scholarly journals Nebulization Practice and use of Antibiotic in the Treatment of Childhood Asthma at the Rural Area

2021 ◽  
Vol 11 (2) ◽  
pp. 471-474
Author(s):  
MD Shafiul Alam ◽  
B H Nazma Yasmeen ◽  
Md Benzamin ◽  
Nadia Haq ◽  
Md Shariful Hasan
Keyword(s):  
Normal Saline ◽  
Childhood Asthma ◽  
Ipratropium Bromide ◽  
Acute Asthma ◽  
Community Level ◽  
Severe Exacerbation ◽  
Cross Sectional ◽  
Medical College ◽  
Nebulized Salbutamol ◽  
Asthma In Children

Background : Management of childhood asthma is not optimum in our country especially at the community level. Objectives : The study was conducted to see the nebulization practice in the management of moderate and sever acute asthma in children at the community level. Methodology : This cross-sectional observational study was conducted in different private clinics and pharmacy of Daudkandi Upazila of Cumilla during the period of November 2017 to March 2018. Total 30 doctors’ diagnosed cases of acute exacerbation of moderate and severe asthma between 2-15 years of age were included in this study. Each patient’s treatment advice was followed up to see whether the use of nebulized Salbutamol and Antibiotic in the management of acute asthma was appropriate or not. All data were recorded in to a pretested proforma. Data were analyzed manually, and values were expressed as frequency and percentage. Results : Among the cases 25 (83.33%) cases had moderate and 5 (16.67%) cases had severe exacerbation of asthma. For nebulization, salbutamol was used to all cases and ipratropium bromide was added to 11 (36.7%) cases. Nebulization frequency was as per national guideline but the ratio of salbutamol respiratory solution to normal saline was not appropriate in most of the cases. Antibiotic was given to all cases and among them parenteral Ceftriaxone was given to 22 (73.3%) cases. Conclusion : Frequency of nebulization was appropriate but ratio of Salbutamol respiratory solution to normal saline was inappropriate. Antibiotic was given to all cases. Northern International Medical College Journal Vol.11 (2) Jan 2020: 471-474

Nebulization by Isotonic Magnesium Sulphate Solution with Salbutamol Provide Early and Better Response as Compared to Conventional Approach (Salbutamol Plus Normal Saline) in Acute Exacerbation of Asthma in Children.

2015 ◽  
Vol 9 (2) ◽  
pp. 61-67
Author(s):  
Tahmina Akter ◽  
Md Nazrul Islam ◽  
Mohammad Azizul Hoque ◽  
Suraya Khanam ◽  
Husnea Ara Khan ◽  
...  
Keyword(s):  
Acute Exacerbation ◽  
Normal Saline ◽  
Magnesium Sulphate ◽  
Acute Asthma ◽  
Controlled Trial ◽  
Conventional Approach ◽  
Sulphate Solution ◽  
Control Group ◽  
Nebulized Salbutamol ◽  
Asthma In Children

Asthma attacks are serious respiratory problem that can be lethal when not treated appropriately. Till today the main stay of therapy is short acting ß2-agonist. Unfortunately in acute asthma episodes this is not enough to relieve the bronchospasm and reduce dyspnea. The shortcoming of ß2-agonist therapy has resulted in the use of a variety of other treatment in the management of acute asthma. The use of magnesium sulphate is one of the recent treatment options. This study was done to compare the efficacy of nebulized salbutamol with magnesium sulphate versus salbutamol with normal saline in the treatment of acute exacerbation of asthma in children. This randomized controlled trial was carried out among 60 patients with acute exacerbation of bronchial asthma fulfilling the inclusion criteria, admitted in the department of Paediatrics, Mymensingh Medical College Hospital over a period of one year from January 2009 to December 2009. They were distributed randomly, 30 patients received nebulized salbutamol (0.15mg/kg; minimum dose 2.5mg) with 2.0 ml of isotonic magnesium sulphate solution and another 30 patients received the same dose of salbutamol with 2.0 ml of normal saline on 3 occasions at 20 minute intervals. With single dose of nebulization in the magnesium sulphate with salbutamol group, by 20 minute almost all 26 (86.7%) patients achieved at least 60% of predicted PEFR. Within 20 minute from control group none could achieve 60% of predicted PEFR. After second dose of nebulization control group started achieving 60% of predicted value. Regarding response criteria, with second dose of nebulization, at 40 minute 16 (53.3%) patient from magnesium sulphate with salbutamol group showed good response (PEFR>70% predicted). But within the first 40 minutes, none could show good response in control group. With 3rd dose of nebulization all from magnesium sulphate group showed good response but even at 60 minute, 5 (16.7%) patients in control group failed to be included as good responder. In conclusion, nebulization by isotonic magnesium sulphate solution with salbutamol provide early and better response as compared to conventional approach (salbutamol plus normal saline) in acute exacerbation of asthma in children.Faridpur Med. Coll. J. 2014;9(2): 61-67

Comparison of nebulized salbutamol with nebulized ipratropium bromide in acute asthma

1983 ◽  
Vol 77 ◽  
pp. 159-163 ◽  
Author(s):  
Bernard C. Leahy ◽  
Stephanie A. Gomm ◽  
Stephen C. Allen
Keyword(s):  
Ipratropium Bromide ◽  
Acute Asthma ◽  
Nebulized Salbutamol

scholarly journals Comparison of outcome of salbutamol alone and salbutamol in combination with ipratropium bromide in acute asthma in children.

2020 ◽  
Vol 27 (06) ◽  
pp. 1103-1107
Author(s):  
Saima Jabeen Joiya ◽  
Muhammad Azam Khan ◽  
Farhan ul Haq ◽  
Zahid Ahmad
Keyword(s):  
Heart Rate ◽  
Respiratory Rate ◽  
Flow Rate ◽  
Ipratropium Bromide ◽  
Acute Asthma ◽  
Accessory Muscle ◽  
Group A ◽  
Asthma In Children ◽  
Group B ◽  
Mean Heart Rate

Objectives: Asthma affects about 15% of children while it is one of the commonest reason for admissions in pediatric emergencies and wards. We aimed this study to determine outcome of Salbutamol alone and salbutamol in combination with Ipratropium Bromide in acute asthma in children. Study Design: Randomized Controlled trial (RCT). Setting: Unit-II Department of Pediatric Medicine, Nishtar Medical College and Hospital, Multan. Period: 20th Nov 2017 to 30th June 2018. Material & Methods: The study consisted of 104 children, with 52 children each in Group ‘A’ and ‘B’ who were subjected to salbutamol alone and salbutamol in combination with Ipratropium bromide respectively. In both groups oxygen was administered via nasal prongs at a flow rate of 3L/minute. These children was monitored at 30 minutes interval for 2 hours (least value out of these 4 values was taken). Both groups were compared for outcome in terms of mean heart rate, respiratory rate, accessory muscle score, peak expiratory flow rate (PERF) percentage and SPO2. Results: Of these 104 study cases, 61 (58.7%) were boys while 43 (41.3%) were girls. Mean age of our study cases was noted to be 9.92 ± 3.01 years. Mild level of asthma severity was noted in 35 (33.7%) and moderate severity in 69 (66.3%). Mean heart rate in group A was noted to be 119.40 ± 12.22 and in group was 119.29 ± 8.51 beats per minute. (p=0.956). Mean respiratory rate in group A was 29.98 ± 4.00 while in group B was 27.88 ± 3.85 (p=0.000). Mean accessory muscle score in group  A was 0.537 ± 0.336 while in group B was 0.130 ± 0.030 (p = 0.000). Mean PEFR percentage in group A was 68.69 ± 18.64 while in group B was 87.12 ± 17.10 (p = 0.000). Mean SPO2 in group A was 96.15 ± 1.05 while it was 95.94 ± 1.29 (p = 0.362). Conclusion: Our study results have shown that nebulization of salbutamol in combination with Ipratropium Bromide is more effective in the management of children with acute asthma. It was safe, effective and reliable as there was no adverse side effect noted in our study. We recommend the use of this combination nebulization therapy in children with acute asthma.

scholarly journals Efficacy of Nebulized Magnesium Sulphate in the Treatment of Acute Bronchial Asthma Compared to Nebulized Salbutamol: A Randomized Control Trial

2020 ◽  
Vol 44 (1) ◽  
pp. 24-29
Author(s):  
Zannat Ul Sarmin ◽  
Sayeeda Anwar ◽  
Tafazzal Hossain Khan ◽  
Md Abid Hossain Mollah ◽  
Rokeya Khanam ◽  
...  
Keyword(s):  
Acute Exacerbation ◽  
Acute Asthma ◽  
Treatment Options ◽  
Controlled Study ◽  
Control Group ◽  
College Hospital ◽  
Bronchodilator Effect ◽  
Nebulized Salbutamol ◽  
Asthma In Children ◽  
Group B

Background: Nebulized salbutamol is commonly used in treatment of asthma in children. The use of nebulized MgSO4 is one of the different treatment options available during acute exacerbation. Objective: To compare the efficacy of nebulized MgSO4 with nebulized salbutamol in the treatment of acute asthma in children. Materials and method: This randomized controlled study was conducted in Dhaka Medical College Hospital between January to December 2016. Children of 7-12 years with acute exacerbation of asthma were randomized into study group-A (MgSO4 group, n=30) and control group-B (Salbutamol group, n=30). Children of both groups were treated with serial nebulization thrice at 20 minute intervals by either 2.4 ml (4% MgSO4, 96 mg) or salbutamol (0.15 mg/kg minimum 2.5 mg) with 2.5 ml of isotonic normal saline. Results: The mean final PEFR were not different between the two groups (275.0±41.42 L/min in MgS04 group and 263±36.17 L/min in salbutamol group). The increase in PEF was statistically significant and comparable in both groups (by 35.1% in the MgS04 group and by 42.1% in the salbutamol group). Fischl score improvement was comparable and significant in both groups (4.31 to 0.43 in MgS04 group and 4.29 to 0.76 in salbutamol group). Statistically significant increase in oxygen saturation and reduction of heart rate was found in MgS04 group without any side effects. Nebulized MgSO4 was found having significant bronchodilator effect which is comparable to salbutamol. Conclusion: Nebulized MgS04 was found equally effective as nebulized salbutamol in the treatment of severe acute asthma in children. Bangladesh J Child Health 2020; VOL 44 (1) :24-29

scholarly journals Clinical manifestations of acute asthma in children at the Department of Child Health Cipto Mangunkusumo Hospital

2016 ◽  
Vol 43 (4) ◽  
pp. 132
Author(s):  
Kadek Ayu Lestari ◽  
Imam Budiman ◽  
Sudigdo Sastroasmoro
Keyword(s):  
Child Health ◽  
Acute Asthma ◽  
Early Recognition ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Female Ratio ◽  
Asthma Attack ◽  
Pediatric Pulmonology ◽  
Asthma In Children

Background Acute asthma is an asthma attack or worsening ofasthma manifestation and pulmonary function. Severe asthma at-tack might be prevented by early recognition of the attack and ap-propriate therapy. Clinical manifestations of asthma in children varywidely, so does the assessment of the attack that is often not accu-rately defined by doctors. This leads to delayed and inadequatetreatment of the attack.Objective This study aimed to know the clinical manifestationsof acute asthma in children at the Department of Child Health, Medi-cal School University of Indonesia/Cipto Mangunkusumo Hospi-tal.Methods This was a descriptive, cross sectional study, conductedat the emergency room (ER), the Pediatric Pulmonology Outpa-tient Clinic, and the Pediatric Outpatient Clinic. Subjects were asth-matics who were having attack and aged 2-18 year-old. Data ofage, sex, pulse rate, respiratory rate, duration of attack, expiratory,and inspiratory effort signs were obtained by history and physicalexamination followed by the assessment of attack severity.Results Subjects consisted of 92 children, mostly obtained fromthe ER (40%), with male to female ratio of 1.5:1 and average ageof 5.8 years old. Most of the subjects had mild attack (83%) andduration of attack of less than 24 hours (56%). Most subjects (70%)only had signs of increased expiratory effort, in which all of themhad mild attack. The rest of the subjects showed the combinationof inspiratory and expiratory efforts; 12 patients with mild attack,15 with moderate attack, and 1 with severe attack.Conclusion Patients who only showed expiratory effort usuallyhad mild attack. Patients showing expiratory and inspiratory ef-forts usually had mild or moderate attack. Treatment should betailored to the degree of attack

scholarly journals Formaldehyde exposure and asthma in children: a systematic review

2011 ◽  
Vol 16 (9) ◽  
pp. 3845-3852 ◽  
Author(s):  
Gerald McGwin Jr. ◽  
Jeffrey Lienert ◽  
John I. Kennedy Jr.
Keyword(s):  
Systematic Review ◽  
Random Effects ◽  
Childhood Asthma ◽  
Fixed Effects ◽  
Positive Association ◽  
Fixed Effects Model ◽  
Moderate Amount ◽  
Cross Sectional ◽  
Formaldehyde Exposure ◽  
Asthma In Children

Despite multiple published studies regarding the association between formaldehyde exposure and childhood asthma, a consistent association has not been identified. Here we report the results of a systematic review of published literature in order to provide a more comprehensive picture of this relationship. After a literature search, we identified seven studies providing quantitative results regarding the association between formaldehyde exposure and asthma in children. Studies were heterogeneous with respect to the definition of asthma. For each study, an odds ratio (OR) and 95% confidence interval (CI) for asthma were abstracted from published results or calculated based on the data provided. We used fixed- and random-effects models to calculate pooled ORs and 95% CIs; measures of heterogeneity were also calculated. A fixed-effects model produced an OR of 1.03 (95% CI, 1.021.04), and random effects model produced an OR of 1.17 (95% CI, 1.011.36), both reflecting an increase of 10 mg/m3 of formaldehyde. Both the Q and I2 statistics indicated a moderate amount of heterogeneity. Results indicate a positive association between formaldehyde exposure and childhood asthma. Given the largely cross-sectional nature of the studies underlying this meta-analysis, further well-designed prospective epidemiologic studies are needed.

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