scholarly journals Integration of the Thiol Redox Status with Cytokine Response to Physical Training in Professional Basketball Players

2010 ◽  
pp. 239-245 ◽  
Author(s):  
A Zembron-Lacny ◽  
M Slowinska-Lisowska ◽  
A Ziemba
Keyword(s):  
Reduced Glutathione ◽  
Redox Status ◽  
Cytokine Response ◽  
Basketball Players ◽  
Professional Basketball ◽  
Sport Training ◽  
Preparatory Period ◽  
Thiol Redox ◽  
Factor Α ◽  
Necrosis Factor

The present study was designed to evaluate the plasma markers of reactive oxygen species (ROS) activity and cytokines, and their relationship with thiol redox status of basketball players during training. Sixteen professional players of the Polish Basketball Extraleague participated in the study. The study was performed during the preparatory period and the play-off round. Markers of ROS activity (lipid peroxidation TBARS, protein carbonylation PC) and reduced glutathione (GSH) demonstrated regularity over time, i.e. TBARS, PC and GSH were elevated at the beginning and decreased at the end of training periods. Oxidized glutathione (GSSG) was not affected by exercise training. Thiol redox status (GSHtotal-2GSSG/GSSG) correlated with TBARS and PC in both training periods. The level of interleukin-6 (IL-6) was increased and positively correlated with thiol redox (r=0.423) in the preparatory period, whereas tumor necrosis factor α (TNFα) was increased and inversely correlated with thiol redox (r=-0.509) in the play-off round. The present study showed significant shifts in markers of ROS activity, thiol redox status and inflammatory mediators (IL-6, TNFα) following professional sport training as well as correlation between changes in thiol redox and cytokine response.

scholarly journals The Effectiveness of Glutathione Redox Status as a Possible Tumor Marker in Colorectal Cancer

2021 ◽  
Vol 22 (12) ◽  
pp. 6183
Author(s):  
Delia Acevedo-León ◽  
Lidia Monzó-Beltrán ◽  
Segundo Ángel Gómez-Abril ◽  
Nuria Estañ-Capell ◽  
Natalia Camarasa-Lillo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Redox State ◽  
Reduced Glutathione ◽  
Redox Status ◽  
Oxidation Products ◽  
Interventional Study ◽  
Thiol Redox State ◽  
Thiol Redox ◽  
Glutathione Redox

The role of oxidative stress (OS) in cancer is a matter of great interest due to the implication of reactive oxygen species (ROS) and their oxidation products in the initiation of tumorigenesis, its progression, and metastatic dissemination. Great efforts have been made to identify the mechanisms of ROS-induced carcinogenesis; however, the validation of OS byproducts as potential tumor markers (TMs) remains to be established. This interventional study included a total of 80 colorectal cancer (CRC) patients and 60 controls. By measuring reduced glutathione (GSH), its oxidized form (GSSG), and the glutathione redox state in terms of the GSSG/GSH ratio in the serum of CRC patients, we identified significant changes as compared to healthy subjects. These findings are compatible with the effectiveness of glutathione as a TM. The thiol redox state showed a significant increase towards oxidation in the CRC group and correlated significantly with both the tumor state and the clinical evolution. The sensitivity and specificity of serum glutathione levels are far above those of the classical TMs CEA and CA19.9. We conclude that the GSSG/GSH ratio is a simple assay which could be validated as a novel clinical TM for the diagnosis and monitoring of CRC.

Influence of “Sneznik-1/79” Mineral Water on Anthropometric, Functional and Biochemical Parameters of Professional Basketball Players: Role of Oxidative Stress

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Dijana Lalovic ◽  
Aleksandra Vranic ◽  
Jovana Jeremic ◽  
Dejan Stanojevic ◽  
Bolevich Sergey ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Drinking Water ◽  
Biochemical Parameters ◽  
Mineral Water ◽  
Redox Status ◽  
Fluid Replacement ◽  
Electrolyte Balance ◽  
Basketball Players ◽  
Professional Basketball ◽  
Adequate Hydration

AbstractAdequate hydration represents the balance between the water intake and loss and has an unambiguous significance for public health and it is essential to sustain life. The changes in electrolyte balance which occur during and after training affect on athletes health and performance. Therefore, fluid replacement with adequate mineral composition is of utmost importance. The aim of the present study was to examine the influence of low mineral water from the well Sneznik-1/79 on anthropometric, functional, biochemical parameters and redox status of professional basketball players. In total, 17 male basketball players were included, during the pre-competitive mesocycle, and after the initial testing, they were randomly divided into two groups: group 1 – consumed the commercial drinking water for four weeks (n = 7), and group 2 – consumed water from the well Sneznik-1/79 for four weeks (n = 10).Determination of the anthropometric, functional, biochemical parameters and redox status was performed. Our results pointed out that consumption of mineral water from the well Sneznik is completely safe from the aspect of affecting various anthropometric, functional and biochemical parameters as well as systemic oxidative stress of professional athletes. In addition, existence of discretely better effects over commercial drinking water indicates that a long period of monitoring may certainly be of interest for further investigation.

scholarly journals Features of disorders of the system of cytokines and lipid peroxidation in acute ulcerative gastroduodenal hemorrhages

2017 ◽  
Vol 98 (5) ◽  
pp. 686-691 ◽  
Author(s):  
D N Gadzhiev ◽  
V A Allakhverdiev ◽  
N D Gadzhiev
Keyword(s):  
Lipid Peroxidation ◽  
Interleukin 6 ◽  
Antioxidant Defense ◽  
Reduced Glutathione ◽  
Malonic Dialdehyde ◽  
Interferon Γ ◽  
Diene Conjugates ◽  
Control Value ◽  
Factor Α ◽  
Necrosis Factor

Aim. Investigation of the local and systemic levels of some pro- and anti-inflammatory cytokines as well as the system of lipid peroxidation - antioxidant defense of the organism in acute ulcerative gastroduodenal hemorrhages, taking into account the severity of the blood loss. Methods. We performed the investigation of cytokines in the blood (tumor necrosis factor α, interferon γ, interleukin-1, -2, -4, -6, -8, -10) and parameters of lipoperoxidation (in plasma - diene conjugates, malonic dialdehyde, catalase; in erythrocytes - reduced glutathione, glutathione peroxidase, total antioxidant activity), interleukin-6 in gastric content and urine, diene conjugates and malonic dialdehyde in biopsy samples from the ulcer edges from patients with acute ulcerative gastroduodenal bleeding. The blood serum of 156 patients with mild (54), moderate (51) and severe (51) bleeding was studied. Interleukin-6 in gastric contents was determined in 37 patients, diene conjugates and malonic dialdehyde in biopsy samples taken from periulcerous zone - in 20 patients. Results. Patients had a statistically significant increase of serum levels of tumor necrosis factor α, interferon γ, interleukins-1, -2, -4, -6, -8, and decrease of interleukin-10 concentration in comparison with the control group. The level of interleukin-6 in gastric juice was 37.5% lower, and in urine - 8.2 times higher than the control value. In plasma and biopsy samples, the content of diene conjugates and malonic dialdehyde was statistically significantly higher, in erythrocytes the level of reduced glutathione was lower than the control value. The depth of imbalance in the system of cytokines and lipid peroxidation - antioxidant defense increased with increasing of blood loss severity. Conclusion. The relationship between cytokine production and lipid peroxidation indices is established, which confirms the role of local and systemic disorders of cytokine and antioxidant status in the occurrence of ulcer bleeding.

Icariin Ameliorates Metabolic Syndrome-Induced Benign Prostatic Hyperplasia in Rats

2021 ◽  
Author(s):  
Abeer A. Aljehani ◽  
Nawal A. Albadr ◽  
Mohammed Z. Nasrullah ◽  
Thikryat Neamatallah ◽  
Basma G Eid ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Benign Prostatic Hyperplasia ◽  
Reduced Glutathione ◽  
Adenosine Monophosphate ◽  
Prostatic Hyperplasia ◽  
High Fructose ◽  
Tnf Α ◽  
Factor Α ◽  
Amp Activated Protein Kinase ◽  
Necrosis Factor

Abstract Metabolic syndrome (MetS) is an immense health issue that causes serious complications in aging males with MetS. Icariin (ICA) is a flavonol glycoside that exerts a plethora of pharmacological effects. The present investigation tested the potential of ICA to ameliorate benign prostatic hyperplasia (BPH) induced by MetS in rats. Animals were allocated to 5 groups in which the first and second groups were kept on water and regular food pellets. MetS was induced in the third, fourth and fifth groups by keeping the animals on high fructose and salt diets for twelve consecutive weeks. These groups were given vehicle, ICA (25 mg/kg) and ICA (50 mg/kg) respectively. MetS was confirmed by the apparent increase in rats’ weight, accumulation of visceral fat, insulin resistance and dyslipidemia. This was accompanied by signs of BPH including increased prostate weight, prostate index and histopathological alterations. Treating the animals with both doses of ICA significantly ameliorated the raise in weight and index of the prostate as well as prostate histopathology. In addition, ICA significantly decreased cyclin D1 expression, up-regulated Bax and down-regulated Bcl2 mRNA expression. ICA prevented lipid peroxidation, reduced glutathione (GSH) depletion and catalase (CAT) exhaustion, which further lowered inflammatory markers of the prostate such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Moreover, ICA prevented the decrease in prostate content of phosphorylated 5ʹ-adenosine monophosphate (AMP)-activated protein kinase (pAMPK). In conclusion, ICA protects against MetS-induced BPH. This is due to its antiproliferative, proapoptotic, antioxidant and anti-inflammatory activities as well as the activation of AMPK.

scholarly journals Pro-Oxidative Processes and Cytokine Response to Training in Professional Basketball Players

2008 ◽  
Vol 20 (1) ◽  
Author(s):  
Agnieszka Zembroń-Łacny ◽  
Małgorzata Slowińska-Lisowska ◽  
Edward Superlak
Keyword(s):  
Cytokine Response ◽  
Basketball Players ◽  
Professional Basketball ◽  
Oxidative Processes

scholarly journals Nimesulide Inhibits MAPK/COX-2 Pathway, and Prevents Oxidative Stress, Inflammation, and Apoptosis in Testes of Cisplatin-Challenged Rats

2020 ◽  
pp. 35-43
Author(s):  
Amr A. Fouad ◽  
Hanaa M. Khalaf ◽  
Usama I. Akl ◽  
Manal I. Abdelghany
Keyword(s):  
Oxidative Stress ◽  
Caspase 3 ◽  
Reduced Glutathione ◽  
Serum Testosterone ◽  
Nuclear Factor Κb ◽  
Mitogen Activated Protein ◽  
Cox 2 ◽  
Factor Α ◽  
Testicular Injury ◽  
Necrosis Factor

The potential testicular protective effect of nimesulide (NSE) was studied in cisplatin (CSP)-challenged rats. NSE therapy (10 mg/kg/day, p.o.) was applied for 15 days, and a single dose of CSP (7 mg/kg, i.p.) was administered on the 10th day. CSP significantly decreased the levels of serum testosterone, testicular reduced glutathione, and superoxide dismutase. CSP also significantly increased testicular malondialdehyde, nitric oxide, tumor necrosis factor-α, interleukin-1β, cyclooxygenase-2 (COX-2), prostaglandin E2, nuclear factor-κB p65, Bax, and caspase-3. NSE significantly ameliorated all the biochemical changes observed in CSP-challenged rats. Moreover, NSE significantly reduced the histopathological injury, and the expressions of phosphorylated c-Jun N-terminal kinase (p-JNK) and p38 mitogen-activated protein kinases (MAPKs) in testes of rats received CSP. It was concluded that NSE significantly blocked the CSP-induced acute testicular injury in rats through inhibition of MAPK/COX-2 signaling pathway, and by combating oxidative stress, inflammation, and apoptosis.

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