scholarly journals Formulation and evaluation of herbal tablet containing Terminalia chebula extract

2019 ◽  
Vol 8 (4) ◽  
pp. 692-697 ◽  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
International Diabetes Federation ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Albino Rats ◽  
Terminalia Chebula ◽  
Disintegration Time ◽  
Weight Variation

According to WHO, the prevalence of diabetes is likely to increase by 35%. Currently there are over 150 million diabetics worldwide and this is likely to increase to 300 million or more by the year 2025. International Diabetes Federation (IFD) estimates the total number of diabetic subjects to be around 40.9 million in India and this if further set to rise to 66.9 million by the 2025. In view of the above discussion this study was undertaken to investigate antidiabetic activity of herbal tablet of Terminalia chebula in alloxan induced diabetic rats. Solid pharmaceutical dosage formulations using a novel dry plant extract (Terminalia chebula fruits) using various excipients i.e.carbopol, lactose, gelatin, magnesium stearate and dicalcium phosphate by the wet granulation was reported to the statically significant. The present communication deals with the evaluation of formulated tablets (weight variation, friability and hardness and disintegration time). Diabetes was induced in Wistar albino rats (170-200g) by a single dose (I.P.) of alloxan monohydrate (150mg/kg) dissolved in normal saline, treatment were given orally for 21days and blood glucose level was estimated on Two different batches of herbal tablets of Terminalia chebula extract (carbopol & gelatin) were studied for blood glucose level in two different groups of animals. Oral administration of Terminalia chebula tablet having carbopol to diabetic rats at a dose of 200mg/kg body weight to wistar rats in a significant reduction in biochemical parameters in alloxan diabetic rats, and the best formulation according to disintegration time. Thus our investigation clearly shows that the Terminalia chebula tablet has antidiabetic effects.

Antidiabetic Activity of the Methanolic Extracts of Thuja occidentalis Twings in Alloxan-induced Rats

2019 ◽  
Vol 5 (2) ◽  
pp. 126-131
Author(s):  
C.K. Tyagi ◽  
Pawan Porwal ◽  
Neeraj Mishra ◽  
Amit Sharma ◽  
A. Chandekar ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Elevated Serum ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Thuja Occidentalis ◽  
Methanolic Extracts ◽  
Elevated Serum Cholesterol

Objective and Background: In hyperglycemic and alloxan-induced diabetic rats, the effect of Thuja occidentalis methanolic residue extract on blood glucose levels and some biochemical parameters were investigated. Methods: Significantly decreased blood glucose level by 22.85% and 27.66%, in hyperglycemic rats, respectively after 3 h, were seen in a single oral administration of the extract at a dose of 200 and 400 mg/kg. Blood glucose level was decreased by 50% in alloxan-induced diabetic rats within three weeks of daily treatment of Thuja occidentalis methanolic residue extract (200 and 400 mg/kg p.o). Alloxan-induced diabetic rats showed significant hypercholesterolemia in comparison with the control in alloxan induced rats. Results: In both normal and diabetic rats, there was also a significant decrease of elevated serum cholesterol and triglycerides. Hypertriglyceridemia was also shown to be prevented by treatment with plant extract (200 and 400mg/kg p.o) (p<0. 05). As compared with the control animals, diabetic control rats did not show any change in a level of creatinine and urea. Conclusion: Thuja occidentalis treatment may improve glucose homeostasis in alloxaninduced diabetes and alleviate kidney and liver function. Thuja occidentalis twigs could be a potential source of the new oral antidiabetic drug.

scholarly journals Antidiabetic activity of musa acuminata colla fruit peel (MACFP) ethanol extract in glucose-induced diabetic rats

2018 ◽  
Vol 197 ◽  
pp. 07007
Author(s):  
Erza Genatrika ◽  
Visda Nila Happy Laksari ◽  
Tjiptasurasa Tjiptasurasa
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Ethanol Extract ◽  
Positive Control ◽  
Diabetic Rats ◽  
Musa Acuminata ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Fruit Peel

Diabetes mellitus is a metabolic disorder disease characterized by increased blood glucose levels due to impaired insulin secretion or increased insulin resistance. The study was performed to investigate the blood glucose lowering effect of Musa acuminata Colla fruit peel (MACFP) ethanol extract in experimentally induced diabetic rats. 25 rats were divided into five groups, i.e negative control group (0.5% NaCMC), positive control group (glibenclamide), and treatment group of MACFP ethanol extract with dose 250, 375, and 500 mg/kg body weight (mg/kg BW). The blood sample was taken from the lateral vein of the tail, and then blood glucose level was observed on 0, 30, 60, 90, and 120 minutes. The results provide information that MACFP ethanol extract with dose 250, 375, and 500 mg/kg BW have the same effect with a positive control (glibenclamide) in lowering blood glucose level on diabetic rats (p>0,05). MACFP ethanol extract with dose 500 mg/kg BW had the highest percentage of decrease in blood glucose level (42,62%), followed by doses 375 mg/kg BW (37,26%) and 250 mg/kg BW (24,12%).

scholarly journals Hypoglycemic Activity of Ethanol Extract of Jasminum Grandiflorum Flowers in Vivo and Cytotoxicity of Its Chloroform Isolate in Vitro

2018 ◽  
Vol 3 (2) ◽  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Ethanol Extract ◽  
Diabetic Rats ◽  
Hypoglycemic Activity ◽  
Albino Rats ◽  
Chloroform Fraction ◽  
Dependent Manner ◽  
Flower Extract

Ethno pharmacological relevance: Traditionally different parts of Jasminum grandiflorum have been used to treat various ailments, including diabetes. However, antidiabetic potential of Jasminum grandiflorum on animal models of diabetes have not been evaluated. Aim of the study: The objective of this study was to determine antidiabetic potential of ethanol extract of leaves and flowers of Jasminum grandiflorum, and different fractions of the flower extract in rodent model of streptozotocin-induced diabetes. Materials and methods: Ethanol extract of both leaves and flowers of Jasminum grandiflorum were screened for the presence of various phytochemicals followed by acute and sub-acute toxicity in rats. Effect of Jasminum grandiflorum leaf and flower extracts on blood glucose level in normal albino rats, in glucose-overloaded healthy albino rats, and in streptozotocininduced diabetic rats was evaluated. Furthermore, based on preliminary results, fractionalization of the flower extract was carried out using petroleum ether, ethyl acetate, methanol, and chloroform. Different fractions were further tested for hypoglycemic activity in streptozotocin-induced diabetic rats. Results: Preliminary phytochemical evaluation suggested presence of various antidiabetic metabolites in both the extracts and were found to safe up to 5000 mg/kg dose. Flower extract (500 mg/kg, p.o.) demonstrated significant hypoglycemic effect than leaf extract (500 mg/kg, p.o.) in normal rats, glucose-overloaded rats, and streptozotocin-induced diabetic rats when compared to control. Long-term effect of different fractions of ethanol extract of Jasminum grandiflorum flowers in streptozotocin model suggested that all four fractions were able to reduce blood glucose level in a time-dependent manner at 200 mg/kg dose with chloroform fraction being highly significant (p<0.001) amongst all when compared to diabetic untreated rats. Chloroform isolate from Jasminum grandiflorum flowers demonstrated enhanced glucose uptake and dosedependent cytotoxicity in L6 cell line. Conclusion: The ethanol extract of Jasminum grandiflorum flowers as well as its various fractions have potential therapeutic value in treating diabetes, which may be due to the presence of various antidiabetic metabolites, by enhancing insulin secretion and antioxidant defense. These observations rationalize its use as ethnomedicine and hence can be considered in treating diabetes.

scholarly journals EVALUATION OF ANTI-DIABETIC ACTIVITY OF FICUS BENGALENSIS LINN IN ALLOXAN INDUCED RATS

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Fegade Sachin A ◽  
Siddaiah M
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Research Work ◽  
Diabetic Rats ◽  
Hypoglycemic Effect ◽  
Albino Rats ◽  
Standard Drug ◽  
Wistar Albino Rats ◽  
Ficus Bengalensis

The present study was aimed to evaluate the anti-diabetic activity of isolated compounds from aerial parts of Ficus bengalensis in alloxan induced diabetic rats. Diabetic wistar albino rats were treated with standard drug Glibenclamide and prepared drug extract in 150 mg/kg. Hypoglycemic effect was evaluated in these rats and the efficacy of isolated compounds was administered in alloxan induced diabetic rats. At the end of study period blood glucose level were statistically analyzed based on the results. Isolated fractions produced a significant reduction in blood glucose level when compared with non-treated diabetic rats. So the present research work was confirmed that the isolated compounds possess hypoglycemic effect significantly. Keywords: Ficus begalensis, antidiabetic, allaxon induced, Diabetes mellitus.

scholarly journals Antimicrobial and antidiabetic potentials of processed finger millet (Eleusine coracana)

2018 ◽  
Vol 6 (1) ◽  
pp. 18
Author(s):  
Japhet Erasmus Aisoni ◽  
Muhammad Yusha’u ◽  
Olukayode Olugbenga Orole
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Finger Millet ◽  
Islet Cells ◽  
Salmonella Typhi ◽  
Glycaemic Index ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Methanolic Extracts

Finger millet is a food crop with energy value, phytochemical constituents, and minerals, hence its use as whole flour for traditional food preparation among traditional people. The study was designed to determine the glycaemic index and blood glucose level in albino rats, and the antimicrobial potential of processed finger millets. Finger millets were processed by fermentation and roasting, and methanolic extracts obtained used to test antimicrobial activity. Albino rats (18) divided into three groups were fed fermented, roasted, and unprocessed millet (control), and glycaemic index and blood glucose level determined. Another 25 rat were treated into 5 groups of diabetic rats without treatment, diabetic rats treated daily with Metformin, diabetic rats fed 20% millet, diabetic rats fed 40% millet, and untreated group (control). At 100% concentration, roasted and fermented millet obtained inhibition of 15mm and 14mm against Salmonella typhi, while the control drug 25mg/ml streptomycin had 17mm inhibition. While values obtained for the glycemic indexes were close though significantly different from each other (roasted - 36.83±1.23; fermented - 38.73±1.87), roasted millet brought about the highest reduction in blood glucose level 90.9 and 65.1mg/dl at 60 and 120min respectively compared with fermented millet with 125.1 and 100.2mg/dl respectively at the same time. Animals administered finger millet in Groups 3 and 4-showed regeneration of the islet cells. The millet had the capacity to bring about healing of necrotic cells while also restoring and maintaining glucose levels in blood of subjects. 

scholarly journals ANTIDIABETIC EVALUATION OF ISOLATED COMPOUNDS FROM TINOSPORA CORDIFOLIA IN ALLOXON INDUCED DIABETIC RAT MODEL

2020 ◽  
Vol 8 (6) ◽  
Author(s):  
Ram Bindurani L G P ◽  
Anoop Singh
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Research Work ◽  
Diabetic Rats ◽  
Drug Formulation ◽  
Hypoglycemic Effect ◽  
Tinospora Cordifolia ◽  
Albino Rats ◽  
Standard Drug

Natural products with medicinal value are gradually gaining importance in clinical research due to their well-known property of no side effects as compared to synthetic drugs. Tinospora cordifolia commonly named as “Guduchi” is known for its immense application in the treatment of various diseases in the traditional Ayurveda literature. The present study was aimed to evaluate the anti-diabetic activity of isolated compounds from aerial parts of Tinospora cordifolia (Guduchi) in alloxan induced diabetic rats. Diabetic wistar albino rats were treated with standard drug Glibenclamide and prepared drug formulation in two different doses 250 mg and 500 mg/kg. Hypoglycemic effect was evaluated in these rats and the efficacy of isolated compounds was administered in alloxan induced diabetic rats. At the end of study period blood glucose level were statistically analyzed based on the results. Isolated compounds produced a significant reduction in blood glucose level when compared with non-treated diabetic rats. So the present research work was confirmed that the isolated compounds possess hypoglycemic effect significantly.

scholarly journals Antidiabetic Activity ofAcacia tortilis(Forsk.) Hayne ssp. raddiana Polysaccharide on Streptozotocin-Nicotinamide Induced Diabetic Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Pradeep Kumar Bhateja ◽  
Randhir Singh
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Total Cholesterol ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Fasting Blood Glucose Level

The present study was designed to investigate the antidiabetic activity of aqueous extract ofAcacia tortilispolysaccharide (AEATP) from gum exudates and its role in comorbidities associated with diabetes in STZ-nicotinamide induced diabetic rats. Male albino Wistar rats were divided into control, diabetic control, glimepiride treated (10 mg/kg), and diabetic rats treated with 250, 500, and 1000 mg/kg dose of AEATP groups and fasting blood glucose, glycated hemoglobin, total cholesterol, triglyceride, LDL, VLDL, HDL, SGOT, and SGPT levels were measured. STZ significantly increased fasting blood glucose level, glycated hemoglobin, total cholesterol, triglyceride, LDL, VLDL, SGOT, and SGPT levels, whereas HDL level was reduced as compared to control group. After 7 days of administration, 500 and 1000 mg/kg dose of AEATP showed significant reduction(P<0.05)in fasting blood glucose level compared to diabetic control. AEATP has also reduced total cholesterol, triglyceride, LDL, VLDL, SGOT, and SGPT levels and improved HDL level as compared to diabetic control group. Our study is the first to report the normalization of fasting blood glucose level, lipid profile, and liver enzyme in AEATP treated diabetic rats. Thus, it can be concluded that AEATP may have potentials for the treatment of T2DM and its comorbidities.

EVALUATION OF PHYTOCHEMICAL PROFILE AND ANTIDIABETIC ACTIVITY OF FICUS RACEMOSA (LINN.) STEM BARK IN RATS

INDIAN DRUGS ◽  
2017 ◽  
Vol 54 (01) ◽  
pp. 49-54
Author(s):  
N. D Solanki ◽  
S. K. Bhavsar ◽  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Phytochemical Analysis ◽  
Phytochemical Profile ◽  
Ficus Racemosa ◽  
Tlc Analysis ◽  
Mean Blood Glucose

Herbal plants are true bio-resources in traditional systems of medicine. Ficus racemosa (FR) Linn is a herb mentioned in ancient scriptures of Ayurveda having great medicinal importance. The present study aims to investigate phytochemical & antidiabetic activity of FR. Aqueous (AE) and ethanolic (EE) extracts of powdered shade dried bark of FR was used in the study. Phytochemical profile of extracts were evaluated by standard chemical tests & TLC analysis. The antidiabetic activity of AE and EE of FR was evaluated through STZ induced diabetes model by analyzing the blood glucose level before and after the study & mean blood glucose level through an HPLC method in Wistar rats. Prelimianry phytochemical analysis of EE showed presence of major phytoconstituents like alkaloid, glycoside, sterols, flavanoid, phenol, tannins while AE contains carbohydrates, cardiac glycosides, phytosterol, saponin, phenols, and protein. TLC analysis showed higher Rf value in EE in a different set of mobile phase. In acute toxicity study, a single oral dose (2000 mg/kg) did not produce any mortality in rats. 28 days treatment with AE (500 mg/kg) & EE (400 mg/kg) of FR showed a significant reduction (P<0.05) in blood glucose level compared to diabetic control rats (562.4±14.4), while the mean blood glucose level in treated diabetic rats was found significantly 92.69 mg/dl (AE) & 97.6 mg/dl (EE) (P<0.05) low as compared to diabetic rats (171.4 mg/dl). Our study concluded that presence of varieties of phytochemicals in FR provided strong antidiabetes potential.

The effect of oral administration of green tea and ginger extracts on blood glucose in diabetic rats.

2019 ◽  
Vol 9 (o3) ◽  
Author(s):  
Khulood Saadoon Salim
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Green Tea ◽  
Glucose Level ◽  
Diabetic Rats ◽  
Diabetic Group ◽  
Control Group ◽  
Albino Rats ◽  
Diabetic Patients ◽  
Ginger Extract

In recent years,green tea and ginger have become a subject of interest because of their beneficial effects on human health. The aim of the present study was to compare the effect of long term administration of green tea and ginger each alone to the effect of their combination on blood glucose level in streptozotocin-induced diabetic rats. Method: A group of 50 male albino rats was divided into five groups (10 rats each group). The normal control group( NC) administered tap water, other animals were injected by streptozotocin 45mg/Kg body weight intraperitonially to induce diabetes mellitus and then divided into four groups ,diabetic control (DC) without treatment, diabetic group administered green tea extract for four weeks (DGT), diabetic group administered ginger extract for four weeks(DGI), and diabetic group administered mixture of green tea and ginger for four weeks (DGG), then we compare the blood glucose level at 1st,2nd,3rd, and 4th week of experiment. Results:We observed that in groups whose water drink was substituted by green tea and ginger extract, the blood glucose level was significantly( p less than 0.05) reduced as compared to diabetic animals. Importantly, we observed that blood glucose level was near control level when green tea was administered simultaneously with ginger extract.Conclusion: Combination of green tea and ginger may be of great value as hypoglycemic agent in diabetic patients, the synergism of their effect on glucose regulation process is underlying this results.

scholarly journals Antidiabetic activity of herbal green tea extract from white mangrove (Avicennia marina) leaves towards blood glucose level of diabetic wistar rats (Rattus novergicus)

2019 ◽  
Vol 8 (2) ◽  
Author(s):  
Hardoko Hardoko ◽  
Binti Nafi’ah ◽  
Bambang B. Sasmito ◽  
Yuniwaty Halim
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Green Tea ◽  
Glucose Level ◽  
Avicennia Marina ◽  
Diabetic Rats ◽  
Green Tea Extract ◽  
Antidiabetic Activity ◽  
White Mangrove ◽  
Tea Extract

Green tea Camellia sinensis contains polyphenol that has antidiabetic activity.  Mangrove leaves also contain polyphenol which potentially gives these leave antidiabetic activity. The aim of this research was to determine the ability of herbal green tea extract from white mangrove (Avicennia marina) leaves to decrease blood glucose level of diabetic Wistar rats (Rattus novergicus). The method used was experimental and involved giving a herbal green tea extract from white mangrove leaves with concentration of 100, 200 and 300 mg/200g BW/day, and positive control, i.e. glybenclamid (0.09 mg/200 g BW/day), to diabetic rats injected with Streptozotocin (STZ) and Nicotinamide (NA). The rats were observed on day 0, 5, 10 and 15. The results showed that the herbal green tea extract from white mangrove leaves decreased the blood glucose level of diabetic rats. The effective extract dose that decreased the blood glucose level of diabetic rats was 300 mg/200 g BW, which is comparable to the effect produced by glybenclamid (antidiabetic medicine). This dose could decrease the blood glucose level of diabetic rats to reach a normal blood glucose level after 20 days.

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