Common pathogenesis of cardiovascular diseases and inflammatory processes of the oral cavity and maxillofacial region from the standpoint of the relationship of systemic proinflammatory biomarkers

2021 ◽  
Vol 9 (1) ◽  
pp. 39-48
Author(s):  
I.A. Lebedeva ◽  
◽  
G.N. Magradze ◽  
S.A. Partsernyak ◽  
V.S. Ustyuzhaninov ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Oral Cavity ◽  
Maxillofacial Region ◽  
Inflammatory Processes ◽  
Common Pathogenesis ◽  
Relationship Of ◽  
The Relationship

scholarly journals Involvement of the Androgen and Glucocorticoid Receptors in Bladder Cancer

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Lucien McBeth ◽  
Maria Grabnar ◽  
Steven Selman ◽  
Terry D. Hinds
Keyword(s):  
Bladder Cancer ◽  
Glucocorticoid Receptors ◽  
Lifestyle Risk Factors ◽  
Glucocorticoid Signaling ◽  
Major Player ◽  
Inflammatory Processes ◽  
Lifestyle Risk ◽  
Relationship Of ◽  
The Relationship ◽  
Male To Female

Bladder cancer is encountered worldwide having been associated with a host of environmental and lifestyle risk factors. The disease has a male to female prevalence of 3 : 1. This disparity has raised the possibility of the androgen receptor (AR) pathway being involved in the genesis of the disease; indeed, research has shown that AR is involved in and is likely a driver of bladder cancer. Similarly, an inflammatory response has been implicated as a major player in bladder carcinogenesis. Consistent with this concept, recent work on anti-inflammatory glucocorticoid signaling points to a pathway that may impact bladder cancer. The glucocorticoid receptor- (GR-)αisoform has an important role in suppressing inflammatory processes, which may be attenuated by AR in the development of bladder cancer. In addition, a GR isoform that is inhibitory to GRα, GRβ, is proinflammatory and has been shown to induce cancer growth. In this paper, we review the evidence of inflammatory mediators and the relationship of AR and GR isoforms as they relate to the propensity for bladder cancer.

scholarly journals The Relationship of Serum Antigen-Specific and Total Immunoglobulin E with Adult Cardiovascular Diseases

2018 ◽  
Vol 15 (11) ◽  
pp. 1098-1104 ◽  
Author(s):  
Zhiyan Xu ◽  
Tao Wang ◽  
Xiaoxiao Guo ◽  
Yao Li ◽  
Yi Hu ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Immunoglobulin E ◽  
Serum Antigen ◽  
Relationship Of ◽  
The Relationship ◽  
Total Immunoglobulin

scholarly journals Relationship Between Polycyclic Aromatic Hydrocarbons and Cardiovascular Diseases: A Systematic Review

2021 ◽  
Vol 9 ◽  
Author(s):  
Manthar Ali Mallah ◽  
Mukhtiar Ali Mallah ◽  
Yang Liu ◽  
He Xi ◽  
Wei Wang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cardiovascular Diseases ◽  
The United States ◽  
Systemic Review ◽  
Human Populations ◽  
Increased Risk ◽  
Polycyclic Aromatic ◽  
Pah Exposure ◽  
Relationship Of ◽  
The Relationship

Objective: The primary aim of this systematic review was to examine the relationship of polycyclic aromatic hydrocarbon (PAH) exposure with cardiovascular diseases (CVDs) and elaborate the current knowledge and recent advances in the area of PAH and its effects on CVDs and discuss the growing epidemiological evidence linking PAH to CVDs on the health of human populations. In this systematic review, the increased risk of cardiovascular diseases and their relationship with PAHs were discussed in detail.Methods: On 05th April 2021, a systematic literature search was conducted using PubMed/Medline and Web of Science search engines in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. The search was limited to articles that were written in English and dealt with human issues. All original peer-review publications were considered for inclusion. Comments, case reports, reviews, duplicated papers, and conference reports were excluded. Data was collected from included papers by two independent reviewers.Results: Conclusively, 20 research articles published between 2005 and 2021 were chosen for the final analysis. The systemic review included 20 studies with a variety of geographical studies. The most common research category among the nominated studies were time-series studies followed by retrospective cohort, cross-sectional, quasi-experimental, panel, and case-control studies. Most of the studies were conducted in the United States, whereas others were showed in various geographical countries around the world, such as Denmark, Germany, Finland, Netherlands, France, China, Norway, Korea, Sweden, Saudi Arabia, and Belgium. Eight studies assessed the association between PAH exposure and CVDs, four articles observed this relationship with blood pressure (BP), two observed association between atherosclerotic CVD and PAH, one congenital heart disease, cardiovascular events, and two with obesity. Furthermore, in some investigations, a favorable association between PAH exposure and hypertension as well as PAH exposure and obesity was found.Conclusion: In conclusion, this systematic review examined the relationship of PAH exposure with CVDs and CVD-related risk factors by searching several digital databases. After a comprehensive literature searches and summarizing findings from 20 articles, the authors concluded that a positive relationship was observed between PAH exposure and CVD risks.

scholarly journals The relationship of obstructive sleep apnea and cardiovascular diseases from the perspective of evidence-based medicine. Part 1

2020 ◽  
Vol 19 (3) ◽  
pp. 2405
Author(s):  
М. V. Agaltsov ◽  
O. M. Drapkina
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Cardiovascular Diseases ◽  
Sleep Disorders ◽  
Developed Countries ◽  
Obstructive Sleep ◽  
Number Of Patients ◽  
High Prevalence ◽  
Relationship Of ◽  
The Relationship

The results of prospective studies, meta-analyzes and systematic reviews on the associations of obstructive sleep apnea (OSA) with various cardiovascular diseases (CVD) were analyzed. Currently, the mechanisms related to high prevalence of breathing-related sleep disorders among population of economically developed countries are clear, and an increase in the number of OSA patients has been shown. The relationship between OSA and CVD has been widely confirmed in large cohort studies. The first review part discusses the relationship of hypertension (HTN) and various heart arrhythmias (atrial fibrillation (AF), bradyarrhythmias, premature ventricular contraction, sudden death during sleep) with breathing-related sleep disorders. These groups of cardiovascular disorders currently show the most proven relationship with sleep apnea. In addition to cross-sectional studies indicating the high prevalence of OSA in patients with HTN and AF, some observational studies indicate an increase in the number of patients with HTN and paroxysmal AF with history of untreated sleep apnea. An analysis of the current issues of OSA phenotypes (in particular, REM-related OSA in hypertensive patients) as the most unfavorable cardiovascular factors is carried out.

Beyond anemia: hepcidin, monocytes and inflammation

2013 ◽  
Vol 394 (2) ◽  
pp. 1-10 ◽  
Author(s):  
Xiaolan Zhang ◽  
Brad H. Rovin
Keyword(s):  
Iron Homeostasis ◽  
Regulatory Protein ◽  
Mononuclear Phagocyte ◽  
Hepcidin Expression ◽  
Systemic Level ◽  
Monocytes And Macrophages ◽  
Inflammatory Processes ◽  
Serum Hepcidin ◽  
Relationship Of ◽  
The Relationship

Abstract Hepcidin is an iron regulatory protein mainly synthesized by the liver. Hepatocyte production of hepcidin is responsible for serum hepcidin, is responsive to body iron stores, and is critical for maintaining iron homeostasis. Monocytes and macrophages also express hepcidin, and in contrast to the liver, hepcidin expression is primarily regulated by inflammatory mediators and infectious agents. Monocyte and macrophage hepcidin is likely to be more important on a local rather than systemic level, contributes to host defense and may modulate inflammatory processes. This review summarizes recent findings and hypotheses on the relationship of hepcidin to the mononuclear phagocyte system.

scholarly journals The relationship of breast arterial calcification detected in mammographic examinations with cardiovascular diseases, cardiovascular risk factors, parity, and breastfeeding

2016 ◽  
Vol 46 ◽  
pp. 641-645 ◽  
Author(s):  
Kadihan YALÇIN ŞAFAK ◽  
Ayşegül ERATALAY ◽  
Ebru DÜLGER İLİŞ ◽  
Neslihan UMARUSMAN TANJU ◽  
Begüm Damla ŞENCAN ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Diseases ◽  
Cardiovascular Risk Factors ◽  
Arterial Calcification ◽  
Relationship Of ◽  
The Relationship

Laryngeal cysts: clinical relevance of a modified working classification

1988 ◽  
Vol 102 (10) ◽  
pp. 923-925 ◽  
Author(s):  
Keith Ramesar ◽  
Claudio Albizzati
Keyword(s):  
Oral Cavity ◽  
Clinical Relevance ◽  
Surface Epithelium ◽  
Epithelial Cyst ◽  
Operative Trauma ◽  
Epithelial Cysts ◽  
Relationship Of ◽  
The Relationship

AbstractLaryngeal cysts from 72 patients were examined and reclassified according to a modified working classification. In this series, 47 patients (66 per cent) had epithelial cysts, 11 patients (15 per cent) oncocytic cysts and 14 patients (19 per cent) tonsillar cysts. Epithelial cysts were commonest in the region of the epiglottis (20/47) and laryngeal ventricle (24/47). Oncocytic cysts tended to lie in the region of the ventricle whereas tonsillar cysts occurred almost exclusively in the valleculae, epiglottis and pyriform region (13/14).The authors conclude that the modified working classification of laryngeal cysts is easy to apply, of clinical relevance, and allows classification of cysts where operative trauma to the specimen obscures the relationship of the cyst to the surface epithelium. The origin and significance of tonsillar cysts are discussed and a relationship to the lympho-epithelial cyst of the oral cavity is suggested.

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