EVALUATION OF PHYTOCHEMICAL PROFILE AND ANTIDIABETIC ACTIVITY OF FICUS RACEMOSA (LINN.) STEM BARK IN RATS

INDIAN DRUGS ◽  
2017 ◽  
Vol 54 (01) ◽  
pp. 49-54
Author(s):  
N. D Solanki ◽  
S. K. Bhavsar ◽  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Phytochemical Analysis ◽  
Phytochemical Profile ◽  
Ficus Racemosa ◽  
Tlc Analysis ◽  
Mean Blood Glucose

Herbal plants are true bio-resources in traditional systems of medicine. Ficus racemosa (FR) Linn is a herb mentioned in ancient scriptures of Ayurveda having great medicinal importance. The present study aims to investigate phytochemical & antidiabetic activity of FR. Aqueous (AE) and ethanolic (EE) extracts of powdered shade dried bark of FR was used in the study. Phytochemical profile of extracts were evaluated by standard chemical tests & TLC analysis. The antidiabetic activity of AE and EE of FR was evaluated through STZ induced diabetes model by analyzing the blood glucose level before and after the study & mean blood glucose level through an HPLC method in Wistar rats. Prelimianry phytochemical analysis of EE showed presence of major phytoconstituents like alkaloid, glycoside, sterols, flavanoid, phenol, tannins while AE contains carbohydrates, cardiac glycosides, phytosterol, saponin, phenols, and protein. TLC analysis showed higher Rf value in EE in a different set of mobile phase. In acute toxicity study, a single oral dose (2000 mg/kg) did not produce any mortality in rats. 28 days treatment with AE (500 mg/kg) & EE (400 mg/kg) of FR showed a significant reduction (P<0.05) in blood glucose level compared to diabetic control rats (562.4±14.4), while the mean blood glucose level in treated diabetic rats was found significantly 92.69 mg/dl (AE) & 97.6 mg/dl (EE) (P<0.05) low as compared to diabetic rats (171.4 mg/dl). Our study concluded that presence of varieties of phytochemicals in FR provided strong antidiabetes potential.

scholarly journals Antidiabetic Potential of Alcoholic and Aqueous Extracts of Ficus racemosa Linn. Bark In Normal and Alloxan Induced Diabetic Rats

2009 ◽  
Vol 1 (01) ◽  
Author(s):  
Nikhil K. Sachan ◽  
Yatindra Kumar ◽  
Seema Pushkar ◽  
R. N. Thakur ◽  
Sudhir S. Gangwar ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Aqueous Extract ◽  
Ethanolic Extract ◽  
Diabetic Rats ◽  
Alcoholic Extract ◽  
Glucose Lowering ◽  
Ficus Racemosa ◽  
Lowering Activity

The present investigation aims to examine the diabetic potential of the plant Ficus racemosa in normal and alloxan induced diabetic rats. The bark extract with water, petroleum ether and with alcohol were screened for blood glucose lowering activity and the alcoholic extract having better therapeutic potential was prepared through Soxhlet extraction for further study. Alcoholic and aqueous extract of bark of Ficus racemosa at a dose of 400 mg/Kg was given to normal and alloxan induced diabetic rats and the blood samples taken from the retero-orbital plexus vein were analyzed for blood glucose level as per standard protocol with available kits through Auto-analyzer. The comparison of blood sugar level as per model schedule showed that in normal group the ethanolic extract, at a dose of 400 mg/Kg intra-peritoneal, the blood glucose lowering 28.66 % while in aqueous extract given group it was 25.90 %. In alloxan induced diabetic rats decrease in blood glucose level in aqueous and ethanolic extract group was found to be 27.01 % and 45.03 % respectively. In conclusion, the ethanolic extract of Ficus racemosa reflected anti-diabetic potential through its glucose lowering activity in experimental animals. It supported the folklore claim of anti-diabetic activity of the plant.

Antidiabetic Activity of the Methanolic Extracts of Thuja occidentalis Twings in Alloxan-induced Rats

2019 ◽  
Vol 5 (2) ◽  
pp. 126-131
Author(s):  
C.K. Tyagi ◽  
Pawan Porwal ◽  
Neeraj Mishra ◽  
Amit Sharma ◽  
A. Chandekar ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Elevated Serum ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Thuja Occidentalis ◽  
Methanolic Extracts ◽  
Elevated Serum Cholesterol

Objective and Background: In hyperglycemic and alloxan-induced diabetic rats, the effect of Thuja occidentalis methanolic residue extract on blood glucose levels and some biochemical parameters were investigated. Methods: Significantly decreased blood glucose level by 22.85% and 27.66%, in hyperglycemic rats, respectively after 3 h, were seen in a single oral administration of the extract at a dose of 200 and 400 mg/kg. Blood glucose level was decreased by 50% in alloxan-induced diabetic rats within three weeks of daily treatment of Thuja occidentalis methanolic residue extract (200 and 400 mg/kg p.o). Alloxan-induced diabetic rats showed significant hypercholesterolemia in comparison with the control in alloxan induced rats. Results: In both normal and diabetic rats, there was also a significant decrease of elevated serum cholesterol and triglycerides. Hypertriglyceridemia was also shown to be prevented by treatment with plant extract (200 and 400mg/kg p.o) (p<0. 05). As compared with the control animals, diabetic control rats did not show any change in a level of creatinine and urea. Conclusion: Thuja occidentalis treatment may improve glucose homeostasis in alloxaninduced diabetes and alleviate kidney and liver function. Thuja occidentalis twigs could be a potential source of the new oral antidiabetic drug.

scholarly journals Antidiabetic activity of musa acuminata colla fruit peel (MACFP) ethanol extract in glucose-induced diabetic rats

2018 ◽  
Vol 197 ◽  
pp. 07007
Author(s):  
Erza Genatrika ◽  
Visda Nila Happy Laksari ◽  
Tjiptasurasa Tjiptasurasa
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Ethanol Extract ◽  
Positive Control ◽  
Diabetic Rats ◽  
Musa Acuminata ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Fruit Peel

Diabetes mellitus is a metabolic disorder disease characterized by increased blood glucose levels due to impaired insulin secretion or increased insulin resistance. The study was performed to investigate the blood glucose lowering effect of Musa acuminata Colla fruit peel (MACFP) ethanol extract in experimentally induced diabetic rats. 25 rats were divided into five groups, i.e negative control group (0.5% NaCMC), positive control group (glibenclamide), and treatment group of MACFP ethanol extract with dose 250, 375, and 500 mg/kg body weight (mg/kg BW). The blood sample was taken from the lateral vein of the tail, and then blood glucose level was observed on 0, 30, 60, 90, and 120 minutes. The results provide information that MACFP ethanol extract with dose 250, 375, and 500 mg/kg BW have the same effect with a positive control (glibenclamide) in lowering blood glucose level on diabetic rats (p>0,05). MACFP ethanol extract with dose 500 mg/kg BW had the highest percentage of decrease in blood glucose level (42,62%), followed by doses 375 mg/kg BW (37,26%) and 250 mg/kg BW (24,12%).

scholarly journals Antidiabetic Activity ofAcacia tortilis(Forsk.) Hayne ssp. raddiana Polysaccharide on Streptozotocin-Nicotinamide Induced Diabetic Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Pradeep Kumar Bhateja ◽  
Randhir Singh
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Total Cholesterol ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Fasting Blood Glucose Level

The present study was designed to investigate the antidiabetic activity of aqueous extract ofAcacia tortilispolysaccharide (AEATP) from gum exudates and its role in comorbidities associated with diabetes in STZ-nicotinamide induced diabetic rats. Male albino Wistar rats were divided into control, diabetic control, glimepiride treated (10 mg/kg), and diabetic rats treated with 250, 500, and 1000 mg/kg dose of AEATP groups and fasting blood glucose, glycated hemoglobin, total cholesterol, triglyceride, LDL, VLDL, HDL, SGOT, and SGPT levels were measured. STZ significantly increased fasting blood glucose level, glycated hemoglobin, total cholesterol, triglyceride, LDL, VLDL, SGOT, and SGPT levels, whereas HDL level was reduced as compared to control group. After 7 days of administration, 500 and 1000 mg/kg dose of AEATP showed significant reduction(P<0.05)in fasting blood glucose level compared to diabetic control. AEATP has also reduced total cholesterol, triglyceride, LDL, VLDL, SGOT, and SGPT levels and improved HDL level as compared to diabetic control group. Our study is the first to report the normalization of fasting blood glucose level, lipid profile, and liver enzyme in AEATP treated diabetic rats. Thus, it can be concluded that AEATP may have potentials for the treatment of T2DM and its comorbidities.

scholarly journals Formulation and evaluation of herbal tablet containing Terminalia chebula extract

2019 ◽  
Vol 8 (4) ◽  
pp. 692-697 ◽  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
International Diabetes Federation ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Albino Rats ◽  
Terminalia Chebula ◽  
Disintegration Time ◽  
Weight Variation

According to WHO, the prevalence of diabetes is likely to increase by 35%. Currently there are over 150 million diabetics worldwide and this is likely to increase to 300 million or more by the year 2025. International Diabetes Federation (IFD) estimates the total number of diabetic subjects to be around 40.9 million in India and this if further set to rise to 66.9 million by the 2025. In view of the above discussion this study was undertaken to investigate antidiabetic activity of herbal tablet of Terminalia chebula in alloxan induced diabetic rats. Solid pharmaceutical dosage formulations using a novel dry plant extract (Terminalia chebula fruits) using various excipients i.e.carbopol, lactose, gelatin, magnesium stearate and dicalcium phosphate by the wet granulation was reported to the statically significant. The present communication deals with the evaluation of formulated tablets (weight variation, friability and hardness and disintegration time). Diabetes was induced in Wistar albino rats (170-200g) by a single dose (I.P.) of alloxan monohydrate (150mg/kg) dissolved in normal saline, treatment were given orally for 21days and blood glucose level was estimated on Two different batches of herbal tablets of Terminalia chebula extract (carbopol & gelatin) were studied for blood glucose level in two different groups of animals. Oral administration of Terminalia chebula tablet having carbopol to diabetic rats at a dose of 200mg/kg body weight to wistar rats in a significant reduction in biochemical parameters in alloxan diabetic rats, and the best formulation according to disintegration time. Thus our investigation clearly shows that the Terminalia chebula tablet has antidiabetic effects.

scholarly journals Antidiabetic activity of herbal green tea extract from white mangrove (Avicennia marina) leaves towards blood glucose level of diabetic wistar rats (Rattus novergicus)

2019 ◽  
Vol 8 (2) ◽  
Author(s):  
Hardoko Hardoko ◽  
Binti Nafi’ah ◽  
Bambang B. Sasmito ◽  
Yuniwaty Halim
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Green Tea ◽  
Glucose Level ◽  
Avicennia Marina ◽  
Diabetic Rats ◽  
Green Tea Extract ◽  
Antidiabetic Activity ◽  
White Mangrove ◽  
Tea Extract

Green tea Camellia sinensis contains polyphenol that has antidiabetic activity.  Mangrove leaves also contain polyphenol which potentially gives these leave antidiabetic activity. The aim of this research was to determine the ability of herbal green tea extract from white mangrove (Avicennia marina) leaves to decrease blood glucose level of diabetic Wistar rats (Rattus novergicus). The method used was experimental and involved giving a herbal green tea extract from white mangrove leaves with concentration of 100, 200 and 300 mg/200g BW/day, and positive control, i.e. glybenclamid (0.09 mg/200 g BW/day), to diabetic rats injected with Streptozotocin (STZ) and Nicotinamide (NA). The rats were observed on day 0, 5, 10 and 15. The results showed that the herbal green tea extract from white mangrove leaves decreased the blood glucose level of diabetic rats. The effective extract dose that decreased the blood glucose level of diabetic rats was 300 mg/200 g BW, which is comparable to the effect produced by glybenclamid (antidiabetic medicine). This dose could decrease the blood glucose level of diabetic rats to reach a normal blood glucose level after 20 days.

PENGENDALIAN KADAR GLUKOSA DARAH OLEH TEH HIJAU DAN ATAU TEH DAUN MURBEI PADA TIKUS DIABETES

2010 ◽  
Vol 5 (2) ◽  
pp. 87
Author(s):  
Rusman Efendi ◽  
Evy Damayanthi ◽  
Lilik Kustiyah ◽  
Nastiti Kusumorini
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Green Tea ◽  
Glucose Level ◽  
Diabetic Rats ◽  
Feed Consumption ◽  
Font Size ◽  
High Prevalence ◽  
The Difference ◽  
Control Diabetes

<p class="MsoNormal" style="margin: 0cm 7.1pt 6pt 14.2pt; text-align: justify; text-indent: 1cm;"><span style="font-size: 10pt;">Diabetes mellitus is degeneratif disease with high prevalence that happens in many countries. Several studies had been done to control diabetes by using green tea, mullberry leaf  tea, and their mixture. The aim of this research was to analyze the influence of the administration green tea, mullbery leaf tea, and their mixtures to blood glucose level of diabetic rats both during 120 minutes after administration. This research had four phases, first to determine the best mullberry leaf tea, second to fourth phases respectively, determine turnover of blood glucose level on normal rats; attempt during 120 minutes on diabetic rats.  The result of research during 120 minutes have showed that blood glucose level on diabetic rats which were administered by green tea, mullberry leaf tea and their mixture is significantly difference with diabetic rats which were administered by water. Blood glucose level at baseline increased at 30<sup>th </sup>minutes and showed the difference significantly and then until 60<sup>th</sup> and 120<sup>th</sup> minutes and relatively stable. During 120 minutes after feed consumption, inhibition of blood glucose level occured increasingly on diabetic rats which were administered by green tea, mullberry leaf tea, and their mixture compared to diabetic rats which were administered by water.</span></p>

Anti-diabetic activity of diphenhydramine in diabetic rats

2020 ◽  
Vol 11 (4) ◽  
pp. 5067-5070
Author(s):  
Pang Jyh Chayng ◽  
Nurul Ain ◽  
Kaswandi Md Ambia ◽  
Rahim Md Noah
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Insulin Level ◽  
Diabetic Rats ◽  
Group Iv ◽  
Diabetic Rat ◽  
Control Group ◽  
Group I

The purpose of this project is to study the anti-diabetic effect of on a diabetic rat model. A total of Twenty male Sprague rats were used and it randomly distributed into four groups which are Group I: , Group II: negative control, Group III: and Group IV: and . In diabetic model were induced with via injection at the dosage of 65mg/kg. and FBG (Fasting Blood Glucose) level of diabetic rats were assessed every three days. Blood was collected via cardiac puncture at day 21 after the induction of treatment. Insulin level of the rats was assessed with the Mercodia Rat Insulin ELISA kit. FBG level of group I (12.16 ±3.96, p&lt;0.05) and group IV (11.34 ±3.67, p&lt;0.05) were significantly decreased. Meanwhile, the for all rats did not show any significant increase. However, the insulin level was escalated in group IV (0.74+0.25, p&lt;0.05) significantly. The present study shows that the and the combination of and lowered blood glucose level and enhanced insulin secretion.

scholarly journals Hypoglycemic and antioxidative activities of ethanol seed extract of Hunteria umbellate (Hallier F.) on streptozotocin-induced diabetic rats

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Olubanke O. Ogunlana ◽  
Babatunde O. Adetuyi ◽  
Miracle Rotimi ◽  
lohor Esalomi ◽  
Alaba Adeyemi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Seed Extract ◽  
The Body ◽  
High Concentration ◽  
Group 5

Abstract Background Diabetes, a global cause of mortality in developing countries is a chronic disorder affecting the metabolism of macromolecules and has been attributed to the defective production and action of insulin characterized by persistent hyperglycemic properties. This global disorder harms organs of the body such as the liver, kidney and spleen. Medicinal plants such as Hunteria umbellate have been shown to possess hypoglycemic, antioxidative and anti-diabetic properties owing to the high concentration of active phytochemical constituents like flavonoids and alkaloids. The present study seeks to evaluate the hypoglycemic activities of ethanolic seed extract of Hunteria umbellate on streptozotocin-induced diabetes rats. Methods Thirty (30) female experimental rats were randomly divided into five groups with six rats per group and were administered streptozotocin (STZ) and Hunteria umbellate as follows. Group 1 served as control and was given only distilled water, group 2 rats were administered 60 mg/kg STZ; Group 3 was administered 60 mg/kg STZ and 100 mg/kg metformin; group 4 rats were administered 60 mg/kg STZ and 800 mg/kg Hunteria umbellate, group 5 rats 60 mg/kg STZ and 400 mg/kg Hunteria umbellate. The fasting blood glucose level of each rat was measured before sacrifice. Rats were then sacrificed 24 h after the last dose of treatment. Results The results showed that Hunteria umbellate significantly reversed STZ-induced increase in fasting blood glucose and increase in body and organs weight of rats. Hunteria umbellate significantly reversed STZ-induced decrease in antioxidant enzyme in liver, kidney and spleen of rats. Hunteria umbellate significantly reversed STZ-induced increase in oxidative stress markers in liver, kidney and spleen of rats. Conclusion Collectively, our results provide convincing information that inhibition of oxidative stress and regulation of blood glucose level are major mechanisms through which Hunteria umbellate protects against streptozotocin-induced diabketes rats.

scholarly journals EVALUATION OF ANTIHYPERGLYCAEMIC EFFECT OF BUTEA MONOSPERMA LEAF EXTRACT ON ADRENALIN INDUCED AND HIGH GLUCOSE FEED ANIMAL MODEL

2017 ◽  
Vol 10 (12) ◽  
pp. 301
Author(s):  
Biswaranjan Ray ◽  
Santosh Kumar Mahapatra ◽  
Pradipta Kumar Behera ◽  
Ashok K Panigrahi
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
High Glucose ◽  
Ethanolic Extract ◽  
Biologically Active ◽  
Antidiabetic Activity ◽  
Blood Levels ◽  
Active Components ◽  
Butea Monosperma

Objective: As per the ethnopharmacological information has Butea monosperma been used to treat diabetes mellitus by the tribal people of tropical and subtropical areas. However, there is no much more scientific report available about the antidiabetic property of the leaves of the plant. Hence, the study was undertaken to evaluate the antidiabetic effect of ethanolic extract of B. monosperma on blood levels of adrenaline-induced and glucose feed diabetic rabbits.Methods: The three different doses of the extracts (100, 200, and 400 mg/kg) were administered orally to an experimental animal. The animals were induced diabetics by adrenaline and high glucose diet. Blood glucose level was measured accordingly. For antidiabetic activity, photocolorimeter was used to monitoring the blood glucose level with crest kit box (GOP-POD method).Results: The extracts showed considerable dose-dependent activity. However, the dose 400 mg/kg showed considerable lower of blood glucose level. p<0.01 indicates the significance result. 8 hrs reading 182.5±3.83 for 400 mg does is most effective for reducing blood sugar.Conclusion: The study indicates that the ethanolic extract of B. monosperma leaves possesses antidiabetic properties which suggest the presence of biologically active components.

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