scholarly journals Probability of Survival in Patients with Gastric Cancer

2020 ◽  
Vol 5 (2) ◽  
Keyword(s):  
Gastric Cancer ◽  
Survival Rate ◽  
Cox Model ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Special Effects ◽  
Factors Affecting ◽  
Probability Of Survival ◽  
Kaplan Meier ◽  
Age Of Diagnosis

Background: Gastric cancer is the most common cancer and currently, the prevalence of gastric cancer is 10 percent among all cancers in the world. There are more than 870 thousand new cases worldwide each year and it causes the death of more than 650 thousand patients. This study was performed to estimate the life table survival in patients with gastric cancer in province Qazvin of Iran at 2010-2020. Methods: This is cross – sectional study whit analytical type method which has been conducted using the process of longitudinal and survival study. The study population includes all patients diagnosed with gastric cancer in Qazvin province between the years 2010 to 2020. The samples size (600 patient) selected by the random systematic simple sample method than all the patients diagnosed with gastric cancer referred to Qazvin hospitals for treatments including surgery, radiotherapy and chemotherapy that were in the same group from the time aspect, which was recorded from 2010 until 2020. The most important factors affecting survival rate were marked and analyzed with the Kaplan-Meier and cox model. Results: 68 % of 600 patients, were male with a mean age of (48.23± 8 years), and 32% of patients were female with a mean age of (46±9) and median survival rate were 36 and 40 months, and the survival rate of 1 to 5-year of patients were 16,22,28,34,52 respectively. In cox model, factors including sex, age of diagnosis, lead-time and type of treatment have significant correlation with survival rate (p ≤0.05). Conclusion: Early diagnosis and treatment of disease in the early stages with suitable surgery increase the survival of patients. However, it does not have special effects on life length of patient but it will increase the quality of life for patients.

scholarly journals Outcomes of late Kasai portoenterostomy in biliary atresia: a single-center experience

2021 ◽  
Vol 49 (5) ◽  
pp. 030006052110125
Author(s):  
Ammar Khayat ◽  
Aisha M. Alamri ◽  
Omar I. Saadah
Keyword(s):  
Biliary Atresia ◽  
Survival Rates ◽  
Cross Sectional Study ◽  
Late Presentation ◽  
Hepatic Decompensation ◽  
Cross Sectional ◽  
Factors Affecting ◽  
Single Center Experience ◽  
Kasai Procedure ◽  
Kaplan Meier

Objectives To describe the clinical, histopathologic, and outcomes data for a cohort of patients with biliary atresia (BA), and to identify the factors affecting survival. Methods This was a cross-sectional study of all BA patients diagnosed between 1999 and 2017. Clinical, biochemical, imaging, and histopathologic data were analyzed, and Kaplan–Meier survival rates were compared to identify potential prognostic factors. Results We evaluated 23 patients. The median age at the Kasai procedure was 77 ± 34 days, and the median overall survival was 12.5 ± 65 months. Thirteen (56%) patients survived with their native livers, 3 (13%) received a transplant, and 6 died (26%) while awaiting a transplant. Cholangitis and the use of ursodeoxycholic acid were associated with longer survival, while impaired synthetic function was associated with shorter survival. Conclusions Most patients presented late for the Kasai procedure. The survival rate with the native liver was comparable to other cohorts. Therefore, clinicians are encouraged to refer for the Kasai procedure even with late presentation (between 60 and 90 days), provided there is no hepatic decompensation.

The Variant rs145204276 of GAS5 is Associated with the Development and Prognosis of Gastric Cancer

2018 ◽  
Vol 27 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Qianjun Li ◽  
Gang Ma ◽  
Huimin Guo ◽  
Suhua Sun ◽  
Ying Xu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Survival Rate ◽  
Cancer Progression ◽  
Regulatory Mechanism ◽  
Tumor Stage ◽  
Kaplan Meier ◽  
Non Coding Rna ◽  
Early Tumor ◽  
Long Non Coding Rna ◽  
Clinicopathological Variables

Background & Aims: Down-regulation of the growth arrest specific transcript 5 (GAS5) (long non-coding RNA) is associated with cell proliferation of gastric cancer (GC) and a poor prognosis. We aimed to investigate whether the variant rs145204276 of GAS5 is associated with the prognosis of GC in the Chinese population, and to unveil the regulatory mechanism underlying the GAS5 expression in GC tissues.Method: 1,253 GC patients and 1,354 healthy controls were included. The frequency of the genotype del/del and the allele del of rs145204276 were compared between the patients and the controls and between different subgroups of patients classified by clinicopathological variables. The overall survival rate was analyzed according to the Kaplan-Meier method using the log-rank test.Results: The frequency of genotype del/del was significantly lower in patients than in the controls (7.0% vs. 9.1%, p = 0.001). Kaplan-Meier analysis showed that genotype del/del was significantly associated with a higher survival rate (p = 0.01). Patients with late tumor stage were found to have a significantly lower rate of genotype del/del than those with an early tumor stage (4.9% vs. 8.8%, p = 0.01). Patients with UICC III and IV were found to have a significantly lower rate of genotype del/del than those with UICC I and II (5.3% vs. 8.1%, p = 0.02).Conclusion: The variant rs145204276 of GAS5 is associated with the development and prognosis of GC. The allele del of rs145204276 is associated with a remarkably lower incidence of cancer progression and metastasis.

scholarly journals Data of the COVID-19 mRNA-Vaccine V-Safe Surveillance System and Pregnancy Registry Reveals Poor Embryonic and Second Trimester Fetal Survival Rate. Comment on Stuckelberger et al. SARS-CoV-2 Vaccine Willingness among Pregnant and Breastfeeding Women during the First Pandemic Wave: A Cross-Sectional Study in Switzerland. Viruses 2021, 13, 1199

Viruses ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1545 ◽  
Author(s):  
Serge Stroobandt ◽  
Roland Stroobandt
Keyword(s):  
Survival Rate ◽  
Surveillance System ◽  
Cross Sectional Study ◽  
Second Trimester ◽  
Sectional Study ◽  
Cross Sectional ◽  
Fetal Survival ◽  
Pregnancy Registry ◽  
Pandemic Wave

Dr. Sarah Stuckelberger and her colleagues should be commended for their cross-sectional study assessing the willingness of Swiss pregnant and breastfeeding women to be vaccinated against SARS-CoV-2 [...]

scholarly journals The Effects of the Civility, Respect, and Engagement in the Workplace (CREW) Program on Social Climate and Work Engagement in a Psychiatric Ward in Japan: A Pilot Study

2021 ◽  
Vol 11 (2) ◽  
pp. 320-330
Author(s):  
Utako Sawada ◽  
Akihito Shimazu ◽  
Norito Kawakami ◽  
Yuki Miyamoto ◽  
Lisa Speigel ◽  
...  
Keyword(s):  
Work Engagement ◽  
Cross Sectional Study ◽  
Social Climate ◽  
Psychiatric Ward ◽  
Medical Doctors ◽  
Cross Sectional ◽  
Factors Affecting ◽  
Staff Members ◽  
Utrecht Work Engagement Scale ◽  
Healthcare Settings

Background: Good social climate and high work engagement are important factors affecting outcomes in healthcare settings. This study observed the effects of a program called Civility, Respect, and Engagement in the Workplace (CREW) on social climate and staff work engagement in a psychiatric ward of a Japanese hospital. Methods: The program comprised 18 sessions installed over six months, with each session lasting 30-min. Participation in the program was recommended to all staff members at the ward, including nurses, medical doctors, and others, but it was not mandatory. A serial cross-sectional study collected data at four time-points. Nurses (n = 17 to 22), medical doctors (n = 9 to 13), and others (n = 6 to 10) participated in each survey. The analysis of variance was used to evaluate the changes in the following dependent variables, the Essen climate evaluation schema (EssenCES), the CREW civility scale, and the Utrecht work engagement scale (UWES) over time. Result: We found no significant effects. The effect size (Cohen’s d) for EssenCES was 0.35 from baseline to post-installation for all staff members. Effect sizes for EssenCES for medical doctors and UWES for nurses were 0.79 and 0.56, respectively, from baseline to post-program. Conclusions: Differences in social climate and work engagement among Japanese healthcare workers between the baseline and post-installation of the CREW program were non-significant.

scholarly journals 33. Concerning Trends of Pediatric Leprosy in Minas Gerais, Brazil and Associations with Number of Municipality Medical Facilities

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S17-S17
Author(s):  
Taylor Landay ◽  
Julie A Clennon ◽  
José A Ferreira ◽  
Lucia A Fraga ◽  
Maria Aparecida F Grossi ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Minas Gerais ◽  
Chi Square ◽  
Cross Sectional ◽  
Period 2 ◽  
Time Period ◽  
Medical Facilities ◽  
Age Of Diagnosis ◽  
Using Data ◽  
Incident Cases

Abstract Background Leprosy in children under 15 years of age, and in particular, the presence of leprosy grade 2 disability (G2D) in children, signifies ongoing transmission and the need for improved surveillance. Our objective was to describe the epidemiology of pediatric leprosy in Minas Gerais, Brazil and to explore associations with access to medical facilities. Methods A cross-sectional study was conducted using data from the Brazilian Notifiable Diseases Surveillance System (SINAN) from 2002–2017. Incident cases were included if they resided in a municipality with both adult and pediatric cases. Municipalities were divided by the number of medical facilities per municipality: < 5, 5–17, and 18 or higher. Analyses compared pediatric cases across two time periods (2002–2009 and 2010–2017) and number of medical facilities / municipality using chi-square, t-tests, and logistic regression. Results A total of 27,725 cases were reported with 1,611 under 15 years of age. Overall incidence declined from 34.8 per 100,000 to 13.6 per 100,000 during the study period with pediatric incidence declining from 2.6 per 100,000 to 0.8 per 100,000. Time period 2 (TP2) showed an increase in the proportion of pediatric G2D (2.58% vs 1.91%, p < 0.0001) when compared to time period 1 (TP1). Mean age of diagnosis in children was younger in TP2 then in TP1 (10.06 vs 10.43, p=0.02). In 2017, the pediatric incidence in municipalities with the fewest medical facilities was 0.95 per 100,000 compared to 0.23 per 100,000 in municipalities with > 5 facilities (p=0.009). There was significantly higher odds of disability at diagnosis (grades 1 and 2) in pediatric cases residing in municipalities with < 5 medical facilities (aOR 1.88; 95% CI 1.37–2.59), adjusted for age and sex. See map (Fig 1). Figure 1. Cases of Pediatric Disability By Number of Municipality Medical Facilities from 2002–2017 (White areas without reported pediatric leprosy) Conclusion The increasing proportion of G2D in children in the second half of the study period despite declining incidence suggest occult infections among children and adults alike in Minas Gerais. Furthermore, the average age of diagnosis in children should increase, not decrease, if M. leprae transmission was truly declining. Lastly, the association between fewer municipality health facilities and increased disability suggest barriers to timely diagnosis and a critical area of focus for research into access to healthcare and leprosy risk. Disclosures All Authors: No reported disclosures

scholarly journals How Does the Cause of Infantile Hemiparesis Influence Other Conditioning Factors? A Preliminary Study in a Spanish Population

Children ◽  
2021 ◽  
Vol 8 (5) ◽  
pp. 323
Author(s):  
Rocío Palomo-Carrión ◽  
Rita Pilar Romero-Galisteo ◽  
Helena Romay-Barrero ◽  
Inés Martínez-Galán ◽  
Cristina Lirio-Romero ◽  
...  
Keyword(s):  
Ad Hoc ◽  
Cross Sectional Study ◽  
Motor Dysfunction ◽  
Sensory Loss ◽  
Speech Impairments ◽  
Cross Sectional ◽  
Conditioning Factors ◽  
Age Of Diagnosis ◽  
The Mean ◽  
Preliminary Study

Infantile hemiparesis may be associated with significant morbidity and may have a profound impact on a child’s physical and social development. Infantile hemiparesis is associated with motor dysfunction as well as additional neurologic impairments, including sensory loss, mental retardation, epilepsy, and vision, hearing, or speech impairments. The objective of this study was to analyze the association between the cause of infantile hemiparesis and birth (gestational age), age of diagnosis, and associated disorders present in children with infantile hemiparesis aged 0 to 3 years. An observational and cross-sectional study was performed. A simple and anonymous questionnaire was created ad hoc for parents of children diagnosed with infantile hemiparesis aged between 0 and 3 years about the situation regarding the diagnosis of hemiparesis, birth, cause of hemiparesis, and presence of other associated disorders. Perinatal stroke (60.1%) was the most common cause of hemiparesis, and the most typical associated disorder was epilepsy (34.2%), with the second largest percentage in this dimension corresponding to an absence of associated disorders (20.7%). The most frequent birth was “no premature” (74.1%). The mean age of diagnosis of infantile hemiparesis was registered at 8 months (IQR: 0–36). Knowing the possible association between different conditioning factors and the cause of infantile hemiparesis facilitates the prevention of severe sequelae in children and family, implementing an early comprehensive therapeutic approach in children with infantile hemiparesis.

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