CT Guided Stereotactic Brain Tumor Biopsy

153 cases of CT guided stereotactic biopsies for intra-axial deep seated brain lesions performed by one neurosurgeon has been analyzed regarding procedure, success rate and complications. Of the 153 cases, positive tissue biopsy was found in 143 cases. In 6 patients, biopsy showed gliotic grain tissue or normal brain tissue.4 patients had complications after the procedure. Three patient developed intracerebral haemorrhage of the two died, and other died Massive MI. There was no post operative new deficits seen. CT guided Stereotactic biopsy is a very effective and low cost procedure caomparing with frameless image guided brain biopsies or open craniotomy for biopsy due to it’s higher complication rate. The detail procedure are being discussed Bang. J Neurosurgery 2020; 9(2): 86-93

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Complications of CT-guided stereotactic biopsy of intra-axial brain lesions

Journal of Neurosurgery ◽

10.3171/jns.1994.81.2.0165 ◽

1994 ◽

Vol 81 (2) ◽

pp. 165-168 ◽

Cited By ~ 171

Author(s):

Mark Bernstein ◽

Andrew G. Parrent

Keyword(s):

Intracranial Hypertension ◽

Stereotactic Biopsy ◽

Brain Lesions ◽

The Other ◽

Ct Guided ◽

Major Morbidity ◽

Content Type ◽

Number Of Patients ◽

Stereotactic Biopsies ◽

Fine Print

✓ A series of 300 consecutive stereotactic biopsies for intra-axial brain lesions performed by one neurosurgeon was critically analyzed regarding complications of the procedure. Complications were incurred by a total of 19 patients (6.3%). Five patients (1.7%) died following the procedure, all due to intracranial hypertension: one from subarachnoid hemorrhage, one from intracerebral hemorrhage, and three from increased edema without hemorrhage. The three patients who died without hemorrhage all had marked intracranial hypertension at the time of biopsy. All five patients who died harbored a glioblastoma multiforme. The surviving 14 patients (4.7%) with complications suffered increased neurological deficit due to hemorrhage. In 10 (3.3%), the deficit was mild and/or transient; in the other four (1.3%), a major deficit was incurred which markedly affected the remainder of the patient's life. Therefore, mortality or major morbidity was seen in 3.0% of patients and minor morbidity in 3.3%. Stereotactic biopsy is a very effective procedure with a complication rate significantly lower than that of craniotomy (particularly in the population of patients selected for stereotactic biopsy), but in a small number of patients the outcome is devastating.

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Frame-Based CT-Guided Stereotactic Biopsy in Treatment of Different Brain Lesions

Journal of Neurological Surgery Part A Central European Neurosurgery ◽

10.1055/s-0035-1566377 ◽

2015 ◽

Vol 76 (S 02) ◽

Author(s):

Bojan Jelača ◽

Petar Vuleković ◽

Vladimir Papić ◽

Mladen Karan ◽

Tomislav Cigić ◽

...

Keyword(s):

Stereotactic Biopsy ◽

Brain Lesions ◽

Ct Guided

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Quantitative Measurements of Regional Glucose Utilization and Rate of Valine Incorporation into Proteins by Double-Tracer Autoradiography in the Rat Brain Tumor Model

Journal of Cerebral Blood Flow & Metabolism ◽

10.1038/jcbfm.1989.12 ◽

1989 ◽

Vol 9 (1) ◽

pp. 87-95 ◽

Cited By ~ 22

Author(s):

Michihiro Kirikae ◽

Mirko Diksic ◽

Y. Lucas Yamamoto

Keyword(s):

Protein Synthesis ◽

Brain Tumor ◽

Rat Brain ◽

Brain Tissue ◽

Glucose Utilization ◽

Tumor Model ◽

Normal Brain ◽

Normal Brain Tissue ◽

Rat Brain Tumor ◽

Brain Tumor Model

We examined the rate of glucose utilization and the rate of valine incorporation into proteins using 2-[18F]fluoro-2-deoxyglucose and L-[1-14C]-valine in a rat brain tumor model by quantitative double-tracer autoradiography. We found that in the implanted tumor the rate of valine incorporation into proteins was about 22 times and the rate of glucose utilization was about 1.5 times that in the contralateral cortex. (In the ipsilateral cortex, the tumor had a profound effect on glucose utilization but no effect on the rate of valine incorporation into proteins.) Our findings suggest that it is more useful to measure protein synthesis than glucose utilization to assess the effectiveness of antitumor agents and their toxicity to normal brain tissue. We compared two methods to estimate the rate of valine incorporation: “kinetic” (quantitation done using an operational equation and the average brain rate coefficients) and “washed slices” (unbound labeled valine removed by washing brain slices in 10% thrichloroacetic acid). The results were the same using either method. It would seem that the kinetic method can thus be used for quantitative measurement of protein synthesis in brain tumors and normal brain tissue using [11C]-valine with positron emission tomography.

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Correlation of CT and MR with Impedance Monitoring and Histopathology in Stereotactic Biopsies

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/s0317167100030420 ◽

1990 ◽

Vol 17 (2) ◽

pp. 184-189 ◽

Cited By ~ 5

Author(s):

J. Gorecki ◽

E.J. Dolan ◽

R.R. Tasker ◽

W. Kucharczyk

Keyword(s):

Stereotactic Biopsy ◽

Computer Assisted ◽

Pathologic Examination ◽

Resonance Imaging ◽

Mr Images ◽

Ct Guided ◽

Computer Assisted Tomography ◽

Radiologic Imaging ◽

Impedance Monitoring ◽

Stereotactic Biopsies

ABSTRACT:Magnetic Resonance Imaging (MR) and Computer Assisted Tomography (CT) guided stereotaxis combined with intraoperative impedance monitoring and multiple sequential biopsies provides the opportunity to correlate the results of radiologic imaging with impedance and histopathology. The authors present the methods used and preliminary results obtained from 30 stereotactic biopsies with complete correlation in 12 cases. Impedance changes correlate accurately with lesion margins as defined by histology. CT images of enhancing lesions correlate quite closely to the histopathologic lesion margins whereas the appearance of the lesion on MR images is often larger than subsequently identified by either impedance or at pathologic examination. Impedance monitoring is a useful adjunct to stereotactic biopsy as it helps to accurately define lesion margins and can help direct the choice of biopsy sites.

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Tumor necrosis factor identified in multiple sclerosis brain.

Journal of Experimental Medicine ◽

10.1084/jem.170.2.607 ◽

1989 ◽

Vol 170 (2) ◽

pp. 607-612 ◽

Cited By ~ 569

Author(s):

F M Hofman ◽

D R Hinton ◽

K Johnson ◽

J E Merrill

Keyword(s):

Multiple Sclerosis ◽

Subacute Sclerosing Panencephalitis ◽

Brain Lesions ◽

Normal Brain ◽

Lesion Site ◽

Normal Brain Tissue ◽

Neurologic Diseases ◽

Immunocytochemical Techniques ◽

Necrosis Factor ◽

Made In

Frozen brain specimens from patients with multiple sclerosis (MS) and other neurologic diseases were analyzed using immunocytochemical techniques for the presence of TNF. In brain lesions in MS, and subacute sclerosing panencephalitis, TNF+ cells were demonstrated. At the lesion site in MS, TNF+ staining is associated with both astrocytes and macrophages. These observations were not made in Alzheimer's disease or normal brain tissue. The presence of TNF in MS lesions suggests a significant role for cytokines and the immune response in disease progression.

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Image-Guided Stereotactic Biopsy for the Brain Lesions: 2,315 Case Reports

Journal of Neurological Surgery Part B Skull Base ◽

10.1055/s-0034-1383947 ◽

2014 ◽

Vol 75 (S 02) ◽

Author(s):

J. Zhang ◽

Y. Wang ◽

X. Yu ◽

R. Hui ◽

R. Liu ◽

...

Keyword(s):

Stereotactic Biopsy ◽

Case Reports ◽

Brain Lesions ◽

Image Guided ◽

The Brain

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Origami Lesion-Targeting Device for CT-Guided Interventions

Journal of Imaging ◽

10.3390/jimaging5020023 ◽

2019 ◽

Vol 5 (2) ◽

pp. 23

Author(s):

Austin Taylor ◽

Sheng Xu ◽

Bradford Wood ◽

Zion Tse

Keyword(s):

3D Printing ◽

Minimally Invasive ◽

Laser Cutting ◽

Low Cost ◽

Needle Insertion ◽

Ct Guided ◽

Surgical Tools ◽

Image Guided ◽

Radiocontrast Agent ◽

Guided Therapy

The objective of this study is to preliminarily evaluate a lesion-targeting device for CT-guided interventions. The device is created by laser cutting the structure from a sheet of medical grade paperboard, 3D printing two radiocontrast agent grids onto the surface and folding the structure into a rectangular prism with a viewing window. An abdominal imaging phantom was used to evaluate the device through CT imaging and the targeting of lesions for needle insertion. The lesion-targeting trials resulted in a mean targeting error of 2.53 mm (SD 0.59 mm, n = 30). The device is rigid enough to adequately support standard biopsy needles, and it attaches to the patient, reducing the risk of tissue laceration by needles held rigidly in place by an external manipulator. Additional advantages include adequate support for the insertion of multiple surgical tools at once for procedures such as composite ablation and the potential to guide off-axial needle insertion. The low-cost and disposability of the device make it well-suited for the minimally invasive image-guided therapy environment.

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