scholarly journals Metastatic malignant PEComa of the brain: An unusual entity with rare presentation

2021 ◽  
Vol 7 (3) ◽  
pp. 83-86
Author(s):  
Reena Bharadwaj ◽  
Gaurav Pratap Singh Gahlot ◽  
Rekha Vashisth ◽  
Rajeev Saxena ◽  
Siddarth Shukla ◽  
...  
Keyword(s):  
Rare Presentation ◽  
The Brain ◽  
Malignant Pecoma

Scrub typhus with cerebral venous sinus thrombosis: a rare presentation

2021 ◽  
Vol 14 (4) ◽  
pp. e241401
Author(s):  
Sayonee Das ◽  
Sidhartha Chattopadhyay ◽  
Kausik Munsi ◽  
Sagar Basu
Keyword(s):  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Scrub Typhus ◽  
Sinus Thrombosis ◽  
Hormonal Contraception ◽  
Neurological Involvement ◽  
Rare Presentation ◽  
Specific Test ◽  
Satisfactory Outcome ◽  
The Brain

This is a rare presentation of scrub typhus with cerebral venous thrombosis. A 32-year-old woman presented with signs of raised intracranial tension. Examination revealed maculopapular skin rashes and an ‘eschar’ over the right thigh. Nuchal rigidity and bilateral papilloedema were found. Scrub typhus was diagnosed by the presence of IgM antibody in serum. CT scan of the brain showed cerebral oedema. MRI of the brain was normal. Magnetic resonance venography of the brain showed thrombosis of several venous sinuses. Cerebrospinal fluid analysis revealed lymphocytic pleocytosis with raised protein level. Other causes of prothrombotic states were ruled out by doing specific test results. There was no history of hormonal contraception and prolonged bed rest. A case of scrub typhus complicated with meningoencephalitis and cerebral venous thrombosis was diagnosed. She responded to treatment with doxycycline, anticoagulants, antipyrectics and intravenous saline. Early identification of such atypical neurological involvement in scrub typhus was helpful in satisfactory outcome.

scholarly journals PAPILLARY CARCINOMA, A METASTASIS OF THE BRAIN AND BONE: A RARE CASE

2020 ◽  
Vol 73 (10) ◽  
pp. 2306-2308
Author(s):  
Volodymyr B. Dobrorodniy ◽  
Anatoliy D. Bedenyuk ◽  
Viktoria G. Khoperiia ◽  
Andriy V. Dobrorodniy
Keyword(s):  
Papillary Carcinoma ◽  
Rare Case ◽  
Cerebral Metastases ◽  
Papillary Thyroid ◽  
Rare Presentation ◽  
Large Size ◽  
Multiple Metastases ◽  
Uncommon Condition ◽  
Metastatic Sites ◽  
The Brain

Cerebral metastases from papillary carcinoma of the thyroid are a very uncommon condition. These metastases almost always involve concomitant lung or bone metastases which may be the first metastatic sites. In a 59-year-old woman found metastases of papillary thyroid cancer (PTC) in the frontal sinus, scapula, multiple bones of the skeleton and lungs. Evaluation confirmed that it is multiple metastases from PTC. This is a very rare presentation with such a large size of metastasis. We present this rare clinical case of massive distal lesions in PTC.

Beware of cryptococcomas when treating Cryptococcal meningitis

2020 ◽  
Vol 10 (5) ◽  
pp. 183-184
Author(s):  
Rafael Ferreira Nascimento ◽  
Diogo Raposo André, ◽  
Fabiana Gouveia ◽  
Nancy Faria ◽  
Ana Paula Reis
Keyword(s):  
Immunocompromised Patient ◽  
Brain Mri ◽  
Hiv Positive ◽  
Rare Presentation ◽  
Neck Stiffness ◽  
Viral Loads ◽  
Hiv Rna ◽  
Neurological Exam ◽  
History Of ◽  
The Brain

Introduction: The authors describe a rare presentation of central nervous system cryptococcosis in an immunocompromised patient. Case description: An HIV-positive patient, with poor adherence to the treatment, presented with a seventeen days history of severe headache. On the neurological exam there was only evidence of neck stiffness, he had a CD4 count of 23 cells/μl and plasma HIV RNA viral loads of 364,000 copies/ml. Lumbar puncture revealed positive for cryptococcal antigen virus and so treatment with amphotericin B was started. During his admission the patient developed an expressive aphasia with visual hallucinations and the brain MRI revealed cerebral cryptococcomas. After 98 days of treatment general and neurological examination was normal and the patient was discharged home. Conclusion: This case highlights a rare and severe complication of Cryptococcus neoformans infection in immunocompromised patients.

scholarly journals Tetraventricular central neurocytoma: A rare presentation with imaging.pathologic correlation

2015 ◽  
Vol 06 (04) ◽  
pp. 594-597 ◽  
Author(s):  
Akin Akakin ◽  
Baran Yilmaz ◽  
Mustafa Kemal Demir ◽  
Ozlem Yapicier ◽  
Zafer Orkun Toktas ◽  
...  
Keyword(s):  
Treatment Options ◽  
Central Neurocytoma ◽  
Surgical Removal ◽  
Resonance Imaging ◽  
Rare Presentation ◽  
The Third ◽  
Favorable Prognosis ◽  
Atypical Features ◽  
The Brain ◽  
4Th Ventricle

ABSTRACTCentral neurocytoma (CN) is a benign intraventricular neuronal tumor with a favorable prognosis. It accounts approximately 0.25–0.5% of intracranial tumors. In this report, we describe a very rare case of tetraventricular CN with imaging-pathologic correlation, and discuss their atypical features in a location together with treatment options. A 27-year-old man was admitted to the hospital with symptoms of progressive headaches of several months' duration. Magnetic resonance imaging of the brain revealed a well-circumscribed, lobulated intraventricular mass with numerous intratumoral cystlike areas. The mass was located in the enlarged lateral ventricles bilaterally extending to the third and the fourth ventricle. Surgical removal of the 4th ventricle component of the tumor was performed. Histomorphological and immunohistochemical findings of the tumor were consistent with CN. After pathological diagnosis, gamma knife surgery was performed. CN may present with atypical features in a location with a usual histopathological findings. To our knowledge, we described the third case of tetraventricular CN, which was partially treated with both surgical resection and radiosurgery.

Multiple Myeloma Presenting as a Clivus and Brain Stem Plasmacytoma.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 5061-5061
Author(s):  
Arash Rezazadeh ◽  
Goetz H. Kloecker ◽  
Damian A. Laber
Keyword(s):  
Multiple Myeloma ◽  
Brain Stem ◽  
Plasma Cell ◽  
Plasma Cells ◽  
Complete Blood Count ◽  
Thoracic Vertebrae ◽  
Rare Presentation ◽  
Organ Systems ◽  
Brain Involvement ◽  
The Brain

Abstract Multiple myeloma is the most common hematological malignancy. MM can affect many organ systems; therefore, it may mimic different clinical syndromes at presentation. We report an extremely rare presentation of MM. CASE REPORT: A 62-year-old man presented with progressive cervical pain for 2 months and double vision for 2 weeks. Physical exam demonstrated a cranial nerve 6 palsy, nuchal rigidity and no other abnormalities. A magnetic resonance image (MRI) of the brain revealed a 5 cm enhancing mass in the clivus which extended into the brain stem, left internal auditory and carotid canal, nasopharynx, sphenoid and cavernous sinuses, without midline shift or hydrocephalus. MRI of the spine showed 2 small enhancing lesions in thoracic vertebrae 4 and 11. Computer tomography of the chest abdomen and pelvis demonstrated a lesion in the sternum and no other abnormalities. Technetium-99 bone scan showed uptake in the skull base mass only. Complete blood count and metabolic profile were normal except for an albumin of 3.2 g/dL. Serum protein electrophoresis with immunofixation revealed hypogammaglobulinemia without a monoclonal protein. 24 hour urine collection demonstrated monoclonal free kappa light chains. Transsphenoidal stereotactic biopsy of the mass showed an atypical plasma cell proliferation with multi-nucleation and mitotic activity, positive for kappa light chain. Bone marrow aspirate revealed 17% of the nucleated cell to be abnormal plasma cells, some with plasmablastic morphology. He improved rapidly with dexamethasone and was referred for radiotherapy. DISCUSSION: The most common neurologic complications of MM are spinal cord compression due to epidural plasmacytomas or vertebral fractures, and peripheral polyneuropathy due to the presence of antibodies directed against myelin structures or due to amyloid deposits. Brain involvement in MM is uncommon. Furthermore, neurologic symptoms due to plasmacytomas located either in the clivus and brain stem are extremely rare. A MEDLINE search from 1950 until July 2005 revealed only 9 cases of MM or plasmacytoma involving the brain stem. Since there is no published autopsy series on MM patients describing the percentage of patients with brain involvement at death, the denominator is difficult to assess. Clinically, extramedullary involvement from MM bears a poor prognosis, and has been described in cases of plasma cell leukemia. We speculate that the aggressive behavior of the MM in our patient might be consistent with the atypical phenotype of the plasma cells. CONCLUSION: The unusual presentation of this patient adds to the medical knowledge about the clinical spectrum of multiple myeloma.

Central nervous system metastases: a rare presentation of nasopharyngeal carcinoma

2021 ◽  
Vol 14 (8) ◽  
pp. e243892
Author(s):  
Sehrish Abrar ◽  
Nasir Ali ◽  
Bilal Mazhar Qureshi ◽  
Rabia Tahseen
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Standard Treatment ◽  
Systemic Disease ◽  
Lumbar Region ◽  
Rare Presentation ◽  
Limb Weakness ◽  
Cervical Lymph Nodes ◽  
Bilateral Lower Limb ◽  
Thoracic Cord ◽  
The Brain

We report a case of a male patient. He presented with nasal obstruction and epistaxis. The MRI of the brain showed a mass in the nasopharynx and enlarged cervical lymph nodes. Besides this, there was an extra-axial, dural-based lesion in brain and subcentimetre nodules in both lungs. He received induction chemotherapy followed by chemoradiation therapy to the primary site and dural-based metastatic deposit. He re-presented with bilateral lower limb weakness. The MRI of the spine showed metastatic deposits within the thoracic cord parenchyma and meningeal deposits at the lumbar region. Palliative radiation was used to treat spinal cord and meningeal metastases. He died a few months later because of systemic disease progression. Considering the rarity of this presentation in nasopharyngeal carcinoma and lack of clear guidelines for standard treatment, we report this case to share our experience of management.

scholarly journals Right Gaze Palsy and Hoarseness: A Rare Presentation of Mediastinal Tuberculosis with an Isolated Prepontine Cistern Tuberculoma

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Chidozie Charles Agu ◽  
Olufemi Aina ◽  
Md Basunia ◽  
Bikash Bhattarai ◽  
Vikram Oke ◽  
...  
Keyword(s):  
Mediastinal Mass ◽  
Lymph Node Biopsy ◽  
Chest Ct ◽  
Resonance Imaging ◽  
Antituberculous Therapy ◽  
Rare Presentation ◽  
Prepontine Cistern ◽  
Node Biopsy ◽  
The Brain ◽  
Gaze Palsy

We describe a previously healthy young man who presented with headaches, diplopia with right lateral gaze palsy, dysphagia, and hoarseness over a 2-month period. Magnetic resonance imaging of the brain revealed a small enhancing mass at the prepontine cistern and chest CT showed a left mediastinal mass. Mediastinoscopy and lymph node biopsy were performed. DNA probe and culture of the biopsy specimen were confirmed to beMycobacterium tuberculosiscomplex. Resolution of neurologic symptoms was noted after 6 weeks, in addition to regression of brain stem and mediastinal lesions after 12 weeks of antituberculous therapy.

scholarly journals Biliary Dyskinesia as a Rare Presentation of Metastatic Breast Carcinoma of the Gallbladder: A Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
A. Markelov ◽  
H. Taheri ◽  
K. Vunnamadala ◽  
G. Ibrahim
Keyword(s):  
Breast Carcinoma ◽  
Invasive Lobular Carcinoma ◽  
Lobular Carcinoma ◽  
Metastatic Breast ◽  
Rare Presentation ◽  
Metastatic Breast Carcinoma ◽  
Carcinoma Metastasis ◽  
Invasive Lobular Breast Cancer ◽  
The Brain ◽  
Common Malignancy

Background. Breast carcinoma is the most common malignancy in women worldwide. It is most commonly associated with metastases to the liver, lung, bone, and the brain. Invasive lobular carcinoma is a less common pathology with slightly higher metastases to the upper gastrointestinal tract. Invasive lobular carcinoma metastasis to the gallbladder is extremely rare.Method. In this paper we are presenting a case of a 67-year-old female with metastases of invasive lobular breast cancer to the gallbladder six years after her therapy.Conclusion. This case clearly signifies the nature of the micrometastatic foci of the invasive lobular carcinoma even many years after a successful treatment.

scholarly journals Pseudotumor Cerebri : A Rare Presentation of Systemic Lupus Erythematosus

2017 ◽  
Vol 34 (2) ◽  
pp. 104-107
Author(s):  
Aparna Das ◽  
Jiban Chandra Das ◽  
Abdullah Al Ahmad ◽  
Md Azizul Kahhar
Keyword(s):  
Intracranial Pressure ◽  
Lupus Erythematosus ◽  
Pseudotumor Cerebri ◽  
Systemic Lupus ◽  
Increased Intracranial Pressure ◽  
Radiological Findings ◽  
Rare Presentation ◽  
Complex Deposition ◽  
The Brain ◽  
Csf Absorption

Raised intracranial pressure in the absence of an intracranial mass or hydrocephalus (BIH or pseudotumor cerebri) has been described in association with many conditions including SLE. Several pathogenic pathways tie BIH with SLE as thrombotic obliteration of cerebral arteriolar and venous systems and immune complex deposition within the arachnoid villi that are responsible for cerebrospinal fluid (CSF) absorption. The diagnosis of BIH was confirmed by increased intracranial pressure in the absence of any abnormal radiological findings of the brain. We report a young woman with SLE complicated by BIH which resolved with corticosteroid therapy and osmotic diuretics.J Bangladesh Coll Phys Surg 2016; 34(2): 104-107

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