scholarly journals Synthesis and biological activity of acetylacetone thiosemicarbazone and their metallic complexes

2013 ◽  
Vol 2 (4) ◽  
pp. 88-91 ◽  
Author(s):  
Sandeep Kumar ◽  
Nitin Kumar
Keyword(s):  
Staphylococcus Epidermidis ◽  
Ultra Violet ◽  
Pharmaceutical Journal ◽  
Molar Conductance ◽  
Bidentate Ligand ◽  
Azomethine Nitrogen ◽  
Central Metal Atom ◽  
Gram Negative Bacteria ◽  
Central Metal ◽  
Gram Positive Bacteria

In present work, Ligand acetylacetone thiosemicarbazone and their 11 complexes of the type ML2X2, ML2X’, where M = Cu(II), Cd(II), Co(II), Zn(II), Hg(II); L = acetylacetone thiosemicarbazone; X = Cl, NO3 or CH3COO; X’ = SO4 have been synthesized and characterized with the help of molar conductance, magnetic susceptibility measurements, infra-red and ultra-violet spectroscopy. The spectral data revealed that the thiosemicarbazone act as bidentate ligand, making use of thionic sulphur and the azomethine nitrogen atom for co-ordination to the central metal atom. All the compounds have been screened for their antibacterial activity against Gram positive bacteria Staphylococcus aureus, Staphylococcus epidermidis and Gram negative bacteria Escherichia coli and Pseudomonas aeruginosa. Some of complexes exhibited appreciable activity.DOI: http://dx.doi.org/10.3329/icpj.v2i4.14057 International Current Pharmaceutical Journal, March 2013, 2(4): 88-91

scholarly journals Synthesis, Characterization, and Biological Evaluation of Some 3d-Metal Complexes of Schiff Base Derived from Xipamide Drug

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Suman Malik ◽  
Suparna Ghosh ◽  
Bharti Jain ◽  
Archana Singh ◽  
Mamta Bhattacharya
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Elemental Analysis ◽  
Biological Evaluation ◽  
Molar Conductance ◽  
Bidentate Ligand ◽  
Azomethine Nitrogen ◽  
Spectral Studies ◽  
Elemental Analysis Data ◽  
Central Metal

The present paper deals with the synthesis and characterization of metal complexes of Schiff base derived from xipamide, a diuretic drug. The bidentate ligand is derived from the inserted condensation of 5-aminosulfonyl-4-chloro-N-2,6-dimethyl phenyl-2-hydroxybenzamide (Xipamide) with salicylaldehyde in a 1 : 1 molar ratio. Using this bidentate ligand, complexes of Hg(II), Zn(II), and VO(IV) with general formula ML2 have been synthesized. The synthesized complexes were characterized by several techniques using molar conductance, elemental analysis, magnetic susceptibility, FT-IR spectroscopy, electronic spectra, mass spectra, and particle size analysis. The elemental analysis data suggest the stoichiometry to be 1 : 2 [M : L]. All the complexes are nonelectrolytic in nature as suggested by molar conductance measurements. Infrared spectral data indicate the coordination between the ligand and the central metal ion through deprotonated phenolic oxygen and azomethine nitrogen atoms. Spectral studies suggest tetrahedral geometry for Hg(II), Zn(II) complexes, and square pyramidal geometry for VO(IV) complex. The pure drug, synthesized ligand, and metal complexes were screened for their antifungal activities against Aspergillus niger and Aspergillus flavus. The ligand and its Hg(II) and VO(IV) complexes were screened for their diuretic activity too.

scholarly journals Synthesis, Characterization and Biological Activity of a Bidentate NS Schiff Base Containing S-Benzyl Dithiocarbazate and Its Zr(IV), Sn(II) Complexes

2020 ◽  
pp. 14-24
Author(s):  
Md. Kudrat-E- Zahan ◽  
Md. Faruk Hossen ◽  
Rausan Zamir ◽  
Md. Ali Asraf
Keyword(s):  
Biological Activity ◽  
Magnetic Measurements ◽  
Free Ligand ◽  
Antimicrobial Activities ◽  
Molar Conductance ◽  
Bidentate Ligand ◽  
Azomethine Nitrogen ◽  
Gram Negative Bacteria ◽  
Strong Activity ◽  
Gram Negative

Zr (IV) and Sn (II) complexes were prepared with bidentate ligand, benzyl 2-(3-phenylallylidene) hydrazinecarbodithioate, derived from the condensation of S-benzyldithiocarbazate (SBDTC) with cinnamaldehyde and characterized by microanalysis, molar conductance and magnetic measurements, IR, electronic and ESI-MS studies. It was found that the ligand coordinated to the metal center through azomethine nitrogen and thiol sulfur atoms to form octahedral complexes with both the metal ions. The antimicrobial activities of the ligand and its complexes were investigated against the gram-positive and gram-negative bacteria and the fungus strain. The metal complexes showed strong activity than the free ligand.

scholarly journals Synthetic, structural and biological studies of organosilicon(IV) complexes of Schiff bases derived from pyrrole-2-carboxaldehyde

2010 ◽  
Vol 75 (7) ◽  
pp. 917-927 ◽  
Author(s):  
Kiran Singh ◽  
Dharam Pal
Keyword(s):  
Schiff Bases ◽  
Pathogenic Bacteria ◽  
Antimicrobial Properties ◽  
Molar Conductance ◽  
Azomethine Nitrogen ◽  
Spectral Studies ◽  
Central Metal Atom ◽  
Central Metal ◽  
Biological Studies

Selected new organosilicon(IV) complexes having the general formula R2SiCl[L] and R2Si[L]2 were synthesized by the reactions of Me2SiCl2 with Schiff bases [5-mercapto-4-(2-pyrrolecarboxalideneamino)-s-triazole, 5-mercapto-3-methyl-4-(2-pyrrolecarboxalidene amino)-s-triazole and 3-ethyl-5-mercapto-4-(2-pyrrolecarboxalideneamino)-s-triazole] in 1:1 and 1:2 molar ratios. All of the compounds were characterized by elemental analysis, molar conductance, and IR, UV, 1H-, 13C- and metal-NMR spectral studies. All the spectral data suggest an involvement with an azomethine nitrogen in coordination to the central metal atom. With the help of above-mentioned spectral studies, penta and hexacoordinated environments around the central metal atoms in the 1:1 and 1:2 complexes, respectively, are proposed. Finally, the free ligands and their metal complexes were tested in vitro against some pathogenic bacteria and fungi to assess their antimicrobial properties.

Synthesis, Spectral and Antimicrobial Investigation of 2-(Naphthalenel-ylamino)-2- Phenylacetonitrile and 1, 10-Phenanthroline with Five Divalent Transition Metal Ions

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Mohammed Al-Amery1 ◽  
Ashraf Saad Rasheed ◽  
Dina A. Najeeb
Keyword(s):  
Transition Metal ◽  
Metal Ions ◽  
Transition Metal Ions ◽  
Molar Conductance ◽  
Octahedral Geometry ◽  
Mixed Ligand ◽  
Gram Negative Bacteria ◽  
Magnetic Studies ◽  
Gram Positive Bacteria

Five new mixed ligand metal complexes have been synthesized by the reaction of divalent transition metal ions (Hg, Ni, Zn, Cu and Cd) with 2-(naphthalen-l-ylamino)-2-phenylacetonitrile (L1 ) and 1,10-phenanthroline (L2). The coordination likelihood of the two ligands toward metal ions has been suggested in the light of elemental analysis, UV-Vis spectra, FTIR, 1H-NMR, flam atomic absorption, molar conductance and magnetic studies. Results data suggest that the octahedral geometry for all the prepared complexes. Antibacterial examination of synthesized complexes in vitro was performed against four bacterias. Firstly, Gram-negative bacteria namely, Pseudomonas aerugin and Escherichia. Secondly, Gram-positive bacteria namely, Bacillus subtilis, Staphylococcuaurouss. Results data exhibit that the synthesized complexes exhibited more biological activity than tetracycline pharmaceutical.

scholarly journals Antimicrobial Activities of Mefloquine and a Series of Related Compounds

2000 ◽  
Vol 44 (4) ◽  
pp. 848-852 ◽  
Author(s):  
C. M. Kunin ◽  
W. Y. Ellis
Keyword(s):  
Staphylococcus Epidermidis ◽  
Antimicrobial Activities ◽  
Walter Reed Army Institute ◽  
Gram Negative Bacteria ◽  
Antimicrobial Drugs ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
Resistant Strains ◽  
Vancomycin Resistant ◽  
Related Compounds

ABSTRACT Mefloquine was found to have bactericidal activity against methicillin- and fluoroquinolone-susceptible and -resistant strains ofStaphylococcus aureus and Staphylococcus epidermidis and gentamicin- and vancomycin-resistant strains ofEnterococcus faecalis and Enterococcus faecium. The MICs were 16 μg/ml, and the minimal bactericidal concentrations (MBCs) were 16 to 32 μg/ml. These concentrations cannot be achieved in serum. Mefloquine was active at a more achievable concentration against penicillin-susceptible and -resistant Streptococcus pneumoniae, with MICs of 0.2 to 1.5 μg/ml. Mefloquine was not active against gram-negative bacteria and yeasts. In an attempt to find more active derivatives, 400 mefloquine-related compounds were selected from the chemical inventory of The Walter Reed Army Institute of Research. We identified a series of compounds containing a piperidine methanol group attached to pyridine, quinoline, and benzylquinoline ring systems. These had activities similar to that of mefloquine against S. pneumoniae but were far more active against other gram-positive bacteria (MICs for staphylococci, 0.8 to 6.3 μg/ml). They had activities similar to that of amphotericin B againstCandida spp. and Cryptococcus neoformans. Combinations of the compounds with gentamicin and vancomycin were additive against staphylococci and pneumococci. The MIC and MBC of gentamicin were decreased by four- to eightfold when this drug was combined with limiting dilutions of the compounds. There was no antagonism with other antimicrobial drugs. The compounds were rapidly bactericidal. They appear to act by disrupting cell membranes. Combinations of the compounds with aminoglycoside antibiotics may have potential for therapeutic use.

scholarly journals Antibacterial Activity of Macrocyclic Complexes of Cu(II), Ni(II) and VO(II) Derived fromo-Aminobenzaldehyde

2012 ◽  
Vol 9 (1) ◽  
pp. 481-486
Author(s):  
K. Anuradha ◽  
R. Rajavel
Keyword(s):  
Antibacterial Activity ◽  
Elemental Analysis ◽  
Molar Conductance ◽  
Macrocyclic Complexes ◽  
Spectral Studies ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative ◽  
Gram Positive Bacteria

Novel Cu(II),Ni(II) and VO(II) complexes are synthesized with N1,N4-bis(2-aminobenzylidene)benzene-1,4-diamine (L). Complexes were characterized by elemental analysis, molar conductance, IR, UV and EPR. Spectral studies reveals a square planner geomentry for Cu(II), Ni(II) complexes and square pyramidal for VO(II) complex. The ligand and its complexes were also evaluated against the growth of gram positive bacteria and gram negative bacteria.

scholarly journals Equilibria in Aqueous Cobalt(II)—Reduced Schiff Base N-(2-hydroxybenzyl)alanine System: Chemical Characterization, Kinetic Analysis, Antimicrobial and Cytotoxic Properties

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3462
Author(s):  
Magdalena Woźniczka ◽  
Manas Sutradhar ◽  
Armando J. L. Pombeiro ◽  
Mirosława Świątek ◽  
Marek Pająk ◽  
...  
Keyword(s):  
Schiff Base ◽  
Kinetic Analysis ◽  
Staphylococcus Epidermidis ◽  
Antimicrobial Properties ◽  
Chemical Characterization ◽  
Point Of View ◽  
Gram Negative Bacteria ◽  
Gram Positive Bacteria ◽  
Mononuclear Complexes ◽  
Reduced Schiff Base

The present study describes the coordination properties of a reduced Schiff base, N-(2-hydroxybenzyl)alanine, towards cobalt(II) using potentiometric as well as spectroscopic (UV-Vis and ESI-MS) methods. The results indicate the formation of six mononuclear complexes showing high stability in aqueous solution. Coordination occurs in the {O−phenolic,N,O−carboxyl} and {N,O−carboxyl} chelation modes, depending on the degree of ligand deprotonation. Examination of the complexation equilibria at pH ca 7, which is important from a biological point of view, allowed to identify two species: [CoL] and [CoL2H]−. The kinetic analysis showed a structural change of those cobalt(II) complexes from octahedral to tetrahedral in accordance with a first-order time relationship. The antimicrobial properties of N-(2-hydroxybenzyl)alanine, cobalt(II) nitrate and of the Co(II) – ligand complexes were determined against Gram-positive bacteria (Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis), Gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli, Helicobacter pylori) and a fungal strain (Candida). The results indicate that the complexes are more active for more strains than the ligand alone. Nevertheless, the complexes induce a higher decrease in the metabolic activity of cells but without damage to nuclei. Tetrahedral structures show stronger anti-cellular toxicity than octahedral complexes, which is most likely due to the higher accessibility of the cobalt(II) center.

Synthesis and Properties of a New Kind of One-Dimensional Conductors. 1. General Aspects

1979 ◽  
Vol 34 (8) ◽  
pp. 983-985 ◽  
Author(s):  
Michael Hanack ◽  
Friedrich Franz Seelig ◽  
Joachim Strähle
Keyword(s):  
Experimental Studies ◽  
Bidentate Ligand ◽  
Central Metal Atom ◽  
Central Metal ◽  
Bridging Ligands ◽  
One Dimensional ◽  
Bridging Ligand ◽  
Linear Chains ◽  
Square Planar ◽  
General Aspects

AbstractA model for a new kind of one-dimensional conductors is presented. The compounds consist of square-planar metal complexes MX4 which are polymerised via bridging ligands L to linear chains. The bidentate ligand L, e.g. C22-, leads to the formation of a linear π-system along the chain, which is essential for the conductivity. The square-planar complex can be, for example, a metal phthalocyanine. MO-calculations show that this kind of polymer gives rise to a suitable energy band structure. An advantage of the new one-dimensional conductors is their flexibility; different combinations of the square-planar ligand system, the bridging ligand, and the central metal atom can be used. First experimental studies show that the preparation of the proposed conductors is possible.

scholarly journals Some Organotellurium(IV) Complexes of 1-Methyl-3-(p-tolylimino)indolin-2-one Schiff Base

2021 ◽  
Vol 33 (6) ◽  
pp. 1236-1244
Author(s):  
Manish Kumar ◽  
K.K. Verma ◽  
Sapana Garg
Keyword(s):  
Schiff Base ◽  
Xanthomonas Campestris ◽  
Computational Study ◽  
Molar Conductance ◽  
Bidentate Ligand ◽  
Octahedral Geometry ◽  
Azomethine Nitrogen ◽  
Spectral Studies ◽  
Distorted Octahedral Geometry ◽  
No Donor

Six new hexa-coordinated organotellurium(IV) complexes of type RTeCl3·NMeIPT and R2TeCl2·NMeIPT (R = 4-hydroxyphenyl, 4-methoxyphenyl or 3-methy-4-hydroxyphenyl; NMeIPT(L) = Schiff base (1-methyl-3-(p-tolylimino)indolin-2-one) derived from condensation of 4-methylisatin and p-toluidine) have been synthesized and characterized by different spectral studies like elemental analyses, molar conductance, infrared, mass spectrometry, 1H NMR, 13C NMR and UV-visible spectroscopy. On the basis of spectroscopic data, it is evident that Schiff base behaves as NO donor bidentate ligand via azomethine nitrogen atom and oxygen atom from carbonyl group for all the tellurium(IV) complexes. The results showed that all the organotellurium(IV) complexes possess distorted octahedral geometry. Geometry of the all organotellurium(IV) complexes was optimized and their theoretical quantum mechanical parameters were calculated. This computational study also suggests octahedral geometry for complexes. The antimicrobial activity of NMeIPT and all the organotellurium(IV) complexes were screened against bacteria i.e. Xanthomonas campestris and Bacillus cereus and fungi i.e. Fusarium oxysporum, Candida albicans and Sclerotinia sclerotium.

scholarly journals Preparation, Characterization and Antimicrobial Activity of Schiff Base of (E) - N - (4-(Thiophen-2-ylmethyleneamino) Phenylsulfonyl) Acetamide Metal Complexes

2018 ◽  
Vol 6 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Ahmad S. Abu-Khadra ◽  
Ahmed S. Afify ◽  
Amr Mohamed ◽  
Rabie S. Farag ◽  
Hassan Y. Aboul-Enein
Keyword(s):  
Metal Complexes ◽  
Inductively Coupled Plasma ◽  
Uv Spectroscopy ◽  
Spectroscopic Studies ◽  
Molar Conductance ◽  
Molar Ratio ◽  
Central Metal Atom ◽  
Central Metal ◽  
Mass Spectral ◽  
Aspergillus Fumigates

Aim:Metal complexes of (E)-N-(4-(thiophen-2-ylmethyleneamino) phenylsulfonyl) acetamide (S.TH) Schiff bases derived from sulfacetamide (N-[4-(amino-phenyl) sulfonil] acetamide) and 2-thiophenecarboxaldehyde were synthesized and characterized.Methods and Results:The synthesized compositions have been characterized using different physico-chemical techniques. The investigation included elemental analysis, melting point measurements, proton NMR, UV spectroscopy, FT-IR, magnetic susceptibility, conductance measurements, mass spectral analysis, and inductively coupled plasma mass spectrometry (ICP-MS) for determining the concentrations of metal ions. The measured values for molar conductance indicated that the majority of the prepared complexes were nonelectrolytes. The biological activity of the prepared compositions has been investigated.Conclusion:Spectroscopic studies suggested that most of the complexes were coordinated in a regular octahedral arrangement where S.TH ligand and the central metal atom were coordinated through two N amino azomethine groups (−HC=N−) and two sulfur atoms of S thiophene rings in 2L:1M molar ratio. Complexes have shown a promising activity upon screening for the antibacterial characteristics, and antifungal (Aspergillus fumigatesandCandida albicans)

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