scholarly journals Chordoma in the Nasopharynx- Treated with Radiotherapy after Surgical Resection

2009 ◽  
Vol 22 (2) ◽  
pp. 295-297
Author(s):  
Dayem Uddin ◽  
AB MA Hannan ◽  
Saber Ali ◽  
S Kundu
Keyword(s):  
Renal Function ◽  
Liver Function ◽  
Surgical Resection ◽  
Liver Function Tests ◽  
Medical College Hospital ◽  
College Hospital ◽  
Medical College ◽  
Function Tests ◽  
Renal Function Tests

Chordoma is very rare bony tumour which arises from the notochordal remnants .Nine cases of Chordoma in the nasopharynx were identified in Rajshahi Medical College Hospital since January 1997 to December 2009. All the patients were non-diabetic and 2 of them were hypertensive. Their renal function tests and liver function tests were normal.TAJ 2009; 22(1): 295-297

scholarly journals Effect of Chemotherapy on Liver Function During Induction of Remission in Children with Acute Lymphoblastic Leukemia Receiving Standard Protocol

2021 ◽  
Vol 29 (1) ◽  
pp. 33-37
Author(s):  
Meftahul Jannat ◽  
AKM Amirul Morshed ◽  
Sayeeda Anwer ◽  
Shahnoor Islam
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Liver Function ◽  
Serum Albumin ◽  
Lymphoblastic Leukemia ◽  
Liver Function Tests ◽  
Medical College Hospital ◽  
Standard Protocol ◽  
College Hospital ◽  
Medical College ◽  
Pediatric Hematology

Objective: The present study was undertaken to assess liver function (using markers like SGPT, serum bilirubin, prothrombin time, serum albumin) in children suffering from Acute Lymphoblastic Leukemia. Materials & Methods: This study was carried out in the Department of Pediatric Hematology & Oncology, Dhaka Medical College Hospital, Dhaka, over a period 12 months from the day of approval of the protocol. All acute lymphoblastic leukaemia children admitted in Pediatric Hematology & Oncology Department in Dhaka Medical College Hospital and receiving chemotherapy of standard protocol for induction of remission were the study population. A total of outcome variable was hepatotoxicity resulting from chemotherapy given for induction of remission. Result: The mean age of the children was 4.4 years (range 2- 8 years). Males were a bit higher in the series with male to female ratio being 11:9. Liver function tests before therapy revealed that none of the children exhibited raised serum billirubin and only 2(4.5%) children had increased SGPT. However, 50% of the children had raised prothrombin and 43.2% had reduced serum . albumin. Liver function tests after therapy after induction of remission shows that 9(20.5%) children exhibited raised serum billirubin, the proportion of children with raised prothrombin remained almost same as before but the status of serum billirubin improved to some extent. However, proportion of children with raised SGPT was increased to 25%. Comparison of liver function in children after therapy during induction of remission with that before induction did not show any significant difference, except that the serum SGPT was significantly raised during induction of remission (p < 0.001). Conclusion: The study concluded that the current therapy for induction of remission of ALL cases does not produce any toxic effect on liver. Although, enzymes like SGPT take a sharp rise during induction of remission, it is transient and does produce any deleterious effect on liver. J Dhaka Medical College, Vol. 29, No.1, April, 2020, Page 33-37

scholarly journals Assessment of Liver Function Tests in Children with Typhoid Fever: A Hospital Based Study

2019 ◽  
Vol 17 (2) ◽  
pp. 21-22
Author(s):  
Shakil Ahmad
Keyword(s):  
Liver Function ◽  
Typhoid Fever ◽  
Liver Function Test ◽  
Liver Function Tests ◽  
Serum Glutamic Oxaloacetic Transaminase ◽  
Medical College ◽  
Endemic Diseases ◽  
Function Tests ◽  
Function Test ◽  
Loss Of Appetite

Background: Typhoid fever is among the most endemic diseases in the tropics and which causes significant morbidity and mortality. It can lead to liver damage if not properly treated. Therefore, the liver function test assessment was conducted in children with typhoid fever. Our study aimed to evaluate the liver function test abnormalities in typhoid fever. Material and methods: This was a prospective observational study conducted at the department of paediatrics, Nepalgunj Medical College and Teaching hospital, Nepalgunj for a period of one year August 2018-July 2019.In the present study total 60 children of Typhoid fever were included on the basis of inclusion and exclusion criteria. On admission a detailed history and complete physical examination was carried out. Routine investigations were also carried out. The diagnosis was confirmed by serum Widal test. Liver function tests were performed i.e. Serum glutamic oxaloacetic transaminase [SGOT] and serum glutamic pyruvic transaminase [SGPT] estimation. Result: In the present study total children were 60 in which 43.33% were boys and 56.66% were girls. Fever was present in all the cases loss of appetite, cough, vomiting was present in majority of cases. On admission, SGOT and SGPT levels were found > 35 IU/L in 26 cases (43.33%) and 34 cases (56.66%) respectively. On discharge after 7 days of antibiotic, majority of patients had SGOT and SGPT levels < 35 IU/L. Conclusion: Our study concluded that on admission of children SGOT and SGPT levels were found > 35 IU/L in 43.33% and 56.66% respectively. On discharge after 7 days of antibiotic, majority of patients had SGOT and SGPT levels < 35 IU/L.

scholarly journals Comparison of Liver Function Tests in Normal Pregnancy with Non-pregnant Matched Controls

2020 ◽  
Vol 33 (1) ◽  
pp. 17-24
Author(s):  
M Rokeya Khatun ◽  
Amina Khatun ◽  
Md Nowshad Ali
Keyword(s):  
Liver Function ◽  
Serum Albumin ◽  
Pregnant Women ◽  
Liver Function Tests ◽  
Albumin Concentration ◽  
Third Trimester ◽  
Serum Globulin ◽  
College Hospital ◽  
Cross Sectional ◽  
Function Tests

Background: Change of liver biochemical profiles is normal during pregnancy. It is almost impossible to understand disease processes that can threaten women during pregnancy without understanding normal physiological change. Aim of this study is to evaluate changes in serum liver function tests in normal pregnant women in first, second and third trimester. Material and Methods: The cross-sectional comparative study was carried out in the Department of Obstetrics & Gynaecology of Rajshahi Medical College Hospital, Bangladesh in 2019. This study consists of 90 pregnant women and 90 matched control. Among the 90 pregnant women, 30 were in first trimester, 30 were in second trimester and 30 were in third trimester. Blood samples were taken for routine liver function and protein profiles Results: Serum total and direct bilirubin concentrations were significantly lower in second and third trimester. The mean ALP level was slightly increased in 2nd trimester and drastically increased in 3rd trimesters during pregnancy. Serum ALT and AST activity was significantly increased in third trimester. No significant change in serum total proteins concentration, but serum albumin concentration was significantly lower and serum globulin concentration was significantly higher in all three trimester. Serum albumin/globulin ratio was significantly reduced in second and third trimester. Conclusion: Relative values of various liver function tests during gestational trimesters appear to be the best guide to confirm the diagnosis and treatment strategies. Thus, gynecologists should routinely monitor liver function tests in all gestational trimesters to avoid the future complications to mother and offspring. TAJ 2020; 33(1): 17-24

scholarly journals Drug eruptions and hepatic involvement: a study

2018 ◽  
Vol 4 (4) ◽  
pp. 501
Author(s):  
Vimala Manne ◽  
Padmaja Pinjala
Keyword(s):  
Liver Function ◽  
Liver Function Test ◽  
Liver Function Tests ◽  
Drug Induced ◽  
Medical College ◽  
Hepatic Involvement ◽  
Function Tests ◽  
Drug Eruptions ◽  
Function Test ◽  
Drug Rash

<p class="abstract"><strong>Background:</strong> Assessment by liver biopsy remains the gold standard in defining drug induced liver disease. Liver biopsy is an invasive procedure. Hence, a technique that is simpler is required to detect drug induced liver dysfunction. The profile of liver function tests (LFT) abnormalities, provides an initial guide to the clinical syndrome of drug induced hepatotoxicity. This study attempts to draw a possible correlation as well as to derive insight into the involvement of liver in drug eruptions through simple liver function tests.</p><p class="abstract"><strong>Methods:</strong> 112 cases of patients with drug rash whom we have a tendency to saw within the department of medicine as out-patients and in-patients since 2015 to 2018 in Osmania General Hospital, Katuri Medical College and Hospital and Dr. V. R. K Women’s Medical College, Teaching Hospital and Research Centre were enclosed during this study. Total number of cutaneous drug rash cases enrolled: 83 Total number of drug rash cases with Liver Function Test abnormalities: 17.<strong></strong></p><p class="abstract"><strong>Results:</strong> Out of 83 patients of drag rash 20% (17) had liver function test abnormalities while 80% (66) had normal hepatic function. Out of 17 drug rash cases with liver function test abnormalities 35% (6) were between 4-14 years of age group. Out of 17 drug rash cases with liver function test abnormalities 70.6% (12) were males and 29.4% (5) were females.</p><p class="abstract"><strong>Conclusions:</strong> To conclude, a sound knowledge of morphological patterns of drug rashes with hepatic involvement, drugs implicated in causing drug rashes and hepatic dysfunction and an easy detection of impending danger by the simple biochemical tests (liver function tests) can evert a major crisis and thus help the clinicians to better manage their cases.</p>

Iron Chelation with Deferasirox in Thalassemia Major Patients with Low Iron Burdens and Moderate to High Transfusion Regimens.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 4070-4070
Author(s):  
Elizabeth Evans ◽  
Dorothy A. Kleinert ◽  
Kevin Mennitt ◽  
Robert W. Grady ◽  
Patricia J. Giardina
Keyword(s):  
Renal Function ◽  
Liver Function ◽  
Serum Ferritin ◽  
Conflicts Of Interest ◽  
Gastrointestinal Symptoms ◽  
Liver Function Tests ◽  
Thalassemia Major ◽  
Serious Adverse Events ◽  
Liver Iron ◽  
Function Tests

Abstract Abstract 4070 Poster Board III-1005 Introduction A worldwide multicenter clinical trial of deferoxamine (DFO) in comparison to deferasirox (DFX/Exjade) established optimal therapeutic doses of DFX for use in b-thalassemia patients (pts) with moderate to severe iron burdens as determined by serum ferritin levels greater than 1000 ng/mL and liver iron concentrations (LICs) greater than 3 mg/g-dry weight (dw) resulting from regular red blood cell (RBC) transfusion regimens designed to maintain pre-tx hemoglobin (Hgb) levels greater than 9 to 10 gm/dL. To date, the use of DFX in less heavily iron overloaded transfused patients is not well documented. Therefore, we studied the safety and efficacy of DFX at a dose of approximately 20 mg/kg/day in a group of regularly transfused thalassemia major pts who had previously been well chelated with subcutaneous (sc) DFO as evidenced by serum ferritin levels less than 1000 ng/mL and LICs less than 3 mg/gm-dw. Patients The pt group consisted of eight transfusion dependent thalassemia major pts (2M/6F) who ranged in age from 13 to 49 yrs (mean ± SEM 28.3 ± 13.2 yrs). Six of the pts were splenectomized (2M/4F) and maintained on moderate to high transfusion regimens (2 to 4 RBC units per month) so as to maintain a pre-tx Hgb level of 9 to 10 gm/dL. Assessments/Methods Clinical parameters, including pre-tx Hgb levels, RBC units transfused, serum ferritins, liver function tests (ALT/AST), and renal function studies (BUN/creatinine) were determined at baseline and monitored monthly thereafter in all patients for one year. Hearing tests, eye exams and determinations of LIC by T2* magnetic resonance imaging (MRI) were done at baseline and 12 months. Annual tx requirements were calculated and expressed as mL of RBCs/kg/yr. All pts previously infused DFO sc 5 days each week at doses of 40 to 60 mg/kg/day. During the study, they ingested DFX daily 30 minutes prior to breakfast at a dose of 20 to 30 mg/kg as a suspension in water, apple or orange juice. Dose adjustments were made depending upon trends in serum ferritin levels, liver function tests or renal studies. Results Each pt received 2 to 4 leukocyte depleted washed RBC units per month (mean 119 ± 8.2 mL/kg/yr). Their mean pre-tx Hgb levels were 9.7 ± 0.2 gm/dL. Average monthly chemistry parameters were as follows: serum ferritin = 550 ± 9.4 ng/mL; AST = 36 ± 5; ALT = 36 ± 7; BUN = 14.8 ± 1.0; creatinine = 0.7 ± 0.1. There were no significant changes in the parameters related to liver or renal function, or in LICs during the 12-month observation period, the mean LICs were 2.0 ± 0.4 mg/gm-dw at baseline vs. 1.6 ± 0.3 mg/gm-dw at 12 months. Serum ferritin levels also remained stable during the course of therapy (577 ± 71 ng/mL at baseline vs. 480 ± 106 ng/mL at 12 months). The starting dose of DFX ranged from 20 to 30 mg/kg/day. Over the course of the study, the dose was increased to 25 and 30 mg/kg/day in pts 2 and 7, respectively, owing to a progressive increase in serum ferritin levels and decreased to 10 mg/kg in pt 3 and 18 mg/kg in pt 8 due to declining ferritin levels. On average, a dose of 20.5 ± 2 mg/kg/day was needed to maintain iron balance. No serious adverse events occurred during the 12-month course of DFX and no significant side effects (e.g. rash or gastrointestinal symptoms) were reported. Conclusion Moderate doses of DFX, slightly more than 20 mg/kg/day, were safe and effective in maintaining iron balance as measured by LICs (MRI) and serum ferritin levels in thalassemia major patients with low iron burdens (LICs <3 mg/g-dw and serum ferritin levels <1000 ng/mL) receiving regular tx therapy to maintain pre-tx Hgb levels of 9 to 10 gm/dL. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Utilization of Diagnostic Facilities In Non-government Medical College Hospital: A Study on HFRCMCH

2012 ◽  
Vol 18 (Number 1) ◽  
pp. 38-47
Author(s):  
K S Anwar ◽  
AKM S Uddin
Keyword(s):  
Blood Sugar ◽  
Liver Function Tests ◽  
Medical College Hospital ◽  
Routine Examination ◽  
Radiological Investigation ◽  
College Hospital ◽  
Medical College ◽  
Laboratory Facilities ◽  
Blood Grouping ◽  
Patient Department

A retrospective study was done to evaluate the availability of medical investigation facilities in Holy Family Red Crescent Medical College Hospital (HFRCMCH) for a period of 6 months. The study was designed to find out the gaps in the study Institute which is a tertiary level hospital in Dhaka city. Data was collected from medical records by check list and interview schedule. Out of 49687 patients. 85.28% received services from out patient department and 14.72% from in patient department. Among them. 26151 cases were referred for investigation from out patient and inpatient departments. Out of those 24.36% were blood for routine examination. 17.72% urine for routine examination and 10.77% blood urea and 24.46% blood sugar. 3.82% stool for routine examination and 18.87% for radiological investigation of chest. hi the inpatient department, routine examination of blood was highest (25.38%). next was blood sugar (23.01%). Some specific investigation namely S. Creatinin, S. Electrolytes, Liver function tests, VDRL, widal test, Blood grouping. Culture & sensitivity test were done. Out of specific tests. Blood grouping was highest followed by serum electrolytes. Majority of doctors (86.67) expressed satisfaction in regard to availability of Reagent and Films. Most doctors (93.33) expressed satisfactions in regard to result of laboratory tests and imaging. Regarding the skill of laboratory technician, 43.33% doctors opined good and 56.67% opined as moderate. The results of the study might help the administrator and planner to take steps for further improvement and appropriate utilization of laboratory facilities. However, there is an urgent need for improvement and horizon of investigation facilities should be expanded.

scholarly journals A study of effect of alcohol on liver function tests (LFT) in Garhwal hills, India

2017 ◽  
Vol 6 (1) ◽  
pp. 94
Author(s):  
Javin Bishnu Gogoi ◽  
Mayank Bhasin ◽  
Joshil Kumar Behera ◽  
Kailash Gairola ◽  
Haren Baruah
Keyword(s):  
Liver Function ◽  
Liver Function Tests ◽  
Primary Objective ◽  
North India ◽  
Standard Drink ◽  
Cross Sectional ◽  
Medical College ◽  
Function Tests ◽  
Frequent Consumption ◽  
The Hill

Background: There has been frequent researches on liver pathologies and its variables in the world. There is no known research carried on liver in Garhwal region. Uttarakhand is one area where the hill people are more habitual of alcohol abuse and alcoholism is more endemic here. Primary objective was to correlate alcohol intake and its effect on liver function test. Secondary objectives were to screen the patients for abnormal LFTs and to observe and understand changes needed in lifestyle to reduce risk of developing liver disorders.Methods: A cross sectional observational study was conducted on patients in a medical college in north India. The participants above the age of 10 years were included for the study.Results: Out of all the 150 study participants screened, 120 (80%) were detected to have abnormal liver function tests (LFT) (65 females and 55 males). Maximum numbers of participants with abnormal LFT belong to age group of 21-30 yrs. More frequent and higher amount of alcohol consumption was found to adversely affect the liver physiology.Conclusions: The most important risk factor for liver damage is frequent consumption of alcohol in excess of 4 pegs a day for males and 2 for females (One standard drink contains 10 grams of alcohol). 

scholarly journals Comparative study of postoperative hepatic and renal function changes in laparoscopic and open cholecystectomy

2019 ◽  
Vol 6 (4) ◽  
pp. 1194
Author(s):  
Fazle Rab Malik ◽  
Ankur Dutt Tripathi ◽  
Santosh Kumar Singh ◽  
Anish Kola ◽  
Devendra Kumar Shukla
Keyword(s):  
Blood Flow ◽  
Renal Function ◽  
Laparoscopic Cholecystectomy ◽  
Liver Function ◽  
Open Cholecystectomy ◽  
Liver Function Tests ◽  
P Value ◽  
Renal Function Test ◽  
Function Tests ◽  
Function Test

Background: It has been shown that there is a transient elevation of serum liver enzymes after laparoscopic surgeries and major causative factor seemed to be the CO2 pneumoperitoneum. In most of the cases, it does not have any clinical significance in the patient with normal preoperative liver function. However, in patients with deranged liver function, these changes can have great significance.Methods: The present study was designed to determine and compare changes in liver function tests and renal function test following laparoscopic cholecystectomy and open cholecystectomy. This study was conducted on 100 patients admitted to Swaroop Rani Nehru Hospital, Allahabad, India from August 2017 to January 2019 who were having symptomatic cholelithiasis with a history of either acute cholecystitis, biliary colic or chronic cholecystitis. All patients were investigated for complete liver function tests and renal function test including serum bilirubin, SGOT, SGPT, alkaline phosphatase, LDH, S. urea, S. creatinine, S. Na+, S. K+, S. Ca+ and urinary sodium (UNa+). The laboratory tests were carried out in the same laboratory using one type of instrument.Results: In open cholecystectomy, bilirubin decreased by 11% (p value equals 0.191) and remained decreased to the preoperative value on day 1 and day 7. While, laparoscopic cholecystectomy at 14 mmHg pressure, mean bilirubin decreases by 14% immediately postoperatively (p value equals 0.1733) and returns to normal level in 7 days. These changes are clinically insignificant and statistically insignificant.Conclusions: Enzyme elevations could mostly be attributed to the adverse effects of the pneumoperitoneum on the hepatic blood flow and renal blood flow and CO2 absorption in the blood. Though, these changes do not seem to be clinically significant, care should be taken before deciding to perform laparoscopic cholecystectomy. This study suggested that laparoscopic cholecystectomy is a safe operative procedure and have added advantages. The disturbances in the function of the kidney after laparoscopic cholecystectomy are self-limited and not associated with any morbidity in patients with a healthy kidney function.

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