scholarly journals Alteration in Lipid Profile Levels in Women with Subclinical Hypothyroidism

2017 ◽  
Vol 8 (1) ◽  
pp. 10-15 ◽  
Author(s):  
S Ferduosi ◽  
R Haque ◽  
N Hoque ◽  
MM Rahman ◽  
MH Rahman
Keyword(s):  
Lipid Profile ◽  
Subclinical Hypothyroidism ◽  
Serum Lipid ◽  
Lipid Level ◽  
Thyroid Stimulating Hormone ◽  
Elderly Subjects ◽  
Fasting Serum ◽  
Main Concept ◽  
Previously Treated ◽  
Free Thyroxine Level

Thyroid hormones play an important role in regulating energy balance and metabolism of glucose and lipids. A relationship between dyslipidemia and atherosclerosis is well established in clinical hypothyroidism. Whether subclinical hypothyroidism (SCH) is associated with lipid profile alteration, is the main concept behind the study. SCH is defined as an elevated thyroid stimulating hormone (TSH>5mIU/l) and normal free thyroxine level (FT4 9.5- 25.0 pmol/l). It is highly prevalent in elderly subjects, especially in women but it is frequently overlooked. We examined 40 women with SCH and 50 healthy controls (TSH 0.5-5.0 mIU/l and FT4 9.5- 25.0 pmol/l). None of the patients had been previously treated with thyroxine. In all participants we measured blood pressure, BMI, TSH, FT4 and fasting serum lipid profile. We conclude that SCH in middle aged women is associated with hypertension and significant increase of TC (p<0.001), LDL-C (p<0.001), TG (p<0.001) and decreased level of HDLC p<0.001) in comparison to euthyroid Controls. SCH patients showed significant positive correlation between TSH and total cholesterol (r=.492, p<0.01), LDL-C (r=.355, p<0.05) and TG (r=.274, p<0.05) and negative but nonsignificant corelationship with HDL-C (r = - .058,p=0.361). Dyslipidemia is one of the established risk factors of cardiovascular diseases. Therefore, this study indicates that monitoring of lipid level in SCH patients would be helpful in preventing cardiovascular diseases.Bangladesh J Med Biochem 2015; 8(1): 10-15

Pattern of dyslipidemia among patients with subclinical hypothyroidism and its relation with thyroid stimulating hormone

2021 ◽  
Vol 11 (3) ◽  
pp. 172-178
Author(s):  
Nazma Akter ◽  
Tangera Akter
Keyword(s):  
Lipid Profile ◽  
Subclinical Hypothyroidism ◽  
Lipid Level ◽  
Density Lipoprotein ◽  
Thyroid Stimulating Hormone ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Thyroid Disorder ◽  
Serum Tsh ◽  
Stimulating Hormone

Background: The relationship between subclinical hypothyroidism (SCH) and dyslipidemia is still debatable about whether SCH is constantly associated with lipid disorder. The aim of this study was to assess the lipid abnormalities in patients with SCH and to evaluate the relation between thyroid stimulating hormone (TSH) and lipid profile. Methods: This cross-sectional observational study was conducted in outpatient department (OPD) of the Hormone and Diabetes Clinic at MARKS Medical College & Hospital in Dhaka, Bangladesh from May 2018 to October 2019. A total of 308 subjects (age 30 - 60 years) were included in this study using covenience sampling. Among them, 156 were diagnosed case of SCH, while 152 were euthyroid healthy individuals in control group (matched for age, gender and weight). Laboratory test included serum TSH and free thyroxine (FT4) and fasting lipid profile. Data were analyzed using SPSS version 18 statistical software. Results: In this study, dyslipidemia was more prevalent in patients with SCH compared to control group [p<0.001]. SCH group showed altered lipid profile i.e. significantly higher serum total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), triglycerides (TGs) and lower high density lipoprotein cholesterol (HDL-C) when compared with the euthyroid subjects [p < 0.05 for each]. Pearson’s correlation coefficient for the relationships between serum TSH and lipid level showed that TSH levels were positively correlated with TC, LDL-C, TG and negatively correlated with HDL-C in patients with SCH [p < 0.05 for each]. Conclusions: Dyslipidemia is a common feature in SCH compared to euthyroid controls. The study showed that TSH level was positively correlated with TC, LDL-C, TG and negatively correlated with HDL-C. SCH should be a matter for further investigation because dyslipidemia is associated with this thyroid disorder. BIRDEM Med J 2021; 11(3): 172-178

scholarly journals Study of Fasting Lipid Profile in Patients with Subclinical Hypothyroidism in a Tertiary Care Hospital in Bangladesh

2021 ◽  
Vol 16 (1) ◽  
pp. 17-20
Author(s):  
Mohammad Afjal Hossain ◽  
- Atiquzzaman ◽  
Mirza Sharifuzzaman ◽  
Farzana Amin ◽  
Lutful Kabir ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Subclinical Hypothyroidism ◽  
Tertiary Care ◽  
Thyroid Function Test ◽  
Significant Negative Correlation ◽  
Thyroid Stimulating Hormone ◽  
Care Hospital ◽  
Cross Sectional ◽  
Metabolic Complications ◽  
Normal Thyroid Function

Subclinical hypothyroidism (SCH) is a metabolic disorder with prevalence about 4-10% in general population. This study was conducted to observe the pattern of fasting lipid profile in SCH and to correlate the components of it with thyroid stimulating hormone and free thyroxin level. This cross sectional observational study included 31 newly diagnosed cases of SCH and 17 age and BMI matched healthy control subjects with normal thyroid function test. Fasting lipid profile was recorded and compared. TSH was significantly higher in SCH compared to controls (9.09±2.79 vs 2.31±0.92 μIU/ml; p=0.001). FT4 was comparable between the groups (1.17±0.18 vs 1.28±0.20 ng/dl; p=0.938). Significantly higher level of Total cholesterol and LDL-C were observed in SCH compared to controls (TC 194.77±29.70 vs 156.59±20.45 mg/dl; p=0.042 and LDL-C 124.81±27.85 mg/dl vs 88.59±18.41mg/dl; p=0.045 respectively). Triglycerides and HDL-C were comparable between the groups (TG 134.90±80.97 vs 118.12±49.14 mg/dl; p=0.171 and HDL-C 42.87±4.83 vs 44.47±5.66; p=0.633 respectively). TSH showed significant positive correlation with TC and LDL-C (r=0.591, p<0.001 and r=0.644, p<0.001 respectively), but not with TG or HDL-C (r=0.011, p=0.943 and r=0.115, p=0.435 respectively). FT4 only showed significant negative correlation with LDL-C (r=0.302; P=0.037) but not with TC, TG or HDL-C (TC: r=0.245, P=0.093; TG: r=0.121, p=0.411 and HDL-C: r=0.108, p=0.466 respectively). SCH is associated with raised TC and LDL-C. So patients with SCH are more vulnerable to develop future adverse cardio-metabolic complications. Faridpur Med. Coll. J. 2021;16(1):17-20

scholarly journals A Lifestyle (Dietary) Intervention Reduces Tiredness in Children with Subclinical Hypothyroidism, a Randomized Controlled Trial

2020 ◽  
Vol 17 (10) ◽  
pp. 3689
Author(s):  
Ellen van der Gaag ◽  
Job van der Palen ◽  
Pim Schaap ◽  
Mirthe van Voorthuizen ◽  
Thalia Hummel
Keyword(s):  
Lipid Profile ◽  
Subclinical Hypothyroidism ◽  
Dietary Intervention ◽  
Controlled Trial ◽  
Intervention Group ◽  
Well Being ◽  
Thyroid Stimulating Hormone ◽  
Control Group ◽  
Significant Difference ◽  
Scale Scores

Purpose: Subclinical hypothyroidism (SH) in children and adults is a subject for discussion in terms of whether to treat it or not with respect to the short-term clinical implications and consequences of SH and in the long term. If treatment with thyroxine supplementation is not indicated, no other treatment is available. We investigated whether a lifestyle (dietary) intervention improves or normalizes SH or decreases the presence of Thyroid Stimulating Hormone (TSH) and/or tiredness. Methods: We randomized children aged 1–12 years with SH to the control group (standard care = no treatment) or intervention group (dietary intervention). The dietary intervention consisted of green vegetables, beef, whole milk and butter for 6 months. The rest of the diet remained unchanged. We measured TSH, FreeT4, Lipid profile, Body Mass Index (BMI) and Pediatric Quality of Life (PedQL) multidimensional fatigue scale scores. Results: In total, 62 children were included. After 6 months, TSH decreased in both groups without a significant difference between the groups (p = 0.98). PedQL fatigue scores for sleep (p = 0.032) and total fatigue scores (p = 0.039) improved significantly in the intervention group, compared to the control group. No unfavorable effects occurred in the lipid profile or BMI. Conclusion: The lifestyle (dietary) intervention did not normalize SH and TSH levels, but it significantly reduced tiredness. These results suggest that children’s well-being can be improved without medication.

scholarly journals EFFECT OF TAMOXIFEN ON FASTING SERUM LIPID PROFILE IN BREAST CANCER PATIENTS

2021 ◽  
Vol 9 (01) ◽  
pp. 1013-1018
Author(s):  
Anum Khan ◽  
Fauzia Abdus Samad ◽  
Abdus Samad Syed ◽  
Asif Riaz ◽  
Sharmin Arif ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Density Lipoprotein ◽  
Mammary Epithelium ◽  
Serum Lipid Profile ◽  
P Value ◽  
Breast Cancer Patients ◽  
Fasting Serum

Background:Tamoxifen acts as a selective estrogen receptor modulator by binding to the estrogenreceptors on mammary epithelium andblockingtheproliferative action of estrogen on mammaryepithelium. In contrast to that it has a weak estrogen agonistic effect on bone, liver and endometrium.Tamoxifen therapy has favorable effects on serum lipid profile by decreasing serum levels of Total cholesterol and low density lipoprotein (LDL), while its effect on high density lipoprotein (HDL) and triglyceride (TG)is still controversial. So this study is to evaluate the effects of tamoxifenTherapy on fasting serum lipid profile in patients with breast cancer. Results: Mean age was 43.56±3.53yrs , most common BMI was 30-34.9. Patient serum TG levels were raised from baseline after 3 months of tamoxifen with p values of (0.000) which was statistically significant while HDL levels were raised but with p value of (0.008 ) which was statistically insignificant. Serum LDL and total cholesterol were reduced from baseline after 3 month with p value of (0.000) and (0.000) respectively. Conclusion: This study concludes that tamoxifen has effects on serum lipid profile by increasing TG levels and lowering TC and LDL levels so this should be in consideration while prescribing tamoxifen to the patients having other risk factors for cardiovascular abnormalities.

scholarly journals Night sleep duration and risk of each lipid profile abnormality in a Chinese population: a prospective cohort study

2020 ◽  
Author(s):  
Qiaofeng Song ◽  
Xiaoxue Liu ◽  
Wenhua Zhou ◽  
Shouling Wu ◽  
xizhu wang
Keyword(s):  
Lipid Profile ◽  
Sleep Duration ◽  
Chinese Population ◽  
Serum Lipid ◽  
Proportional Hazards Model ◽  
Lipid Level ◽  
Cox Proportional Hazards ◽  
Cox Proportional Hazards Model ◽  
Long Sleep ◽  
Low Hdl

Abstract Background To explore the associations between sleep duration and abnormalities in serum lipid levels in a Chinese population. Methods A prospective study was conducted with 34,260 participants from the general Chinese population. Sleep duration was categorized as ≤5, 6, 7, 8 or ≥9 h. Each lipid profile abnormality was defined according to the Chinese Guidelines for the Prevention and Treatment of Dyslipidemia in Adults (2016). The Cox proportional hazards model was used to assess the association between sleep duration and dyslipidemia. Results Compared with a 7 h sleep duration, long sleep duration (≥9 h) was significantly associated with low high-density lipoprotein cholesterol (HDL-C) levels (hazard ratio (HR): 1.24; 95% CI: 1.12–1.38). In subgroup analyses, the positive association between long sleep duration and low HDL-C level in men and in the different age groups was more pronounced than the association in women. No significant interactions were observed in the association between sleep duration and each abnormal serum lipid level by sex/age in the study population (P-interaction>0.05). Conclusions These findings suggest that long sleep duration is associated with low HDL-C level among the Kailuan community population.

scholarly journals Relationship between serum lipid level and meibomian gland dysfunction subtype in Korea : A propensity score analysis

2021 ◽  
Author(s):  
Minji Ha ◽  
Jiyun Song ◽  
Sunkyoung Park ◽  
Kyungdo Han ◽  
Ho Sik Hwang ◽  
...  
Keyword(s):  
General Population ◽  
Propensity Score ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Lipid Level ◽  
Density Lipoprotein ◽  
Serum Lipid Level ◽  
Meibomian Gland ◽  
Meibomian Gland Dysfunction ◽  
The Mean

Abstract Purpose: To analyze the correlation between systemic lipid profile levels and each meibomian gland dysfunction (MGD) subtype in Korea.Methods: The ophthalmic data of 95 eyes and the serum lipid profiles of 95 patients were reviewed. These factors were compared with those of the general population using data from the Korean National Health and Nutrition Examination Survey (KNHANES), which evaluated 2,924 subjects. Of these, 475 propensity score-matched normal controls were selected for comparison with the 95 MGD patients based on a 1:5 ratio. In addition, we analyzed the correlations between serum lipid profile levels and MGD subtypes in MGD patients.Results: The mean high-density lipoprotein (HDL) value of the MGD patients was significantly higher than that of the general population (P < 0.0001). However, the mean total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL) levels of the MGD patients were not significantly different from those of the general population (TC: P = 0.3950, TG: P = 0.6331, LDL: P = 0.2079). In addition, no serum lipid levels statistically differed among the MGD subtypes (TC: P = 0.7650, HDL: P = 0.2480, LDL: P = 0.3430, TG: P = 0.7030).Conclusion: A statistically significant, but marginal, increase in HDL concentration was observed in the MGD group, although there was no difference in any serum lipid level among the MGD subtypes.

scholarly journals Plasma homocysteine concentrations and serum lipid profile as atherosclerotic risk factors in subclinical hypothyroidism

2008 ◽  
Vol 28 (2) ◽  
pp. 96-101 ◽  
Author(s):  
Serpil Turhan ◽  
Sevilay Sezer ◽  
Gonul Erden ◽  
Ali Guctekin ◽  
Fatma Ucar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lipid Profile ◽  
Subclinical Hypothyroidism ◽  
Serum Lipid ◽  
Plasma Homocysteine ◽  
Serum Lipid Profile ◽  
Atherosclerotic Risk Factors
Sign in / Sign up

Export Citation Format

Share Document