Involvement of the Androgen and Glucocorticoid Receptors in Bladder Cancer

Bladder cancer is encountered worldwide having been associated with a host of environmental and lifestyle risk factors. The disease has a male to female prevalence of 3 : 1. This disparity has raised the possibility of the androgen receptor (AR) pathway being involved in the genesis of the disease; indeed, research has shown that AR is involved in and is likely a driver of bladder cancer. Similarly, an inflammatory response has been implicated as a major player in bladder carcinogenesis. Consistent with this concept, recent work on anti-inflammatory glucocorticoid signaling points to a pathway that may impact bladder cancer. The glucocorticoid receptor- (GR-)αisoform has an important role in suppressing inflammatory processes, which may be attenuated by AR in the development of bladder cancer. In addition, a GR isoform that is inhibitory to GRα, GRβ, is proinflammatory and has been shown to induce cancer growth. In this paper, we review the evidence of inflammatory mediators and the relationship of AR and GR isoforms as they relate to the propensity for bladder cancer.

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The Relationship of Lifestyle Risk Factors and Depression in Korean Adults: A Moderating Effect of Overall Nutritional Adequacy

Nutrients ◽

10.3390/nu13082626 ◽

2021 ◽

Vol 13 (8) ◽

pp. 2626

Author(s):

Minjeong Kang ◽

Mingyu Joo ◽

Haeryun Hong ◽

Hyunsik Kang

Keyword(s):

Risk Factors ◽

Moderating Effect ◽

Nutritional Adequacy ◽

Lifestyle Risk Factors ◽

Korean Adults ◽

Lifestyle Risk ◽

Mean Adequacy Ratio ◽

Relationship Of ◽

The Relationship

Background: Little is known regarding the role of nutrition in determining the associations between lifestyle risk factors and depression. Objectives: This study examined whether or not nutritional adequacy modulates the relationship between depression and lifestyle risk factors in Korean adults aged 18-65 years (n = 7446). Methods: Data were obtained from the 2016 and 2018 Korea National Health and Examination Survey. Depression, smoking, at-risk alcohol consumption, physical inactivity, sleep deprivation, and mean adequacy ratio (MAR) were assessed. Results: Individuals with two (OR = 1.960, p < 0.001), three (OR = 4.237, p < 0.001), or four (OR = 5.312, p < 0.001) risk factors had a significantly higher risk of depression compared to individuals with one or zero risk factor. In contrast, individuals with moderate MAR (OR = 0.607, p < 0.001) and high (OR = 0.698, p < 0.001) MAR had a lower depression risk compared to individuals with low MAR. Moderation analysis showed a moderating effect of MAR (coefficient = −0.220, p = 0.007) on the relationship between risk factors and depression. Conclusions: The current findings suggest that overall nutritional adequacy plays a modulating role in determining the relationship between depression and lifestyle risk factors in Korean adults.

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Common pathogenesis of cardiovascular diseases and inflammatory processes of the oral cavity and maxillofacial region from the standpoint of the relationship of systemic proinflammatory biomarkers

Cardiology: News, Opinions, Training ◽

10.33029/2309-1908-2021-9-1-39-48 ◽

2021 ◽

Vol 9 (1) ◽

pp. 39-48

Author(s):

I.A. Lebedeva ◽

◽

G.N. Magradze ◽

S.A. Partsernyak ◽

V.S. Ustyuzhaninov ◽

...

Keyword(s):

Cardiovascular Diseases ◽

Oral Cavity ◽

Maxillofacial Region ◽

Inflammatory Processes ◽

Common Pathogenesis ◽

Relationship Of ◽

The Relationship

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The relationship of histamine H2 receptor-bearing suppressor cells with the growth and metastasis of FANFT-induced bladder cancer

Journal of Surgical Oncology ◽

10.1002/jso.2930240113 ◽

1983 ◽

Vol 24 (1) ◽

pp. 53-58 ◽

Cited By ~ 4

Author(s):

Richard K. Babayan ◽

Michael E. Osband ◽

Gennaro A. Carpinito ◽

Zheng Sen Ho ◽

Ellen B. Cohen ◽

...

Keyword(s):

Bladder Cancer ◽

Suppressor Cells ◽

Histamine H2 Receptor ◽

H2 Receptor ◽

Relationship Of ◽

The Relationship

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The Relationship between Depression and Lifestyle Risk Factors in Office Workers

Medicine & Science in Sports & Exercise ◽

10.1249/01.mss.0000485681.11819.1e ◽

2016 ◽

Vol 48 ◽

pp. 227

Author(s):

YoungYun Jin ◽

Sunghun Yang ◽

Haeryon Hong ◽

Changduk Ha ◽

Jiyoung Kong ◽

...

Keyword(s):

Risk Factors ◽

Office Workers ◽

Lifestyle Risk Factors ◽

Lifestyle Risk ◽

The Relationship

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Lifestyle Risk Factors and the Population Attributable Fractions for Overweight and Obesity in Chinese Students of Zhejiang Province

Frontiers in Pediatrics ◽

10.3389/fped.2021.734013 ◽

2021 ◽

Vol 9 ◽

Author(s):

Fang Gu ◽

Siliang Zhou ◽

Ke Lou ◽

Rui Deng ◽

Xingxiu Li ◽

...

Keyword(s):

Risk Factors ◽

Chinese Students ◽

Lifestyle Factors ◽

Overweight And Obesity ◽

Zhejiang Province ◽

Lifestyle Risk Factors ◽

Population Attributable Fractions ◽

Attributable Fractions ◽

Lifestyle Risk ◽

The Relationship

Objectives: To assess the relationship between modifiable lifestyle factors and risk of overweight/obesity in Chinese students, and to evaluate the predicting prevalence of overweight if the lifestyle risk factors were removed.Methods: A cross-sectional survey was conducted among 40,141 students in grade three and above (8–24yrs) in 2019 in Zhejiang Province, China. Physical examination was performed, and a self-administered questionnaire was used to collect lifestyle information, including dietary behavior, physical activity, TV watching, sleeping, smoking, drinking, and tooth-brushing habits. Logistic regression models were performed to assess the relationship between overweight/obesity and a series of lifestyle factors. Population attributable fractions (PAFs) were used to calculate the predicting prevalence of overweight/obesity if lifestyle risk factors were removed.Results: The prevalence of overweight/obesity of participants was 25.5% (male 32.3%, female 18.1%). Overweight/obesity were associated with adverse lifestyle factors, such as watch TV ≥1 h/day (OR = 1.14, 95% CI: 1.11–1.22), insufficient sleep (OR = 1.14, 95% CI: 1.11–1.22), and irregular toothbrushing habits (OR = 1.19, 95% CI: 1.01–1.39). Based on the calculated PAFs, the predicted prevalence of overweight/obesity would decline moderately if lifestyle factors were modified, with the magnitudes of decrease vary by sex, age and residence. Generally, a larger reduction was estimated if the sleeping time was increased and TV time was reduced, with the prevalence of overweight/obesity decreased by 1.1% (95% CI: 0.7, 1.5%) and 0.9% (95% CI: 0.6, 1.2%), respectively.Conclusions: Predicted prevalence of overweight/ obesity in Chinese students may decrease if modifiable lifestyle risk factors were removed. The attributable risk for obesity of lifestyle behaviors varied in age, sex and residence groups. The findings of this study may provide insights for planning and optimizing future obesity intervention endeavors.

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The Relationship of Local Control to Distant Metastasis in Muscle Invasive Bladder Cancer

The Journal of Urology ◽

10.1097/00005392-199512000-00026 ◽

1995 ◽

pp. 2059-2063 ◽

Cited By ~ 2

Author(s):

Alan Pollack ◽

Gunar K. Zagars ◽

Christopher J. Cole ◽

Colin P. N. Dinney ◽

David A. Swanson ◽

...

Keyword(s):

Bladder Cancer ◽

Local Control ◽

Distant Metastasis ◽

Invasive Bladder Cancer ◽

Muscle Invasive Bladder Cancer ◽

Muscle Invasive ◽

Relationship Of ◽

The Relationship

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Incidence of squamous cell carcinoma of the head and neck: Report of 1,000 cases

The Journal of Laryngology & Otology ◽

10.1017/s0022215100099217 ◽

1986 ◽

Vol 100 (3) ◽

pp. 315-328 ◽

Cited By ~ 18

Author(s):

Shaukat Ali ◽

Rammohan Tiwari ◽

Gordon B. Snow ◽

I. V.D. Waal

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Age Distribution ◽

Distant Metastases ◽

University Hospital ◽

Relationship Of ◽

The Relationship ◽

Male To Female

AbstractThe purpose of this paper is to define the incidence of squamous cell carcinoma (SCC) of the head and neck as seen at the Free University Hospital, Amsterdam, the Netherlands, in the last six years, according to the latest revised classification system of the International Union against Cancer (UICC, 1982). In addition, male to female ratios, relative frequencies at the various sites, age distribution, incidence of second or third primary and the relationship of distant metastases to the nodal metastases and the T-stage of the primary lesion are reported. These incidences are compared with those in other countries and the major differences are discussed.

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Diet and Cancer

Psycho-Oncology ◽

10.1093/med/9780190097653.003.0003 ◽

2021 ◽

pp. 13-20

Author(s):

Marian L. Fitzgibbon ◽

Lisa Tussing-Humphreys ◽

Angela Kong ◽

Alexis Bains

Keyword(s):

Risk Factors ◽

Cancer Research ◽

Lifestyle Changes ◽

Lifestyle Modifications ◽

Cancer Society ◽

Lifestyle Risk Factors ◽

Dietary Components ◽

Lifestyle Risk ◽

Obesity And Cancer ◽

The Relationship

Diet contributes to the development of 30% to 35% of cancers. Shifts in the food landscape have contributed to changes in dietary intake, energy balance, and the development of obesity. Obesity, defined as a body mass index (BMI) greater than or equal to 30 kg/m², is associated with several cancers. The World Cancer Research Fund (WCRF), the American Institute for Cancer Research (AICR), the American Cancer Society (ACS), and several large U.S.-based randomized trials are studying the relationship between diet, dietary patterns, lifestyle risk factors, obesity, and cancer. Prior research reported an association between individual nutrients and cancer risk. This research, however, did not fully investigate the complexity of diet and interactions between specific dietary components. Overall, according to data reported by the WCRF and the AICR, primary prevention of many cancers is possible through modifiable lifestyle changes. Identifying and intervening on barriers to lifestyle modifications remains a challenge, but it is increasingly apparent that there is a relationship between diet, lifestyle risk factors, and cancer development and that many cancers can be prevented.

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Beyond anemia: hepcidin, monocytes and inflammation

Biological Chemistry ◽

10.1515/bchm-2012-0217 ◽

2013 ◽

Vol 394 (2) ◽

pp. 1-10 ◽

Cited By ~ 3

Author(s):

Xiaolan Zhang ◽

Brad H. Rovin

Keyword(s):

Iron Homeostasis ◽

Regulatory Protein ◽

Mononuclear Phagocyte ◽

Hepcidin Expression ◽

Systemic Level ◽

Monocytes And Macrophages ◽

Inflammatory Processes ◽

Serum Hepcidin ◽

Relationship Of ◽

The Relationship

Abstract Hepcidin is an iron regulatory protein mainly synthesized by the liver. Hepatocyte production of hepcidin is responsible for serum hepcidin, is responsive to body iron stores, and is critical for maintaining iron homeostasis. Monocytes and macrophages also express hepcidin, and in contrast to the liver, hepcidin expression is primarily regulated by inflammatory mediators and infectious agents. Monocyte and macrophage hepcidin is likely to be more important on a local rather than systemic level, contributes to host defense and may modulate inflammatory processes. This review summarizes recent findings and hypotheses on the relationship of hepcidin to the mononuclear phagocyte system.

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