scholarly journals Spirometric Lung Function Tests in School Children with Asthma

1970 ◽  
Vol 5 (2) ◽  
pp. 75-79
Author(s):  
Jesmin Ara Begum ◽  
Mohammad Imnul Islam ◽  
Abdul Matin
Keyword(s):  
Lung Function ◽  
Eosinophil Count ◽  
Healthy Children ◽  
Asthmatic Children ◽  
Medical College ◽  
Children With Asthma ◽  
History Of ◽  
Predicted Values ◽  
New Generation ◽  
Apparently Healthy

Background: Asthma is one of the important chronic disorder in childhood, the incidence of paediatric asthma is increasing in many countries. Atopy is highly associated with childhood asthma. Spirometric measurements of lung function are playing a key role in the diagnosis and management of asthma in children. Objective: To observe the lung function status in asthmatic children aged 6-15 years of both sexes. Method: The present observational study was carried out in the Department of Physiology, Ibrahim Medical College, Dhaka between January 2010 and June 2010. For this, 30 asthmatic children were selected from Out Patient Department of Paediatric, Dhaka Medical College as a case and 30 apparently healthy children were taken as control. Subjects with history of pneumonia, congenital heart disease were excluded from the study. Spirometry was conducted on all patients by using Spirolab a new generation spirometer according to American Thoracic Society standards FEV1, FVC, FEV1/FVC% were measured. Measurement of PEFR was also done at the same time by using a new Mini-Wright Peak Flow Meter. Serum Ig-E level was measured by ELISA method and circulating eosinophil count was also measured by observing in peripheral blood flim. Data were analyzed by using SPSS. Statistical analysis was performed by unpaired student t test. Results: The mean percentages of predicted values FEV1, FVC, FEV1/FVC%, PEFR were significantly lower in asthmatic children compared to those of apparently healthy children(P<0.001). Statistically significant differences of mean circulating eosinophil count and Ig E level( P<0.001) were observed between the groups. Again significant number of parents of the subject had history of allergic rhinitis. Conclusion: The outcome of this study shows lung function status were lower in asthmatic children. DOI: 10.3329/jbsp.v5i2.6781J Bangladesh Soc Physiol. 2010 December; 5(2): 75-79

scholarly journals Relationship between Ig-E Levels and Lung Function Tests in Children with Asthma

1970 ◽  
Vol 19 (1) ◽  
pp. 3-6 ◽  
Author(s):  
JA Begum ◽  
MI Islam ◽  
SKA Hoque ◽  
MT Islam ◽  
MZ Hossain ◽  
...  
Keyword(s):  
Lung Function ◽  
Healthy Children ◽  
Normal Children ◽  
Total Ige ◽  
Medical College ◽  
Lower Lung ◽  
Children With Asthma ◽  
Predicted Values ◽  
High Level ◽  
Apparently Healthy

Background: Asthma is the most common chronic disorder in childhood. A high level of Ig E is associated with asthma. Objectives: The present study was carried out to observe the relation of serum IgE level with lung function parameters in asthma children and apparently healthy normal children. Methods: This study was carried out in the out patient department of paediatrics, Dhaka Medical College, Dhaka between January 2010 and June 2010. Total sixty children with age range from six to fifteen years of both sexes were included in this study. Thirty children suffering from asthma and thirty apparently healthy children with no systemic disorder were taken as study population. Serum Ig-E levels were measured in all subjects using a standard Immulite assay by ELISA method. Subjects were classified as having high IgE if their total IgE level was greater than or equal to 100 IU /ml .Subjects were classified as having low IgE if their total IgE level was less than 100 IU /ml. Spirometry was conducted on all patients by using Spirolab a new generation spirometer according to American Thoracic Society standards. Data were analyzed by unpaired t test and Chi-squares test. Results: The mean percentage of predicted values of FEV1, FVC, FEV1/FVC% were significantly lower in high Ig E (>100 IU/ml) level group in comparison with low Ig E(<100 IU/ml) group. Conclusion: Therefore the result of the present study reveals that higher IgE is related with lower lung function and also there were more chance in symptoms based asthma in our study populations.  DOI: 10.3329/jdmc.v19i1.6242 J Dhaka Med Coll. 2010; 19(1) : 3-6.

scholarly journals Correlation between vitamin D serum level and total IgE in asthmatic children

2020 ◽  
Vol 12 (2) ◽  
pp. 37-45
Author(s):  
Vesna Micevska ◽  
Tatjana Jakovska Mareti ◽  
Ilija Kirovski ◽  
Olivera Jordanova
Keyword(s):  
Vitamin D ◽  
Serum Level ◽  
P Value ◽  
Healthy Children ◽  
Total Ige ◽  
Asthmatic Children ◽  
Significant Difference ◽  
Children With Asthma ◽  
The Mean ◽  
Chronical Disease

Asthma is a chronical disease of the airways characterized by reversible obstruction of the bronchi and airway inflammation. In recent decades, the scientific interest of the vitamin D system and its role in development of asthma and other alergic diseases has been increased. Aims of this study are to mesure and compare the serum level of 25 OHD in asthmatic and healthy children and corelate the level of 25OHD and total IgE in asthmatic children. This prospective study includes 70 children at age 2 to 14, of which 32 are children with diagnosed asthma and 38 healthy children. In both  of the groups the serum level of 25 OHD was measured  and by the results 18 % of the healthy children (C) and 28% of the asthma children (E) had 25OHD  deficiency, 45%  of C and 50% of E were insufficient and 37 % of C / 22% of E were with normal 25 OHD serum level. The mean level of 25OHD in C was 27,83 +/- 10,24 and in E 20,9 ng/ml +/- 10,72. The mean levels in both groups had statistic significant difference with p-value < 0,05. According to age no statistic significant difference was found in both of the groups. There was a statisticaly significant decreased serum level of 25 OHD in asthmatic females.In the examined group (children with asthma) there was a negative linear correlation (association) of the level of 25OHD and total IgE serum level with r=- 0,55  Vitamin D serum level measurements in asthma patients gives the possibility for discovering the connection between its deficiency and development of asthma symptoms.

scholarly journals TO STUDY THE ONSET AND PROGRESSION OF AIRWAY ABNORMALITY IN TERMS OF ALTERATION IN PFT IN ASYMPTOMATIC SMOKERS.

2019 ◽  
Vol 3 (11) ◽  
Author(s):  
Dr. Hitesh Kumar Solanki ◽  
Dr. Omnath P Yadav ◽  
Dr. Anita J Gojiya
Keyword(s):  
Lung Function ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Medical College ◽  
Group I ◽  
Significant Difference ◽  
History Of ◽  
Young Smokers ◽  
The Mean ◽  
Group Ii

The study was conducted in department of physiology, B J Medical College, Ahmedabad from Mar. 2012 to Feb. 2013. This was a cross-sectional study to evaluate the effect of smoking on lung   function and serum lipids in asymptomatic smokers   and comparable non   smokers. The mean of the various spirometric parameters were calculated of the subjects for both the groups. The mean FVC in group I and group II was 2.60 ± 0.62 L and 4.10 ± 0.64L respectively. The mean FEV1 in group I was 1.91 ± 0.57L and     3.19 ± 0.77L in group II Group I had mean FEF25% - 75% and PEFR of 1.98 ± 0.67L/sec and 4.50 ± 1.57L/sec respectively. Group II had mean FEF25 – 75% of 4.22 ± 1.23L/sec and a mean PEFR of 7.22 ± 1.42L/sec. In young smokers and asymptomatic, still the spirometric values were significantly deranged as compared to controls. Even smokers with history of less pack years of smoking also had significant abnormalities of lung function. All he spirometric values in the two groups had statistically highly significant difference and were higher in non-smokers as compared to smokers. The spirometric values were reduced in smokers with history of smoking for as low as two pack years. Keywords: Progression, PFT, Asymptomatic & Smokers

scholarly journals Respiratory function declines in children with asthma associated with chemical species of fine particulate matter (PM2.5) in Nagasaki, Japan

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Yoonhee Kim ◽  
Eun Ha Park ◽  
Chris Fook Sheng Ng ◽  
Yeonseung Chung ◽  
Kunio Hashimoto ◽  
...  
Keyword(s):  
Air Pollution ◽  
Lung Function ◽  
Urban Areas ◽  
Chemical Species ◽  
Mixed Effects ◽  
Linear Mixed Effects Model ◽  
Linear Mixed Effects ◽  
Asthmatic Children ◽  
Transboundary Air Pollution ◽  
Children With Asthma

Abstract Background The differential effects of PM2.5 fractions on children’s lung function remain inconclusive. This study aimed to examine whether lung function in asthmatic children was associated with increased PM2.5 fractions in urban areas in Nagasaki prefecture, Japan, where the air pollution level is relatively low but influenced by transboundary air pollution. Methods We conducted a multiyear panel study of 73 asthmatic children (boys, 60.3%; mean age, 8.2 years) spanning spring 2014–2016 in two cities. We collected self-measured peak expiratory flow (PEF) twice a day and daily time-series data for PM2.5 total mass and its chemical species. We fitted a linear mixed effects model to examine short-term associations between PEF and PM2.5, adjusting for individual and time-varying confounders. A generalized linear mixed effects model was also used to estimate the association for worsening asthma defined by severe PEF decline. Back-trajectory and cluster analyses were used to investigate the long-range transboundary PM2.5 in the study areas. Results We found that morning PEFs were adversely associated with higher levels of sulfate (− 1.61 L/min; 95% CI: − 3.07, − 0.15) in Nagasaki city and organic carbon (OC) (− 1.02 L/min; 95% CI: − 1.94, − 0.09) in Isahaya city, per interquartile range (IQR) increase at lag1. In addition, we observed consistent findings for worsening asthma, with higher odds of severe PEF decline in the morning for sulfate (odds ratio (OR) = 2.31; 95% CI: 1.12, 4.77) and ammonium (OR = 1.73; 95% CI: 1.06, 2.84) in Nagasaki city and OC (OR = 1.51; 95% CI: 1.06, 2.15) in Isahaya city, per IQR increase at lag1. The significant chemical species were higher on days that could be largely attributed to the path of Northeast China origin (for sulfate and ammonium) or both the same path and local sources (for OC) than by other clusters. Conclusions This study provides evidence of the differential effects of PM2.5 fractions on lung function among asthmatic children in urban areas, where the Japanese national standards of air quality have been nearly met. Continuous efforts to promote mitigation actions and public awareness of hazardous transboundary air pollution are needed to protect susceptible children with asthma.

Detection of Human Parvovirus B19 Infection in Children with Chronic Haemolytic Anaemia in Benha University Hospitals

2021 ◽  
Vol 30 (2) ◽  
pp. 51-58
Author(s):  
Amal M. Matta ◽  
Elsayed M. Abd-Elghany ◽  
Abeer A. Aboelazm ◽  
Osama Abo. Zaki, ◽  
Doaa Abd. Shaker
Keyword(s):  
Hemolytic Anemia ◽  
Parvovirus B19 ◽  
Control Group ◽  
P Value ◽  
Healthy Children ◽  
Igg Antibodies ◽  
University Hospitals ◽  
History Of ◽  
Chronic Hemolytic Anemia ◽  
Apparently Healthy

Background: Due to the tropism of human parvovirus B19 to erythroid progenitor cells, infection in patients with an underlying hemolytic disorder such as thalassemia, hereditary spherocytosis, sickle cell disease and Glucose-6-phosphate dehydrogenase deficiency leads to suppression of erythrocyte formation, referred to as transient aplasia crisis (TAC), which may be life-threatening. Objectives: Detection of parvovirus B19 DNA and its IgG antibodies in the serum of children with chronic hemolytic anemia and in apparently healthy children in Benha University Hospitals. Methodology: The study was conducted on 80 children. Forty of them with chronic hemolytic anemia, they were subdivided into 2 groups, Group (1a) included 20 patients without history of aplastic crisis, Group (Ib) included 20 patients with a history of aplastic crisis and 40 age and sex-matched apparently healthy children representing control (Group II). All patients were subjected to full history taking, clinical examination and laboratory investigations. Parvovirus B19 IgG was measured using anti-parvovirus B19 ELISA kits (SUNRED), and parvovirus B19 DNA was detected by using nestedpolymerase chain reaction. Results: The seroprevalence of parvovirus B19 IgG was significantly higher (P value =0.016) in Group Ia (50%) (10 out of 20) and Group Ib (45%) (9 out of 20) than the control group (Group II) (17.5%) (7 out of 40). There was a significant positive correlation between anti-parvovirus B19 IgG and age of all patients, frequency of blood transfusion. The prevalence of parvovirus B19 DNA was 10% (2 out of 20) in group Ia and 30% (6 out of 20) in group Ib and no viral DNA was detected in the controls (P value=0.001). Although 42.3% (11 out of 26) of children with β thalassemia major had a detectable level of antiparvovirus B19 virus IgG antibodies, only (23.1%) (6 out of 26) of them had B19 DNA. Anti-parvovirus B19 IgG antibodies were detected in 4 children out of 5 children of sickle cell anemia (80%) but the the prevalence of Parvovirus B19 DNA was 20% among them. Conclusion: Measures to keep away from iatrogenic and nosocomial infection transmission should be implemented including screening of donated blood for parvovirus B19 especially blood given to patients with blood disorders. Recommendation: Data from this study support the need for introduction of an approved vaccine that mainly protects children with chronic hemolytic anemia against that infection.

Mothers of Children with Asthma: Perceptions of Parenting Stress and the Mother-Child Relationship

1992 ◽  
Vol 71 (3_suppl) ◽  
pp. 1139-1148 ◽  
Author(s):  
David K. Carson ◽  
Roger W. Schauer
Keyword(s):  
Parenting Stress ◽  
Comparison Group ◽  
Healthy Children ◽  
Perceived Parenting ◽  
Asthmatic Children ◽  
Child Relationship ◽  
Behavioral Difficulty ◽  
Children With Asthma ◽  
Mother Child Relationship

In a study of 41 mothers of asthmatic children ranging from 8 to 13 years of age, perceived parenting stress was greater and the quality of the mother-child relationship more problematic than for a comparison group of mothers with healthy children. These mothers also perceived certain areas of behavioral difficulty in their asthmatic children that were greater than those of children in a comparative sample of mothers. The findings suggested that mothers and their asthmatic children may be at risk for a variety of individual and relational problems.

scholarly journals Association between tuberculosis and bronchial asthma

2017 ◽  
Vol 5 (8) ◽  
pp. 3566
Author(s):  
Kranti Garg ◽  
Jai Kishan Karahyla
Keyword(s):  
Family History ◽  
Lung Function ◽  
Bronchial Asthma ◽  
Positive Family History ◽  
Government Medical College ◽  
Medical College ◽  
Asthma Patients ◽  
History Of

Background: Everything that wheezes is not asthma. In patients of tuberculosis (TB), wheezing can be because of bronchial asthma, or many other causes. Asthma and other causes of wheezing need to be differentiated, as the treatment should be planned accordingly.Methods: Patients of active/quiescent tuberculosis who presented to Department of Tuberculosis and Chest Diseases, Government Medical College, Patiala, Punjab, India, with complaints of breathlessness and had rhonchi on examination were subjected to bronchodilator reversibility testing to prove if they were suffering from concomitant asthma. Patients thus found to have tuberculosis along with asthma were analyzed with respect to age, sex, rural urban differences and timing of diagnosis of either disease. Patients who developed asthma after tuberculosis were further analyzed for duration between completion of anti-tubercular treatment (ATT) and onset of asthma, family history of asthma and correlation of radiological manifestations and lung function measurements. Aim was to find association, if any, between tuberculosis and asthma.Results: Over 6 months, 69 patients of tuberculosis along with asthma were found. Only 21/69 (30.4%) patients developed tuberculosis after asthma. 48/69 (69.6%) patients developed asthma after tuberculosis. Majority (25/48=52.1%) of them developed asthma within 5 years of completion of ATT (p=0.020). Only 2/48 (2.9%) patients had a positive family history for asthma. Lung function abnormalities correlated with the extent of radiological involvement in these patients who developed asthma after tuberculosis (p ≤0.0001).Conclusions: Patients of active/quiescent tuberculosis who present with breathlessness and have rhonchi on examination should be treated for asthma only after confirmation of the diagnosis, as there can be other reasons for the same.

scholarly journals Socio-demographic and Clinical Profile of Children with Asthma attending Chest Clinic at B. P. Koirala Institute of Health Sciences, Nepal

2021 ◽  
Vol 6 (2) ◽  
pp. 1426-1431
Author(s):  
Satish Yadav
Keyword(s):  
Parental Smoking ◽  
Clinical Profile ◽  
Upper Respiratory Tract ◽  
Asthmatic Children ◽  
Co Morbidity ◽  
Children With Asthma ◽  
Chest Clinic ◽  
Pediatric Chest ◽  
History Of ◽  
At Home

Introduction: Asthma in children is one of the most common chronic diseases and little information available on factors associated with this disease in our part of the world. Objective:  The present study is an attempt to find out the socio-demographic and clinical profile of children with asthma. Methodology: This was a retrospective analysis of data of asthmatic children below 14 years attending pediatric chest clinic from July 2014 till March 2016. Results:  Of the 200 children, there were 142 (71%) males. The median age of presentation was 3 years and 139 (69.5%) from the age group 1-5years One third had poorly controlled asthma. Comorbidity was present in 59(29.5%) and allergic rhinitis (7%) was the most common. 90.5% had onset of wheezing before 5 years of age. Family history of asthma and/or atopy and smoking was present in 24% and 31%, respectively. 22% had exposure to pet animals. Upper respiratory tract infection (URTI) (37%) was the most common trigger for exacerbation. Cough (99%) and fast breathing (98%) were the most common symptoms. Conclusion: The majorities were males of young age with rhinitis as most common co-morbidity and many of them had a history of parental smoking at home. One third of them had poorly controlled asthma which shows the need for proper management of asthma including its comorbidity in younger children and changing certain habits like parental smoking at home.

scholarly journals Tuberculin sensitivity among inmates of children’s home

2017 ◽  
Vol 4 (5) ◽  
pp. 1581
Author(s):  
Usha Kiran C. B. ◽  
Sowmya J. ◽  
Jayamala R.
Keyword(s):  
Early Diagnosis ◽  
Nutritional Status ◽  
Vaccination Status ◽  
Healthy Children ◽  
Sensitivity Testing ◽  
Feasible Method ◽  
Tuberculin Sensitivity ◽  
Children's Home ◽  
History Of ◽  
Apparently Healthy

Background: Tuberculin sensitivity and its relationship to nutritional status in inmates of children's home.Methods: Tuberculin sensitivity was checked in 180 apparently healthy orphan children and its relationship with nutritional status, previous vaccination status was studied. setting: children's home run by NGOs participants: all inmates of children's home aged 2-15 years who meet inclusion and exclusion criteria.Results: Out of 180 apparently healthy children 27 (15%) were tuberculin positive. 109 (60.5%) were undernourished children out of which 15 (55.56%) were tuberculin positive. Out of 71 normal nourished children, 12 (44.4%) were tuberculin positive. BCG scar was present in 120 (66.6%) children out of which 19 were tuberculin positive and BCG scar was absent in 60% children out of which 8 were tuberculin positive. 8 children had history of contact with TB and 6 of them were tuberculin positive.Conclusions: Tuberculin sensitivity testing using 5 TU PPD-RT23 is a simple feasible method to screen inmates of children home at the time of entry and it is not influenced by nutritional status or previous BCG vaccination. Early diagnosis and treatment of TB will go a long way in reducing the burden of TB in our country.

scholarly journals Lung Function in a Cohort of Italian Children Born Preterm

2020 ◽  
Author(s):  
Valentina Fainardi ◽  
ilaria bonacini ◽  
eleonora sapienza ◽  
mara corradi ◽  
cinzia magnani ◽  
...  
Keyword(s):  
Lung Function ◽  
Gestational Age ◽  
Lung Development ◽  
University Hospital ◽  
Mean Values ◽  
School Aged Children ◽  
Appropriate For Gestational Age ◽  
History Of ◽  
Predicted Values ◽  
Italian Children

Abstract Background and aim: in children born preterm lung development may be affected with impairment of lung function in later ages. The aim of the study was assessing lung function in a cohort of school-aged children born preterm and assess the influence of perinatal variables. Methods: we measured lung function with impulse oscillometry system (IOS) and spirometry in 54 children [(male 48.1%, mean age 8.1 (0.8)] born preterm [mean birth weight (BW) 1462 (546.9) g, mean gestational age 31.5 (3) weeks] at Parma Children University Hospital (Italy). Maternal and perinatal data and respiratory medical history were also collected.Results: compared to predicted values, children born preterm showed higher mean values of airway impedance Z, airway resistance R5, R20, R5-20, area under the reactance curve AX and resonance frequency Fres, lower mean values of reactance X5 and FEF25-75. The mean difference between observed and predicted values of R5-R20 was higher in children born small for gestational age than in those born appropriate for gestational age. An inverse relationship was found between BW z-score and Z (r -0.40, r2 0.16; p 0.012) and R5 (r -0.44, r2 0.20; p 0.005) in children born with a BW <1500 g. Thirty-one per cent of children had a history of wheezing and 14.8% a history of lower respiratory infection requiring admission to the hospital.Conclusions: school-aged children born preterm had an impaired lung function, especially in the peripheral airways, as resulted by IOS and spirometry assessment. BW may have a role in lung development.

Sign in / Sign up

Export Citation Format

Share Document