scholarly journals Oral lesions in older patients: a descriptive analysis of a brazilian population

2021 ◽  
Vol 10 (15) ◽  
pp. e516101523227
Author(s):  
Roberta Freire Almeida ◽  
Karla Daniella Malta Ferreira ◽  
Alexandre Marques Paes da Silva ◽  
Mayra Stambovsky Vieira ◽  
Fábio Ramôa Pires ◽  
...  

The objective of this retrospective, observational study was to describe the oral lesions diagnosed in older patients through histopathological reports from the oral pathology service of a private university in Rio de Janeiro over a 19 year period (1999-2017) and to call attention to the oral health of the elderly. Information was collected and analyzed from 713 medical records of patients aged ≥ 60 years old. The data collected included the patient's age, gender and the type and location of the injury. The mean age of the patients was 68.1 years old, with a higher prevalence of lesions in the 60 to 74 age group. The results showed that three of the four most common oral lesions were more frequent in women and only one (oral squamous cell carcinoma) was more common in men. The 4 most common injuries were: fibrous inflammatory hyperplasia (187; 26.2%), oral squamous cell carcinoma (78; 10.9%), leukoplakia (40; 5.6%) and oral lichen planus (36; 5.0%). These lesions were distributed mainly in the alveolar edge (71; 20.8%) followed by tongue (57; 16.7%), bottom of the vestibule (55; 16.1%), and buccal mucosa (44; 12.9%). The results obtained should be used to alert health professionals, especially dentists, so that early diagnoses of such lesions can be made and thus contribute to improving the quality of care for the elderly.

2020 ◽  
Vol 99 (6) ◽  
pp. 666-675 ◽  
Author(s):  
L. Wen ◽  
W. Mu ◽  
H. Lu ◽  
X. Wang ◽  
J. Fang ◽  
...  

Increasing evidence has revealed a significant association between microorganisms and oral squamous cell carcinoma (OSCC). Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, is considered an important potential etiologic agent of OSCC, but the underlying immune mechanisms through which P. gingivalis mediates tumor progression of the oral cancer remain poorly understood. Our cohort study showed that the localization of P. gingivalis in tumor tissues was related to poor survival of patients with OSCC. Moreover, P. gingivalis infection increased oral lesion multiplicity and size and promoted tumor progression in a 4-nitroquinoline-1 oxide (4NQO)–induced carcinogenesis mouse model by invading the oral lesions. In addition, CD11b+ myeloid cells and myeloid-derived suppressor cells (MDSCs) showed increased infiltration of oral lesions. Furthermore, in vitro observations showed that MDSCs accumulated when human-derived dysplastic oral keratinocytes (DOKs) were exposed to P. gingivalis, and CXCL2, CCL2, interleukin (IL)–6, and IL-8 may be potential candidate genes that facilitate the recruitment of MDSCs. Taken together, our findings suggest that P. gingivalis promotes tumor progression by generating a cancer-promoting microenvironment, indicating a close relationship among P. gingivalis, tumor progression of the oral cancer, and immune responses.


2018 ◽  
Vol 47 (6) ◽  
pp. 541-546 ◽  
Author(s):  
Sara Ferreira dos Santos Costa ◽  
Peter A. Brennan ◽  
Ricardo Santiago Gomez ◽  
Eduardo Rodrigues Fregnani ◽  
Alan Roger Santos-Silva ◽  
...  

Author(s):  
ROBECI ALVES MACEDO FILHO ◽  
INGRID MORGANA FERNANDES GONÇALVES ◽  
CASSIANO FRANCISCO WEEGE NONAKA ◽  
POLLIANNA MUNIZ ALVES

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Vikram Bhatia ◽  
Madhu Mati Goel ◽  
Annu Makker ◽  
Shikha Tewari ◽  
Alka Yadu ◽  
...  

Promoter methylation and relative gene expression of O6-methyguanine-DNA-methyltransferase (MGMT) andp16genes were examined in tissue and blood samples of patients with premalignant oral lesions (PMOLs) and oral squamous cell carcinoma (OSCC). Methylation-specific PCR and reverse transcriptase PCR were performed in 146 tissue and blood samples from controls and patients with PMOLs and OSCC. In PMOL group, significant promoter methylation ofMGMTandp16genes was observed in 59% (P=0.0010) and 57% (P=0.0016) of tissue samples, respectively, and 39% (P=0.0135) and 33% (P=0.0074) of blood samples, respectively. Promoter methylation of both genes was more frequent in patients with OSCC, that is, 76% (P=0.0001) and 82% (P=0.0001) in tissue and 57% (P=0.0002) and 70% (P=0.0001) in blood, respectively. Significant downregulation ofMGMTandp16mRNA expression was observed in both tissue and blood samples from patients with PMOLs and OSCC. Hypermethylation-induced transcriptional silencing ofMGMTandp16genes in both precancer and cancer suggests important role of these changes in progression of premalignant state to malignancy. Results support use of blood as potential surrogate to tissue samples for screening or diagnosing PMOLs and early OSCC.


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