scholarly journals Relationship between Ig-E Levels and Lung Function Tests in Children with Asthma

1970 ◽  
Vol 19 (1) ◽  
pp. 3-6 ◽  
Author(s):  
JA Begum ◽  
MI Islam ◽  
SKA Hoque ◽  
MT Islam ◽  
MZ Hossain ◽  
...  
Keyword(s):  
Lung Function ◽  
Healthy Children ◽  
Normal Children ◽  
Total Ige ◽  
Medical College ◽  
Lower Lung ◽  
Children With Asthma ◽  
Predicted Values ◽  
High Level ◽  
Apparently Healthy

Background: Asthma is the most common chronic disorder in childhood. A high level of Ig E is associated with asthma. Objectives: The present study was carried out to observe the relation of serum IgE level with lung function parameters in asthma children and apparently healthy normal children. Methods: This study was carried out in the out patient department of paediatrics, Dhaka Medical College, Dhaka between January 2010 and June 2010. Total sixty children with age range from six to fifteen years of both sexes were included in this study. Thirty children suffering from asthma and thirty apparently healthy children with no systemic disorder were taken as study population. Serum Ig-E levels were measured in all subjects using a standard Immulite assay by ELISA method. Subjects were classified as having high IgE if their total IgE level was greater than or equal to 100 IU /ml .Subjects were classified as having low IgE if their total IgE level was less than 100 IU /ml. Spirometry was conducted on all patients by using Spirolab a new generation spirometer according to American Thoracic Society standards. Data were analyzed by unpaired t test and Chi-squares test. Results: The mean percentage of predicted values of FEV1, FVC, FEV1/FVC% were significantly lower in high Ig E (>100 IU/ml) level group in comparison with low Ig E(<100 IU/ml) group. Conclusion: Therefore the result of the present study reveals that higher IgE is related with lower lung function and also there were more chance in symptoms based asthma in our study populations.  DOI: 10.3329/jdmc.v19i1.6242 J Dhaka Med Coll. 2010; 19(1) : 3-6.

scholarly journals Spirometric Lung Function Tests in School Children with Asthma

1970 ◽  
Vol 5 (2) ◽  
pp. 75-79
Author(s):  
Jesmin Ara Begum ◽  
Mohammad Imnul Islam ◽  
Abdul Matin
Keyword(s):  
Lung Function ◽  
Eosinophil Count ◽  
Healthy Children ◽  
Asthmatic Children ◽  
Medical College ◽  
Children With Asthma ◽  
History Of ◽  
Predicted Values ◽  
New Generation ◽  
Apparently Healthy

Background: Asthma is one of the important chronic disorder in childhood, the incidence of paediatric asthma is increasing in many countries. Atopy is highly associated with childhood asthma. Spirometric measurements of lung function are playing a key role in the diagnosis and management of asthma in children. Objective: To observe the lung function status in asthmatic children aged 6-15 years of both sexes. Method: The present observational study was carried out in the Department of Physiology, Ibrahim Medical College, Dhaka between January 2010 and June 2010. For this, 30 asthmatic children were selected from Out Patient Department of Paediatric, Dhaka Medical College as a case and 30 apparently healthy children were taken as control. Subjects with history of pneumonia, congenital heart disease were excluded from the study. Spirometry was conducted on all patients by using Spirolab a new generation spirometer according to American Thoracic Society standards FEV1, FVC, FEV1/FVC% were measured. Measurement of PEFR was also done at the same time by using a new Mini-Wright Peak Flow Meter. Serum Ig-E level was measured by ELISA method and circulating eosinophil count was also measured by observing in peripheral blood flim. Data were analyzed by using SPSS. Statistical analysis was performed by unpaired student t test. Results: The mean percentages of predicted values FEV1, FVC, FEV1/FVC%, PEFR were significantly lower in asthmatic children compared to those of apparently healthy children(P<0.001). Statistically significant differences of mean circulating eosinophil count and Ig E level( P<0.001) were observed between the groups. Again significant number of parents of the subject had history of allergic rhinitis. Conclusion: The outcome of this study shows lung function status were lower in asthmatic children. DOI: 10.3329/jbsp.v5i2.6781J Bangladesh Soc Physiol. 2010 December; 5(2): 75-79

scholarly journals Correlation between vitamin D serum level and total IgE in asthmatic children

2020 ◽  
Vol 12 (2) ◽  
pp. 37-45
Author(s):  
Vesna Micevska ◽  
Tatjana Jakovska Mareti ◽  
Ilija Kirovski ◽  
Olivera Jordanova
Keyword(s):  
Vitamin D ◽  
Serum Level ◽  
P Value ◽  
Healthy Children ◽  
Total Ige ◽  
Asthmatic Children ◽  
Significant Difference ◽  
Children With Asthma ◽  
The Mean ◽  
Chronical Disease

Asthma is a chronical disease of the airways characterized by reversible obstruction of the bronchi and airway inflammation. In recent decades, the scientific interest of the vitamin D system and its role in development of asthma and other alergic diseases has been increased. Aims of this study are to mesure and compare the serum level of 25 OHD in asthmatic and healthy children and corelate the level of 25OHD and total IgE in asthmatic children. This prospective study includes 70 children at age 2 to 14, of which 32 are children with diagnosed asthma and 38 healthy children. In both  of the groups the serum level of 25 OHD was measured  and by the results 18 % of the healthy children (C) and 28% of the asthma children (E) had 25OHD  deficiency, 45%  of C and 50% of E were insufficient and 37 % of C / 22% of E were with normal 25 OHD serum level. The mean level of 25OHD in C was 27,83 +/- 10,24 and in E 20,9 ng/ml +/- 10,72. The mean levels in both groups had statistic significant difference with p-value < 0,05. According to age no statistic significant difference was found in both of the groups. There was a statisticaly significant decreased serum level of 25 OHD in asthmatic females.In the examined group (children with asthma) there was a negative linear correlation (association) of the level of 25OHD and total IgE serum level with r=- 0,55  Vitamin D serum level measurements in asthma patients gives the possibility for discovering the connection between its deficiency and development of asthma symptoms.

scholarly journals FINGERPRINT PATTERN CHARACTERISTICS OF INTELLECTUALLY DISABLED CHILDREN - AN ORIGINAL STUDY

2015 ◽  
Vol 05 (01) ◽  
pp. 014-016
Author(s):  
Meril Ann Soman ◽  
Ramakrishna Avadhani ◽  
Rani Nallathamby ◽  
Meera Jacob ◽  
Charly Chacko Joseph
Keyword(s):  
Original Study ◽  
Healthy Children ◽  
Disabled Children ◽  
Intellectually Disabled ◽  
Normal Children ◽  
Medical College ◽  
Ulnar Loop ◽  
Fingerprint Pattern ◽  
Loop Pattern ◽  
Males And Females

AbstractFingerprint patterns are unique patterns made by friction ridges and furrows present on the pads of finger tips. Uniqueness and persistence are the two underlying features of fingerprint patterns. Aim of this present study was to determine the differences in the incidence of fingerprint patterns in intellectually disabled children compared to normal healthy children. Intellectual disability is a generalized disorder appearing before adulthood and is characterized by limitations in both intellectual functioning and in adaptive behavior. The present study comprising of 120 students (60 intellectually disabled and 60 controls) was carried out in Pediatrics outpatient department, Yenepoya Medical College and Hospital, Mangalore. The incidence of the four fingerprint patterns (Ulnar loop, Radial loop, Whorls and Arches) were determined in both the groups. Ulnar loop pattern had the highest incidence in both the groups and the least incidence was shown by arch pattern. There exists difference in the frequency of the fingerprint patterns in males and females of both the groups. The study was conducted to observe for any difference in the incidence of fingerprint patterns between intellectually disabled and normal children.

scholarly journals State of respiratory function and features of airway inflammation in children with asthma combined with gastroesophageal reflux disease

2021 ◽  
pp. 62-65
Author(s):  
A.A. Buratynska ◽  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Lung Function ◽  
Gastroesophageal Reflux ◽  
Airway Inflammation ◽  
Reflux Disease ◽  
Induced Sputum ◽  
Bronchial Obstruction ◽  
Healthy Children ◽  
Children With Asthma ◽  
The Difference

The prevalence of gastroesophageal reflux disease (GERD) in children with asthma ranges from 32% to 80%. The intensity of respiratory symptoms, bronchial obstruction are more pronounced in children with asthma combined with GERD than in children with isolated asthma. However, there are limited and conflicting data on the difference between the induced sputum in asthmatic children with or without GERD. Purpose — to examine the status of lung function and features of airway inflammation in children with asthma combined with gastroesophageal reflux disease. Materials and methods. Sixty-seven children ages 6–17 years with moderate asthma and 30 healthy children ages 6–17 years were observed. They were assigned to three groups: group 1 (32 children with isolated asthma), and group 2 (35 children with asthma and GERD) and group 3 (30 healthy children). All children included in the study were identical in age and gender. Clinical assessment, spirometry with test of reversibility of airway obstruction, and cytological analysis of induced sputum samples were performed on all patients. Upper gastrointestinal endoscopy was done in the asthmatic groups. Results. There were 10 (28.57%) children in the 2nd group with first degree obstructive spirometry pattern and none in the 1st group of children. First degree restrictive spirometry pattern was more significant observed in the 1st group of children — 10 (31.25%) than in the 2nd group of children — 2 (5.71%) (OR, CI 95% 7.50 (1.50–37.57)). In the 2nd group of children, induced sputum had a significantly higher number of neutrophils, lymphocytes and macrophages compared to the 3rd group (p<0.05). Also the difference between these parameters were significant compared to the 1st group of children. The number of induced sputum epithelial cells in 2nd group was significantly less than in 1st group of children. Conclusions. GERD negatively affects the parameters of lung function in children with asthma. Airway inflammation in children with asthma combined with GERD appears to be more significant compared to isolated asthma. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of an participating institution. The informed consent of the child's parents was obtained from the studies. No conflict of interest was declared by the authors. Key words: asthma, gastroesophageal reflux disease, children, spirometry, induced sputum.

scholarly journals Lung function assessment using the interrupter technique in infants and preschool children

2009 ◽  
pp. 55-58
Author(s):  
E. G. Furman ◽  
M. S. Ponomareva ◽  
A. M. Yarulina ◽  
I. P. Koryukina ◽  
A. R. Abdullaev
Keyword(s):  
Atopic Dermatitis ◽  
Preschool Children ◽  
Lung Function ◽  
Airway Resistance ◽  
Acute Bronchitis ◽  
Healthy Children ◽  
Mathematic Modeling ◽  
Children With Asthma ◽  
Function Assessment

There are numerous problems regarding lung function assessment in infants and preschool children despite the great interest to this field worldwide. Therefore, investigations of the interrupter technique in infants and preschool children are of great importance. This article contains results of measurement of airway resistance in children with asthma, atopic dermatitis, acute bronchitis and croup and in healthy children using the interrupter technique. Results of mathematic modeling have also been discussed in the article.

scholarly journals Importance of measuring CO2-production rate when using 13C-breath tests to measure fat digestion

1998 ◽  
Vol 79 (6) ◽  
pp. 541-545 ◽  
Author(s):  
S. Amarri ◽  
W. A. Coward ◽  
M. Harding ◽  
L. T. Weaver
Keyword(s):  
Production Rate ◽  
Co2 Production ◽  
Healthy Children ◽  
Production Rates ◽  
Normal Children ◽  
Breath Tests ◽  
Non Invasive ◽  
Fat Digestion ◽  
Invasive Method ◽  
Predicted Values

Stable isotope breath tests offer a safe, repeatable non-invasive method of measuring fat digestion. They involve the ingestion of a substrate labelled with 13C followed by serial measurements of the 13C: 12C ratio in expired CO2, from which the percentage of the 13C dose recovered (PDR) can be calculated. However PDR depends on the CO2-production rate. Our aim was to compare results obtained using directly measured CO2-production rates with those calculated from two predicted values. Twelve normal healthy children and twenty-four children with cystic fibrosis (CF) (without or with the normal dose of enzyme supplementation) were studied with 1,3-distearyl, 2[carboxyl[13C]octanoyl glycerol. The volume of CO2 produced (litres/min) was measured at rest for 30 min approximately 3 h after substrate ingestion, and the results were converted to mmol/min. For each subject the expected BMR was calculated from the equation of Schofield (1985), based on sex, age, weight and height, and from these values, CO2-production rate was derived. Surface area was calculated and an estimated value of 5 mmol/m2 per min (Shreeve et al. 1970) was used. Using these three CO2-production rates, three different PDR were calculated and compared. In healthy children there was a close concordance between measured and predicted CO2-production rates, but children with CF had a mean measured CO2-production rate 39% higher than normal children. This use of normal data for predicted CO2-production rates in children with CF underestimates cumulative PDR. If direct measurements of CO2-production rate are not available or impossible to perform the Vco2 obtained from the BMR calculated using the equations of Schofield (1985) or Shreeve et al. (1970) can be used in normal children. However, if accurate results for PDR are to be obtained, CO2-production rates should be measured when performing breath tests in conditions where energy expenditure and/or CO2-production rate are not expected to be normal.

scholarly journals Spirometric changes in children with asthma exposed to environmental tobacco smoke and treated with inhaled corticosteroids

2019 ◽  
Vol 76 (3) ◽  
pp. 321-330
Author(s):  
Snezana Radic ◽  
Branislava Milenkovic ◽  
Branislav Gvozdenovic ◽  
Biljana Medjo ◽  
Sanja Dimic-Janjic
Keyword(s):  
Lung Function ◽  
Fluticasone Propionate ◽  
Environmental Tobacco Smoke ◽  
Tobacco Smoke ◽  
Inhaled Corticosteroids ◽  
Persistent Asthma ◽  
Forced Expiratory Volume ◽  
The Family ◽  
Lower Lung ◽  
Children With Asthma

Background/Aim. Corticosteroids are the most frequently prescribed anti-inflammatory treatment in asthma. A purpose of this study was to compare the spirometric parameters as a response to inhaled fluticasone propionate (FP) treatment in children with asthma, exposed and nonexposed to environmental tobacco smoke (ETS). Methods. The study included 527 children aged between 1 and 16 years with persistent asthma divided into the groups of ETS exposed (ETSE, n = 337) and ETS free (ETSF, n = 190) children. Spirometry was performed before (1st set of results) and after 6 months of FP treatment (2nd set of results). Good lung function (GLF) was defined as forced expiratory volume in one second (FEV1) ? 85%, and ?poor lung function? (PLF) as FEV1 < 85%. Results. Among the ETSE children, 208 had one smoking parent, 129 had two, 228 had smoking mothers and 238 smoking fathers. The ETSE children received a higher FP dose (p < 0.0001) which was increased with the increase of the number of smokers in the family. The ETSE children had significantly lower lung function both in the 1st and 2nd sets of tests compared to the ETSF children (p < 0.05). After the FP treatment, both groups improved all spirometric parameters (p < 0.001). In the 2nd set of the spirometric tests, the children of smoking mothers had lower spirometry values compared to the children of smoking fathers (p < 0.05). The proportion of the children improving from the PLF to GLF after 6 months of FP was much higher among the ETSF than the ETSE children (p < 0.05). Conclusions. The ETSE children had lower spirometric values before FP. After 6-months of the FP treatment children in both groups improved the spirometric values, but the improvement was higher in the ETSF children.

scholarly journals Procalcitonin and Inflammatory Cytokines in Children with Asthma

2005 ◽  
Vol 3 (2) ◽  
pp. 75-81 ◽  
Author(s):  
M. Emporiadou ◽  
M. Hatzistilianou ◽  
K. Haidopoulou ◽  
C. Aggouridaki ◽  
A. Reklity ◽  
...  
Keyword(s):  
Inflammatory Cytokines ◽  
Allergic Inflammation ◽  
Inflammatory Disorder ◽  
Healthy Children ◽  
Mean Values ◽  
Airway Mucosa ◽  
Children With Asthma ◽  
Group A ◽  
The Mean ◽  
Predicted Values

Asthma is currently defined as a chronic inflammatory disorder of the airway mucosa. The resulting inflammation of the airway mucosa shows signs of an acute as well as a more chronic type of inflammation. Cytokine-mediated interactions among the inflammatory cells may play a role in the pathogenesis of bronchial asthma. The aim of this study is to assess inflammatory agents as markers of chronic inflammation in childhood asthma and as indicators for determining the state of the disease. This study included 3 groups of children. Group A consisted of 35 children with asthma and FEV1<80% of predicted values, 24 boys, 11 girls, aged (mean age ± SE) 9.3 ± 0.4 years, Group B of 70 children with asthma and FEV1≥80% of predicted values, 44 boys, 26 girls, aged 8.65 ± 0.36 years and Group C of 48 healthy children, 33 boys, 15 girls, aged 10.73 ± 0.4 years. In serum, levels of PCT were determined by immunoluminescence, CRP by nephelometry and cytokines IL-1β, IL-6, IL-4 and IL-5 by ELISA. Our results show that the mean concentration of CRP and PCT were not significantly different between groups A, B and C. The mean values of IL-1β were significantly different between groups A, B and C. The mean values of IL-6 were higher in group A than those of Groups B and C, although the difference between the groups was not statistically significant. The mean values of Th2 cytokines IL-4 and IL-5 were significantly different between groups A, B and C. In conclusion, CRP and PCT levels did not play any role in airway allergic inflammation, while strong indications were found that sera levels of inflammatory cytokines associated mainly with Th2 responses play a key role in airway allergic inflammation.

scholarly journals PEFR, FEF25-75 and MVV In Type-1 Diabetic Male And Their Relationships With HbA1c

2013 ◽  
Vol 8 (1) ◽  
pp. 16-20
Author(s):  
Khan Mohammad Arif ◽  
Nasim Jahan ◽  
Nayma Sultana
Keyword(s):  
Glycemic Control ◽  
Lung Function ◽  
Glycosylated Hemoglobin ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Medical College ◽  
Control Serum ◽  
Apparently Healthy

Background: Diabetes mellitus is a chronic and debilitating disease. Its complications give rise to microvascular, macrovascular and neuropathic diseases which affect eyes, kidneys, heart, blood vessels and also lungs. So, there may be a relationship between type-1 diabetes and reduced lung function. Objectives: To observe PEFR, FEF25-75 and MVV and their relationship with HbA1c in type- 1 diabetic male in Bangladesh. Methods: This cross-sectional study was carried out in the Department of Physiology, Sir Salimullah Medical College, Dhaka between 1st January and 31st December 2009. A total 30 type-1 diabetic male subjects, age 18-30 years were taken as study group. Another 30 apparently healthy age, sex, BMI and socioeconomic status matched non-diabetic persons were also included as control. For assessment of lung function PEFR, FEF25-75 and MVV of all the subjects were measured by a digital spirometer. Again, to observe glycemic control serum blood glucose and glycosylated hemoglobin (HbA1c) levels of diabetic patients were also measured by usual laboratory technique. Data were analyzed by unpaired‘t’ test and Pearson’s correlation coefficient test. Results: PEFR (p<0.001), FEF25-75 (p<0.001), and MVV (p <0.001) were significantly lower in type-1 diabetic patients in comparison to those of apparently healthy non-diabetic male. Again, their PEFR (p < 0.05), FEF25-75 (p>0.05), and MVV (p<0.05) were negatively correlated with HbA1c. Conclusion: The lung functions were lower in type-1 diabetic male in comparison to those of non-diabetic counterpart and this reduction is mainly due to poor glycemic control. DOI: http://dx.doi.org/10.3329/jbsp.v8i1.16642 J Bangladesh Soc Physiol. 2013, June; 8(1): 16-20

Age development of cortical rhythmics in the EEG depending on the formation of the child’s personal psychical characteristics

2019 ◽  
Vol 1 (8) ◽  
pp. 42-50
Author(s):  
A. V. Budkevich ◽  
L. B. Ivanov ◽  
G. R. Novikova ◽  
G. M. Dzhanumova
Keyword(s):  
Alpha Rhythm ◽  
Age Groups ◽  
Healthy Children ◽  
Brain Organization ◽  
Age Related ◽  
Mathematical Processing ◽  
Functional Brain Organization ◽  
Child's Brain ◽  
Attention Function ◽  
Apparently Healthy

According to the authors, rationing the age-related EEG parameters in children should be based on personal psychical characteristics. A comparative analysis of personal psychical characteristics and electroencephalographic data was carried out in 300 apparently healthy children aged 3-15 years. According to this principle, two subgroups of conditionally healthy children in each age group were singled out: 1) with an immature attention function and 2) with an increased anxious background that do not reach the pathological level. Registration and analysis of EEG was performed by the Neurokariograf computer complex (MBN, Moscow) using mathematical processing methods.The EEG interpretation was based on the principle of assessing the functional state of a child's brain using a three-component model according to: 1) wakefulness level and its dissociation, 2) severity of signs of the EEG neurotic pattern, 3) directionality of formation of traits of the system-functional brain organization (severity of signs functional hypofrontality).lt was found the presence of EEG signs was indicative of a lower level of wakefulness in children with an immature function of attention in all age groups, compared with the indicators of the average population of group and children with an increased background of anxiety. Children with an increased background of anxiety have a tendency to prevalence and excessive spatial synchronization of the alpha rhythm. ln healthy children, the fact of a decrease in wakefulness and the presence of signs of anxiety in the clinic and in EEG patterns indicates individual personalities and should not be considered as pathology.

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