scholarly journals Plasma Total Homocysteine Level Is Associated with the Pulsatility Index of Cerebral Arteries in Lacunar Infarction

2013 ◽  
Vol 54 (4) ◽  
pp. 819 ◽  
Author(s):  
Se-A An ◽  
Han-Bin Lee ◽  
Yoon Kim ◽  
Jinkwon Kim ◽  
Hyun-Sook Kim ◽  
...  
2014 ◽  
Vol 2014 ◽  
pp. 1-6
Author(s):  
Hui Zhang ◽  
Qi Sun ◽  
Teng Liu ◽  
Lu Ma ◽  
Panpan Zhen ◽  
...  

Hyperhomocysteinemia is strongly associated with cardiovascular diseases. Previous studies have shown that phytoestrogenα-zearalanol can protect cardiovascular system from hyperhomocysteinemia and ameliorate the level of plasma total homocysteine; however, the underlying mechanisms remain to be clarified. The aim of this research is to investigate the possible molecular mechanisms involved in ameliorating the level of plasma homocysteine byα-zearalanol. By the successfully established diet-induced hyperhomocysteinemia rat models, we found that, afterα-zearalanol treatment, the activity of cystathionineβ-synthase, the key enzyme in homocysteine metabolism, was significantly elevated and level of nitrative stress in liver was significantly reduced. In correlation with this, results also showed a decreased nitration level of cystathionineβ-synthase in liver. Together data implied that alleviation of plasma homocysteine level by phytoestrogenα-zearalanol might be related to the reduction of cystathionineβ-synthase nitration.


2013 ◽  
Vol 16 (2) ◽  
pp. 164-170 ◽  
Author(s):  
Mie Shiraishi ◽  
Megumi Haruna ◽  
Masayo Matsuzaki ◽  
Erika Ota ◽  
Ryoko Murayama ◽  
...  

2014 ◽  
Vol 66 (7) ◽  
pp. 1097-1108 ◽  
Author(s):  
Saeed Pirouzpanah ◽  
Forough-Azam Taleban ◽  
Parvin Mehdipour ◽  
Morteza Atri ◽  
Mitra Foroutan-Ghaznavi

2000 ◽  
Vol 132 (9) ◽  
pp. 760
Author(s):  
Jeremy D. Kark ◽  
Joseph H. Abramson ◽  
Irwin H. Rosenberg

2021 ◽  
Vol 13 (2) ◽  
pp. 120-127
Author(s):  
Md Shamim Reza ◽  
AM Asif Rahim ◽  
AHM Bashar ◽  
M Shahidul Islam ◽  
SAN Alam

Background: Homocysteine is increasingly recognized as an independent risk factor for vascular disease specially peripheral arterial occlusive diseases. In the present study, an attempt was made to find out the association between the raised fasting plasma total homocysteine level and early onset atherosclerotic peripheral arterial occlusive diseases (PAOD). Methods: In this prospective observational study a total of 50 study subjects were included. All patients were clinically and angiographically documented for atherosclerotic PAOD. All patients underwent surgical intervention as well as estimation of serum total homocysteine level. Arterial segment was sent for histopathological examination to find out whether atherosclerosis was present or not. Patients were divided into two groups- Group-1 included patients of 20-40 years of age and group-II included those of 41-60 years of age. The groups were compared to see association between elevated level of plasma homocysteine and atherosclerotic peripheral arterial occlusive diseases in elderly as well as in early age. Results: 41 (82%) patients were male and 9 (18%) patients were female. Serum homocysteine level was higher in group I than group II (71.4% vs. 40.9%). Besides, the level of mean serum homocysteine level was significantly (p=0.02) higher in group I than group II (21.18±9.53 vs. 17.24±8.92 μmol/L). Conclusion: In conclusion, this study suggests that serum homocysteine has an association with early onset atherosclerotic PAOD. Therefore, a raised serum homocysteine level can be used as an independent biochemical predictor of early onset atherosclerotic PAOD. Cardiovasc. j. 2021; 13(2): 120-127


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