypertrophic turbinate caused by allergic rhinitis.Keywords: Vascular endothelial growth factor receptor, hypertrophic turbinate, allergic rhinitis, immunohistochemistry

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Genetic variants of vascular endothelial growth factor predict risk and survival of gliomas

Tumor Biology ◽

10.1177/1010428318766273 ◽

2018 ◽

Vol 40 (3) ◽

pp. 101042831876627 ◽

Cited By ~ 2

Author(s):

Paulo Linhares ◽

Marta Viana-Pereira ◽

Mónica Ferreira ◽

Júlia Amorim ◽

Rui Nabiço ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Odds Ratio ◽

Multiple Testing ◽

Cox Regression ◽

Vascular Endothelial ◽

Increased Risk ◽

Endothelial Growth Factor ◽

Vegf Polymorphisms

The vascular endothelial growth factor regulates angiogenesis that is increased in glioma. VEGF polymorphisms are thought to modulate vascular endothelial growth factor plasma levels and therefore may be implicated in glioma risk. We aimed to clarify the role of VEGF and von Willebrand factor polymorphisms in glioma susceptibility and prognosis. A case–control study of 126 glioma patients and 180 cancer-free controls was performed. Using Sequenom MassARRAY platform, 11 VEGF and 1 VWF polymorphisms were genotyped. Unconditional multivariate logistic regression models were used to calculate odds ratios and 95% confidence intervals. The associations between polymorphisms and survival were evaluated using a Cox regression model. Bonferroni’s adjustment was used to correct for multiple testing. The VEGF polymorphism rs833061 was strongly associated with increased risk for glioma (odds ratio = 164.85) and glioblastoma (odds ratio = 155.66), confirmed after Bonferroni correction. Also, the VEGF polymorphisms rs3024994, rs2010963, and particularly the homozygous carriers of rs1005230 were associated with a worse prognosis for glioma and glioblastoma. Our data support a role of VEGF and VWF polymorphisms as glioma biomarkers, with additional potential relevance for molecular stratification of patients for anti-angiogenic therapies.

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Role of vascular endothelial growth factor polymorphisms (-2578C > A, -460 T > C, -1154G > A, +405G > C and +936C > T) in endometriosis: a case–control study with Brazilians

BMC Women s Health ◽

10.1186/1472-6874-14-117 ◽

2014 ◽

Vol 14 (1) ◽

Cited By ~ 18

Author(s):

Jamila Alessandra Perini ◽

Jessica Vilarinho Cardoso ◽

Plínio Tostes Berardo ◽

Rosane Vianna-Jorge ◽

Luiz Eurico Nasciutti ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Case Control Study ◽

Case Control ◽

Vascular Endothelial ◽

Endothelial Growth Factor ◽

Control Study

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Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis

Journal of Clinical Oncology ◽

10.1200/jco.2005.06.081 ◽

2005 ◽

Vol 23 (5) ◽

pp. 1011-1027 ◽

Cited By ~ 1795

Author(s):

Daniel J. Hicklin ◽

Lee M. Ellis

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Tumor Growth ◽

Tumor Angiogenesis ◽

Vegf Receptor ◽

Vascular Endothelial ◽

Anti Vegf ◽

Vegf Pathway ◽

Endothelial Growth Factor

New blood vessel formation (angiogenesis) is a fundamental event in the process of tumor growth and metastatic dissemination. Hence, the molecular basis of tumor angiogenesis has been of keen interest in the field of cancer research. The vascular endothelial growth factor (VEGF) pathway is well established as one of the key regulators of this process. The VEGF/VEGF-receptor axis is composed of multiple ligands and receptors with overlapping and distinct ligand-receptor binding specificities, cell-type expression, and function. Activation of the VEGF-receptor pathway triggers a network of signaling processes that promote endothelial cell growth, migration, and survival from pre-existing vasculature. In addition, VEGF mediates vessel permeability, and has been associated with malignant effusions. More recently, an important role for VEGF has emerged in mobilization of endothelial progenitor cells from the bone marrow to distant sites of neovascularization. The well-established role of VEGF in promoting tumor angiogenesis and the pathogenesis of human cancers has led to the rational design and development of agents that selectively target this pathway. Studies with various anti-VEGF/VEGF-receptor therapies have shown that these agents can potently inhibit angiogenesis and tumor growth in preclinical models. Recently, an anti-VEGF antibody (bevacizumab), when used in combination with chemotherapy, was shown to significantly improve survival and response rates in patients with metastatic colorectal cancer and thus, validate VEGF pathway inhibitors as an important new treatment modality in cancer therapy.

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Role of the Heparin Binding Domain in the Clearance and Localization of Vascular Endothelial Growth Factor

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(97)88004-7 ◽

1998 ◽

Vol 31 (2) ◽

pp. 461A ◽

Cited By ~ 1

Author(s):

P Kimson

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Binding Domain ◽

Vascular Endothelial ◽

Heparin Binding ◽

Heparin Binding Domain ◽

Endothelial Growth Factor

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New insights on the role of vascular endothelial growth factor in biliary pathophysiology

JHEP Reports ◽

10.1016/j.jhepr.2021.100251 ◽

2021 ◽

Vol 3 (3) ◽

pp. 100251

Author(s):

Valeria Mariotti ◽

Romina Fiorotto ◽

Massimiliano Cadamuro ◽

Luca Fabris ◽

Mario Strazzabosco

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Vascular Endothelial ◽

Endothelial Growth Factor

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Role of Vascular Endothelial Growth Factor (VEGF) in Human Embryo Implantation: Clinical Implications

Biomolecules ◽

10.3390/biom11020253 ◽

2021 ◽

Vol 11 (2) ◽

pp. 253

Author(s):

Xi Guo ◽

Hong Yi ◽

Tin Chiu Li ◽

Yu Wang ◽

Huilin Wang ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Recurrent Miscarriage ◽

Embryo Implantation ◽

Critical Role ◽

Angiogenic Factor ◽

Vascular Endothelial ◽

Underlying Mechanisms ◽

Endothelial Growth Factor

Vascular endothelial growth factor (VEGF) is a well-known angiogenic factor that plays a critical role in various physiological and pathological processes. VEGF also contributes to the process of embryo implantation by enhancing embryo development, improving endometrial receptivity, and facilitating the interactions between the developing embryo and the endometrium. There is a correlation between the alteration of VEGF expression and reproductive failure, including recurrent implantation failure (RIF) and recurrent miscarriage (RM). In order to clarify the role of VEGF in embryo implantation, we reviewed recent literature concerning the expression and function of VEGF in the reproductive system around the time of embryo implantation and we provide a summary of the findings reported so far. We also explored the effects and the possible underlying mechanisms of action of VEGF in embryo implantation.

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