scholarly journals Mechanisms of Survival and Resistance of Arthropods to Drought in Marine and Stream Habitats and Possible use of its Survival Mechanism for Human

2021 ◽  
Vol 2 (4) ◽  
Author(s):  
Hassan Vatandoost
Keyword(s):  
Survival Mechanism

Role of autophagy as trophoblast survival mechanism in preeclampsia

Placenta ◽  
2017 ◽  
Vol 57 ◽  
pp. 278-279
Author(s):  
Martina Hutabarat ◽  
Noroyono Wibowo ◽  
Berthold Huppertz
Keyword(s):  
Survival Mechanism

scholarly journals A Sacrifice-for-Survival Mechanism Protects Root Stem Cell Niche from Chilling Stress

Cell ◽  
2017 ◽  
Vol 170 (1) ◽  
pp. 102-113.e14 ◽  
Author(s):  
Jing Han Hong ◽  
Maria Savina ◽  
Jing Du ◽  
Ajay Devendran ◽  
Karthikbabu Kannivadi Ramakanth ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Niche ◽  
Chilling Stress ◽  
Survival Mechanism ◽  
Root Stem Cell ◽  
Cell Niche

scholarly journals Upregulated Autophagy in Calcific Aortic Valve Stenosis Confers Protection of Valvular Interstitial Cells

2019 ◽  
Vol 20 (6) ◽  
pp. 1486 ◽  
Author(s):  
Miguel Carracedo ◽  
Oscar Persson ◽  
Peter Saliba-Gustafsson ◽  
Gonzalo Artiach ◽  
Ewa Ehrenborg ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Stenosis ◽  
Interstitial Cells ◽  
Left Ventricular ◽  
Autophagic Flux ◽  
Valvular Interstitial Cells ◽  
Survival Mechanism ◽  
Calcified Tissue ◽  
Left Ventricular Outflow

Autophagy serves as a cell survival mechanism which becomes dysregulated under pathological conditions and aging. Aortic valve thickening and calcification causing left ventricular outflow obstruction is known as calcific aortic valve stenosis (CAVS). CAVS is a chronic and progressive disease which increases in incidence and severity with age. Currently, no medical treatment exists for CAVS, and the role of autophagy in the disease remains largely unexplored. To further understand the role of autophagy in the progression of CAVS, we analyzed expression of key autophagy genes in healthy, thickened, and calcified valve tissue from 55 patients, and compared them with nine patients without significant CAVS, undergoing surgery for aortic regurgitation (AR). This revealed a upregulation in autophagy exclusively in the calcified tissue of CAVS patients. This difference in autophagy between CAVS and AR was explored by LC3 lipidation in valvular interstitial cells (VICs), revealing an upregulation in autophagic flux in CAVS patients. Inhibition of autophagy by bafilomycin-A1 led to a decrease in VIC survival. Finally, treatment of VICs with high phosphate led to an increase in autophagic activity. In conclusion, our data suggests that autophagy is upregulated in the calcified tissue of CAVS, serving as a compensatory and pro-survival mechanism.

scholarly journals Die dialoog tussen die voorblad, die manneplot en die verhale in Dulle Griet van Riana Scheepers

Literator ◽  
2001 ◽  
Vol 22 (2) ◽  
pp. 113-132
Author(s):  
G.H. Taljaard
Keyword(s):  
Short Stories ◽  
Female Character ◽  
Female Characters ◽  
Survival Mechanism ◽  
Male Attitudes ◽  
The Way

The dialogue between image and text in Riana Scheepers's Dulle Griet This article examines the way in which the content and theme of Riana Scheepers’s Dulle Griet (1991) interact with the “manneplot” (traditional and/or stereotypical portrayal of female characters within novels) and with the cover illustration of the book – a detail of “Mad Meg” (as she is often referred to) from Pieter Brueghel’s Dulle Griet (1562). It explores how the women in Scheepers’s short stories are portrayed – not only as vulnerable, but also as evil and corrupt. They are abused victims; but they are also tyrannical abusers. They are innocent maidens and mothers, but also lovers, prostitutes, lesbians and murderers. The way in which the gradual degeneration of the anonymous central female character relates to Brueghel’s image of “Mad Meg” on her way to the jaws of hell is discussed in this article. But the article also demontrates Scheepers’s concern with feminist issues by using the cover as an ironic “frame”, and shows that the moral decline of the women portrayed in the text seems to be as a result of the actions of chauvinistic men, who appear in different forms throughout the text. Female degeneracy can thus be seen as a survival mechanism, in a world – and a text – dominated by the masculine paradigm, the “manneplot” of traditional male attitudes to women.

The feasibility and survival mechanism of a large free flap supported by a novel hybrid perfusion mode

Oral Oncology ◽  
2020 ◽  
Vol 101 ◽  
pp. 104506 ◽  
Author(s):  
Xiaobin Luo ◽  
Junling Liu ◽  
Hongyu Chen ◽  
Baolong Li ◽  
Zeyuan Jin ◽  
...  
Keyword(s):  
Free Flap ◽  
Survival Mechanism ◽  
Perfusion Mode

scholarly journals Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?

2015 ◽  
Vol 40 (11) ◽  
pp. 701-714 ◽  
Author(s):  
Agnel Sfeir ◽  
Lorraine S. Symington
Keyword(s):  
End Joining ◽  
Survival Mechanism

scholarly journals Intracellular Inactivation of Thyroid Hormone Is a Survival Mechanism for Muscle Stem Cell Proliferation and Lineage Progression

2014 ◽  
Vol 20 (6) ◽  
pp. 1038-1048 ◽  
Author(s):  
Monica Dentice ◽  
Raffaele Ambrosio ◽  
Valentina Damiano ◽  
Annarita Sibilio ◽  
Cristina Luongo ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Thyroid Hormone ◽  
Muscle Stem Cell ◽  
Stem Cell Proliferation ◽  
Survival Mechanism

Cyclic Hybridization as a Survival Mechanism in the New Zealand Forest Flora

Evolution ◽  
1962 ◽  
Vol 16 (3) ◽  
pp. 348 ◽  
Author(s):  
J. A. Rattenbury
Keyword(s):  
New Zealand ◽  
Forest Flora ◽  
Survival Mechanism

Life, death and burial: multifaceted impact of autophagy

2008 ◽  
Vol 36 (5) ◽  
pp. 786-790 ◽  
Author(s):  
Lorenzo Galluzzi ◽  
Eugenia Morselli ◽  
José Miguel Vicencio ◽  
Oliver Kepp ◽  
Nicholas Joza ◽  
...  
Keyword(s):  
Cell Death ◽  
Normal Development ◽  
Whole Body ◽  
Causative Role ◽  
Type Ii ◽  
Survival Mechanism ◽  
Metabolic Substrates ◽  
Type Ii Cell ◽  
Intracellular Organelles ◽  
Massive Accumulation

Macroautophagy, often referred to as autophagy, designates the process by which portions of the cytoplasm, intracellular organelles and long-lived proteins are engulfed in double-membraned vacuoles (autophagosomes) and sent for lysosomal degradation. Basal levels of autophagy contribute to the maintenance of intracellular homoeostasis by ensuring the turnover of supernumerary, aged and/or damaged components. Under conditions of starvation, the autophagic pathway operates to supply cells with metabolic substrates, and hence represents an important pro-survival mechanism. Moreover, autophagy is required for normal development and for the protective response to intracellular pathogens. Conversely, uncontrolled autophagy is associated with a particular type of cell death (termed autophagic, or type II) that is characterized by the massive accumulation of autophagosomes. Regulators of apoptosis (e.g. Bcl-2 family members) also modulate autophagy, suggesting an intimate cross-talk between these two degradative pathways. It is still unclear whether autophagic vacuolization has a causative role in cell death or whether it represents the ultimate attempt of cells to cope with lethal stress. For a multicellular organism, autophagic cell death might well represent a pro-survival mechanism, by providing metabolic supplies during whole-body nutrient deprivation. Alternatively, type II cell death might contribute to the disposal of cell corpses when heterophagy is deficient. Here, we briefly review the roles of autophagy in cell death and its avoidance.

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