scholarly journals Anti-fatigue effects of polysaccharides extracted from Rhodiolae Radix

2013 ◽  
Vol 2 (3) ◽  
pp. 49-52 ◽  
Author(s):  
Fenglin Li ◽  
Furen Xiao ◽  
Junsheng Qi
Keyword(s):  
Body Weight ◽  
Forced Swimming Test ◽  
Liver Glycogen ◽  
Pharmaceutical Journal ◽  
Forced Swimming ◽  
Control Group ◽  
Male Mice ◽  
Physical Fatigue ◽  
Swimming Time ◽  
Swimming Test

The purpose of the present study was to determine the effects of polysaccharide from Rhodiolae Radix (PRR) on physical fatigue using a forced swimming test in male mice. 96 mice were divided randomly into four groups based on body weight (n = 24). One of the groups was the control group; the others were PRR supplemented groups (25, 50 and 100 mg/kg body weight). Forced swimming test of mice were carried out after 28 days of PRR administration, and the blood lactic acid (BLA), blood urea nitrogen (BUN), liver glycogen and muscle glycogen contents were determined. The data suggest that PRR can extend the exhaustive swimming time of the mice, as well as increase the tissue glycogen contents, and decrease the BLA and BUN contents. These results indicated that PRR had significant anti-fatigue effects.DOI: http://dx.doi.org/10.3329/icpj.v2i3.13579 International Current Pharmaceutical Journal, February 2013, 2(3): 49-52 

Effects of Polysaccharides from the Root of Codonopsis pilosula (Dangshen) on Physical Fatigue Induced by Forced Swimming

2014 ◽  
Vol 675-677 ◽  
pp. 1591-1594 ◽  
Author(s):  
Lin Min Cai ◽  
Lin Luo ◽  
Yu Hua Zeng
Keyword(s):  
Muscle Glycogen ◽  
Forced Swimming Test ◽  
Liver Glycogen ◽  
Forced Swimming ◽  
Control Group ◽  
Physical Fatigue ◽  
Swimming Time ◽  
Codonopsis Pilosula ◽  
Swimming Test ◽  
Different Doses

This study investigated the effects of polysaccharides from the root ofCodonopsis pilosula(PCP) on physical fatigue induced by forced swimming in mice. The mice were divided into five groups, i.e., one control group and four PCP-treated groups. The control group was given distilled water and four PCP-treated groups were given different doses of PCP (100, 200, 400, 800 mg/kg). After 28 days, anti-fatigue effects of PCP were assessed using the forced swimming test, and the exhaustive swimming times, blood lactic acid (BLA), serum urea nitrogen (SUN), liver glycogen and muscle glycogen were measured. The data showed that PCP could prolong exhaustive swimming time of mice by decreasing BLA and SUN levels, and by improving the liver and muscle glycogen contents. The results clearly demonstrate that PCP had anti-fatigue effects.

Anti-Fatigue Activity of Soy Isoflavones in Mice

2014 ◽  
Vol 955-959 ◽  
pp. 537-540
Author(s):  
Lian Hai Jin ◽  
Xing Yu Zhao ◽  
Ying Xin Qin ◽  
Wen He Zhu ◽  
Zheng Li Luo
Keyword(s):  
Exercise Tolerance ◽  
Biochemical Parameters ◽  
Forced Swimming Test ◽  
Soy Isoflavones ◽  
Forced Swimming ◽  
Control Group ◽  
Time To Exhaustion ◽  
Distilled Water ◽  
Swimming Time ◽  
Swimming Test

In the present study, we investigated the anti-fatigue activity in male Kunming mice with Soy isoflavones using a forced swimming test. Mice were divided into four groups (three Soy isoflavones administered groups and a control group). The control group was gavaged with distilled water and Soy isoflavones administered groups were gavaged with Soy isoflavones (10, 20 and 40mg/10g body weight /d). After four weeks, a forced swimming test was performed and the biochemical parameters related to fatigue were examined. The results suggested that Soy isoflavones could extend the swimming time to exhaustion of the mice. This indicated that Soy isoflavones had anti-fatigue activity and could elevate the exercise tolerance.

In Vivo Anti-Hypoxia and Anti-Fatigue Activities of Flavonoids from Bark of Eucommia ulmoides

2014 ◽  
Vol 675-677 ◽  
pp. 1608-1611 ◽  
Author(s):  
Jin Yang Lin ◽  
Zhuo Ying Zhang
Keyword(s):  
Low Dose ◽  
Forced Swimming Test ◽  
Saline Solution ◽  
Liver Glycogen ◽  
Control Group ◽  
High Dose ◽  
Eucommia Ulmoides ◽  
Swimming Time ◽  
Swimming Test

The present study was carried out to investigate anti-hypoxia and anti-fatigue activities of flavonoids from bark of Eucommia ulmoides (FEU) in mice. The animal were divided into four groups: control (C) group, low-dose FEU treated (LF) group, intermediate dose FEU treated (IF) group and high-dose FEU treated (HF) group. The treated groups received FEU (5, 15, 45mg/kg), while the control group received saline solution for 28 days. After 28 days, anti-hypoxia activity of FEU was assessed by the normobarie hypoxia test and anti-fatigue activity of FEU was assessed by the forced swimming test. The data showed that FEU could prolong survival time of oxygen deprivation and exhaustive swimming time by reducing BLA and BUN levels and increasing liver glycogen and muscle glycogen contents. Therefore, FEU had anti-hypoxia and anti-fatigue activities.

Anti-Fatigue Effects of Polysaccharides from Gynostemma pentaphyllum Makino by Forced Swimming Test

2014 ◽  
Vol 881-883 ◽  
pp. 426-429 ◽  
Author(s):  
Bo Qi ◽  
Hui Huang
Keyword(s):  
Muscle Glycogen ◽  
Forced Swimming Test ◽  
Physiological Saline ◽  
Liver Glycogen ◽  
Treated Group ◽  
Forced Swimming ◽  
Control Group ◽  
High Dose ◽  
Gynostemma Pentaphyllum ◽  
Swimming Test

The current study was designed to investigate the anti-fatigue effects of polysaccharide ofGynostemma pentaphyllumMakino (GMP). The mice were randomly divided into four groups: control group, low-dose GMP-treated group, middle-dose GMP-treated group and high-dose GMP-treated group. The animals of control group received an oral administration of physiological saline in a volume of 1.0 mL, and the animals of treated group received the same volume of GMP (50, 100 and 200 mg/kg bodyweight/day) for 28 days. After 28 days, anti-fatigue effects of GMP were assessed by forced swimming test and some biochemical parameters related to fatigue including blood lactic acid (BLA), blood urea nitrogen (BUN), superoxide dismutase (SOD), glutathione peroxidase (GPH-Px), liver glycogen and muscle glycogen were measured using commercial kits. The results demonstrated that GMP prolonged the exhaustive swimming time, increased the liver glycogen and muscle glycogen contents, and decreased the BLA and BUN levels. It also improved the SOD and GPH-Px activities in blood of mice. These results indicated that FPR had anti-fatigue effects.

scholarly journals Identification of actoprotective compounds among Krebs cycle acid/aminoethanol derivatives

2020 ◽  
Author(s):  
Vera Ts. Bolotova ◽  
Evgeniy B. Shustov ◽  
Sergey V. Okovityi
Keyword(s):  
Physical Performance ◽  
Forced Swimming Test ◽  
Krebs Cycle ◽  
Optimal Dose ◽  
Forced Swimming ◽  
Male Mice ◽  
Swimming Time ◽  
Screening Study ◽  
Swimming Test ◽  
Krebs Cycle Intermediates

The screening study of the effects of several new diethylamino- and dimethylaminoethanol fumaric esters with Krebs cycle intermediates on the physical performance of male mice in the forced swimming test have been conducted. The compounds: Fumarate-DMAE-Fumarate at a dose of 75 mg/kg and Fumarate-DEAE-Succinate at a dose of 10 mg/kg, as well as Diethylaminoethanol (DEAE base) at a dose of 50 mg/kg. The study has shown that their effect on physical performance surpassed the comparison drug, deanol aceglumate, used at the optimal dose of 50 mg/kg. The latter provided a 74% increase in the maximum swimming time of animals, while the studied compounds showed +175%, +162%, +121% results compared to control. The actoprotective activity of the compounds Fumarate-DMAE-Fumarate (75 mg/kg dose) and Fumarate-DEAE-Succinate (FDES) (10 mg/kg dose) is comparable to the effect of ethylthiobenzimidazole hydrochloride (25 mg/kg dose).

Anti-Fatigue Activity of Pecan Oil in Mice

2013 ◽  
Vol 750-752 ◽  
pp. 1524-1528 ◽  
Author(s):  
Wei Zhang ◽  
Jun Jie Xu ◽  
Yan Li ◽  
Xing Yu Zhao ◽  
Yan Chun Wang
Keyword(s):  
Exercise Tolerance ◽  
Biochemical Parameters ◽  
Forced Swimming Test ◽  
Forced Swimming ◽  
Control Group ◽  
Time To Exhaustion ◽  
Serum Urea ◽  
Swimming Time ◽  
Swimming Test ◽  
Nitrogen Contents

In the present study, we investigated the anti-fatigue activity in male Kunming mice with pecan oil using a forced swimming test. Mice were divided into four groups (three pecan oil administered groups and a control group). The control group was gavaged with distilled water and pecan oil administered groups were gavaged with pecan oil (10, 20 and 30mg/10g body weight /d). After four weeks, a forced swimming test was performed and the biochemical parameters related to fatigue were examined. The results suggested that pecan oil could extend the swimming time to exhaustion of the mice, as well as increase the tissue glycogen contents, while decreasing the blood lactate and serum urea nitrogen contents. This indicated that pecan oil had anti-fatigue activity and could elevate the exercise tolerance.

Preliminary Observations on the Anti-Fatigue Effects of Radix Astragali Polysaccharides

2013 ◽  
Vol 448-453 ◽  
pp. 1099-1103
Author(s):  
Chun Fang Wang
Keyword(s):  
Forced Swimming Test ◽  
Liver Glycogen ◽  
Treated Group ◽  
Forced Swimming ◽  
Control Group ◽  
Time To Exhaustion ◽  
Radix Astragali ◽  
Swimming Test ◽  
Nitrogen Contents

The purpose of this study was to determine the anti-fatigue effects of Radix Astragali polysaccharides (RAP) using the forced swimming test in mice. The mice were randomly divided into four groups: one control group and three RAP-treated groups. The mice of control group received an oral administration of saline solution, and the mice of treated group received RAP (100, 200 and 400 mg/kg) for 28 days. After 28 days, the mice performed the forced swimming exercise, along with the determination of some biochemical parameters related to fatigue. The data showed that RAP could increase swimming time to exhaustion, liver glycogen and muscle glycogen contents, decrease blood lactic acid and blood urea nitrogen contents. These results indicated that RAP had anti-fatigue effects. RAP may be useful for the prevention and treatment diseases related to fatigue.

scholarly journals Antidepressant and Antiamnesic Potential of Foeniculum vulgare

2020 ◽  
pp. 131-138 ◽  
Author(s):  
Afshan Abbas ◽  
Rahila Ikram ◽  
Faiza Hasan ◽  
Abeer Adil ◽  
Uzair Nisar ◽  
...  
Keyword(s):  
Water Maze ◽  
Forced Swimming Test ◽  
Forced Swimming ◽  
Antidepressant Effect ◽  
Control Group ◽  
Enhancement Effect ◽  
Foeniculum Vulgare ◽  
Group 3 ◽  
Swimming Test ◽  
Group 2

Aim: To evaluate the antiamnesic and antidepressant effect of Foeniculum vulgare whole crushed seeds. Study Design: Laboratory based randomized control study. Place and Duration of Study: Department of Pharmacology, University of Karachi between January 2018 to August 2018.  Methodology: Thirty swiss albino mice and wistar rats were divided equally in three groups. Control group was fed on standard rodent diet, group 2 was fed on 2% Foeniculum vulgare diet and group 3 was given 4% Foeniculum vulgare diet. Antidepressant activity was assessed using forced swimming test. Memory enhancement effect was evaluated by stationary rod test, passive avoidance test and water maze test. Results: Increased duration of struggling time was noted in both group 2 and group 3 as compared to control in forced swimming test. Decrease in time to reach platform in both water maze and stationary rod test was recorded in both the study group (group 2 & 3). Increase in step through latency was also seen in group 2 and group 3 as compared to control group. Conclusion: The results showed the memory enhancing and antidepressant actions of Foeniculum.

scholarly journals Evaluation of the comparison of anti-depressant effects of oral fluoxetine and riluzole in albino rats by using the forced swimming test model

2021 ◽  
Vol 10 (4) ◽  
pp. 391
Author(s):  
Hansraj Kumar ◽  
Akash Chandra ◽  
Uma Shankar Prasad Keshri ◽  
Rajiv Kumar
Keyword(s):  
Selective Serotonin Reuptake Inhibitors ◽  
Forced Swimming Test ◽  
Antidepressant Activity ◽  
Forced Swimming ◽  
Control Group ◽  
Albino Rats ◽  
Test Duration ◽  
Test Model ◽  
Significant Difference ◽  
Swimming Test

Background: Depression is a group of disorders results from a combination of multiple etiologic factors- genetic, biochemical, psychodynamic and socio-environmental. A depression consists of following clinical features as sadness, apathy, changes in sleep pattern, impaired concentration, feeling of shame or guilt and thoughts of dying or death. Fluoxetine and riluzole both are used for the treatment of depression in human being. Fluoxetine is SSRI (selective serotonin reuptake inhibitors) and riluzole is anxiolytic and mood stabilizer.Methods: Healthy male albino rats weighing between 150-200 grams were taken for the present study. Study animals were divided into three groups randomly with each group consisting of ten animals. Drugs were powdered with help of mortar and pestle and mixed in gum acacia solution. Appropriate volume of the freshly prepared solution was administered orally daily between 9 am to 10 am to all animal as per their individual body weight. Group A administered 1ml of 0.9% normal saline orally and serves as control group. Group B administered 0.4 mg of fluoxetine orally. Group C administered 2 mg of riluzole orally. Animals were evaluated for antidepressant activity using model- forced swimming test.Results: The results in the forced swimming test were assessed by duration of immobility in last 4 minutes of total 6 minute test duration. Antidepressant activity is indicated by the reduction in the duration of immobility i.e. lesser the duration more the efficacy. The results have been expressed as mean±standard deviation of duration of immobility in seconds during 6 minute period.Conclusions: There was significant difference in antidepressant activity of fluoxetine with antidepressant activity of riluzole. Riluzole showed antidepressant activity after two weeks of starting the drugs.

Antidepressant-like Effect of Baccharis Ilimita in the Forced Swimming Test in Mice

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1 ◽  
Author(s):  
A. Kikko ◽  
P. Koerich ◽  
E. Bondan ◽  
F. Nunes ◽  
M. Pizzolatti ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Open Field ◽  
Leaf Extract ◽  
Forced Swimming Test ◽  
Positive Control ◽  
Forced Swimming ◽  
Control Group ◽  
Swiss Mice ◽  
Immobility Time ◽  
Swimming Test

The aim of the present work was to investigate if flowers extract (FE) and leaf extract (LE) of Baccharis ilimita (Asteraceae) induced antidepressant-like effect. Previous phytochemical investigations have shown the presence of structurally and biogenetically diverse secondary metabolites in this gene, such as flavonoids, diterpenes and triterpenes. Male Swiss mice were injected with FE and LE (12.5; 25.0 or 50.0 mg/kg; i.p.) or saline (S) and after 30 min, they were tested in the forced swimming test (FST). The results showed that FE and LE (50 mg/kg) decreased the duration of immobility time in comparison to the control group (S: 114.8s ± 10.23; FE50: 47.52s ± 9.45; LE50: 53.36s ± 10.38). However, the 12.5 and 25.0 mg/kg doses had no effect on the immobility time in comparison to the control group. The FE and LE did not produce any change in ambulation in mice when tested in an open field. The imipramine (IMP; 15.0 mg/kg i.p.) was used as the positive control. Our results suggested that FE and LE of Baccharis ilimita presents antidepressant-like effect in mice. Such results suggest that the antidepressant-like effect may be attributed at lest partially the flavonoids or the interaction of the active(s) principle(s) present in this plant.Descritores:Baccharis ilimita. Forced swimming test. Depression. Mice.

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