scholarly journals Primary Male Breast Cancer: Analysis of Eight Cases and Review of Literature

1970 ◽  
Vol 25 (1) ◽  
pp. 18-22
Author(s):  
JU Ahmed ◽  
MM Hussain
Keyword(s):  
Breast Cancer ◽  
Male Breast Cancer ◽  
Surgical Excision ◽  
Duct Cell ◽  
Female Breast Cancer ◽  
Male Breast ◽  
Biological Behavior ◽  
Treatment Modalities ◽  
Duration Of Symptoms ◽  
Primary Male

This is a hospital based retrospective study with 8 cases of newly diagnosed primary male breast cancer. Among 413 cases of breast cancer of both male and females, treated between 1988 to 2002 at Chittagong, eight were males. The incidence is 1.94%. The mean age of diagnosis is 50.13 years, which is later than females. A breast mass was the earliest, most important symptom. The duration of symptoms before treatment ranged from few weeks to years. Male breast cancer is of the same common pathologic types as in females that is 75% patients had duct cell carcinoma. The rarity of the tumor hinders the study of its biological behavior and etiology, which in consequence, are still not well understood. As with the female breast cancer, surgical excision followed by adjuvant CT, RT, hormone therapy are the treatment modalities. (J Bangladesh Coll Phys Surg 2007; 25 : 18-22)

scholarly journals Management of male breast cancer

2011 ◽  
pp. 44-52
Author(s):  
Nikolay V. Dimitro v ◽  
Sunil Nagpal ◽  
Shalini Chitneni
Keyword(s):  
Breast Cancer ◽  
Clinical Trials ◽  
Male Breast Cancer ◽  
Randomized Clinical Trials ◽  
Treatment Options ◽  
Female Breast Cancer ◽  
Male Breast ◽  
Treatment Modalities ◽  
Lack Of Information ◽  
Low Incidence

The management of male breast cancer is still under discussion due to lack of information from prospective, randomized clinical trials and low incidence of this disease. Current management is based largely on extrapolation from data related to treatment of female breast cancer. Over the last two decades, several review articles have discussed mainly retrospective and anecdotal data related to hormonal and chemotherapy treatment modalities. In this review, we present the most recent information and future considerations related to the management of male breast cancer. In addition to the conventional treatment options we will discuss the possible role of targeted therapy. Establishing a national or global registry for male breast cancer will provide more precise information about the natural history of the disease and will facilitate the design and execution of prospective, randomized multicenter clinical trials.

scholarly journals Male breast cancer: a 5-year experience from a State Cancer Institute

2021 ◽  
Author(s):  
Shashi Singh Pawar ◽  
Manish Kumar ◽  
Kunal Kishor ◽  
Nadeem Ahmad ◽  
Sanjeet Kumar Singh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Male Breast Cancer ◽  
Ductal Carcinoma ◽  
Radical Mastectomy ◽  
Female Breast Cancer ◽  
Male Breast ◽  
Biological Behavior ◽  
Clinicopathological Profile ◽  
Her 2 ◽  
Male Patients

Background: Male breast cancer (MBC) is an uncommon malignancy accounting for <1% of all cancers in men and <1 % of overall breast cancer cases. Although there are many similarities between MBC and female breast cancer (FBC), they are not identical in clinical behaviour. There is need to understand the exact biological behavior of MBC.Methods: A retrospective observational study was done at State Cancer Institute, IGIMS, Patna which included all MBC patients registered during a 5-year study period (January 2016 to April 2021). 16 consecutive cases of MBC were identified and their detailed clinicopathological profile was analyzed.Results: MBC accounted for 1.10% of the total breast cancer cases. The median age of presentation was 58 years. Most common presentation was lump. Invasive ductal carcinoma (IDC) was most common histology. Majority of the patient presented to us in advanced stage. Estrogen receptor (ER)/progesterone receptor (PR) status was found to be positive in 12 patients. HER-2/neu receptor was positive in 4 patients. 2 patients had triple negative disease (TNBC) status. Surgery in the form of modified radical mastectomy (MRM) was done in 10 patients. All patients received adjuvant therapy as per NCCN guidelines.Conclusions: MBC is rare disease presenting at a relatively early age in Indian male patients. Most of them have positive ER/PR status. As outcomes have not improved comparatively, there is a need to evolve separate guidelines for MBC.

Outcomes of male breast cancer in the United States: A SEER database analysis from 1973 to 2008.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 1586-1586 ◽  
Author(s):  
Akm Mosharraf Hossain ◽  
Ravi Kiran Bobba ◽  
Carl G. Kardinal ◽  
Carl Freter
Keyword(s):  
Breast Cancer ◽  
Male Breast Cancer ◽  
The United States ◽  
Female Breast Cancer ◽  
Male Breast ◽  
Treatment Modalities ◽  
Seer Database ◽  
Asian Patients ◽  
Hormone Receptor Positive ◽  
Over Time

1586 Background: Male breast cancer (MBC) is rare compared to female breast cancer (FBC). There has been no systemic study to examine the epidemiology of MBC in USA in the past decade. Methods: We examined 6,157 cases of MBC reported in SEER database from 1973-2008 (released 2011). We performed rate, frequency and survival sessions to examine age, sex, stage, grade, treatment modalities and survival using the SEER*Stat Software 7.0.5. These variables were compared with that of 877,885 FBC cases reported in SEER 1973-2008. Results: The incidence rate was 1.3 (MBC) and 124 (FBC) per 100,000, respectively. Median age of diagnosis was higher in MBC compared to FBC (72 vs. 61 yrs. P<0.001). 18% of MBC were seen at age less than 60 years compared to 32% in FBC (p<0.001). FBC tend to be more hormone receptor positive (74% vs. 61%; p<0.001). There were 5,145 Caucasians (WH), 701 African Americans (AA), 258 Hispanics and 42 Asian patients. Stage III and IV, Grade III and IV histologies were more common in MBC. Staging and Grading did not differ among the different ethnicities except for Grade IV histology in AA 19%, Asians 20% when compared to WH 13% (p<0.001). Treatment modalities included, surgery (MBC 78% vs. FBC 93%; p<0.001), chemotherapy (MBC 82% vs. FBC 43%; p<0.001) and radiation therapy (MBC 19% vs. 36% FBC; p<0.001). Treatment modalities were similar among WH and AA. Survival was higher in FBC compared to MBC (table) but improved over time in MBC. AA and Asians had lower 1-5 year survival compared to WH. Conclusions: MBC presents at a later age, higher stage and grade, predominantly requiring chemotherapy with an overall poor survival compared to FBC. But 1-5 year survival improved over time in MBC. This can be explained by early diagnosis, better treatment and other factors. Further studies should be performed in this regard. [Table: see text]

Her-2/neu Gene Amplification and Protein Expression in Primary Male Breast Cancer

2004 ◽  
Vol 84 (3) ◽  
pp. 215-223 ◽  
Author(s):  
Christian Rudlowski ◽  
Nicolaus Friedrichs ◽  
Andree Faridi ◽  
Lazlo Füzesi ◽  
Roland Moll ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Protein Expression ◽  
Gene Amplification ◽  
Male Breast Cancer ◽  
Male Breast ◽  
Her 2 ◽  
Primary Male

scholarly journals Assessment of Knowledge and Attitude Regarding Female and Male Breast Cancer among Adults of South India

2021 ◽  
pp. 13-20
Author(s):  
Anwitha Johns ◽  
Satish Kumar B P ◽  
Lavanya P R
Keyword(s):  
Breast Cancer ◽  
Male Breast Cancer ◽  
Female Breast Cancer ◽  
Incidence Rates ◽  
Male Breast ◽  
Basic Knowledge ◽  
Nominal Data ◽  
Female Breast ◽  
South Indian ◽  
Knowledge And Attitude

Background & Objectives: Breast cancer is the second leading reason for cancer death in women. Incidence rates of male breast cancer have increased by 0.2- 1% per year. The lack of knowledge and awareness of male breast cancer leads to its detection at a late stage in men. This study is to assess the knowledge and attitude of south Indian adults towards male and female breast cancer. Methods: To assess the knowledge and attitude of adults on breast cancer, a questionnaire regarding basic knowledge and attitudes was formulated using Google forms. Numbers and percentages were formed to review categorical and nominal data. Chi-square (χ2) test was used for the comparison between the awareness of female breast cancer and male breast cancer. P < 0.05 was set as the level of significance.

Is Male Breast Cancer Similar or Different than Female Breast Cancer?

2004 ◽  
Vol 83 (1) ◽  
pp. 77-86 ◽  
Author(s):  
William F. Anderson ◽  
Michelle D. Althuis ◽  
Louise A. Brinton ◽  
Susan S. Devesa
Keyword(s):  
Breast Cancer ◽  
Male Breast Cancer ◽  
Female Breast Cancer ◽  
Male Breast ◽  
Female Breast

scholarly journals Evaluation of General, Pathological, and Radiological Features of Male Breast Cancer

2020 ◽  
Vol 17 (3) ◽  
Author(s):  
Fariba Zarei ◽  
Fereshte Bagheri ◽  
Amin Dehdashtian ◽  
Majid Akrami
Keyword(s):  
Breast Cancer ◽  
Survival Time ◽  
Male Breast Cancer ◽  
Medical Records ◽  
Male Breast ◽  
Treatment Modalities ◽  
Time Interval ◽  
Number Of Patients ◽  
History Of

Background: Male breast cancer (MBC) is an infrequent disease and a scarcely researched topic. Since the incidence of male breast cancer is increasing and so far, management advices have been concluded from results of trials in female patients, there has been a growing interest in this field of research. Objectives: In this study, we aimed to evaluate the general, radiological and pathological features of MBC patients. Patients and Methods: We retrospectively reviewed the medical records of MBC patients who had been referred to breast clinic, Shahid Motahari in Shiraz, Iran, between 2005 and 2018. Data regarding general characteristics of patients such as demographic information, age, and also past history of any cancer, family history of breast cancer, mammogram and ultrasound findings, stage, size and location of tumor, histopathology of tumor, metastasis, treatment modalities and follow-up time were attained by reviewing medical records. Results: Fifty-one patients with MBC were included with the mean age of 58.4 years. Invasive ductal carcinoma was the most prevalent pathologic type. By use of the Kaplan Meier survival estimate, survival probability of patients for each time interval after diagnosis was calculated. There was a decline over time until about 85 months after diagnosis when it reached a plateau state above 50%. Age, human epidermal growth factor receptor 2 (HER2) and metastasis showed to lower the survival time by increasing the hazard ratio. Only 13 patients had mammography and 22 had an ultrasound, which are less than 50% of the total number of patients. Conclusions: This study showed that there is still unfulfilled need to evaluate MBC in order to find the best management guidelines such as screening in high risk populations, diagnosis, treatment, and follow-up. Risk factor evaluation, survival time, and diagnostic radiologic modalities have not been well assessed in MBC so far.

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