scholarly journals RECURRENT NASOPHARYNGEAL CARCINOMA: PROBLEM AND MANAGEMENT

2020 ◽  
Vol 2 (02) ◽  
pp. 47-49
Author(s):  
Rusina Hayati
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Conductive Hearing Loss ◽  
Undifferentiated Carcinoma ◽  
Treatment Results ◽  
Mortality And Morbidity ◽  
Appropriate Treatment ◽  
Nasopharyngeal Biopsy ◽  
Complete Treatment ◽  
Recurrent Nasopharyngeal Carcinoma ◽  
Conductive Hearing

Abstract Introduction: Treatment results for nasopharyngeal carcinoma (NPC) have been improved, but there were still some patients who developed localized persistent or local recurrent. Local recurrence still represents a major cause of mortality and morbidity also management still challenging issues. Case Report: A 27-year-old woman presented with bilateral conductive hearing loss, dysphagia, rhinorrhoea, epistaxis, and cranial nerve palsy after chemo radiation for NPC. The results of nasopharyngoscopy, CT scan, and PET scan were not found a mass in the nasopharynx. The result of nasopharyngeal biopsy result was undifferentiated carcinoma. Patient diagnosed with recurrent NPC and planned for re-radiotherapy. Conclusion: After complete treatment for NPC we must immediately ensure recurrence and choose the next appropriate treatment.

scholarly journals OVEREXPRESSION VASCULAR ENDOTHELIAL GROWTH FACTOR IN NASOPHARYNGEAL CARCINOMA WITH UNDIFFERENTIATED CARCINOMA TYPE IN ADVANCED STAGE

2019 ◽  
Vol 1 (02) ◽  
pp. 66-68
Author(s):  
Kadek Kris Aryana
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Nasopharyngeal Carcinoma ◽  
Tumor Stage ◽  
Undifferentiated Carcinoma ◽  
Vascular Endothelial ◽  
Advanced Stage ◽  
Vegf Expression ◽  
Nasopharyngeal Biopsy ◽  
Endothelial Growth Factor

Introduction: Nasopharyngeal Carcinoma (NPC) is a malignancy that tends to diagnosed at an advanced stage with low survival and prognosis rate. One of the factors that may play a role in progressivity and metastasis of tumor is overexpression of vascular endothelial growth factor (VEGF), which is a key role in tumor angiogenesis. Objective: This study aims to learn the expression of VEGF in NPC with Undifferentiated Carcinoma type and to learn the association pf VEGF Expression with tumor stage of NPC Method: This is a cross-sectional study performed in ENT-HNS Department of ENT-HNS of Udayana University/Sanglah Hospital. The sample was collected by consecutive nonprobability sampling, starting from January 2016. NPC patients underwent Histopathologic examination from a nasopharyngeal biopsy. The result is Undifferentiated Carcinoma. VEGF expression analyzed by red-brown stained cytoplasm. Data were analyzed by Spearman's Correlation Test Chi-Square test, and Paired Sample t-Test. Result: VEGF positive Expression was found in 27 of 28 (96.4%) Undifferentiated Carcinoma type of NPC cases. VEGF overexpression was found in 23 of 28 (82.4%) Undifferentiated Carcinoma type of NPC cases.There is significant correlation found between tumor stage and VEGF expression (p<0.05). Conclusion: From the research, it could conclude that there is significant correlation between tumor stage and VEGF Expression.

scholarly journals Dermal Metastasis from Nasopharyngeal Carcinoma: A Rare Form of Metastasis

2011 ◽  
Vol 26 (1) ◽  
pp. 42-45
Author(s):  
Johanna Patricia A. Cañal
Keyword(s):  
Lymph Node ◽  
Nasopharyngeal Carcinoma ◽  
Cervical Lymphadenopathy ◽  
Undifferentiated Carcinoma ◽  
Metastatic Carcinoma ◽  
University Hospital ◽  
Selective Neck Dissection ◽  
Rare Form ◽  
Nasopharyngeal Biopsy ◽  
Four Quadrant

Objective: To report a rare form of metastasis from a primary nasopharyngeal carcinoma, a creeping form of dermal metastasis.   Methods: Design: Case Report Setting: Tertiary Public University Hospital Patient: One   Results: A 47-year-old male referred for radiotherapy after having undergone a selective neck dissection for multiple cervical lymphadenopathy with histopathologic diagnosis of undifferentiated carcinoma and no known primary underwent a four-quadrant nasopharyngeal biopsy which confirmed the presence of nasopharyngeal carcinoma. Subsequent radiotherapy resolved the primary mass , and a new posterior cervical lymph node that appeared five months after completion of radiotherapy also resolved with additional radiotherapy. He was asymptomatic for two years until he noted thickening of the skin in his left supraclavicular area. A Computed Tomography (CT) scan showed deep cervical adenopathy and skin thickening, and biopsy confirmed dermal metastatic carcinoma. Two courses of radiotherapy to the affected skin and left axilla where a lymph node had developed resulted in resolution and he was referred for chemotherapy.   Conclusion: Dermal metastasis from nasopharyngeal carcinoma is rare and does not present with pathognomonic symptomatology. It may therefore be confused for a benign side effect (dermatitis), not the malignant manifestation that forebodes a bad prognosis. Patients with dermal metastasis should receive treatment, and radiotherapy may play a significant part. Chemotherapy may also play a role in its management.   Keywords: Nasopharyngeal carcinoma, dermal metastasis

Nasopharyngeal carcinoma presenting as carotidynia in an 18-year-old patient

2007 ◽  
Vol 122 (2) ◽  
pp. 207-209 ◽  
Author(s):  
D Ellul ◽  
J Cutajar ◽  
H Borg xuereb ◽  
M Said
Keyword(s):  
Hearing Loss ◽  
Case Report ◽  
Nasopharyngeal Carcinoma ◽  
Severe Pain ◽  
Cervical Lymph Node ◽  
Literature Search ◽  
Conductive Hearing Loss ◽  
Cervical Lymph Node Metastases ◽  
Node Metastases ◽  
Conductive Hearing

AbstractIntroduction:Nasopharyngeal carcinoma can present with a variety of symptoms the most common being painless cervical lymph node metastases, epistaxis and conductive hearing loss.Case report:We report a case of an 18-year-old male patient presenting to the ENT department with left sided carotidynia – severe pain in the neck radiating up to his ear. He had a small, exquisitely tender lump just below the bifurcation of the left common carotid artery. After the appropriate investigations he was diagnosed with nasopharyngeal carcinoma.Discussion:In a literature search on Medline and Pubmed we found no reported cases of nasopharyngeal carcinoma presenting with carotidynia, nor was carotidynia ever found to be associated with nasopharyngeal carcinoma.Conclusion:We believe that this is the first reported case of such a presentation of nasopharyngeal carcinoma.

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