scholarly journals High CA-125 in Endometrioma: An Unusual Presentation

KYAMC Journal ◽  
2018 ◽  
Vol 9 (3) ◽  
pp. 139-140
Author(s):  
Raihana Musawwir ◽  
Sheuly Akhter ◽  
Fatema Begum
Keyword(s):  
Abdominal Mass ◽  
Female Genital Tract ◽  
High Plasma ◽  
Carbohydrate Antigen ◽  
Ca 125 ◽  
Ovarian Malignancy ◽  
Cancer Antigen 125 ◽  
Carbohydrate Antigen 125 ◽  
Ovarian Endometrioma ◽  
Female Genital

CA-125 (cancer antigen 125, carcinoma antigen 125, or carbohydrate antigen 125) also known as mucin 16 or MUC16 is a protein of mucin family glycoprotein that is encoded by the MUC16 gene. It is the most frequently used biomarker for ovarian cancer. It may also be elevated in other cancers, including endometrium, fallopian tube, lung, breast and gastrointestinal cancer and in a number of relatively benign conditions, such as endometriosis, menstruation and pregnancy. High plasma levels of more than 200 U/mL are usually suggestive of malignancy but rarely found in benign conditions of female genital tract, like endometriosis. Very high CA- 125 level is suggestive of ovarian malignancy, was noted in case of ovarian endometrioma. This paper describes a case of a 36 years old lady, mother of 2 children, was admitted with large abdominal mass and abdominal pain. CA-125 was found 3500 U/ML. Ovarian malignancy was suspected. During laparotomy, ruptured endometrioma was noted and it was supported by histopathological report which mentioned," No malignancy seen". Endometrioma can't be excluded in high CA-125 level even without features of endometriosis.KYAMC Journal Vol. 9, No.-3, October 2018, Page 139-140

scholarly journals High levels of ca125 in a patient with large uterine fibroid.

2020 ◽  
Vol 19 (4) ◽  
pp. 167-170
Author(s):  
Konstantinos Zacharis ◽  
Konstantinos Dafopoulos
Keyword(s):  
Abdominal Mass ◽  
Female Genital Tract ◽  
Uterine Fibroids ◽  
Reproductive Age ◽  
Benign Tumors ◽  
Caucasian Woman ◽  
Cancer Antigen 125 ◽  
Cancer Antigen ◽  
Present Case Report ◽  
Female Genital

Uterine leiomyomas, also known as uterine fibroids, are the most common benign tumors of the female genital tract and affect 60 to 80% of women at their reproductive age. Although elevated tumor markers may be measured in benign gynaecological diseases, the association of uterine fibroids with increased levels of serum cancer antigen 125 (CA125) has not been proven to date. In the present case report we present a rare case of a 21-year-old Caucasian woman attended to our outpatient department with hypermenorrhea and pelvic discomfort that was treated for an enlarged intra-abdominal mass with an abnormally high CA-12 (777.3 U/mL).

scholarly journals Benign Ovarian Cysts with Raised CA-125 Levels: Do We Need to Evaluate the Fallopian Tubes?

2020 ◽  
Vol 12 (04) ◽  
pp. 276-280
Author(s):  
Devesh Sharma ◽  
Anjali Vinocha
Keyword(s):  
Ovarian Cancer ◽  
Ovarian Cyst ◽  
Transvaginal Ultrasound ◽  
Premenopausal Women ◽  
Carbohydrate Antigen ◽  
Ca 125 ◽  
Ovarian Cysts ◽  
Fallopian Tubes ◽  
Case Record ◽  
Carbohydrate Antigen 125

Abstract Objectives It is not clearly known whether some benign (simple) ovarian cysts can convert into cancerous cysts. Size of cyst and wall abnormalities do predict the potentiality of malignancy. Not many studies have been done to explore the malignant potential of large-sized (> 5 cm) unilocular ovarian cysts without wall abnormalities. This study evaluated the correlation between ultrasonographic size of benign ovarian cysts and carbohydrate antigen 125 (CA-125) levels. Methodology Sixty (60) premenopausal women were recruited for the study preoperatively, based on transvaginal ultrasound (TVUS) findings present in the case record sheet received along with the CA-125 sample in the biochemistry laboratories. Those cases with elevated CA-125 levels were selected, where patients had unilocular ovarian cysts without wall abnormalities. CA-125 was done using ECLIA methodology (Cobas e411, Germany). Statistical correlation was calculated between the ovarian cyst size and CA-125 levels using Spearman’s Rho coefficient. Results Mean age group of subjects were 29.7 ± 7.3 years and mean value of CA-125 (normal < 35 IU/mL) was found to be increased: 118.0 ± 147.1 IU/mL so was the mean diameter of cysts (cut off ≤ 5 cm): 48.6 ± 59.8 cm. No correlation was found between CA-125 levels and volume of ovarian cyst (r = 0.005, p = 0.680) for all subjects. Conclusions The lack of correlation between size of ovarian cysts and CA-125 levels provides a hint that the ovarian cyst epithelium does not directly express CA-125 and it may come from sites like the fallopian tube. Thus, raised level of CA-125 in benign ovarian cyst should be followed-up more closely, demanding assessment of fallopian tubes for early diagnosis of ovarian cancer. Also, algorithms can be explored to include size of ovarian cyst and CA 125 levels to predict ovarian cancer.

scholarly journals Carbohydrate Antigen 125 Is a Biomarker of the Severity and Prognosis of Pulmonary Hypertension

2021 ◽  
Vol 8 ◽  
Author(s):  
Yi Zhang ◽  
Qi Jin ◽  
Zhihui Zhao ◽  
Qing Zhao ◽  
Xue Yu ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Carbohydrate Antigen ◽  
Left Ventricular ◽  
World Health ◽  
Right Atrial ◽  
Ca 125 ◽  
Carbohydrate Antigen 125 ◽  
Increased Risk ◽  
Pulmonary Arterial ◽  
Clinical Worsening

Background: Emerging evidence has showed that serum carbohydrate antigen 125 (CA 125) levels are associated with the severity and prognosis of heart failure. However, its role in pulmonary hypertension remains unclear. This study aimed to investigate the clinical, echocardiographic, hemodynamic, and prognostic associations of CA 125 in pulmonary hypertension.Methods and Results: We conducted a retrospective cohort study of all idiopathic pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension patients receiving CA 125 measurement in Fuwai Hospital (January 1, 2014–December 31, 2018). The primary end-point was cumulative 1-year clinical worsening-free survival rate. Linear regression was performed to assess the association between CA 125 and clinical, echocardiographic, and hemodynamic parameters. Cox proportional hazards models were used to assess the association between CA 125 and clinical worsening events. Receiver operating characteristic (ROC) curve analysis was performed to determine the predictive performance of CA 125. A total of 231 patients were included. After adjustment, CA 125 still positively correlated with World Health Organization functional class, NT-proBNP, right ventricular end-diastolic diameter, pericardial effusion, mean right atrial pressure and pulmonary arterial wedge pressure; negatively correlated with 6-min walk distance, left ventricular end-diastolic diameter, mixed venous oxygen saturation, and cardiac index. After adjustment, CA 125 &gt; 35 U/ml was associated with over 2 folds increased risk of 1-year clinical worsening. Further, ROC analysis showed that CA 125 provided additional predictive value in addition to the established pulmonary hypertension biomarker NT-proBNP.Conclusion: CA 125 was associated with functional status, echocardiography, hemodynamics and prognosis of pulmonary hypertension.

scholarly journals Carbohydrate antigen-125, calcium, and hemoglobin as predictive clinical indicator for ocular metastasis in male liver cancer patients

2020 ◽  
Vol 40 (2) ◽  
Author(s):  
Qian-Hui Xu ◽  
Pei-Wen Zhu ◽  
Biao Li ◽  
Wen-Qing Shi ◽  
Qi Lin ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Primary Liver Cancer ◽  
Carbohydrate Antigen ◽  
Serum Biomarkers ◽  
Ca 125 ◽  
Carbohydrate Antigen 125 ◽  
Male Patients ◽  
Ocular Metastasis ◽  
Relationship Of ◽  
The Relationship

Abstract Background Primary liver cancer (PLC) is a common type of cancer among men worldwide. Little is known regarding the relationship of liver cancer with ocular metastasis (OM). Drinking has been also reported to be related not only to the occurrence of liver cancer but also to the causes of some ocular lesions. Purpose A diagnostic standard for the levels of serum biomarkers associated with OM derived from liver cancer in men is urgently needed. Material and methods We examined the association between OM in liver cancer and its serum biomarkers. A total of 1254 male patients with liver cancer were recruited in this retrospective study between July 2002 and December 2012. We assessed the relationship between drinking preference and OM in male patients with liver cancer, and aimed to identify an independent prognostic factor or establish a quantitative indicator for OM. Results By assessing the potential indicators, carbohydrate antigen-125 (CA-125), calcium, and hemoglobin (Hb) were found to be most valuable in the diagnosis of OM in male patients with liver cancer. Conclusion CA-125, calcium, and Hb are independent risk factors of OM in patients with liver cancer who consume alcohol.

High serum carbohydrate antigen-125 (CA-125) level predicts poor outcome in patients with follicular lymphoma independently of the FLIPI score

2012 ◽  
Vol 96 (1) ◽  
pp. 58-64 ◽  
Author(s):  
Vít Procházka ◽  
Edgar Faber ◽  
Luděk Raida ◽  
Zuzana Kapitáňová ◽  
Kateřina Langová ◽  
...  
Keyword(s):  
Follicular Lymphoma ◽  
Carbohydrate Antigen ◽  
High Serum ◽  
Ca 125 ◽  
Carbohydrate Antigen 125 ◽  
Poor Outcome ◽  
Serum Carbohydrate Antigen

scholarly journals Serum tumor marker carbohydrate antigen 125 levels and carotid atherosclerosis in patients with coronary artery disease

Open Medicine ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. 534-538
Author(s):  
Guo-Yao Sang ◽  
Zhao-Yun Chen ◽  
Cun-Ren Meng ◽  
Tian Tian ◽  
Zhao-Xia Zhang
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Carotid Atherosclerosis ◽  
Linear Regression Analysis ◽  
Intima Media Thickness ◽  
Carbohydrate Antigen ◽  
Ca 125 ◽  
Carbohydrate Antigen 125 ◽  
Serum Ca125 ◽  
Artery Disease

AbstractObjectiveWe assessed the correlation between serum carbohydrate antigen 125 (CA125) and carotid intima-media thickness (cIMT) in patients with coronary artery disease (CAD).MethodsWe collected 518 CAD patients from the cardiovascular disease center in our hospital, and all cIMT values were measured in patients with CAD.ResultsThe serum CA125 concentrations were found to be increased in CAD patients with early carotid atherosclerosis compared with patients without early carotid atherosclerosis (20.1±7.72 vs. 17.7±6.41 U/mL, p<0.001). The cIMT values were increased in patients with higher serum CA-125 levels than those with lower serum CA-125 concentrations (1.16±0.32 vs. 0.98±0.29 mm, p<0.001). There was a positive correlation between serum CA125 and cIMT in CAD patients (r=0.262, p<0.001). Moreover, the serum CA125 concentrations also were positively correlated with cIMT in subjects with early carotid atherosclerosis and without early carotid atherosclerosis (r=0.255, p<0.001; r=0.189, p=0.002). We found that serum CA-125 concentrations were independently correlated with cIMT (beta = 0.293, p<0.001) in multiple linear regression analysis.ConclusionsWe found that serum CA125 concentrations were positively correlated with cIMT in CAD patients, serum CA125 might be a potential biochemical marker for the estimation of atherosclerosis in patients with CAD.

Lymphoepithelioma-like Carcinoma of the Ovary: A Case Report and Review of the Literature

2007 ◽  
Vol 131 (11) ◽  
pp. 1715-1718 ◽  
Author(s):  
Sun Lee ◽  
Sang Yoon Park ◽  
Eun Kyung Hong ◽  
Jae Yoon Ro
Keyword(s):  
Lymph Nodes ◽  
Female Genital Tract ◽  
Undifferentiated Carcinoma ◽  
Ca 125 ◽  
Epithelioid Cells ◽  
Supraclavicular Lymph Nodes ◽  
Node Metastases ◽  
The Right ◽  
Carcinoma Of The Ovary ◽  
Female Genital

Abstract Lymphoepithelioma-like carcinoma is an undifferentiated carcinoma morphologically characterized by sheets of pleomorphic epithelioid cells with an intense lymphoid infiltrate. A 51-year-old woman presenting with low abdominal pain was found to have a right ovarian mass and enlarged pelvic, left para-aortic, and left supraclavicular lymph nodes. Based on a clinical diagnosis of right ovarian carcinoma with lymph node metastases, she received 9 cycles of chemotherapy, resulting in a reduction of her ovarian tumor, disappearance of the enlarged pelvic and para-aortic lymph nodes, and normalization of serum CA 125 level. The residual mass was removed surgically. The histology of the multinodular tumor resembled that of lymphoepithelioma of the nasopharynx and was observed in the right ovary. However, there was no viable tumor in either supraclavicular or para-aortic lymph nodes. Seven months after surgery, the patient has no evidence of disease. Lymphoepithelioma-like carcinoma appears to be rare in the female genital tract.

Carbohydrate Antigen 19-9 and Carcinoembryonic Antigen Immunostaining in Benign Multicystic Mesothelioma of the Peritoneum

2001 ◽  
Vol 125 (7) ◽  
pp. 944-947
Author(s):  
Robert N. N. Holtzman ◽  
A. Douglas Heymann ◽  
Fausto Bordone ◽  
Gianfilippo Marinoni ◽  
Paolo Barillari ◽  
...  
Keyword(s):  
Carcinoembryonic Antigen ◽  
Elevated Serum ◽  
Liver Cyst ◽  
Carbohydrate Antigen ◽  
Ca 125 ◽  
Imaging Studies ◽  
Cancer Antigen 125 ◽  
Mesothelial Cyst ◽  
Serum Carcinoembryonic Antigen ◽  
Benign Multicystic Mesothelioma

Abstract A 58-year-old Italian man was incidentally discovered to have an elevated carbohydrate antigen 19-9 (CA-19-9) level of 132 U/mL on routine blood testing. Multisystem imaging studies revealed multiple benign-appearing cysts of the liver and single cysts in the pancreas and kidney parenchyma. Throughout 14 months, fluctuations were observed in the elevated serum CA-19-9 levels from 99 to 450 U/mL. Serum carcinoembryonic antigen (CEA) and other tumor markers were normal. Laparoscopy disclosed multiple cystic lesions on the surface of the liver, on the serosal surface of the ileum, and in the mesentery. Electron microscopy characterized the cells as mesothelial. The pathologic diagnosis was benign multicystic mesothelioma of the peritoneum (BMMP). Aspirated fluid from the liver cyst revealed CA-19-9 levels at 28 500 U/mL, strongly linking the elevated serum CA-19-9 levels with mesothelial cyst secretion. Immunostaining was positive for CA-19-9, CEA, and cancer antigen 125 (CA-125). We believe this is the first documented instance of CA-19-9 and CEA secretion in BMMP.

scholarly journals CA-125:Use as a tumor marker with mixed mesodermal tumors of the female genital tract

Cancer ◽  
1986 ◽  
Vol 58 (12) ◽  
pp. 2625-2627 ◽  
Author(s):  
William A. Peters ◽  
Charles M. Bagley ◽  
Michael R. Smith
Keyword(s):  
Tumor Marker ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Ca 125 ◽  
Female Genital

scholarly journals Plasma carbohydrate antigen-125 for prediction of atrial fibrillation recurrence after radiofrequency catheter ablation

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Qingya Wang ◽  
Chengjing Dang ◽  
Haoyu Liu ◽  
Jie Hui
Keyword(s):  
Atrial Fibrillation ◽  
Catheter Ablation ◽  
Radiofrequency Catheter Ablation ◽  
High Sensitivity ◽  
Carbohydrate Antigen ◽  
Ca 125 ◽  
Cox Models ◽  
Carbohydrate Antigen 125 ◽  
The Relationship ◽  
Af Recurrence

Abstract Background Elevated plasma carbohydrate antigen-125 (CA-125) levels are strongly associated with new-onset atrial fibrillation (AF) and heart failure, but the relationship between plasma CA-125 level and AF recurrence following radiofrequency catheter ablation (RFCA) remains poorly investigated. We aimed to assess whether elevated CA-125 levels are related to long-term AF recurrence following RFCA. Methods Preoperative CA-125 levels were determined in AF patients undergoing initial RFCA. Multivariate-adjusted Cox models were constructed to determine the relationship between CA-125 levels and AF recurrence. Multivariate logistic regression analyses were performed to determine predictors of AF recurrence. Results Of the 353 enrolled patients, 85 patients (24.1%) had AF recurrence at the 12-month follow-up. These patients had significantly higher baseline CA-125 levels than those without AF recurrence [(18.71 ± 12.63) vs. (11.27 ± 5.40) U/mL, P < 0.001]. The incidence of AF recurrence across quartiles 1–4 of CA-125 was 11.5%, 13.3%, 21.6% and 50.0%, respectively (P-trend < 0.001). The adjusted hazard ratios (aHRs) for AF recurrence across quartiles 1–4 of CA-125 were 1.00 (reference), 1.085 (95% CI, 0.468–2.520), 1.866 (95% CI, 0.867–4.019), and 4.246 (95% CI, 2.113–8.533), respectively (P-trend < 0.001). A similar effect was obtained when CA-125 was studied as continuous data (aHR per unit increase in LnCA-125, 3.225, 95% CI, 2.258–4.606; P < 0.001). When a predefined CA-125 cut-off of 13.75 U/mL was established, patients with CA-125 ≥ 13.75 U/mL had a higher risk of recurrent AF than those with CA-125 < 13.75 U/mL (aHR, 3.540, 95% CI, 2.268–5.525, P < 0.001). Multivariate analysis revealed CA-125, high-sensitivity C-reactive protein, and left atrium anteroposterior diameter as independent risk factors for AF recurrence. Conclusions Elevated preoperative CA-125 levels are related to a higher risk of AF recurrence and can independently predict AF recurrence following RFCA.

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