scholarly journals Dermal Metastasis from Nasopharyngeal Carcinoma: A Rare Form of Metastasis

2011 ◽  
Vol 26 (1) ◽  
pp. 42-45
Author(s):  
Johanna Patricia A. Cañal
Keyword(s):  
Lymph Node ◽  
Nasopharyngeal Carcinoma ◽  
Cervical Lymphadenopathy ◽  
Undifferentiated Carcinoma ◽  
Metastatic Carcinoma ◽  
University Hospital ◽  
Selective Neck Dissection ◽  
Rare Form ◽  
Nasopharyngeal Biopsy ◽  
Four Quadrant

Objective: To report a rare form of metastasis from a primary nasopharyngeal carcinoma, a creeping form of dermal metastasis.   Methods: Design: Case Report Setting: Tertiary Public University Hospital Patient: One   Results: A 47-year-old male referred for radiotherapy after having undergone a selective neck dissection for multiple cervical lymphadenopathy with histopathologic diagnosis of undifferentiated carcinoma and no known primary underwent a four-quadrant nasopharyngeal biopsy which confirmed the presence of nasopharyngeal carcinoma. Subsequent radiotherapy resolved the primary mass , and a new posterior cervical lymph node that appeared five months after completion of radiotherapy also resolved with additional radiotherapy. He was asymptomatic for two years until he noted thickening of the skin in his left supraclavicular area. A Computed Tomography (CT) scan showed deep cervical adenopathy and skin thickening, and biopsy confirmed dermal metastatic carcinoma. Two courses of radiotherapy to the affected skin and left axilla where a lymph node had developed resulted in resolution and he was referred for chemotherapy.   Conclusion: Dermal metastasis from nasopharyngeal carcinoma is rare and does not present with pathognomonic symptomatology. It may therefore be confused for a benign side effect (dermatitis), not the malignant manifestation that forebodes a bad prognosis. Patients with dermal metastasis should receive treatment, and radiotherapy may play a significant part. Chemotherapy may also play a role in its management.   Keywords: Nasopharyngeal carcinoma, dermal metastasis

R414 – Nasopharyngeal Undifferentiated Carcinoma: Study of 46 Cases

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P182-P182
Author(s):  
Carlos Neutzling Lehn ◽  
Helma Maria Chedid ◽  
Alex Freitas Porsani
Keyword(s):  
Lymph Node ◽  
Nasopharyngeal Carcinoma ◽  
Metastatic Lymph Node ◽  
Clinical Stage ◽  
Bimodal Distribution ◽  
Undifferentiated Carcinoma ◽  
Regional Control ◽  
Kaplan Meier ◽  
Age Range

Problem The nasopharyngeal carcinoma (NPC) has been a rare cancer in the world. The incidence is higher in the southern Asiatic, Groveland and Tunisia. The age range follows the bimodal distribution. It appears most frequently in males, with a ratio of 3:1. Carcinogenic factors such as tobacco and alcohol have a role of little importance in the carcinogenesis of nasopharyngeal undifferentiated carcinoma. The diagnosis has gotten in elderly phase, named noiseless phase of growing and is not common the initial presentation with metastatic lymph node in the neck. The aim of this study was the assessment of demographic, clinical and treatment factors of nasopharyngeal undifferentiated carcinoma in Department of Head and Neck Surgical and Otorrinolaryngology of Heliópolis Heliópolis-Hosphel. Methods This was the retrospective study of 46 patients on January 1998 to august 2000. All patients with nasopharyngeal carcinoma had presented histopathological diagnostic of undifferentiated type. The treatment was the radiotherapy concomitant to chemotherapy to the clinical stage III and IV. Statistic analysis: Kaplan-Meier methods. Results The symptom of the most importance was the lymph node of neck. The local recurrences were not retreat and three of four regional recurrences were treated with neck dissection. All patients that spread out distance metastasis had presented loco-regional control. Conclusion The tobacco and alcohol were not factors related to disease presentation. The survival free of disease to three years was of 52%. Significance The incidence, clinical factors and treatments and survival among patients with nasopharyngeal undifferentiated carcinoma.

scholarly journals OVEREXPRESSION VASCULAR ENDOTHELIAL GROWTH FACTOR IN NASOPHARYNGEAL CARCINOMA WITH UNDIFFERENTIATED CARCINOMA TYPE IN ADVANCED STAGE

2019 ◽  
Vol 1 (02) ◽  
pp. 66-68
Author(s):  
Kadek Kris Aryana
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Nasopharyngeal Carcinoma ◽  
Tumor Stage ◽  
Undifferentiated Carcinoma ◽  
Vascular Endothelial ◽  
Advanced Stage ◽  
Vegf Expression ◽  
Nasopharyngeal Biopsy ◽  
Endothelial Growth Factor

Introduction: Nasopharyngeal Carcinoma (NPC) is a malignancy that tends to diagnosed at an advanced stage with low survival and prognosis rate. One of the factors that may play a role in progressivity and metastasis of tumor is overexpression of vascular endothelial growth factor (VEGF), which is a key role in tumor angiogenesis. Objective: This study aims to learn the expression of VEGF in NPC with Undifferentiated Carcinoma type and to learn the association pf VEGF Expression with tumor stage of NPC Method: This is a cross-sectional study performed in ENT-HNS Department of ENT-HNS of Udayana University/Sanglah Hospital. The sample was collected by consecutive nonprobability sampling, starting from January 2016. NPC patients underwent Histopathologic examination from a nasopharyngeal biopsy. The result is Undifferentiated Carcinoma. VEGF expression analyzed by red-brown stained cytoplasm. Data were analyzed by Spearman's Correlation Test Chi-Square test, and Paired Sample t-Test. Result: VEGF positive Expression was found in 27 of 28 (96.4%) Undifferentiated Carcinoma type of NPC cases. VEGF overexpression was found in 23 of 28 (82.4%) Undifferentiated Carcinoma type of NPC cases.There is significant correlation found between tumor stage and VEGF expression (p<0.05). Conclusion: From the research, it could conclude that there is significant correlation between tumor stage and VEGF Expression.

scholarly journals Cervical-facial adenopathies in Odonto-stomatology: Study of 82 observations

2017 ◽  
Author(s):  
Boubacar Ba ◽  
Issa Konaté ◽  
Drissa Goita ◽  
Abdoulaye Kassambara ◽  
A Toure ◽  
...  
Keyword(s):  
Lymph Node ◽  
Medical Records ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
University Hospital ◽  
Tuberculous Lymphadenitis ◽  
Early Management ◽  
Node Biopsy ◽  
The University ◽  
Anatomic Region

Objective: The objective of this study is to describe the etiological profile of patients with cervical lymphadenopathy in relation to tuberculosis in our practice Odonto-stomatologique.Materials and Methods: We conducted a retrospective study over a period of four years at the University Hospital of Stomatology Odonto (CHU OS) Bamako. The successive cases of cervical lymphadenopathy of tuberculous origin confirmed by skin test (TST) to tuberculin 10 units or lymph node biopsy for histological referred. Data were collected from medical records and entered and analyzed with the software Epiinfo.fr 6.0Results: The lesions involved 82 patients including 37 men (45.1%) with a sex ratio of 1.21. The age group most represented was that of 20 and 29 years (28%). The anatomic region was privileged bilateral cervical (57.30%).Our patients underwent chest radiography in 90.20% of cases. The IDR was performed in 72% of patients and tuberculous lymphadenitis and follicular caseo was found in 8.50% of cases.Conclusion: Our study revealed a prevalence of 0.31% of cervical-facial adenopathies of which 80.50% was tuberculous. In the case of tuberculous endemic tuberculous adenopathy, an IDRT and anatomopathological examination of the lymph node biopsy should be systematic for the early management of tuberculosis

scholarly journals Metastatic cervical lymphadenopathy masquerading as extrapulmonary tuberculosis

2012 ◽  
Vol 18 (2) ◽  
pp. 234-237 ◽  
Author(s):  
Adebolajo A Adeyemo
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Extrapulmonary Tuberculosis ◽  
Cervical Lymphadenopathy ◽  
Needle Aspiration ◽  
Diagnostic Challenge ◽  
Nasopharyngeal Biopsy ◽  
High Prevalence ◽  
Needle Aspiration Cytology ◽  
High Index Of Suspicion ◽  
Tuberculosis Care

Introduction: Cervical lymphadenopathy can be due to various pathologies especially in the young. A high index of suspicion is required in the management of cervical lymphadenopathy to prevent misdiagnosis and wrong treatment.Case report: Here present the diagnostic challenge in the case of a young lady with nasopharyngeal carcinoma who initially presented solely with cervical lymphadenopathy. Previous fine needle aspiration cytology had suggested tuberculosis (TB) and she was commenced on anti-TB drugs. However failure of improvement and worsening symptoms led to another review in ENT clinic. A subsequent nasopharyngeal biopsy confirmed nasopharyngeal carcinoma. She subsequently improved after commencement of appropriate treatment.Conclusion: In regions with a high prevalence rate of tuberculosis, care must be taken to exclude malignancy in patients with cervical lymphadenopathy even when cytology suggests a granulomatous infection. DOI: http://dx.doi.org/10.3329/bjo.v18i2.12030 Bangladesh J Otorhinolaryngol 2012; 18(2): 234-237

scholarly journals Clinico-pathological profile of nasopharyngeal carcinoma at Muhimbili National Hospital, Dares Salaam, Tanzania

2019 ◽  
Vol 5 (4) ◽  
pp. 922 ◽  
Author(s):  
Zephania Saitabau Abraham ◽  
Enica Richard Massawe ◽  
Daudi Ntunaguzi ◽  
Aveline Aloyce Kahinga ◽  
James Joseph Yahaya ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Malignant Neoplasm ◽  
Cervical Lymphadenopathy ◽  
Stage Iv ◽  
Undifferentiated Carcinoma ◽  
Disease Stage ◽  
Wood Dust ◽  
Early Referral ◽  
Set Up ◽  
Age Range

<p class="abstract"><strong>Background:</strong> Nasopharyngeal carcinoma (NPC) is an uncommon malignant tumor which has been reported invariably and cases have been encountered in Tanzania. Though rare they are associated with potential morbidity and mortality. The aim of this study was to characterize the clinico-pathological profile of such neoplasm in our set up.</p><p class="abstract"><strong>Methods:</strong> A retrospective review of 25 cases from hospital archives for 3 consecutive years was done where all patients with a histopathologically confirmed diagnosis of NPC were recruited. Data was analyzed using SPSS version 21.</p><p class="abstract"><strong>Results:</strong> Of the 25 eligible cases, 15 (60%) were males and 10 (40%) were females. Age range was 15-70 years. The peak age was 30-50 years in males and 50-59 years in females. Highest incidence was in the 5<sup>th</sup> decade. The commonest presenting features were cervical lymphadenopathy (92%) epistaxis (80%), hearing loss (80%) and nasal obstruction (76%) while the least common feature was seizures (4%). Histologically, undifferentiated carcinoma (76%) was the commonest variant while the least common one was differentiated non keratinizing squamous cell carcinoma (8%). Identifiable risk factors were consumption of salted smoked fish (80%), tobacco use (60%), alcohol intake (52%) and occupational exposure to wood dust (32%). Majority of patients (80%) were diagnosed with advanced stage of the disease (Stage IV).</p><p class="abstract"><strong>Conclusions:</strong> Findings from this study correlate with what has been reported elsewhere. Clinicians should have a higher index of suspicion in diagnosing NPC to enable early referral and prompt treatment of such malignant neoplasm.</p>

Sinus Histiocytosis with Massive Cervical Lymphadenopathy

1986 ◽  
Vol 95 (4) ◽  
pp. 331-335 ◽  
Author(s):  
Vanessa G. Schweitzer ◽  
Gregg D. Bobier
Keyword(s):  
Lymph Node ◽  
Fatal Outcome ◽  
Cervical Lymphadenopathy ◽  
Metastatic Carcinoma ◽  
Lymph Node Biopsy ◽  
Sinus Histiocytosis ◽  
Tuberculous Lymphadenitis ◽  
Massive Lymphadenopathy ◽  
Polyclonal Hypergammaglobulinemia ◽  
History Of

Sinus histiocytosis with massive cervical lymphadenopathy (SHML) was originally described in 1969 as a benign clinicopathologic entity characterized by massive bilateral cervical lymphadenopathy, fever, leukocytosis, elevated ESR, and hypergammaglobulinemia, usually occurring within the first two decades of life. We present an illustrated case of an elderly patient with polyclonal hypergammaglobulinemia and a 2-year history of multilobulated cervical and submandibular lymphadenopathy. The etiology and pathogenesis of SHML are not known. Diagnosis requires lymph node biopsy to exclude other causes of cervical lymphadenopathy such as malignant lymphoma, malignant histiocytosis, metastatic carcinoma, and tuberculous lymphadenitis. Histologic examination shows marked dilatation of subcapsular and medullary lymph node sinuses containing large, foamy or vacuolated histiocytes. Although no curative treatment is known, corticosteroids, radiation therapy, vinblastine and oral cyclophosphamide, and surgery have been used to palliate constitutional symptoms and mechanical obstruction from massive lymphadenopathy. Since one third of SHML patients have evidence of disease for 5 years, and a mortality rate of 7% exists with benign histologic disease, all patients with SHML should be carefully screened for evidence of immunodeficiencies that may precipitate a fatal outcome.

scholarly journals Undifferentiated Nasopharyngeal Malignancy with Immunohistochemical Features of Diffuse Large B Cell Lymphoma and Undifferentiated Carcinoma: A Collision Tumor?

2012 ◽  
Vol 27 (1) ◽  
pp. 12-17
Author(s):  
January E. Gelera ◽  
Norberto V. Martinez
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Collision Tumor ◽  
Undifferentiated Carcinoma ◽  
University Hospital ◽  
Secondary Malignancy ◽  
Large B Cell Lymphoma ◽  
Nasopharyngeal Biopsy ◽  
Large B Cell

Objective: To describe an unusual presentation of undifferentiated nasopharyngeal malignancy with immunohistochemical features of both diffuse B-cell lymphoma and undifferentiated carcinoma.Methods:     Design: Case Report     Setting: Tertiary Private University Hospital     Patient: OneResults: A 49-year-old female whose initial nasopharyngeal biopsy interpretation was diffuse large B-cell lymphoma underwent three cycles of Rituximab, Cyclophosphamide, Hydroxydaunomycin, Oncovin and Prednisone (R-CHOP). Post-chemotherapy ComputedTomography (CT) scan of the nasopharynx revealed no change in tumor size or appearance. Repeat nasopharyngeal (NP) biopsy findings suggested an epithelial tumor lineage or post chemotherapy reactive mucosal epithelial cells. No residual lymphoma was noted and immunostaining was positive for cytokeratin. The patient underwent 35 fractions of radiotherapy. Re-evaluation by Magnetic Resonance Imaging (MRI) with contrast after four months showed significant tumor shrinkage. Repeat NP biopsy revealed necrotic tissues with foci of high-grade squamous cell carcinoma. Two months after the biopsy, repeat MRI with contrast of the nasopharynx and neck showed increase in the bulk of the nasopharyngeal tumor with inferior extension to the level ofthe orophaynx and possible contralateral involvement. A nasopharyngectomy via left maxillary swing was performed and the final histopathology was undifferentiated carcinoma.Conclusion: Undifferentiated malignancies of the nasopharynx may contain lymphoma or carcinoma and rarely, both lineages in coexistence. In such cases, the possibility of a collision tumor should be considered. Immunohistochemical distinction is important for treatment and prognostication.Keywords: nasopharyngeal carcinoma, undifferentiated tumor, undifferentiated carcinoma, nasopharyngeal lymphoma, collision tumors, immunohistochemistry, Diffuse large B-cell lymphoma,secondary malignancy

scholarly journals RECURRENT NASOPHARYNGEAL CARCINOMA: PROBLEM AND MANAGEMENT

2020 ◽  
Vol 2 (02) ◽  
pp. 47-49
Author(s):  
Rusina Hayati
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Conductive Hearing Loss ◽  
Undifferentiated Carcinoma ◽  
Treatment Results ◽  
Mortality And Morbidity ◽  
Appropriate Treatment ◽  
Nasopharyngeal Biopsy ◽  
Complete Treatment ◽  
Recurrent Nasopharyngeal Carcinoma ◽  
Conductive Hearing

Abstract Introduction: Treatment results for nasopharyngeal carcinoma (NPC) have been improved, but there were still some patients who developed localized persistent or local recurrent. Local recurrence still represents a major cause of mortality and morbidity also management still challenging issues. Case Report: A 27-year-old woman presented with bilateral conductive hearing loss, dysphagia, rhinorrhoea, epistaxis, and cranial nerve palsy after chemo radiation for NPC. The results of nasopharyngoscopy, CT scan, and PET scan were not found a mass in the nasopharynx. The result of nasopharyngeal biopsy result was undifferentiated carcinoma. Patient diagnosed with recurrent NPC and planned for re-radiotherapy. Conclusion: After complete treatment for NPC we must immediately ensure recurrence and choose the next appropriate treatment.

STUDY OF HISTOPATHOLOGY IN PATIENTS WITH HODGKIN AND NON - HODGKIN LYMPHOMA

2016 ◽  
pp. 59-65 ◽  
Author(s):  
Van Mao Nguyen
Keyword(s):  
Lymph Node ◽  
Hodgkin Lymphoma ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Cross Sectional ◽  
Histopathological Classification ◽  
Non Hodgkin Lymphoma ◽  
Key Words Lymphoma ◽  
Malignant Grade

Background: Lymphoma is one of the most ten common cancers in the world as well as in Vietnam which has been ever increasing. It was divided into 2 main groups Hodgkin and non – Hodgkin lymphoma in which non-Hodgkin lymphoma appeared more frequency, worse prognosis and different therapy. Objectives: - To describe some common characteristics in patients with non – Hodgkin lymphoma; - To determine the proportion between Hodgkin and non- Hodgkin lymphoma, histopathological classification of classical Hodgkin by modified Rye 1966 and non-Hodgkin lymphoma by Working Formulation (WF) of US national oncology institute 1982. Materials and Method: This cross-sectional study was conducted on 65 patients with Hodgkin and non- Hodgkin lymphoma diagnosed definitely by histopathology at Hue Central Hospital and Hue University Hospital. Results:. The ratio of male/female for the non-Hodgkin lymphoma was 1.14/1, the most frequent range of age was 51-60 accounting for 35%, not common under 40 years. Non - Hodgkin lymphoma appeared at lymph node was the most common (51.7%), at the extranodal site was rather high 48.3%. The non - Hodgkin lymphoma proportion was predominant 92.3% comparing to the Hodgkin lymphoma only 7.7%; The most WF type was WF7 (53.3%), following the WF6 18,3% and WF5 11,7%; The intermediate malignancy grade of non- Hodgkin lymphoma was the highest proportion accouting for 85%, then the low and the high one 8.3% and 6.7% respectively. Conclusion: The histopathological classification and the malignant grade of lymphoma for Hodgkin and non - Hodgkin lymphoma played a practical role for the prognosis and the treatment orientation, also a fundamental one for the modern classification of non - Hodgkin lymphoma nowadays. Key words: lymphoma, Hodgkin lymphoma, non-Hodgkin lymphoma, classication, grade, histopathology, lymph node

scholarly journals Circulating cell‐free epstein–barr virus DNA levels and clinical features in Moroccan patients with nasopharyngeal carcinoma

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Amina Gihbid ◽  
Raja Benzeid ◽  
Abdellah Faouzi ◽  
Jalal Nourlil ◽  
Nezha Tawfiq ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Lymph Node ◽  
Nasopharyngeal Carcinoma ◽  
Epstein Barr Virus ◽  
Disease Stage ◽  
Barr Virus ◽  
Ebv Dna ◽  
Epstein Barr ◽  
Pre Treatment ◽  
Moroccan Patients

Abstract Background The identification of effective prognosis biomarkers for nasopharyngeal carcinoma (NPC) is crucial to improve treatment and patient outcomes. In the present study, we have attempted to evaluate the correlation between pre-treatment plasmatic Epstein-Barr virus (EBV) DNA load and the conventional prognostic factors in Moroccan patients with NPC. Methods The present study was conducted on 121 histologically confirmed NPC patients, recruited from January 2017 to December 2018. Circulating levels of EBV DNA were measured before therapy initiation using real-time quantitative PCR. Results Overall, undifferentiated non-keratinizingcarcinoma type was the most common histological type (90.1 %), and 61.8 % of patients were diagnosed at an advanced disease stage (IV). Results of pre-treatment plasma EBV load showed that 90.9 % of patients had detectable EBV DNA, with a median plasmatic viral load of 7710 IU/ml. The correlation between pre-treatment EBV DNA load and the conventional prognostic factors showed a significant association with patients’ age (p = 0.01), tumor classification (p = 0.01), lymph node status (p = 0.003), metastasis status (p = 0.00) and overall cancer stage (p = 0.01). Unexpectedly, a significant higher level of pre-treatment EBV DNA was also found in plasma of NPC patients with a family history of cancer (p = 0.04). The risk of NPC mortality in patients with high pretreatment EBVDNA levels was significantly higher than that of those with low pre-treatment plasma EBV-DNA levels (p < 0.05). Furthermore, patients with high pre-treatment EBV-DNA levels (≥ 2000, ≥ 4000) had a significant low overall survival (OS) rates (p < 0.05). Interestingly, lymph node involvement, metastasis status and OS were found to be the most important factors influencing the EBV DNA load in NPC patients. Conclusions The results of the present study clearly showed a high association between pre-treatment EBV DNA load, the crucial classical prognostic factors (T, N, M and disease stage) of NPC and OS, suggesting that pre-treatment EBV DNA can be a useful prognostic biomarker in clinical decision-making and improving NPC treatment in Morocco.

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