scholarly journals Evaluation of Tubercular Cervical Lymphadenopathy: Diagnostic and Therapeutic Utility

2020 ◽  
Vol 23 (2) ◽  
pp. 127-132
Author(s):  
AKM Asaduzzaman ◽  
Md Kabir Uddin ◽  
Mohammmad Ali Azad ◽  
Abdullahis Safi ◽  
Wasim Selimul Haque
Keyword(s):  
Treatment Failure ◽  
Cervical Lymphadenopathy ◽  
Military Hospital ◽  
Excision Biopsy ◽  
Laboratory Findings ◽  
Surgical Interventions ◽  
Time Period ◽  
Tubercular Lymphadenitis

Introduction: Lymphadenitis is the most common extrapulmonary manifestation of tuberculosis. It remains both diagnostic and therapeutic challenge as not only mimics other diseases but also inconsistent physical and laboratory findings. Diagnosis is difficult often requiring biopsy. Aim: Aim of the study was to evaluate the role of surgical dissection of tuberculous cervicle lymphadenopathy for diagnosis as well as therapeutic purpose. Methods: This observational study was conducted during the time period of 01 july 2015 to 30 june 2017 in ENT & Pulmonology department, combined military hospital Dhaka on 100 patients who have undergone surgical neck dissection. Result: In our study total 100 patients were biopsied. Among them 56 patient was diagnosed as tubercular lymphadenitis after lymphnode excision biopsy. Among them 47 tubercular lymphadenitis patient responded to ATT (CAT-1), only 2 patient developed cold abscess which required further surgery. Six patient showed relapse during follow-up and 9 patient did not respond to CAT-1 treatment (treatment failure). Surgical intervention along with CAT-2 treatment showed cure in all of them. 2nd surgical interventions were done in total 17 patients, 2 TB abscess during ATT (CAT-1 HRZE), 9 treatment failure patients and 6 relapse patients along with ATT (CAT-2 SHRZE) and all these patients had no relapse or treatment failure during further follow up. Bangladesh J Otorhinolaryngol; October 2017; 23(2): 127-132

The Role of miRNAs in PI3K Signaling Pathway in Blood Malignancies: A Review Article

2021 ◽  
Author(s):  
Haniyeh Gaffari-Nazari ◽  
Samira Karami ◽  
Leila Noorazar ◽  
Sayeh Parkhideh ◽  
Elham Roshandel ◽  
...  
Keyword(s):  
Treatment Failure ◽  
Signaling Pathway ◽  
Intracellular Signaling ◽  
Pi3k Pathway ◽  
Pi3k Signaling ◽  
Laboratory Findings ◽  
A Cell ◽  
Pi3k Signaling Pathway ◽  
Relationship Of

Background: The PI3K/Akt/mTOR signaling pathway is one of the most important intracellular signaling pathways by regulating the cell cycle process. The direct relationship of this pathway with important mechanisms such as cell quiescence, longevity, and proliferation has been established. The overactive PI3K pathway with decreased and increased apoptosis and cell proliferation respectively is involved in pathogenesis of many cancers, including blood malignancies such as leukemia. Methods: Laboratory findings have shown that different factors, such as miRNAs, play a role in regulating PI3K signaling pathway. These molecules can alter the fate of a cell by interfering in suppression/overexpression of mRNA, transcription factors or stimulating the transcription of some genes. In this article, we reviewed the role of miRNAs in regulating the PI3K/Akt/mTOR pathway and its effect on leukemic progression and treatment failure. Conclusion: At present, miRNAs are known to be one of the causes of treatment failure and relapse in cancers.

Follicular lymphoma presenting as mumps, with persistent cervical lymphadenopathy

2006 ◽  
Vol 121 (5) ◽  
pp. 501-502 ◽  
Author(s):  
A S Cole ◽  
M I Trotter ◽  
J O'Connell
Keyword(s):  
Follicular Lymphoma ◽  
Sore Throat ◽  
Fine Needle Aspiration ◽  
Healthy Individual ◽  
Cervical Lymphadenopathy ◽  
Needle Aspiration ◽  
Excision Biopsy ◽  
Malignant Cells ◽  
Fine Needle

We report a case of follicular lymphoma in a healthy individual, which presented as saliva- and serum-proven mumps. The patient presented with a sore throat and parotid and submandibular lymphadenopathy. Fine needle aspiration, undertaken three weeks following presentation, revealed no malignant cells. An excision biopsy of a level two node was performed due to persistent lymphadenopathy, five weeks following presentation. As far as we are aware, this is the first reported case of follicular lymphoma presenting as mumps. This case highlights the importance of follow up in patients in whom lymphadenopathy is persistent despite the proven diagnosis of mumps.

scholarly journals Oropharyngeal tularemia cases admitted to a military hospital in Ankara, Turkey

2014 ◽  
Vol 8 (08) ◽  
pp. 994-999 ◽  
Author(s):  
Ahmet Karakas ◽  
Omer Coskun ◽  
Cumhur Artuk ◽  
Umit Savasci ◽  
Hanefi Cem Gul ◽  
...  
Keyword(s):  
Cervical Lymphadenopathy ◽  
Military Hospital ◽  
Tuberculous Lymphadenitis ◽  
Treatment Results ◽  
Laboratory Findings ◽  
Duration Of Symptoms ◽  
Laboratory Results ◽  
Sources Of Infection ◽  
The Mean ◽  
Prompt Diagnosis

Introduction: This study aimed to review the possible sources of infection of 16 oropharyngeal tularemia hospital cases, and to document their epidemiological and demographical characteristics, laboratory findings, treatment methods, and treatment results. Methodology: Sixteen cases from a Turkish military hospital between January 2011 and December 2012 were retrospectively evaluated. The age, sex, occupation, place of residence, symptoms, duration of symptoms, laboratory results, treatment and duration, and treatment results were recorded. Tularemia was diagnosed through tularemia-specific tests once the other conditions that may have caused lymphadenopathy were excluded. Results: Twelve of the patients included in this study were males. The average age of the patients was 32.1±17.2 years. Sore throat, fatigue, and fever were the most frequent symptoms. The mean duration of symptoms was 21.6±6.9 days. All the patients had been treated for tonsillopharyngitis in primary healthcare institutions previously. However, despite the treatment, cervical lymphadenopathy had developed in these cases. Patients were given streptomycin, doxycycline, and ciprofloxacin monotherapy or in combination. Ten of the cases fully recovered, while five required surgical lymph node drainage. Spontaneous drainage occurred in the single remaining case. Conclusions: Turkey is considered to be an endemic country with regards to tularemia. Prompt diagnosis and proper treatment of the disease is imperative in providing cure. Since it can be potentially confused with tuberculous lymphadenitis, differential diagnosis is vital. Patients presenting with a condition of tonsillopharyngitis in endemic areas must be carefully monitored.

kikuchi–Fujimoto disease: a report of two cases and an overview

1994 ◽  
Vol 108 (11) ◽  
pp. 1001-1004 ◽  
Author(s):  
N. Louis ◽  
M. Hanley ◽  
N. McD. Davidson
Keyword(s):  
Saudi Arabia ◽  
Malignant Lymphoma ◽  
Young Women ◽  
Cervical Lymphadenopathy ◽  
Original Description ◽  
The Other ◽  
Excision Biopsy ◽  
Laboratory Findings ◽  
The World ◽  
Saudi Patients

AbstractKikuchi-Fujimoto disease (KFD) has been widely reported from Japan and sporadically from many parts of the world including Saudi Arabia, since its original description in 1972 but the disease remains poorly known by clinicians. In this paper we report two Saudi patients seen in Tabuk. Saudi Arabia. One was a 36-year-old Saudi man and the other a 16-yearold Saudi girl. Both presented with cervical lymphadenopathy and pyrexia. Histological examination of biospy material from both showed classical features of KFD. Other laboratory findings were unremarkable except for leucopenia. Following excision biopsy both patients recovered without sequelae. KFD is a self-limiting process of uncertain aetiology that predominantly affects young women aged 20–-30 years. We review the pathology, clinical featuers and possible aetiology of this interesting disease, which may well be underdiagnosed. Increased awareness of KFD will minimize the risk of confusing this entity with malignant lymphoma or other serious conditions.

Plasma presepsin in determining gastric leaks following bariatric surgery

2019 ◽  
Vol 44 (4) ◽  
pp. 565-573
Author(s):  
Sinan Binboga ◽  
Nilgun Isiksacan ◽  
Pinar Kasapoglu ◽  
Elif Binboga ◽  
Murat Koser ◽  
...  
Keyword(s):  
Morbid Obesity ◽  
Sleeve Gastrectomy ◽  
White Blood Count ◽  
Surgical Interventions ◽  
Neutrophil Lymphocyte Ratio ◽  
Reactive Protein ◽  
Stapler Line

Abstract Background To be able to prevent morbid obesity in the long-term, laparoscopic sleeve gastrectomy (LSG) is one of the most effective surgical interventions. However, leakage and bleeding from the stapler line are significant complications. The aim of this study was to determine the role of the levels of plasma presepsin in the detection of stapler leakage. Materials and methods The study included 300 patients with LSG due to morbid obesity and 40 control subjects. Before any medical treatment was applied, blood samples were taken from patients at 12 h preoperatively and on days 1, 3, and 5 postoperatively. Evaluation was made of plasma presepsin levels, white blood count (WBC), C-reactive protein (CRP) and neutrophil-lymphocyte ratio (NLR), in all patients with sleeve gastrectomy line leakage. Results The WBC, CRP, NLR and presepsin values measured on days 1, 3 and 5 postoperatively were determined to be higher in patients with leakage compared to those without. The predictive value of presepsin (p = 0.001), CRP (p = 0.001) and NLR (p = 0.001) was determined to be statistically significantly higher than that of WBC (p = 0.01). Conclusion The results of the study suggest that presepsin levels could have a role in the detection and follow-up of stapler line leaks after LSG. Elevated presepsin levels, on postoperative day 1 in particular, could have a key role in the early detection of possible complications which are not seen clinically.

The role of the carbon dioxide laser in treatment of carcinoma of the tongue

1988 ◽  
Vol 102 (12) ◽  
pp. 1122-1123 ◽  
Author(s):  
S. Rhys Williams ◽  
J. A. S. Carruth
Keyword(s):  
Carbon Dioxide Laser ◽  
Excision Biopsy ◽  
Treatment Programme ◽  
Head And Neck Oncology ◽  
Conventional Radiotherapy ◽  
Laser Excision ◽  
Disease Free ◽  
Carcinoma Of The Tongue

AbstractThis paper present 35 patient with carcinoma of the tongue who have been treated in Southampton using the Carbon laser. The treatment programme for each individual patient was determined by radiotherapists and surgeons in a combined head and neck/oncology clinic. T1 carcinomas were treated by primary laser excision biopsy whereas larger tumours were treated first by conventional radiotherapy unless there was a significant contraindication to this treatment modality.Of 10 patients with T1 lesions nine are alive and well and disease free, but one patient died of other causes with no sign of recurrence. The minimum follow-up period has been two years. Of 25 patients with T2 and T3 lesions treated either before or after radiotherapy, nine are alive and disease-free, eleven died of disease and five patients died of other causes with no evidence of recurrence.

The Utility of Infectious and Neurodiagnostic Testing in Children With Complex Febrile Seizures Requiring Mechanical Ventilation

2021 ◽  
pp. 088307382110005
Author(s):  
Jennifer H. Yang ◽  
Richard Villegas ◽  
Sandeep Khanna ◽  
Julie Kaswick ◽  
Nicole G. Coufal ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Cohort Analysis ◽  
Severity Of Illness ◽  
Febrile Seizures ◽  
Tertiary Hospital ◽  
Surgical Interventions ◽  
Retrospective Cohort Analysis ◽  
Life Threatening

A retrospective cohort analysis was performed on 79 consecutive patients between 6 months and 5 years admitted to a tertiary hospital with a diagnosis of complex febrile seizures requiring mechanical ventilation from 2011 to 2017 to determine the utility of infectious and neurologic diagnostics. Intubation was used as a proxy for severity of illness. The overall intensive care unit stay was short (95% intubated <24 hours, 88% admitted <3 days). No life-threatening infections were identified, and none required surgical interventions. Electroencephalogram (EEG) was obtained on 43%, 26% of which were abnormal. Sixty-six percent of patients were discharged on rescue benzodiazepine and 20% with maintenance antiseizure medications. Duration of follow-up averaged 4 years (range 1 month to 9 years); 8 patients (10%) were subsequently diagnosed with epilepsy. Our findings suggest that extensive diagnostic evaluations may not be necessary for children with complex febrile seizures requiring mechanical ventilation although the role of EEG is less understood.

scholarly journals Development of Areas and Public Purpose Investments in Suburban Territories

2014 ◽  
Vol 22 (2) ◽  
pp. 86-97
Author(s):  
Ada Wolny ◽  
Alina Źróbek-Rózańska ◽  
Ryszard Źróbek ◽  
Marek Piotrowski ◽  
Jens Frey
Keyword(s):  
Local Community ◽  
Social Infrastructure ◽  
Suburban Areas ◽  
Public Investments ◽  
Public Purpose ◽  
Time Period ◽  
The Relationship

Abstract Suburban areas are subjected to particularly strong investment pressure, thus facing the challenge arising from the need to impose new spatial order. Satisfying the residents’ expectations by implementing necessary technical and social infrastructure becomes a priority. Therefore, public investments play an important role in suburban areas. The article discusses the role of public purpose goals and their achievement using a case study which encompassed the outskirts of Olsztyn and consisted of detailed analyses of two gminas (communes) adjacent to the city. The research covered the time period from 2006 to 2010. The relationship between the development of housing functions in a suburban area and the location of public purpose investments such as technical and social infrastructure has been documented. The execution of public purpose projects is a follow-up of the development strategies prepared for the gminas where public investments are shown as a stimulant of suburban development. It has been demonstrated that decisions permitting such investments to be carried out are issued in response to the needs of the local community and investors moving to suburban territories.

scholarly journals Promising results of surgical management of advanced medication related osteonecrosis of the jaws using adjunctive leukocyte and platelet rich fibrin

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Öznur Özalp ◽  
Nelli Yıldırımyan ◽  
Canan Öztürk ◽  
Burak Kocabalkan ◽  
Göksel Şimşek Kaya ◽  
...  
Keyword(s):  
Cost Effective ◽  
Complete Healing ◽  
Stage Ii ◽  
Surgical Interventions ◽  
Platelet Rich Fibrin ◽  
Osteonecrosis Of The Jaws ◽  
Tissue Healing ◽  
Incomplete Healing

Abstract Background Leukocyte- and platelet-rich fibrin (L-PRF) is an autologous matrix scaffold which regulates inflammation by stimulating cytokines and growth factors that are involved in the immune response. L-PRF is suggested as a viable adjunctive method to surgical interventions due to its advantages on tissue healing. This study aims to retrospectively evaluate the adjunctive role of L-PRF in surgically treated medication-related osteonecrosis of the jaws (MRONJ) patients. Methods Between January 2012 and December 2020, patients with AAOMS stage II and III MRONJ lesions, who were treated surgically with adjunctive use of L-PRF in the authors’ institution were enrolled. Surgical interventions consisted of either marginal resection or sequestrectomy with peripheral ostectomy (SPO) or curettage and L-PRF application. Medical records of these patients were retrospectively reviewed and healing was assessed according to certain parameters including mucosal closure and presence of infection, exposed bone, fistula or radiologic markers of disease progression for a minimum of 12 months. Results Thirteen patients (7 women and 6 men) with an average age of 72.4 years (± 10.61, range 54–84) were included in the study, nine of whom had AAOMS stage III and four stage II MRONJ. Three patients had a marginal resection, nine patients had sequestrectomy with peripheral ostectomy (SPO) and one patient underwent a curettage procedure. All marginal resection and six SPO patients showed complete healing while four patients, who had SPO or curettage experienced incomplete healing. Mean follow up was 20.1 ± 18.29 months. Conclusion The use of L-PRF may be a favorable adjunctive option in the treatment of MRONJ owing to its favorable effects on tissue repair, ease of application, minimally invasive and cost-effective character and autogenous nature. Trial registration Retrospectively registered.

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