scholarly journals Comparison of Rate of Infection during Hydroxyapatite and Allogenic Bone Graft Used In Jaw Cyst: A Randomized Clinical Trial

2020 ◽  
Vol 6 (2) ◽  
pp. 29-33
Author(s):  
Showkat Mamun ◽  
Ismat Ara Haider ◽  
Nasiruddin ◽  
Tarin Rahman ◽  
Sheikh Mohammad Jahidul Islam ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Bone Graft ◽  
Cystic Lesion ◽  
Alloplastic Material ◽  
Allogenic Bone ◽  
Jaw Cyst ◽  
Group A ◽  
Study Population ◽  
Group B ◽  
Allogenic Bone Graft

  Background: Post-operative infection can occur after bone grafting among patietns with jaw cyst. Objective: The purpose of the present study was to compare the rate of infection as postoperative outcomes after hydroxyapatite and allogenic bone graft among jaw cyst patients. Methodology: This randomized clinical trial was conducted in the Department of Oral and Maxillofacial Surgery at Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from July 2006 to June 2008. Patients presented with radicular and dentigerous cyst and relatively non infected cystic lesion were selected as study population. The study population were divided into two groups designed as Group A treated with with allogenic-bone graft and Group B treated with hydroxyapatite alloplastic material after enucleation of the cystic lesion. The rate of infection was recorded after surgery in both group A and B. Result: A total number of 28 patients were recruited for this study of which 14 patients were treated with hydroxyapatite crystals bone graft in group A and 14 patients were treated with allogenic bone graft in group B. Post-operative infection was not found in group A and 5(35.7%) in group B (p<0.05). Infection occurred in 1(20.0%) case in one side intact and 4(80.0%) in both side lost. Infection was found in 1(20.0%) case and 4(80.0%) cases in average and poor oral hygiene status respectively. Conclusion: In conclusion more infection occurs in allogenic bone graft group than the group treated with hydroxyapatite alloplastic material Bangladesh Journal of Infectious Diseases 2019;6(2):29-33

scholarly journals Post-Operative Outcomes of Radiological and Histopathological Findings after Hydroxyapatite and Allogenic Bone Graft among Jaw Cyst Patients: A Randomized Clinical Trial

2020 ◽  
Vol 6 (1) ◽  
pp. 48-53
Author(s):  
Showkat Mamun ◽  
Ismat Ara Haider ◽  
Nasiruddin ◽  
Tarin Rahman ◽  
ATM Tarifuzzaman Rubel ◽  
...  
Keyword(s):  
Bone Graft ◽  
Cystic Lesion ◽  
Histopathological Examination ◽  
Alloplastic Material ◽  
Allogenic Bone ◽  
Jaw Cyst ◽  
Group A ◽  
Study Population ◽  
Group B ◽  
Allogenic Bone Graft

Background: Post-surgical outcomes of jaw cyst is very crucial. Objective: The purpose of the present study was to observe the radiological and histological finings as postoperative outcomes after hydroxyapatite and allogenic bone graft among jaw cyst patients. Methodology: This single centre, parallel, randomized clinical trial was conducted in the Department of Oral and Maxillofacial Surgery at Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from July 2006 to June 2008 for a period of two (02) years. Patients presented with radicular and dentigerous cyst with the size of the lesion between 2 cm to 7 cm. in diameter and relatively non infected cystic lesion were selected as study population. The study population were divided into two groups designed as group A treated with hydroxyapatite alloplastic material and group B treated with allogenic-bone graft after enucleation of the cystic lesion. The standard surgical procedure was to be performed meticulously in sterile environment. Post-operative radiograph were taken after one month, three months and six months. Histopathological examination was done after six month of operation which was done in the department of Pathology, BSMMU. Scintigraphic examination was performed after 6 months of the operation to evaluate the viability of the bone graft in the graft site. Result: A total number of 28 patients were recruited for this study of which 14 patients were treated with hydroxyapatite crystals bone graft in group A and 14 patients were treated with allogenic bone graft in group B. The age of patients of both groups ranged between 14 and 58 years. In histopathological examination marked presence of cementing line, woven bone and osteoblast cell was found in patients who were grafted with hydroxyaptite and this had indicated good osteoblastic activity. Increased technetium-99m labeled diphosphonate uptake was found in the patient with allograft. There was a smaller lesion diameter of hydroxyapatite group in comparison with allogenic bone graft group which had indicated comparatively better healing than that of the hydroxyapatite group. Conclusion: In conclusion hydroxyapatite alloplastic material has better radiological and histopathological outcomes than allogenic bone graft after surgery of jaw cyst. Journal of National Institute of Neurosciences Bangladesh, 2020;6(1): 48-53

scholarly journals COMPARISON OF EFFECT OF HIORA MOUTHWASH VERSUS CHLORHEXIDINE MOUTHWASH IN GINGIVITIS PATIENTS: A CLINICAL TRIAL

2018 ◽  
Vol 11 (7) ◽  
pp. 84
Author(s):  
Jaiganesh Ramamurthy ◽  
Visha Mg
Keyword(s):  
Clinical Trial ◽  
Gingival Index ◽  
Mean Values ◽  
Post Operative Period ◽  
Probing Depth ◽  
Group A ◽  
Study Population ◽  
The Mean ◽  
Group B ◽  
Experimental Group

Objective: The aim and objective of this study was to evaluate the effect of Hiora mouthwash versus Chlorhexidine mouthwash for the treatment of gingivitis.Methods: The study population was comprised 30 gingivitis patients. The patients were randomly categorized into two groups of 15 patients in each group. Group A was given Chlorhexidine mouthwash and Group B was given Hiora mouthwash. Pre-operative measurements such as plaque index (PI), gingival index (GI), and probing depth (PD), and loss of attachment (LA) were measured. Oral prophylaxis followed by the prescription of mouthwash was done. The patients were recalled for a review after 15 days, and post-operative measurements were recorded.Results: From the statistical analysis in the experimental Group A and Group B, the mean values of PD, LA, GI, and PI were found to be significantly lower in the post-operative period than the pre-operative mean values. At the end of 15 days, almost comparable reduction in the amount of plaque and gingivitis was found in both Group A and Group B. Hence, the differences in efficacy of these two mouthwashes were non-significant.Conclusion: Hiora and Chlorhexidine mouthwashes were equally effective in the treatment of gingivitis.

scholarly journals Multiple intravenous tranexamic acid doses in total knee arthroplasty in patients with rheumatoid arthritis: a randomized controlled study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Bing-xin Kang ◽  
Hui Xu ◽  
Chen-xin Gao ◽  
Sheng Zhong ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Trial ◽  
Total Knee Arthroplasty ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Randomized Controlled ◽  
Group A ◽  
Total Knee ◽  
Group B ◽  
D Dimer

Abstract Background We aimed to determine the efficacy and safety of multiple doses of intravenous tranexamic acid (IV-TXA) on perioperative blood loss in patients with rheumatoid arthritis (RA) who had undergone primary unilateral total knee arthroplasty (TKA). Methods For this single-center, single-blind randomized controlled clinical trial, 10 male and 87 female participants with RA, aged 50–75 years, who underwent unilateral primary TKA were recruited. The patients received one dose of 1 g IV-TXA 10 min before skin incision, followed by articular injection of 1.5 g tranexamic acid after cavity suture during the surgery. The patients were randomly assigned (1:1) into two groups and received an additional single dose of IV-TXA (1 g) for 3 h (group A) or three doses of IV-TXA (1 g) for 3, 6, and 12 h (group B) postoperatively. Primary outcomes were total blood loss (TBL), hidden blood loss (HBL), and maximum hemoglobin (Hb) level decrease. Secondary outcomes were transfusion rate and D-dimer levels. All parameters were measured postoperatively during inpatient hospital stay. Results The mean TBL, HBL, and maximum Hb level decrease in group B (506.1 ± 227.0 mL, 471.6 ± 224.0 mL, and 17.5 ± 7.7 g/L, respectively) were significantly lower than those in group A (608.8 ± 244.8 mL, P = 0.035; 574.0 ± 242.3 mL, P = 0.033; and 23.42 ± 9.2 g/L, P = 0.001, respectively). No episode of transfusion occurred. The D-dimer level was lower in group B than in group A on postoperative day 1 (P <  0.001), and the incidence of thromboembolic events was similar between the groups (P > 0.05). Conclusion In patients with RA, three doses of postoperative IV-TXA further facilitated HBL and Hb level decrease without increasing the incidence of adverse events in a short period after TKA. Trial registration The trial was registered in the Chinese Clinical Trial Registry (ChiCTR1900025013).

PTH1-34 improves devitalized allogenic bone graft healing in a murine femoral critical size defect

Injury ◽  
2021 ◽  
Author(s):  
Tito Rocha ◽  
Amanda S. Cavalcanti ◽  
Ana Carolina Leal ◽  
Rhayra B. Dias ◽  
Rafaela Sartore da Costa ◽  
...  
Keyword(s):  
Bone Graft ◽  
Critical Size ◽  
Critical Size Defect ◽  
Allogenic Bone ◽  
Graft Healing ◽  
Allogenic Bone Graft

scholarly journals ABO groups can play a role in susceptibility and severity of COVID-19

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
S. Samra ◽  
M. Habeb ◽  
R. Nafae
Keyword(s):  
Blood Group ◽  
Abo Blood Group ◽  
Infection Group ◽  
Mechanically Ventilated ◽  
Blood Group A ◽  
Group A ◽  
Study Population ◽  
Group B ◽  
The Relationship ◽  
Seriously Ill

Abstract Background A few people infected by the coronavirus become seriously ill, while others show little to no signs of the symptoms, or are asymptomatic. Recent researches are pointing to the fact that the ABO blood group might play an important role in a person’s susceptibility and severity of COVID-19 infection. Aim of the study: try to understand the relationship between ABO groups and COVID-19 (susceptibility and severity). Results A total of (507) patients were included in this study. The study population was divided based on the ABO blood group into types A+, A−, B+, AB, O+, and O−. Blood group A was associated with high susceptibility of infection: group A, 381 (75.1%); and less common in group O, 97 (19.2%), group B, 18 (3.5%), and group AB, 11 (2.2%). The severity of COVID-19 infection was common in non-blood group O where (20 (7.1%), 4 (26.7%), 2 (11%), and 1 (9%) in type A+, A−, B+, and AB, respectively), while in type O 3.1%. And mechanically ventilated patients were 22 (5.9%), 2 (13.4%), 2 (11.1%), and 1 (1%). Mortality was high in blood groups A and B, 16 (4.37%) and 1 (5.5%), respectively, while in blood group O, it was 1%. Conclusion The incidence, severity, and mortality of COVID-19 were common in non-blood group O. While blood group O was protected against COVID-19.

scholarly journals Comparative study between two empirical antibiotic regime in the management of childhood malignancy with fever

2015 ◽  
Vol 5 (2) ◽  
pp. 329-331 ◽  
Author(s):  
Laila Helaly ◽  
Md Zakir Hossain Sarker ◽  
MA Mannan ◽  
Md Tafazzal Hossain ◽  
Shafi Ahmed ◽  
...  
Keyword(s):  
Antibiotic Therapy ◽  
Study Drug ◽  
Successful Outcome ◽  
Medical College ◽  
Pediatric Hematology ◽  
Pediatric Cancer Patients ◽  
Group A ◽  
Study Population ◽  
Group B ◽  
Oncology Unit

Objective : The present prospective randomized clinical trial was carried out to assess whether combined cefepime and amikacin as empirical antibiotic therapy was more effective than combined ceftriaxone and gentamicin in the treatment of febrile neutropenic children with malignant diseases.Material & Methods : The study was conducted in the Pediatric Hematology and Oncology unit of BSMMU over a period of 2 years. (From January 2006 to December 2007) Hospitalised pediatric cancer patients who developed febrile neutropenia following chemotherapy or radiotherapy were the study population. A total 64 cases were consecutively included in the study and were randomly assigned to either cefepime & amikacin group (Group- A) or ceftriaxone & gentamicin group (Group-B). The Group-A received cefepime 1500 mg/m2/dose infused over 15 minutes in two divided doses intravenously(IV) while amikacin was administered as thrice daily dose of 200 mg/m2/dose. Patients of Group-B received ceftriaxone 1500 mg/m2/dose in two divided doses and gentamicin 60 mg/m2/dose thrice daily IV. The therapy was continued until absolute neutrophil counts reached >1000 neutrophils/mm3. The treatment outcome was considered successful if fever resolves within 4 days and does not recur within 7 days of completion of therapy. Of the 64 patients, 13 cases were excluded from the final analysis.Results : Bacteria were isolated from culture in only 16.7% of cases Group-A and 9.5% of group-B. Patients E. coli was the most common isolate found in blood specimen (37%). Following intervention, 90% of cefepime & amikacin group and 85.6% of ceftriaxone & gentamicin group improved absolute neutrophil count to >1000/mm3 of blood. Persistence of fever after start of study drug and duration of antibiotic therapy were significantly less in the former group than those in later group (p = 0.049 and p = 0.004 respectively). Only 1 patient of group B had recurrence of infection within 7 days of treatment completion. The mean duration of hospital stay was less in the former group (7.97 ± 2.61 days) than that in the latter group (11.00 ± 3.42 days) (p = 0.06). Evaluation of final outcome shows that majority (86.6%) of cefepime & amikacin group had successful outcome, while majority of ceftriaxone & gentamicin group (81%) failed to resolve infection with continuation of fever for > 4 days.Conclusion : The study concluded that combined cefepime and amikacin is a better option for empirical treatment of fever and neutropenia in children with malignancies than combined ceftriaxone and gentamicin (p<0.001).Northern International Medical College Journal Vol.5(2) 2014: 329-331

Fate of allogenic bone graft for sternal support in pectus excavatum repair

2015 ◽  
Vol 23 (8) ◽  
pp. 961-965 ◽  
Author(s):  
Mahmoud Ashour ◽  
Mohommad Rafay ◽  
Waleed Saleh ◽  
Mohamed Ahmed ◽  
Hassan Robaidi ◽  
...  
Keyword(s):  
Bone Graft ◽  
Pectus Excavatum ◽  
Allogenic Bone ◽  
Allogenic Bone Graft

THERAPEUTICAL DOSES OF SALBUTAMOL INHIBIT THE SOMATOTROPIC RESPONSIVENESS TO GROWTH HORMONE-RELEASING HORMONE IN ASTHMATIC CHILDREN

PEDIATRICS ◽  
1994 ◽  
Vol 94 (2) ◽  
pp. 262-263
Author(s):  
Hemalini Mehta ◽  
Robert F. Lemanske
Keyword(s):  
Growth Hormone ◽  
Systemic Disease ◽  
Forced Expiratory Volume ◽  
Growth Hormone Releasing Hormone ◽  
Assay Sensitivity ◽  
Releasing Hormone ◽  
Children With Asthma ◽  
Group A ◽  
Study Population ◽  
Group B

Purpose of the Study. To determine the effects of therapeutic β2 agonists (specifically salbutamol) on growth hormone (GH) response to growth hormone releasing hormone (GHRH) in children with asthma. Study Population. Fifteen prepubertal children with asthma, ages 6-11 (average age of 9) with normal or normal short stature were studied. Those with an endocrine abnormality, nutritional deficiency, psychological deprivation, or other systemic disease were excluded. Only those children with known bronchial asthma, who showed a 15% decrease of the 1-second forced expiratory volume (FEV1) with methacholine challenge were included. All patients were asymptomatic, and had not experienced an asthma exacerbation, respiratory infection or allergen exposure in the month preceding the study. No child was on medications. Methods. Subjects were divided into two groups. Both groups had baseline GH response to GHRH determined. After an overnight fast, GH levels were obtained the following morning at -60, 0, and then every 15 minutes until 120 minutes after GHRH administration. Two days following this, Group A received salbutamol (0.125 mg/kg) orally at -60 minutes and GH response to GHRH was remeasured. Group B received aerosolized salbutamol (2 mg over 15 minutes) (details of administration were not specified by the authors). All serum GH levels were measured in duplicate by immunoradiometric assay (sensitivity of 0.1 µg/L). Findings. Basal GH levels were similar in both groups. Orally administered salbutamol (Group A) markedly inhibited GH response to GHRH (peak of 3.7 ± 0.6 vs. 18.6 ± 4.7 g/L). Inhaled salbutamol (Group B), although blunting the GHRH-induced GH response, did so to a lesser extent (peak of 20.0 ± 7.5 vs. 35.8 ± 9.4 g/L, P &lt; .02).

scholarly journals Telemanagement of Home-Isolated COVID-19 Patients Using Oxygen Therapy With Noninvasive Positive Pressure Ventilation and Physical Therapy Techniques: Randomized Clinical Trial (Preprint)

2020 ◽  
Author(s):  
Aya Sedky Adly ◽  
Mahmoud Sedky Adly ◽  
Afnan Sedky Adly
Keyword(s):  
Health Care ◽  
Clinical Trial ◽  
Physical Therapy ◽  
Randomized Clinical Trial ◽  
Health Care System ◽  
Oxygen Therapy ◽  
Early Stage ◽  
Home Based ◽  
Group A ◽  
Group B

BACKGROUND With the growing stress on hospitals caused by the COVID-19 pandemic, the need for home-based solutions has become a necessity to support these overwhelmed hospitals. OBJECTIVE The goal of this study was to compare two nonpharmacological respiratory treatment methods for home-isolated COVID-19 patients using a newly developed telemanagement health care system. METHODS In this single-blinded randomized clinical trial, 60 patients with stage 1 pneumonia caused by SARS-CoV-2 infection were treated. Group A (n=30) received oxygen therapy with bilevel positive airway pressure (BiPAP) ventilation, and Group B (n=30) received osteopathic manipulative respiratory and physical therapy techniques. Arterial blood gases of PaO<sub>2</sub> and PaCO<sub>2</sub>, pH, vital signs (ie, temperature, respiratory rate, oxygen saturation, heart rate, and blood pressure), and chest computed tomography scans were used for follow-up and for assessment of the course and duration of recovery. RESULTS Analysis of the results showed a significant difference between the two groups (<i>P</i>&lt;.05), with Group A showing shorter recovery periods than Group B (mean 14.9, SD 1.7 days, and mean 23.9, SD 2.3 days, respectively). Significant differences were also observed between baseline and final readings in all of the outcome measures in both groups (<i>P</i>&lt;.05). Regarding posttreatment satisfaction with our proposed telemanagement health care system, positive responses were given by most of the patients in both groups. CONCLUSIONS It was found that home-based oxygen therapy with BiPAP can be a more effective prophylactic treatment approach than osteopathic manipulative respiratory and physical therapy techniques, as it can impede exacerbation of early-stage COVID-19 pneumonia. Telemanagement health care systems are promising methods to help in the pandemic-related shortage of hospital beds, as they showed reasonable effectiveness and reliability in the monitoring and management of patients with early-stage COVID-19 pneumonia. CLINICALTRIAL ClinicalTrials.gov NCT04368923; https://clinicaltrials.gov/ct2/show/NCT04368923

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