scholarly journals Prospective Study of Bronchial Asthma

1970 ◽  
Vol 6 (2) ◽  
pp. 100-103
Author(s):  
A Halim ◽  
T Alam ◽  
MY Ali ◽  
MMSU Islam ◽  
F Ahammad ◽  
...  
Keyword(s):  
Prospective Study ◽  
Bronchial Asthma ◽  
Acute Asthma ◽  
Airflow Obstruction ◽  
Medical Emergency ◽  
P Value ◽  
College Hospital ◽  
Key Words Bronchial Asthma ◽  
Nebulized Salbutamol ◽  
Severe Acute Asthma

Bronchial asthma is an atopic disease characterized by chronic airway inflammation and hyper-responsiveness. Severe acute asthma is a medical emergency and sometimes difficult to treat. This prospective study was done at Dhaka Medical College Hospital from January 1997 to January 1998. Total 30 patients of bronchial asthma were included in this study. Diagnosis was established on the basis of symptoms, evidence of airflow obstruction and its reversibility by bronchodilator therapy. The age range was 18 to 80 years with a mean 36.64±4.91. Of them, 63% were male and 37% were female. It revealed that all patients had classical triad of dyspnoea, wheeze and cough. Almost all patients (80%) had some precipitating agents for their attack. Regarding treatment of severe acute asthma - Nebulized salbutamol is superior to conventional intravenous aminophylline, as p value of nebulized salbutamol group is <0.001 which is significant. So, severe acute asthma should be managed with nebulized salbutamol instead of intravenous aminophylline. Key words: Bronchial asthma; Bronchodilator; Nebulized salbutamol; Aminophylline. DOI: http://dx.doi.org/10.3329/fmcj.v6i2.9211 FMCJ 2011; 6(2): 100-103

scholarly journals Patterns of recovery of airflow obstruction in severe acute asthma

1979 ◽  
Vol 55 (650) ◽  
pp. 877-880 ◽  
Author(s):  
I. S. Petheram ◽  
D. A. Jones ◽  
J. V. Collins
Keyword(s):  
Acute Asthma ◽  
Airflow Obstruction ◽  
Severe Acute Asthma

scholarly journals Nebulized racemic epinephrine used in the treatment of severe asthmatic exacerbation: a case report and literature review

CJEM ◽  
2007 ◽  
Vol 9 (04) ◽  
pp. 304-308 ◽  
Author(s):  
Kristopher Wiebe ◽  
Brian H. Rowe
Keyword(s):  
Mechanical Ventilation ◽  
Case Report ◽  
Acute Asthma ◽  
Treatment Options ◽  
Non Invasive ◽  
Systemic Corticosteroids ◽  
Severe Asthmatic ◽  
Nebulized Salbutamol ◽  
Life Threatening ◽  
Severe Acute Asthma

ABSTRACT Acute asthma is a common emergency department (ED) problem that is typically treated with bronchodilators and anti-inflammatories. Nebulized selective, short-acting β-agonists, such as salbutamol, are the bronchodilators of choice in most Canadian EDs. Other important treatments in moderate-to-severe cases include systemic corticosteroids and in severe cases may include the addition of ipratropium bromide and magnesium sulfate. Despite aggressive management, some patients do not respond adequately to nebulized salbutamol. Treatment options in these patients are limited to interventions such as parenteral epinephrine, and non-invasive and mechanical ventilation (or both). Both parenteral epinephrine and mechanical ventilation have associated risks, so alternative treatments with a lower risk profile would be useful for the treatment of life-threatening asthma. The following case report describes a patient in whom nebulized racemic epinephrine was used successfully to treat severe acute asthma following failure of standard first-line therapies.

scholarly journals Efficacy of Nebulized Magnesium Sulphate in the Treatment of Acute Bronchial Asthma Compared to Nebulized Salbutamol: A Randomized Control Trial

2020 ◽  
Vol 44 (1) ◽  
pp. 24-29
Author(s):  
Zannat Ul Sarmin ◽  
Sayeeda Anwar ◽  
Tafazzal Hossain Khan ◽  
Md Abid Hossain Mollah ◽  
Rokeya Khanam ◽  
...  
Keyword(s):  
Acute Exacerbation ◽  
Acute Asthma ◽  
Treatment Options ◽  
Controlled Study ◽  
Control Group ◽  
College Hospital ◽  
Bronchodilator Effect ◽  
Nebulized Salbutamol ◽  
Asthma In Children ◽  
Group B

Background: Nebulized salbutamol is commonly used in treatment of asthma in children. The use of nebulized MgSO4 is one of the different treatment options available during acute exacerbation. Objective: To compare the efficacy of nebulized MgSO4 with nebulized salbutamol in the treatment of acute asthma in children. Materials and method: This randomized controlled study was conducted in Dhaka Medical College Hospital between January to December 2016. Children of 7-12 years with acute exacerbation of asthma were randomized into study group-A (MgSO4 group, n=30) and control group-B (Salbutamol group, n=30). Children of both groups were treated with serial nebulization thrice at 20 minute intervals by either 2.4 ml (4% MgSO4, 96 mg) or salbutamol (0.15 mg/kg minimum 2.5 mg) with 2.5 ml of isotonic normal saline. Results: The mean final PEFR were not different between the two groups (275.0±41.42 L/min in MgS04 group and 263±36.17 L/min in salbutamol group). The increase in PEF was statistically significant and comparable in both groups (by 35.1% in the MgS04 group and by 42.1% in the salbutamol group). Fischl score improvement was comparable and significant in both groups (4.31 to 0.43 in MgS04 group and 4.29 to 0.76 in salbutamol group). Statistically significant increase in oxygen saturation and reduction of heart rate was found in MgS04 group without any side effects. Nebulized MgSO4 was found having significant bronchodilator effect which is comparable to salbutamol. Conclusion: Nebulized MgS04 was found equally effective as nebulized salbutamol in the treatment of severe acute asthma in children. Bangladesh J Child Health 2020; VOL 44 (1) :24-29

Risk factors for PICU admission in children with severe acute asthma: a multicenter prospective study

2019 ◽  
Author(s):  
Shelley A. Boeschoten ◽  
Annemie L.M. Boehmer ◽  
Peter J.F.M. Merkus ◽  
Joost Van Rosmalen ◽  
Corinne M.P. Buysse ◽  
...  
Keyword(s):  
Risk Factors ◽  
Prospective Study ◽  
Acute Asthma ◽  
Severe Acute Asthma ◽  
Multicenter Prospective Study

scholarly journals Mistakes of diagnostics, conducting and treatments of the patients with bronchial asthma

2002 ◽  
Vol 1 (1) ◽  
pp. 89-96
Author(s):  
N. A. Karoly ◽  
A. P. Rebrov
Keyword(s):  
Bronchial Asthma ◽  
Acute Asthma ◽  
Asthma Treatment ◽  
Medical Aid ◽  
Local Doctor ◽  
Severe Acute Asthma ◽  
Major Factors ◽  
Main Factor

On the basis of diagnostics of 100 patients, 25 doctors of Saratov and 72 histories of illness of the patients with severe acute asthma in four different hospitals there were presented the results that prove the great amount of defections in diagnostics quality, conducting and treatment of patients at various stages of rendering of medical aid. There were defined the difficulties of diagnostics and the main factor of severe current of asthma and death. The difficulties are both in absence of primary training of the patients, and in absence of constant, regular supervision of these patients by the local doctor. It is connected not only with the absence of time on doctor’s dialogue with the patient, but also with ignorance and frequently unwillingness of the doctor to learn the modern approaches of conducting and treatment of asthma. The received data confirms that the major factors conducting to increase of severe current of asthma and the increase of mortality are bad diagnostics, inadequate conducting and treatment, and the education of the patients is very necessary part of the general common program of asthma treatment.

Prospective study of serum and ionized magnesium pharmacokinetics in the treatment of children with severe acute asthma

2018 ◽  
Vol 75 (1) ◽  
pp. 59-66 ◽  
Author(s):  
Sarah M. Becker ◽  
Kathleen M. Job ◽  
Kelly Lima ◽  
Ty J. Forbes ◽  
Jadon Wagstaff ◽  
...  
Keyword(s):  
Prospective Study ◽  
Acute Asthma ◽  
Ionized Magnesium ◽  
Severe Acute Asthma

scholarly journals Serum lactate as a prognostic marker in patients with sepsis: a prospective study

2020 ◽  
Vol 7 (5) ◽  
pp. 1530
Author(s):  
Suhas T. Shetty ◽  
Dayanand S. Biradar ◽  
Ramakant Balookar ◽  
Shreedevi Kori
Keyword(s):  
Prospective Study ◽  
Prognostic Marker ◽  
Mean Value ◽  
Serum Lactate ◽  
Research Centre ◽  
P Value ◽  
College Hospital ◽  
The Mean ◽  
Lactate Levels ◽  
A Prospective Study

Background: A prospective study to estimate the serum lactate levels and as a prognostic marker in patients with sepsis.Methods: 170 patients admitted with sepsis in B.L.D.E. (Deemed to be University) Shri. B. M. Patil Medical College, Hospital and Research Centre, Vijayapur from October 2014 to June 2016.Results: In this study the mean serum lactate value of first sample in survivors (146 patients) is 3.8±1.2 and non-survivors (24 patients) is 6.2±1.9 with p value<0.001 which is significant. The serum lactate value of the second sample in survivors (146) is 2.7±1.0 and in non survivors (24) is 6.3±1.8 with p value<0.001 which is significant. The mean value of serum lactate 1st sample collected at the time of admission is 4.1±1.6 and the mean value of serum lactate second sample collected at 24 - 48 hours after admission is 3.1±1.6.Conclusions: Lactate level more than 4 mmol/l, patients are at highest risk of mortality and an aggressive resuscitation strategy shall be warranted. Hence serum lactate is considered as an independent and significant prognostic marker in patients with sepsis and evaluates the treatment outcome.

scholarly journals Comparative Efficacy of Phenytoin Versus Lidocaine in the Management of Intractable Seizure in Neonate

2017 ◽  
Vol 25 (2) ◽  
pp. 94-99
Author(s):  
Shah Abdullah Al Baqui ◽  
Md Tafazzal Hossain Khan ◽  
Md Abid Hossain Mollah ◽  
Manisha Banerjee ◽  
Md Mahfuzur Rahman ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Length Of Hospital Stay ◽  
Medical Emergency ◽  
Neonatal Seizure ◽  
P Value ◽  
College Hospital ◽  
Lidocaine Group ◽  
Medical College ◽  
Group A ◽  
Group B

Background : Intractable neonatal seizure are common acute medical emergency in neonatal period than at any other period of life. In our daily practice treatment of intractable neonatal seizures still relies primarily on phenytoin, despite an estimated efficacy of less than 50% and concern over neurodegenerative side effects. Several studies indicate value for lidocaine as an anticonvulsant in the treatment of intractable neonatal seizure.Aim : The objective of this study was to compare the efficacy of Phenytoin with Lidocaine in the management of intractable seizure in neonate.Methodology : A Randomized control trial was carried out in the Department of Neonatology, Dhaka Medical College Hospital (DMCH), Dhaka between July 2013 to June 2014. A total of 78 newborn with neonatal seizure. admitted in SCABU & not responding to total doses of Inj. Phenobarbital (40 mg/kg) were included in the study and were randomly assigned to either Inj. Lidocaine (Group A=39) or to Inj. Phenytoin (Group B=39). The main outcome variables were control of seizure, adverse effects, time of cessation of seizure.Results : The study demonstrated that intractable seizure of 24 neonates (75%) were controlled with Inj. Lidocaine and intractable seizure of 20 neonates (57.1%) were controlled with Inj. Phenytoin(P-Value 0.124). Adverse effects of drugs such as apnea, bradycardia, drowsiness and lethargy were observed in 4 patients (12.5%) of Lidocaine group (Group A) and 10 (28.6%) of Phenytoin group (Group=B) (P-Value 0.106). Time required for cessation of intractable seizures were nearly similar in both groups. In group A 75% of patients responded within 24 hours and in group B 71% patients responded in same duration(P-Value 0.931). Length of hospital stay was less in phenytoin group compare to lidocaine group(P-Value 0.352). None of the following results were statistically significant.Conclusion : The study concluded that Inj. Lidocaine is similar to Inj. Phenytoin in controlling intractable neonatal seizure.J Dhaka Medical College, Vol. 25, No.2, October, 2016, Page 94-99

PICU admission in children with severe acute asthma: a multicenter prospective study

2019 ◽  
Author(s):  
Shelley A. Boeschoten ◽  
Corinne M. Buysse ◽  
Peter J. Merkus ◽  
Joost Van Rosmalen ◽  
Annemie L. Boehmer ◽  
...  
Keyword(s):  
Prospective Study ◽  
Acute Asthma ◽  
Severe Acute Asthma ◽  
Multicenter Prospective Study

Utility of Tolonium Chloride Rinse in the Diagnosis of Oral Cancer

2020 ◽  
Vol 26 (1) ◽  
pp. 11-17
Author(s):  
Md Kamruzzaman ◽  
Kazi Nurjahan ◽  
AS Gazi Sharifuddin ◽  
SK Ballav
Keyword(s):  
Developing Countries ◽  
Oral Cancer ◽  
Prospective Study ◽  
Diagnostic Delay ◽  
College Hospital ◽  
Female Ratio ◽  
Medical College ◽  
Biopsy Report ◽  
Patient Side ◽  
Tolonium Chloride

Background: Oral cancer burden in developing countries is huge. In Bangladesh and India incidence were 10.6% and 10.4% respectively on 2018. At the same time worldwide incident was only 2%. Majority patients present at advanced stage and their survival rate is poor. Diagnostic delay from patient side and health delivery system side is significantly longer and it is more in developing countries. Like other malignancy early diagnosis can save a lot of these patient. Methods: This prospective study was carried out in Khulna Medical College Hospital from July 2017 to July 2019. Patients who will meet the criteria for this prospective study and capable and willing to give informed consent were enrolled. 20 second rinse/gargle with 10ml of 1% Tolonium chloride solution was done. Biopsy were taken from stained lesion, biopsy report were compared with TC stained lesions. Results: Out of 1650 patients in our outdoor department for various problem and only 30 cases were selected for this study according to selection criteria. Of 30 patients, 18 (60%) were male and 12 (40%) were female. The male-to-female ratio was 3:2. It was found that the sensitivity of 1% Tolonium Chloride rinse for oral precancer and cancer detection was 83.33%, whereas the specificity was 84.21%. Conclusion: Tolonium chloride rinse is a good screening test for oral cancer diagnosis with sensitivity 83.33% and specificity 84.21%. Bangladesh J Otorhinolaryngol; April 2020; 26(1): 11-17

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