scholarly journals Influência do óleo de cártamo (Carthamus tinctorius L.) na resistência insulina e hipertrofia ventricular de camundongos dislipidêmicos

2020 ◽  
Vol 9 (9) ◽  
pp. e243997141
Author(s):  
Karine de Paula Caproni ◽  
Ângela Maria Martins ◽  
Brigida Monteiro Villas Boas ◽  
Danielle Aparecida Quintino Silva Sarto ◽  
Aline Manke Nachtigall ◽  
...  
Keyword(s):  
Carthamus Tinctorius ◽  
Picrosirius Red

A regulação do metabolismo lipídico através do consumo de fitoterápicos é uma estratégia para reduzir o risco de doenças cardiovasculares. Diante disso, o objetivo do estudo foi avaliar o efeito do óleo de cártamo sobre a resistência à insulina e hipertrofia ventricular esquerda (HVE) em camundongos com ausência de receptor para LDL (LDLr-/-) com diferentes dietas. Os Camundongos LDLr-/- foram divididos em quatro grupos: C: dieta padrão; CCA: dieta padrão e 2mg/kg/dia de óleo de cártamo; HL: dieta hiperlipídica; HLCA: dieta hiperlipídica e 2mg/kg/dia de óleo de cártamo. Após 15 dias de experimento foi quantificado as concentrações séricas de colesterol total e suas frações, triglicerídeos, proteína C reativa, insulina, glicose e calculado o índice de Homa. Lâminas histológicas com tecido cardíaco foram preparadas e coradas com hematoxilina e eosina, para avaliação histológica geral; e coradas com picrosírius red para avaliar da área de depósito de colágeno. Os resultados obtidos demonstraram que o óleo de cártamo preveniu a redução dos níveis séricos do HDL e do aumento dos níveis da PCR, preveniu parcialmente a resistência insulínica e a hiperinsulinemia nos camundongos do grupo HLCA. O uso de óleo de cártamo equilibrou os fatores anti-hipertróficos em relação aos fatores hipertróficos (hiperinsulinemia e processo inflamatório), prevenindo a HVE nos camundongos do grupo HLCA. Em conclusão o óleo de cártamo preveniu o desenvolvimento da HVE e parcialmente a resistência à insulina.

Antioxidant, antimicrobial, anti-inflammatory and anticancer activities of Carthamus tinctorius flowers

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
NK Bouraoui ◽  
S Oueslati ◽  
H Falleh ◽  
F Harbaoui ◽  
R Ksouri ◽  
...  
Keyword(s):  
Carthamus Tinctorius ◽  
Anticancer Activities ◽  
Anti Inflammatory

The polarization colors of picrosirius red-stained collagen in systemic sclerosis.

1991 ◽  
Vol 53 (1) ◽  
pp. 82-85
Author(s):  
Nobuhiro YAMAMOTO ◽  
Mamoru KASADA ◽  
Yoichiro SASAI
Keyword(s):  
Systemic Sclerosis ◽  
Picrosirius Red

Colchicine Induced Polpyloids of Carthamus tinctorius L. 1

Crop Science ◽  
1961 ◽  
Vol 1 (5) ◽  
pp. 342-345 ◽  
Author(s):  
Stanley C. Schank ◽  
P. F. Knowles
Keyword(s):  
Carthamus Tinctorius

scholarly journals Quantitative Determination of the Effects of He-Ne Laser Irradiation on Seed Thermodynamics, Germination Attributes and Metabolites of Safflower (Carthamus tinctorius L.) in Relation with the Activities of Germination Enzymes

Agronomy ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1411
Author(s):  
Rashida Perveen ◽  
Xiukang Wang ◽  
Yasir Jamil ◽  
Qasim Ali ◽  
Shafaqat Ali ◽  
...  
Keyword(s):  
Seed Germination ◽  
Energy Levels ◽  
Soluble Sugars ◽  
Building Blocks ◽  
Carthamus Tinctorius ◽  
Fast Decline ◽  
Seed Irradiation ◽  
Seed Reserves ◽  
Positive Correlations

The present investigation was undertaken to assess the effects of different doses (100, 300, and 500 mJ) of low power He–Ne laser (632.8 nm) irradiation on seed germination and thermodynamics attributes and activities of potential germinating enzymes in relation with changes in seed metabolites. He–Ne laser seed irradiation increased the amylase (Amy), protease (Pro) and glucosidase (Gluco) activities, with a significant improvement in seed thermodynamics and seed germination attributes. A fast increase was found in free fatty acids (FFA), free amino acids (FAA), chlorophyll (Chl), carotenoids (Car), total soluble sugars (TSS) and reducing sugars (RS) in laser treated seeds in parallel with fast decline in seed oil contents and total soluble proteins (TSP). Significant positive correlations were recorded in laser-induced enhanced seed energy levels, germination, activities of germination enzymes with levels of FAA, FFA, Chl, TSS and RS, but a negative correlation with the levels of TSP and oil. In conclusion, the seed treatment with 100 and 300 mJ He–Ne laser was more effective to improve the seed germination potential associated with an improvement in seed energy levels due to increased activities of germination enzymes due to the speedy breakdown of seed reserves to simple metabolites as building blocks.

scholarly journals Combination of histochemical analyses and micro-MRI reveals regional changes of the murine cervix in preparation for labor

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Antara Chatterjee ◽  
Rojan Saghian ◽  
Anna Dorogin ◽  
Lindsay S. Cahill ◽  
John G. Sled ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Diffusion Tensor ◽  
Ex Vivo ◽  
Muscle Cells ◽  
Pregnant Mouse ◽  
Collagen Fibers ◽  
Muscular Layer ◽  
Tissue Organization ◽  
Picrosirius Red

AbstractThe cervix is responsible for maintaining pregnancy, and its timely remodeling is essential for the proper delivery of a baby. Cervical insufficiency, or “weakness”, may lead to preterm birth, which causes infant morbidities and mortalities worldwide. We used a mouse model of pregnancy and term labor, to examine the cervical structure by histology (Masson Trichome and Picrosirius Red staining), immunohistochemistry (Hyaluronic Acid Binding Protein/HABP), and ex-vivo MRI (T2-weighted and diffusion tensor imaging), focusing on two regions of the cervix (i.e., endocervix and ectocervix). Our results show that mouse endocervix has a higher proportion of smooth muscle cells and collagen fibers per area, with more compact tissue structure, than the ectocervix. With advanced gestation, endocervical changes, indicative of impending delivery, are manifested in fewer smooth muscle cells, expansion of the extracellular space, and lower presence of collagen fibers. MRI detected three distinctive zones in pregnant mouse endocervix: (1) inner collagenous layer, (2) middle circular muscular layer, and (3) outer longitudinal muscular layer. Diffusion MRI images detected changes in tissue organization as gestation progressed suggesting the potential application of this technique to non-invasively monitor cervical changes that precede the onset of labor in women at risk for preterm delivery.

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