scholarly journals Maternal Age Distribution of Down-Syndrome at Pediatric Growth and Development Clinic, 2015-2019

2021 ◽  
Vol 3 (2) ◽  
pp. 73-80
Author(s):  
Musdalipa Musdalipa ◽  
Martira Maddeppungeng ◽  
Rini Wulandari
Keyword(s):  
Down Syndrome ◽  
Risk Factor ◽  
Medical Records ◽  
Growth And Development ◽  
Maternal Age ◽  
Age Distribution ◽  
Population Data ◽  
Advanced Maternal Age ◽  
Paternal Age ◽  
Study Population

Introduction: Down Syndrome is a common chromosome abnormality among infants. This condition is Present in 1 over 800 deliveries. Advanced maternal age is a risk factor for Down syndrome. Other miscellaneous factors are radiation, infection, autoimmune and paternal age. The Aim is to determine maternal age distribution of Down syndrome at pediatric growth and development polyclinic, Wahidin Sudirohusodo hospital. Methods: A Descriptive study. Study population was all outpatients at Pediatric Growth and Development polyclinic, Wahidin Sudirohusodo hospital in Makassar 2015-2019. Samples in this study were collected from total sampling of population data that met the criteria of new Down syndrome patients with complete medical records Results: This study found 237 new pediatric down syndrome patients admitted to growth and development polyclinic from January 2015 – December 2019, 95 complete medical records from 237. 52% (49) boys, 48 % (46) girls from 95 children. No gender difference was found in the presentation. Parental age of Down syndrome patients, the most advanced maternal age was >35, found 46 (48,42%), the most advanced paternal age was >35, found 63 (66,32%).  Parity < 3rd, the most maternal age between 25-35 (23,16%), parity > 3rd, the most maternal age was >34, found 30 (31,57%). Conclusion. Advance maternal and/ or paternal age is a risk factor of Down Syndrome.

scholarly journals Impact of aging on obstetric outcomes: defining advanced maternal age in Barcelona

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Marta Claramonte Nieto ◽  
Eva Meler Barrabes ◽  
Sandra Garcia Martínez ◽  
Mireia Gutiérrez Prat ◽  
Bernat Serra Zantop
Keyword(s):  
Risk Factor ◽  
Gestational Diabetes ◽  
Maternal Age ◽  
Placenta Previa ◽  
Significant Risk ◽  
Advanced Maternal Age ◽  
Obstetric Outcomes ◽  
Chronic Hypertension ◽  
Mediterranean Population ◽  
Confounding Factors

Abstract Background Women of advanced maternal age (AMA) are a growing population, with higher obstetric risks. The Mediterranean population has specific characteristics different from other areas. Thus, the objective of this study was to establish a cut-off to define AMA in a selected mediterranean population coming from a tertiary referral private/mutual health hospital in Barcelona. Methods Retrospective cohort of euploid singleton pregnancies delivered from January 2007 to June 2017. Main maternal outcomes were: gestational diabetes, preeclampsia, placenta previa, c-section and prolonged hospitalization (≥ 7 days). Main adverse perinatal outcomes were: stillbirth, prematurity, preterm prelabor rupture of membranes, low birth weight, need of admission at a neonatal intensive care unit and perinatal mortality. Adjustment for confounding factors (smoking, previous comorbilities, parity, assisted reproductive techniques (ART) and obesity) was performed. Results A total of 25054 pregnancies were included. Mean maternal age was 34.7 ± 4.2 years, with 2807 patients in the group of age between 40 and 44 years (11.2%) and 280 patients ≥45 years (1.1%). Women at AMA had higher incidence of previous comorbilities (compared to the reference group of women < 30 years): prior c-section, chronic hypertension and obesity. In addition, they were more likely to use ART. After adjusting for confounding factors, maternal age was an independent and statistically significant risk factor for gestational diabetes (OR 1.66/2.80/3.14) for ages 30–39, 40–44 and ≥ 45 years respectively, c-section (OR 1.28/2.41/7.27) and placenta previa (OR 2.56/4.83) for ages 40–44 and ≥ 45 years respectively, but not for preeclampsia (neither early-onset nor late-onset). Risk of emergency c-section was only increased in women ≥45 years (OR, 2.03 (95% CI, 1.50–2.74). In the other groups of age, the increase in c-section rate was because of elective indications. Age ≥ 45 years was associated with iatrogenic prematurity < 37 weeks (OR 2.62, 95% CI 1.30–5.27). No other relevant associations between AMA and maternal or neonatal outcomes were found. Conclusions Maternal age is an independent risk factor for adverse obstetric outcomes. Age ≥ 40 years was associated to relevant increased risks and reveals to be an adequate cut-off to define AMA in our population.

scholarly journals Maternal age at first cesarean delivery related to adverse pregnancy outcomes in a second cesarean delivery: a multicenter, historical, cross-sectional cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Shilei Bi ◽  
Lizi Zhang ◽  
Jingsi Chen ◽  
Minshan Huang ◽  
Lijun Huang ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cohort Study ◽  
Cesarean Delivery ◽  
Maternal Age ◽  
Reference Group ◽  
Multivariate Logistic Regression Analysis ◽  
Advanced Maternal Age ◽  
Adverse Outcomes ◽  
Cross Sectional ◽  
Singleton Pregnancies

Abstract Background To determine the effects of maternal age at first cesarean on maternal complications and adverse outcomes of pregnancy with the second cesarean. Methods This was a multicenter, historical, cross-sectional cohort study involving singleton pregnancies ≥28 gestational weeks, with a history of 1 cesarean delivery, and who underwent a second cesarean between January and December 2017 at 11 public tertiary hospitals in 7 provinces of China. We analyzed the effects of maternal age at first cesarean on adverse outcomes of pregnancy in the second cesarean using multivariate logistic regression analysis. Results The study consisted of 10,206 singleton pregnancies. Women were at first cesarean between 18 and 24, 25–29, 30–34, and ≥ 35 years of age; and numbered 2711, 5524, 1751, and 220 cases, respectively. Maternal age between 18 and 24 years at first cesarean increased the risk of placenta accreta spectrum (aOR, 1.499; 95% CI, 1.12–2.01), placenta previa (aOR, 1.349; 95% CI, 1.07–1.70), intrahepatic cholestasis of pregnancy (aOR, 1.947; 95% CI, 1.24–3.07), postpartum hemorrhage (aOR, 1.505; 95% CI, 1.05–2.16), and blood transfusion (aOR, 1.517; 95% CI, 1.21–1.91) in the second cesarean compared with the reference group (aged 25–29 years). In addition, maternal age ≥ 35 years at first cesarean was a risk factor for premature rupture of membranes (aOR, 1.556; 95% CI, 1.08–2.24), placental abruption (aOR, 6.464, 95% CI, 1.33–31.51), uterine rupture (aOR, 7.952; 95% CI, 1.43–44.10), puerperal infection (aOR, 6.864; 95% CI, 1.95–24.22), neonatal mild asphyxia (aOR, 4.339; 95% CI, 1.53–12.32), severe asphyxia (aOR, 18.439; 95% CI, 1.54–220.95), and admission to a neonatal intensive care unit (aOR, 2.825; 95% CI, 1.54–5.17) compared with the reference group (aged 25–29 years). Conclusions Maternal age between 18 and 24 years or advanced maternal age at first cesarean was an independent risk factor for adverse maternal outcomes with the second cesarean. Advanced maternal age at the first cesarean specifically increased adverse neonatal outcomes with the second. Therefore, decisions as to whether to perform a first cesarean at a young or advanced maternal age must be critically evaluated.

scholarly journals Advanced paternal age is associated with an increased risk of spontaneous miscarriage: a systematic review and meta-analysis

2020 ◽  
Vol 26 (5) ◽  
pp. 650-669 ◽  
Author(s):  
Nadia A du Fossé ◽  
Marie-Louise P van der Hoorn ◽  
Jan M M van Lith ◽  
Saskia le Cessie ◽  
Eileen E L O Lashley
Keyword(s):  
Systematic Review ◽  
Maternal Age ◽  
Meta Analysis ◽  
Advanced Maternal Age ◽  
Paternal Age ◽  
Free Text ◽  
Advanced Paternal Age ◽  
Spontaneous Miscarriage ◽  
Risk Estimates ◽  
Increased Risk

Abstract BACKGROUND Although spontaneous miscarriage is the most common complication of human pregnancy, potential contributing factors are not fully understood. Advanced maternal age has long been recognised as a major risk factor for miscarriage, being strongly related with fetal chromosomal abnormalities. The relation between paternal age and the risk of miscarriage is less evident, yet it is biologically plausible that an increasing number of genetic and epigenetic sperm abnormalities in older males may contribute to miscarriage. Previous meta-analyses showed associations between advanced paternal age and a broad spectrum of perinatal and paediatric outcomes. This is the first systematic review and meta-analysis on paternal age and spontaneous miscarriage. OBJECTIVE AND RATIONALE The aim of this systematic review and meta-analysis is to evaluate the effect of paternal age on the risk of spontaneous miscarriage. SEARCH METHODS PubMed, Embase and Cochrane databases were searched to identify relevant studies up to August 2019. The following free text and MeSH terms were used: paternal age, father’s age, male age, husband’s age, spontaneous abortion, spontaneous miscarriage, abortion, miscarriage, pregnancy loss, fetal loss and fetal death. PRISMA guidelines for systematic reviews and meta-analysis were followed. Original research articles in English language addressing the relation between paternal age and spontaneous miscarriage were included. Exclusion criteria were studies that solely focused on pregnancy outcomes following artificial reproductive technology (ART) and studies that did not adjust their effect estimates for at least maternal age. Risk of bias was qualitatively described for three domains: bias due to confounding, information bias and selection bias. OUTCOMES The search resulted in 975 original articles. Ten studies met the inclusion criteria and were included in the qualitative synthesis. Nine of these studies were included in the quantitative synthesis (meta-analysis). Advanced paternal age was found to be associated with an increased risk of miscarriage. Pooled risk estimates for miscarriage for age categories 30–34, 35–39, 40–44 and ≥45 years of age were 1.04 (95% CI 0.90, 1.21), 1.15 (0.92, 1.43), 1.23 (1.06, 1.43) and 1.43 (1.13, 1.81) respectively (reference category 25–29 years). A second meta-analysis was performed for the subgroup of studies investigating first trimester miscarriage. This showed similar pooled risk estimates for the first three age categories and a slightly higher pooled risk estimate for age category ≥45 years (1.74; 95% CI 1.26, 2.41). WIDER IMPLICATIONS Over the last decades, childbearing at later ages has become more common. It is known that frequencies of adverse reproductive outcomes, including spontaneous miscarriage, are higher in women with advanced age. We show that advanced paternal age is also associated with an increased risk of spontaneous miscarriage. Although the paternal age effect is less pronounced than that observed with advanced maternal age and residual confounding by maternal age cannot be excluded, it may have implications for preconception counselling of couples comprising an older aged male.

372: Advanced maternal age is not an independent risk factor for perinatal mortality

2008 ◽  
Vol 199 (6) ◽  
pp. S113
Author(s):  
Shimrit Yaniv Salem ◽  
Amalia Levy ◽  
Arnon Wiznitzer ◽  
Gershon Holcberg ◽  
Moshe Mazor ◽  
...  
Keyword(s):  
Risk Factor ◽  
Perinatal Mortality ◽  
Maternal Age ◽  
Independent Risk Factor ◽  
Advanced Maternal Age

New estimates of down syndrome risks at chorionic villus sampling, amniocentesis, and livebirth in women of advanced maternal age from a uniquely defined population

1995 ◽  
Vol 15 (5) ◽  
pp. 455-465 ◽  
Author(s):  
Jane L. Halliday ◽  
Lyndsey F. Watson ◽  
Judith Lumley ◽  
David M. Danks ◽  
Leslie J. Sheffield
Keyword(s):  
Down Syndrome ◽  
Maternal Age ◽  
Chorionic Villus ◽  
Advanced Maternal Age ◽  
Chorionic Villus Sampling

448 Cost analysis of down syndrome screening in the advanced maternal age population

2001 ◽  
Vol 185 (6) ◽  
pp. S205
Author(s):  
Janice Hartnett ◽  
Adam Borgida ◽  
Peter Benn ◽  
Michael Barsoom ◽  
Michael Deroche ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Cost Analysis ◽  
Maternal Age ◽  
Advanced Maternal Age ◽  
Down Syndrome Screening

scholarly journals MATERNAL CHARACTERISCTICS OF LOW BIRTH WEIGHT WITH KANGAROO MOTHER CARE AND PLASTIC WRAP

2021 ◽  
Vol 4 (3) ◽  
pp. 192
Author(s):  
Yulida Mufidah ◽  
Dominicus Husada ◽  
Esti Yunitasari ◽  
Risa Etika
Keyword(s):  
Risk Factor ◽  
Data Analysis ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Medical Records ◽  
Maternal Age ◽  
Kangaroo Mother Care ◽  
Input Process ◽  
Cross Sectional ◽  
Low Weight

AbstractBackground: Most Infant mortality due to low weight birth (42%). The babies need care to reduce mortality/morbidity such us Kangaroo methode and Plastic Wrap. Both of these methods aim to prevent hypothermia. This research to describes implementation of the Kangaroo Method and Plastic Wrap including input (mother, father and baby), process (staff and duration of care) and outcomes (hypothermia and Lenght of Stay). Method: Descriptive-Cross Sectional with number of sample of low birth weight are 96 (Kangaroo) and 98  babies (Plastic Wrap). The variables research are maternal age, parity, education, risk factor, complications and National health insurance’s participant. The instrument used medical records. Data analysis with frequency distribution. Result: Maternal age majority in Kangaroo Method and Plastic Wrap 20-35 years old (77,08% and 70,41%), multiparity (57,30% and 60,2%), Middle education (43,75% and 60,20%),high risk (71,87% and 55,10%), Preeclampsia (33,33% and 43,88%), Health Insuranse’s participant (79,17% and 63,27). Conclusion: data shows input, process and output of KMC and Plastic Wrap. 

scholarly journals Risk factors for mortality in pregnant women with SARS-CoV-2 infection

2020 ◽  
Author(s):  
Raigam J. Martinez-Portilla ◽  
Alexandros Sotiriadis ◽  
Johnatan Torres-Torres ◽  
Chatzakis Christos ◽  
Ameth Hawkins-Villarreal ◽  
...  
Keyword(s):  
Risk Factor ◽  
Pregnant Women ◽  
Maternal Age ◽  
Adverse Outcome ◽  
Advanced Maternal Age ◽  
Middle Income ◽  
Middle Income Countries ◽  
Obesity And Diabetes ◽  
Increased Risk ◽  
Low And Middle Income

Since the first case of pneumonia was described, SARS-CoV-2 infection (coronavirus disease [COVID]-19) rapidly spread worldwide With 94,288 infections and more than 10,000 deaths, Mexico is the third Latin-American country in number of confirmed cases and second in mortality1. A major risk factor for adverse outcome in COVID-19 infection is the presence of advance age, co-morbidities including diabetes, hypertension and obesity among other non-communicable diseases2. Epidemiological data from high-prevalence countries reveal that compared to men, women are less likely to die or to require hospital admission to intensive care. This may suggest that pregnant women are not more susceptible to infection or to experience serious complications. However, whether the presence of co-morbidities or advanced maternal age confers a higher risk of adverse outcome in pregnant women with COVID-19 is unknown3.In this research letter, we aimed at evaluating the risk factor associated with maternal mortality secondary to COVID-19 infection in a middle-income country.Advanced maternal age is linked to an increased risk of mortality, while diabetes is the most important risk factor for maternal death. This is partly explained by an increasing incidence of non-communicable diseases in women of advanced age which is a common feature in most countries4. In the last decades, low- and middle-income countries have experienced accelerated socio-cultural changes associated with its incorporation into the international economic community, which have increased the number of obese and diabetic population, including pregnant women5. This has caused an increased risk for complications and fatality among COVID-19 positive population2,3. Thus, policies for reducing obesity and diabetes in low- and middle-income countries are most needed to reduce the mortality of COVID-19 in pregnant women.

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