Cardiac performance in Salmo salar with infectious salmon anaemia (ISA): putative role of nitric oxide

2017 ◽

Vol 2017 ◽

pp. 1-10 ◽

Cited By ~ 53

Author(s):

Konstantinos Mantzarlis ◽

Vasiliki Tsolaki ◽

Epaminondas Zakynthinos

Keyword(s):

Oxidative Stress ◽

Nitric Oxide ◽

Intensive Care ◽

Vitamin C ◽

Causes Of Death ◽

Redox Balance ◽

Cardiac Performance ◽

Efficiency Evaluation ◽

Permeability Impairment

Sepsis is one of the most important causes of death in intensive care units. Despite the fact that sepsis pathogenesis remains obscure, there is increasing evidence that oxidants and antioxidants play a key role. The imbalance of the abovementioned substances in favor of oxidants is called oxidative stress, and it contributes to sepsis process. The most important consequences are vascular permeability impairment, decreased cardiac performance, and mitochondrial malfunction leading to impaired respiration. Nitric oxide is perhaps the most important and well-studied oxidant. Selenium, vitamin C, and 3N-acetylcysteine among others are potential therapies for the restoration of redox balance in sepsis. Results from recent studies are promising, but there is a need for more human studies in a clinical setting for safety and efficiency evaluation.

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Post-challenge hyperglycaemia, nitric oxide production and endothelial dysfunction: The putative role of asymmetric dimethylarginine (ADMA)

Nutrition Metabolism and Cardiovascular Diseases ◽

10.1016/j.numecd.2010.10.003 ◽

2011 ◽

Vol 21 (1) ◽

pp. 1-10 ◽

Cited By ~ 23

Author(s):

M. Siervo ◽

M. Corander ◽

S. Stranges ◽

L. Bluck

Keyword(s):

Nitric Oxide ◽

Endothelial Dysfunction ◽

Asymmetric Dimethylarginine ◽

Nitric Oxide Production ◽

Post Challenge ◽

Oxide Production ◽

Putative Role

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Connective tissue mast cells are the target of formaldehyde to induce tracheal hyperresponsiveness in rats: Putative role of leukotriene B4 and nitric oxide

Toxicology Letters ◽

10.1016/j.toxlet.2009.10.006 ◽

2010 ◽

Vol 192 (2) ◽

pp. 85-90 ◽

Cited By ~ 6

Author(s):

Adriana Lino-dos-Santos-Franco ◽

Mey Kuang Shia ◽

Helori Vanni Domingos ◽

Ana Cristina Breithaupt-Faloppa ◽

Ana Paula Ligeiro de Oliveira ◽

...

Keyword(s):

Nitric Oxide ◽

Mast Cells ◽

Connective Tissue ◽

Leukotriene B4 ◽

Putative Role

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PUTATIVE ROLE OF NITRIC OXIDE IN PLANT-PATHOGEN INTERACTIONS

The Japanese Journal of Pharmacology ◽

10.1016/s0021-5198(19)41763-0 ◽

1997 ◽

Vol 75 ◽

pp. 92

Author(s):

V. Beligni ◽

A. Laxalt ◽

L. Lamattina

Keyword(s):

Nitric Oxide ◽

Plant Pathogen ◽

Putative Role ◽

Plant Pathogen Interactions

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REGULATION OF CARDIAC EXCITATION-CONTRACTION COUPLING: A CELLULAR UPDATE

AJP Advances in Physiology Education ◽

10.1152/advan.00028.2003 ◽

2003 ◽

Vol 27 (4) ◽

pp. 192-200 ◽

Cited By ~ 5

Author(s):

Donna H. Korzick

Keyword(s):

Nitric Oxide ◽

Intracellular Signaling ◽

Cardiac Performance ◽

Functional Responses ◽

Signaling Complex ◽

Ec Coupling ◽

Intracellular Ca ◽

New Ideas ◽

Cardiac Excitation

The primary purpose of this paper is to present a basic overview of some “relatively” new ideas related to the regulation of cardiac performance and underlying excitation-contraction (EC) coupling that have yet to be incorporated to textbooks currently used for introductory graduate-level physiology courses. Within the context of cardiac EC coupling, this review incorporates information on microdomains and local control theory, with particular emphasis on the role of Ca2+ sparks as a key regulatory component of ventricular myocyte contraction dynamics. Recent information pertaining to Ca2+ release mechanisms specific to the sarcoplasmic reticulum is also presented, as well as the idea of the ryanodine receptor as a macromolecular signaling complex. Because of the potential relationship to maladaptive functional responses under conditions of cardiovascular pathology, the regulatory role of cardiac adrenergic and additional G protein-coupled receptors known to regulate cardiac function is included, and fundamental concepts related to intracellular signaling are discussed. Finally, information on the roles of vascular and cardiac nitric oxide as an important regulator of cardiac performance is included to allow students to begin to think about the ubiquitous role of nitric oxide in the regulation of the cardiovascular system. An important point of emphasis is that whole organ cardiac dynamics can be traced back to the cellular events regulating intracellular Ca2+ homeostasis and as such provides an important conceptual framework from which the students can begin to think about whole organ physiology in health and disease.

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