scholarly journals Outcome of Nasolabial Flap in Buccal Mucosal Reconstruction in Oral Squamous Cell Carcinoma

KYAMC Journal ◽  
2019 ◽  
Vol 10 (1) ◽  
pp. 48-53
Author(s):  
Rokonuzzaman ◽  
Md Zahedur Rahman ◽  
Md Shahidul Islam
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Surface Texture ◽  
Buccal Mucosa ◽  
Maxillofacial Surgery ◽  
Oral And Maxillofacial Surgery ◽  
Nasolabial Flap ◽  
Cross Sectional ◽  
Orofacial Region

Background: Surgical defects of oral cavity and orofacial region are challenging because of the aesthetic and functional demands and dynamic nature of the area. A multitude of reconstructive options are available and with the advent of musculocutaneous flaps and free microvascular tissue transfer, orofacial reconstruction has entered an era of sophistication whereby repair of defects of all types and sizes has become possible. Objectives: This study was conducted to evaluate the functional outcome, surface texture and complications of nasolabial flap for reconstruction in the buccal mucosal defects. Materials and Methods: A cross-sectional observational study was conducted 20 patients with clinical histological diagnosed squamous cell carcinoma (SCC;T1-T3 ) involving buccal mucosa attending in the Oral and Maxillofacial Surgery department of Dhaka Dental College and Hospital during this study period were included purposively in the study. All patients were treated by excision of the lesion and subsequent reconstruction of the defect by nasolabial flap. If indicated then patients received adjuvant radiotherapy. They were examined preoperatively, immediate postoperatively, on discharge and 3 months after operation. Data were analyzed by SPSS statistics (version 20) software. To find out the significance of the result one way ANOVA was conducted and the Post Hoc Test was done by LSD. Results: Among 20 patients 15% (3) patients developed infection, 15% (3) patients developed dehiscence. Trismus occurred in 5% (1) patient. In assessment of interincisal opening of the patients, 90% (18) presented with adequate interincisal opening but it has been reduced in 10% (2) patients after radiotherapy. In 90% (18) patients surface texture of the flap were smooth and in 10% (2) were partially smooth. Conclusion:The nasolabial flap has proved to be a useful and reliable option for reconstruction of defects of the buccal mucosa in order to allow wound closure without tension and maintain oral function. KYAMC Journal Vol. 10, No.-1, April 2019, Page 48-53

scholarly journals Epidemiological study of oral squamous cell carcinoma: A hospital based study in Dhaka city

2018 ◽  
Vol 28 (2) ◽  
pp. 22-25
Author(s):  
Md Abul Hossain ◽  
Md Mahiuddin Ahmed ◽  
AFM Shahidur Rahman ◽  
Md Nasim Haider ◽  
AKM Serajul Alam
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Maxillofacial Surgery ◽  
Oral And Maxillofacial Surgery ◽  
Dhaka City ◽  
Cross Sectional ◽  
Total Prevalence ◽  
Level Hospital

Objective: To find out the prevalence of oral squamous cell carcinoma among the tertiary and specialized level hospital in Dhaka cityMaterials and methods: A cross sectional study was carried out in the department of Oral and Maxillofacial surgery of DDCH, NICRH, BSMMU and ShSMCH from january2009 to july 2010 .A total of 324 patient of histopatholgically proven cases of oscc were selected as a sample size. Both primary and secondary data were collected for the study. The prevalence OSCC were calculated by dividing the OSCC patient by total number of patient multiplying 100.Results: The total prevalence of OSCC 3.55% among the 4 tertiary and specialized level hospital in Dhaka city.Conclusion: The prevalence of OSCC among tertiary and specialized level hospital of Dhaka city was 3.55%.The rate is quite high. The prevalence of risk factor includes betel quit, smokeless tobacco, smoking and poor oral hygiene mas also high. The majority of the patient were present in advance stage of the diseases.TAJ 2015; 28(2): 22-25

scholarly journals Distribution of oral carcinoma case requiring radiotherapy in the Oral and Maxillofacial Surgery Clinics

2015 ◽  
Vol 27 (2) ◽  
Author(s):  
Dinda Tegar Jelita ◽  
Lucky Riawan ◽  
Herman Hambali
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Adjuvant Radiotherapy ◽  
Maxillofacial Surgery ◽  
Oral Carcinoma ◽  
Oral And Maxillofacial Surgery ◽  
Age Group ◽  
Common Area

Introduction: Carcinoma is a highly malignant tumour of epithelium that occurred in the oral cavity. One of the most common therapies given is radiotherapy, with healing, adjuvant, and palliative intentions. This research was aimed to discover the distribution of oral carcinoma requiring radiotherapy. Methods: This study was a retrospective, descriptive method. Samples were taken from the medical record of patients with oral cavity carcinoma requiring radiotherapy at the Oral and Maxillofacial Surgery Clinics of Hasan Sadikin Hospital, Bandung, of January 2006–December 2010. Results: This study indicated that as many as 23 (20.9%) cases of oral carcinoma requiring radiotherapy from a total of 110 oral carcinoma cases in that period. Type of radiotherapy most frequently found was adjuvant radiotherapy, by 14 (60.8%) cases. The most frequent type of oral carcinoma case requiring radiotherapy was squamous cell carcinoma, by 12 (52.1%) cases. Tongue become the most common area of oral carcinoma requiring radiotherapy, by 7 (30.4%) cases. Oral carcinoma case requiring radiotherapy was most frequently found in men by 14 (60.8%) cases. The age group of 41-50 was become the majority by 7 (30.4%) cases from all of the oral carcinoma case requiring radiotherapy. Conclusion: Distribution of oral carcinoma case requiring radiotherapy in the Oral and Maxillofacial Surgery Clinics of Hasan Sadikin Hospital is found in as many as 23 (20.9%) cases. Most frequent radiotherapy given is adjuvant radiotherapy (14 (60.8%) cases). The most frequent type of oral carcinoma case requiring radiotherapy is squamous cell carcinoma (12 (52.1%) cases). The most common area of oral carcinoma requiring radiotherapy is tongue (7 (30.4%) cases). Oral carcinoma case requiring radiotherapy was most frequently found in men (14 (60.8%) cases). The age group of 41-50 is the majority age suffered from disease (7 (30.4%) cases).

scholarly journals ORAL SQUAMOUS CELL CARCINOMA

2015 ◽  
Vol 22 (01) ◽  
pp. 018-026
Author(s):  
Sofia Ali Syed ◽  
Mulazim Hussain Bukhari ◽  
Riaz Ahmed Warraich ◽  
Fauzia Quadir ◽  
Asifa Iqbal ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Maxillofacial Surgery ◽  
Nucleolar Organizer Regions ◽  
Pathology Laboratory ◽  
Cross Sectional ◽  
Poorly Differentiated ◽  
Well Differentiated

Background: The aim of this study was to evaluate clinico-pathologicalparameters and the status of argyrophilic nucleolar organizer regions stain in various histologicalgrades of oral squamous cell carcinoma. Materials and Methods: A cross sectional studywas conducted on fifty cases of oral squamous cell carcinoma. The specimen were collectedfrom the department of Oral & Maxillofacial Surgery and processed for hematoxylin and eosinstain and AgNOR stain Pathology Laboratory, King Edward Medical University Lahore. Results:Bidi smoking is associated with oral squamous cell carcinoma. The AgNOR (mAgNOR andpAgNOR) status was significantly low in well differentiated and moderately differentiatedcompared to poorly differentiated oral squamous cell carcinoma (p =0.001). AgNOR size inpoorly differentiated was significantly higher than the AgNOR size in well differentiated oralsquamous cell carcinoma. Similarly the distribution of AgNOR in moderately and poorlydifferentiated oral squamous cell carcinoma was significantly high. The AgNORs index wassignificantly high in poorly differentiated squamous cell carcinoma as compared to welldifferentiated and moderately differentiated squamous cell carcinoma. Conclusions: The useof AgNORs stain is easy, valid and reliable method to assess the histological grading of oralsquamous cell carcinoma and should be used to predict the prognosis of patients.

scholarly journals COMPARISON OF EXPRESSION OF E-CADHERIN IN ORAL PSEUDOEPITHELIOMATOUS HYPERPLASIA AND ORAL SQUAMOUS CELL CARCINOMA

2020 ◽  
Vol 17 (3) ◽  
pp. 70-74
Author(s):  
Ayesha Mukhtar Awan ◽  
Iram Naz ◽  
Muhammad Khurram Mahmood ◽  
Hafeez Uddin
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Buccal Mucosa ◽  
Armed Forces ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Inflammatory Processes ◽  
E Cadherin

Background: Pseudo-epitheliomatous Hyperplasia (PEH) is a benign proliferation of epithelium occurring in response to various neoplastic lesions, infections and inflammatory processes. It can be mistaken especially in small biopsies for an invasive oral squamous cell carcinoma (OSCC). The objective of this study was to determine the expression and comparison of immunohistochemical marker E-cadherin in OSCC and PEH lesions. Materials & Methods: This cross-sectional study was conducted in Department of Histopathology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan from January 2013 to March 2016. 60 paraffin embedded cases, 30 each of PEH and OSCC were retrieved and stained with haematoxylin and eosin. They were then immune-stained with E-cadherin and expression evaluated and compared in two lesions by histopathologist. Age, sex, site of lesion and E-cadherin expression were variables. Age was described by mean and SD and other variables as frequency and percentages. Results: Mean age of OSCC group was 60.1±17.3 years and PEH group 52.7±16.6 years. OSCC group included 16 (53.33%) men and 14 (46.67%) women. PEH group included 18 (60%) men and 12 (40%) women. In OSCC group, site of lesion was buccal mucosa 12 (40%) cases, gingiva 10 (33.3%), tongue 7 (23.3%) and floor of mouth 1 (3.4%) case. In PEH group, site of lesion was buccal mucosa 12 (40%) cases, tongue 11 (36.67%), gingiva 6 (20%) and palate 1 (3.3%) case. The expression of E-cadherin was negative in all 30 cases of OSCC and positive in 29/30 (96.67%) cases in PEH. Conclusion: E-cadherin can be used as an ancillary marker in the differentiation of oral squamous cell carcinoma and pseudo-epitheliomatous hyperplasia.

Hubungan ekspresi p53, Bcl-2, c-Myc dan MMP-9 dengan gambaran klinikopatologi karsinoma sel skuamosa kepala-leher

2016 ◽  
Vol 46 (1) ◽  
pp. 53
Author(s):  
Azwar Azwar ◽  
Sofia Mubarika ◽  
Agus Surono
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Tumor Location ◽  
Neck Squamous Cell Carcinoma ◽  
Second Primary ◽  
Cross Sectional ◽  
P53 Expression ◽  
Local Metastasis

Latar belakang: Karsinoma sel skuamosa kepala dan leher merupakan salah satu kanker terseringdi seluruh dunia. Pendekatan pengobatan agresif dan multidisiplin telah dilakukan, namun belum adapeningkatan yang signifikan dalam kelangsungan hidup 5 tahun, selama 20 tahun terakhir. Kegagalanpengobatan terjadi dalam bentuk kekambuhan lokoregional, metastasis jauh, dan/atau tumor primer kedua.Berbagai penanda molekular tumor telah diteliti untuk mengetahui potensinya dalam memprediksi hasilpenyakit atau respon terhadap terapi.Tujuan: Mengetahui hubungan ekspresi protein p53, Bcl-2, c-Myc,dan MMP-9 berdasarkan gambaran klinikopatologis karsinoma sel skuamosa kepala dan leher di RumahSakit dr. Zainoel Abidin.Metode: Studi menggunakan desain cross sectional. Sampel terdiri dari 60blok parafin karsinoma sel skuamosa kepala dan leher. Prosedur pewarnaan imunohistokimia dilakukandengan menggunakan antibodi monoklonal terhadap p53, Bcl-2, c-Myc, dan MMP-9. Ekspresi proteinp53, Bcl-2, c-Myc, dan MMP-9 dianalisis secara imunohistokimia pada karsinoma sel skuamosa kepaladan leher kemudian hasilnya dihubungkan dengan parameter klinikopatologis seperti usia, jenis kelamin,lokasi tumor, diferensiasi tumor, metastasis kelenjar getah bening dan stadium tumor, kemudian dianalisisstatistik dengan Chi square.Hasil: Hasil penelitian menunjukkan terdapat hubungan bermakna tingkatekspresi p53 dengan metastasis lokal (p=0,021) dan ada hubungan bermakna tingkat ekspresi MMP-9dengan lokasi tumor (p=0,026). Tidak terdapat hubungan ekspresi p53, Bcl-2, cMyc, dan MMP-9 terhadapusia, jenis kelamin, stadium tumor, diferensiasi histologi, tingkat T, N, dan metastasis jauh.Kesimpulan:Ada hubungan ekpresi p53 dengan metastasis kelenjar limfe regional dan ekspresi MMP-9 dengan lokasitumor pada karsinoma sel skuamosa kepala dan leher. Kata kunci: Karsinoma sel skuamosa kepala dan leher, p53, Bcl-2, c-Myc, MMP-9 ABSTRACTBackground: Head and neck squamous cell carcinoma (HNSCC) is one of the most commoncancers world wide. Although aggressive and multidisciplinary approach to the treatment has been done,there is no significant improvement in 5-year survival in the last 20 years. Treatment failure occurredin the form of locoregional recurrence, distant metastasis, and/or a second primary tumor. A variety oftumor molecular markers have been studied to determine their potential in predicting disease outcome orresponse to the therapy. Purpose: To investigate correlation p53, Bcl-2, c-Myc, and MMP-9 expressionto clinicopathologic parameter in head and neck squamous cell carcinoma patient in dr. Zainoel Abidinhospital. Methods: Cross sectional design study. The sample was consisted of 60 paraffin blocks ofhead and neck squamous cell carcinoma. Procedure of immunohistochemical staining used monoclonalantibodies against p53, Bcl-2, c-Myc, and MMP-9. Expression of p53 protein, Bcl-2, c-Myc, and MMP-9were analyzed by immunohistochemistry in head and neck squamous cell carcinoma. Then, the results were linked to clinicopathologic parameters such as age, sex, tumor location, tumor differentiation,lymph node metastasis and tumor stage, and statistically analyzed with Chi square. Results: The resultsshowed there were significant correlation between p53 expression level with local metastasis (p=0,021)and significant correlation of MMP-9 expression levels with tumor location (p=0,026). There were norelationship of p53, Bcl-2, cMyc and MMP-9 expressions based on age, sex, stage tumor, histologicdifferentiation, level of T, N, and distant metastases. Conclusion: There were relationships between p53expression with local metastasis and MMP-9 expression with tumor location in head and neck squamouscell carcinoma. Keywords: Head and neck squamous cell carcinoma, p53, Bcl-2, c-Myc, MMP-9

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