scholarly journals Potential drug interactions and profile of antimicrobials prescribed for outpatient use in the interior of Bahia

2021 ◽  
Vol 10 (4) ◽  
pp. e44210414250
Author(s):  
Beatriz da Silva Santos ◽  
Manoela Santos da Silva ◽  
Isadora Oliveira e Pereira ◽  
Lucas Brasileiro Lemos ◽  
Gisele da Silveira Lemos
Keyword(s):  
Drug Interactions ◽  
Cross Sectional Study ◽  
Potential Drug ◽  
Sectional Study ◽  
Electronic Prescription ◽  
Cross Sectional ◽  
Version 2.0 ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
A Chain

This study aimed to analyze the profile of antimicrobials and potential drug interactions, involving these drugs, prescribed for outpatient use in the interior of Bahia. This is a cross-sectional study, carried out based on the analysis of 404 antimicrobial prescriptions listed in the DRC no. 20/2011, made available by the store of a chain of pharmacies, referring to the period of May 2018. The analysis of drug interactions (IM) was made using the MICROMEDEX® version 2.0 database (2011). The most prescribed class of antimicrobials was that of β-lactams (27.7%), followed by macrolides (25.3%) and fluoroquinolones (18.3%). As for the drugs prescribed in combination, there was a predominance of non-steroidal anti-inflammatory drugs (23.3%) and analgesics (19.8%). A total of 20 different drug interactions were observed, involving antimicrobials, most frequently for ciprofloxacin. After analyzing the interactions, it was possible to verify the risks related to drug associations that can be minimized with the analysis of the prescription by a pharmaceutical professional and alert systems in electronic prescription.

Non-Steroidal Anti-Inflammatory Drugs: Usage and Co-prescription with Other Potentially Interacting Drugs in Elderly: a Cross-sectional Study

2019 ◽  
Author(s):  
Nuru Abdu ◽  
Samuel Teweldemedhin ◽  
Asmerom Mosazghi ◽  
Luwam Asfaha ◽  
Makda Teshale ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Drug Interactions ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Female Ratio ◽  
Protective Agents ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract Introduction: Globally, non-steroidal anti-inflammatory drugs (NSAIDs) usage in the elderly with chronic pain has been reported as frequent. Though it is fundamental in maintaining their quality of life, the risk of polypharmacy, drug interactions and adverse effects is of paramount importance as the elderly usually require multiple medications for their co-morbidities. If prescriptions are not appropriately monitored and managed, they are likely to expose patients to serious drug interactions and potentially fatal adverse effects. Thus, the objective of the study was to assess the appropriateness of NSAIDs use and incidence of NSAIDs related potential interactions in elderly. Methods: A descriptive cross-sectional study was conducted among elderly out-patients (aged 60 and above) who visited three hospitals in Asmara between August 22 and September 29, 2018. The sampling design was two-stage random sampling and data was collected using a questionnaire, exit interview and by abstracting information from patients’ clinical cards. Descriptive and analytical statistics including chi-square test and logistic regression were employed using SPSS. Results: A total of 285 elderly respondents were enrolled in the study with similar male to female ratio. One in four of all respondents were chronic NSAIDs users, of which 74.6% were not prescribed prophylactic gastro-protective agents (GPAs). About 20% of the elderly were involved in polypharmacy and nearly all of the encountered potential NSAIDs related interactions (n=322) with prescribed drugs were moderate. Diabetes and hypertension were significantly associated with chronic NSAIDs use (OR=3, 95% CI: 1.54, 5.84; OR=9.99, 95% CI: 4.46, 22.38) and incidence of drug interactions (OR=3.95, 95%CI: 1.92, 8.13; OR=3.12, 95%CI: 1.81, 5.33) while diabetes and cardiac problem were significantly associated with incidence of polypharmacy (OR=4.33, 95% CI: 2.36, 7.96; OR=3.56, 95% CI: 1.05, 12.11). Conclusion: Though the overall reflection of prescription pattern of NSAIDs during the study period was almost satisfactory, gastro-protective agents were poorly prescribed as a prophylaxis.

scholarly journals Are patients with a nasally placed feeding tube at risk of potential drug-drug interactions? A multicentre cross-sectional study

PLoS ONE ◽  
2019 ◽  
Vol 14 (7) ◽  
pp. e0220248
Author(s):  
Fernanda Raphael Escobar Gimenes ◽  
Melissa Baysari ◽  
Scott Walter ◽  
Leticia Alves Moreira ◽  
Rhanna Emanuela Fontenele Lima de Carvalho ◽  
...  
Keyword(s):  
At Risk ◽  
Drug Interactions ◽  
Feeding Tube ◽  
Cross Sectional Study ◽  
Potential Drug ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals A STUDY ON POTENTIAL DRUG-DRUG INTERACTIONS AMONG PATIENTS ADMITTED UNDER DEPARTMENT OF MEDICINE IN A TERTIARY CARE HOSPITAL IN INDIA

2021 ◽  
Vol 10 (1) ◽  
pp. 29-32
Author(s):  
Sanjib Bandyopadhyay ◽  
Kaushik Mitra ◽  
Dipankar Bhaumik ◽  
Saibal Das
Keyword(s):  
Drug Interactions ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Controlled Study ◽  
Care Hospital ◽  
Potential Drug ◽  
Sectional Study ◽  
Cross Sectional ◽  
Different Types

Objective: This study was conducted to evaluate the potential drug-drug interactions (pDDIs) among patients admitted in a tertiary care hospital in India. Methods: This was anobservational and cross sectional study for 3 months. All the patients admitted in the general ward under Department of Medicine. Pre-structured proforma and patient’s charts were be used for data collection on the 2nd day of admission. For drug interactions, online ‘Medscape Drug Interaction Checker’ was used. Results: A total of 61 charts were screened. A total of 304 drugs with 57 different types were admitted to these patients (including all dosage forms and routes). The total number of pDDIs were 217, of them 69 were minor, 130 were significant and 18 were serious (including repetitions in different patients). There were 13 unique serious pDDIs. Conclusion: The incidence of pDDIs in our study was high. Controlled study to evaluate whether good clinical management of DDIs can reduce drug-related morbidity or mortality is needed. Keywords:Potential drug-drug interactions (pDDIs), adverse drug reactions (ADRs), poly-medication, hospitalization, pharmacokinetic and pharmacodynamics interactions.

scholarly journals Drug Therapy Scheduling by Nurses and Resulting Potential Drug Interactions in the Hospital Care Of Adolescents: A Cross-Sectional Study

2019 ◽  
Vol 7 (2) ◽  
Author(s):  
Tainá Bastos dos Santos ◽  
Juliana Almeida de Oliveira ◽  
Luanny Cardoso Souza ◽  
Helena Ferraz Gomes ◽  
Dayana Carvalho Leite ◽  
...  
Keyword(s):  
Drug Therapy ◽  
Drug Interactions ◽  
Hospital Care ◽  
Cross Sectional Study ◽  
Potential Drug ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Potential and clinical relevant drug-drug interactions among elderly from nursing homes: a multicentre study in Murcia, Spain

2019 ◽  
Vol 24 (5) ◽  
pp. 1895-1902
Author(s):  
Carles Iniesta-Navalón ◽  
Juan Jose Gascón-Cánovas ◽  
Zenewton André da Silva Gama ◽  
José Francisco Sánchez-Ruiz ◽  
Erick Angelico Gutiérrez-Estrada ◽  
...  
Keyword(s):  
Nursing Homes ◽  
Drug Interactions ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factors Associated ◽  
Complex Sampling ◽  
Inflammatory Drugs ◽  
Multi Level ◽  
Relevant Factors

Abstract This study purposes to determine the prevalence of potential and clinical relevant Drug-Drug-Interactions (pDDIs) in institutionalized older adults and to identify the pertinent factors associated. We conduct an observational, multicenter and cross-sectional study during the last quarter of 2010. We selected a sample of 275 subjects (aged ≥ 65 years) from 10 nursing homes of Murcia (Spain) by a two-stage complex sampling. pDDIs were identified using the College of Pharmacists Database. We only considered pDDIs of clinical relevance, and thereafter the relevant factors were identified through uni-level and multi-level regression analyses. A total of 210 pDDIs were identified, 120 of which were considered clinically relevant (57.1%), affecting a total of 70 elderly (25.8%). Eight pharmacological groups made up 70.2% of the clinically relevant pDDIs. More clinically relevant DDIs were found in people suffering several pathologies (OR = 2.3; 95%CI = 1.4-4.5), and also in people who take ten or more drugs daily (OR = 9.6; 95%CI = 4.8-19.1), and people who take anti-inflammatory drugs (OR = 3.9; 95%CI = 1.4-10.4). This study reveals that clinically relevant pDDIs are very common in institutionalized elderly people, and that caregivers should aim at improving their practice in order to reduce the prevalence of this phenomenon.

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