scholarly journals PENURUNNYA KECEMASAN TIKUS OVARIEKTOMI SETELAH LATIHAN INVERVAL DENGAN INTENSITAS TINGGI

2019 ◽  
Vol 9 (2) ◽  
pp. 1-8
Author(s):  
Saidah Rauf
Keyword(s):  
Open Field Test ◽  
Animal Experiments ◽  
Ovariectomized Rats ◽  
Depression And Anxiety ◽  
Sprague Dawley ◽  
Interval Exercise ◽  
Sprague Dawley Rats ◽  
High Intensity Interval ◽  
Keywords Anxiety

It is well established that a decrease of estrogen during natural or surgical menopause (ovariectomy)could influence female anxiety behaviour both in human and animal experiments. Several studies haveproved that exercise act as a potential therapy to reduce depression and anxiety behaviours. The currentstudy analyzed the effects of High-Intensity Interval Exercise (HIIE) to anxiety-related behaviours ofrats after long-term ovaries removal. Fifteen Sprague-Dawley rats (twelve weeks old) were used in thisstudy. All rats were divided into sham-operated, ovariectomy, and ovariectomy with HIIE (OVXHIIE). The HIIE group was treated for 7 weeks of interval exercise that started after twelve weeks ofovariectomized using treadmill. Anxiety related behaviour were represented by frequencies toentrances centre arena, freezing and grooming duration on open field test. A significant decrease(p<0.05) in the frequencies to enter open arena was detected in ovariectomized rats compared to shamand ovariectomy with HIIE, while reversed effect has observed in freezing duration. The present resultsshow that HIIE may help to counteract the ovariectomized effect on anxiety-related behaviours of rats.The HIIE may become the promising therapy to treat anxiety behaviour on menopause condition. Keywords: Anxiety, interval exercise, ovariectomy, menopause

Long-term exposure of Sprague Dawley rats to 20 kHz triangular magnetic fields

2006 ◽  
Vol 82 (4) ◽  
pp. 285-291 ◽  
Author(s):  
H. J. Lee ◽  
S. H. Kim ◽  
S. Y. Choi ◽  
Y. M. Gimm ◽  
J. K. Pack ◽  
...  
Keyword(s):  
Magnetic Fields ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Transient Neonatal Cryptosporidium parvum Infection Triggers Long-Term Jejunal Hypersensitivity to Distension in Immunocompetent Rats

2006 ◽  
Vol 74 (7) ◽  
pp. 4387-4389 ◽  
Author(s):  
Rachel Marion ◽  
Asiya Baishanbo ◽  
Gilles Gargala ◽  
Arnaud François ◽  
Philippe Ducrotté ◽  
...  
Keyword(s):  
Cryptosporidium Parvum ◽  
Myeloperoxidase Activity ◽  
Sprague Dawley ◽  
Depressor Response ◽  
Sprague Dawley Rats

ABSTRACT In 5-day-old immunocompetent Sprague-Dawley rats infected with either 102 or 105 Cryptosporidium parvum oocysts, transient infection resulted 120 days later in increased cardiovascular depressor response to jejunal distension and jejunal myeloperoxidase activity (P < 0.05). Nitazoxanide treatment normalized jejunal sensitivity (P < 0.001) but not myeloperoxidase levels (P > 0.05). Data warrant further evaluation of the role of early cryptosporidiosis in the development of chronic inflammatory gut conditions.

Application of Cryopreservation Technique in the Preservation of Rat Limbs

2020 ◽  
Author(s):  
Yu Tian ◽  
Nan Li ◽  
Wei Wang ◽  
Na Li
Keyword(s):  
Animal Experiments ◽  
Storage Conditions ◽  
Sprague Dawley ◽  
Uw Solution ◽  
Tissue Morphology ◽  
University Of Wisconsin ◽  
Sprague Dawley Rats ◽  
Nerve Bundles ◽  
Healthy Adult Male ◽  
The University

Abstract Objective: This study aims to observe the physiological and pathological changes of severed fingers (limbs) under different storage conditions through animal experiments, and to screen out the best preservation conditions. Medthods: Sixty healthy adult male Sprague-Dawley rats were selected and evenly divided into 4 preservation groups, including conventional low-temperature dry (CLTD), the university of wisconsin (UW) solution, cryopreservation and cryopreservation + UW solution preservation group. After harvesting the limbs, were preservated for 72 h and 7 days, respectively. Then the limbs were thawed and replanted in situ. Sciatic nerves were collected for hematoxylin and eosin (HE) staining, and observed the changes in tissue morphology. Results: Replantation was successful in 11 out of 15 rats (73%) in cryopreservation + UW group, and the walking function of the 9 (82%) rats in cryopreservation + UW group were significantly better than that of the cryopreservation preservation group. In addition, the HE staining results shown that the CLTD group nerve bundles were morphologically damaged, and there were more acellular structures and tissue fragments; the UW group nerve bundles were less injured and the perineurium was more complete and orderly; The nerve bundles in the cryopreservation group and cryopreservation + UW group are tightly arranged and the tissue morphology is regular; Compared with the cryopreservation + UW group, the complete of the cryopreservation group is not well. Conclusions: The cryopreservation technology combined with UW solution is a new and effective method for the severed limbs preserving.

scholarly journals Selected Contribution: Phrenic long-term facilitation requires 5-HT receptor activation during but not following episodic hypoxia

2001 ◽  
Vol 90 (5) ◽  
pp. 2001-2006 ◽  
Author(s):  
D. D. Fuller ◽  
A. G. Zabka ◽  
T. L. Baker ◽  
G. S. Mitchell
Keyword(s):  
Receptor Antagonist ◽  
Phrenic Nerve ◽  
Receptor Activation ◽  
Sprague Dawley ◽  
Nerve Activity ◽  
Sprague Dawley Rats ◽  
Episodic Hypoxia ◽  
Baseline Levels ◽  
Long Term Facilitation

Episodic hypoxia evokes a sustained augmentation of respiratory motor output known as long-term facilitation (LTF). Phrenic LTF is prevented by pretreatment with the 5-hydroxytryptamine (5-HT) receptor antagonist ketanserin. We tested the hypothesis that 5-HT receptor activation is necessary for the induction but not maintenance of phrenic LTF. Peak integrated phrenic nerve activity (∫Phr) was monitored for 1 h after three 5-min episodes of isocapnic hypoxia (arterial Po 2 = 40 ± 2 Torr; 5-min hyperoxic intervals) in four groups of anesthetized, vagotomized, paralyzed, and ventilated Sprague-Dawley rats [ 1) control ( n = 11), 2) ketanserin pretreatment (2 mg/kg iv; n = 7), and ketanserin treatment 0 and 45 min after episodic hypoxia ( n = 7 each)]. Ketanserin transiently decreased ∫Phr, but it returned to baseline levels within 10 min. One hour after episodic hypoxia, ∫Phr was significantly elevated from baseline in control and in the 0- and 45-min posthypoxia ketanserin groups. Conversely, ketanserin pretreatment abolished phrenic LTF. We conclude that 5-HT receptor activation is necessary to initiate (during hypoxia) but not maintain (following hypoxia) phrenic LTF.

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