scholarly journals Differential Diagnostics of Vertebrogenic and Nonvertebrogenic Vascular Pathologies

Biomeditsina ◽  
2020 ◽  
pp. 47-59
Author(s):  
N. N. Karkischenko ◽  
A. A. Nikolaev ◽  
Yu. A. Chudina ◽  
D. B. Chaivanov ◽  
A. A. Vartanov
Keyword(s):  
Spinal Cord ◽  
Nervous System ◽  
Cervical Spine ◽  
Autonomic Nervous System ◽  
Vertebral Artery ◽  
Cardiovascular System ◽  
Blood Vessels ◽  
Vascular Diseases ◽  
Differential Diagnostics ◽  
The Brain

This article investigates consistency in the work of the heart and blood vessels in vascular diseases of a vertebrogenic and non-vertebrogenic nature, which are characterized by disorders of the cardiovascular system leading to an insuffi cient blood supply to the spinal cord and the brain. Vertebrogenic vascular pathologies were studied by the example of vertebral artery disorders in osteochondrosis of the cervical spine, while non-vertebrogenic pathologies were considered in the syndrome of somatoform dysfunction of the autonomic nervous system. It is shown that, compared to the norm, the degree of consistence in the work of the heart and blood vessels is lower in vertebrogenic and non-vertebrogenic vascular pathologies.

Mechanisms by which ganglioplegics and atropine enhance cardiovascular responsiveness

1963 ◽  
Vol 205 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Irvine H. Page ◽  
J. W. McCubbin
Keyword(s):  
Spinal Cord ◽  
Nervous System ◽  
Cardiovascular System ◽  
Blood Vessels ◽  
Direct Effect ◽  
Hind Limb ◽  
Single Experiment ◽  
System Responsiveness ◽  
Expected Increase

At least four mechanisms contribute to the increased responsiveness to pressor drugs caused by ganglioplegic agents: 1) Elimination of parasympathetic reflexes alone was found to have a prominent effect on pressor responsiveness, especially to norepinephrine. 2) Elimination of sympathetic compensatory reflexes caused the expected increase in responsiveness. 3) Tetraethylammonium had a direct effect on blood vessels of the dog's perfused hind limb that resulted in sensitization to norepinephrine, though not to angiotensin; this direct effect of the ganglioplegic was similar to that produced by surgical denervation. 4) Tetraethylammonium caused enhancement of response to epinephrine but not to norepinephrine in pithed cats and this effect seems best explained by a blocking action of the ganglioplegic on adrenergic vasodilator receptors. Because of the participation of these different mechanisms, ganglioplegics and surgical denervation do not necessarily affect pressor responsiveness in the same manner. Additionally, the different mechanisms involved account for the various degrees of augmentation of response to different pressor drugs since the latter have their major actions on different portions of the cardiovascular system. Responsiveness may vary greatly during a single experiment and also from day to day; this variability is due in large part to the nervous system since it is abolished by cervical section of the spinal cord.

scholarly journals Modification of Choline Derivatives and the Study of their Pharmacological Activity

2020 ◽  
Vol 11 (03) ◽  
pp. 361-372
Author(s):  
Zinah A. Al-shareeda ◽  
R. A. Abramovich ◽  
O. G. Potanina ◽  
Hassan M. Alhejoj
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Blood Vessels ◽  
Pharmacological Activity ◽  
Parasympathetic Nervous System ◽  
Smooth Muscles ◽  
The Past ◽  
Rapid Hydrolysis ◽  
The Brain ◽  
Body Secretion

Organicmoleculeshavebiologicalactivityforavarietyofstructuralfeatures,someactivitiesareassociatedwiththestructural basis of a known molecule, and others are associated with the type and orientation of additive modifications. However, acetylcholine (ACh) is the main neurotransmitter of the parasympathetic nervous system, the part of the autonomic nervous system that contracts smooth muscles, dilates blood vessels, increases body secretion, and slows the heartrate. Inthecentralnervoussystem,AChhasseveralrulesanditplaysanimportantroleinmemoryandlearning,aswellas,inthe abnormal deficiency of ACh in the brain in people with Alzheimer’s disease. In the past, it has been attempted to use ACh chlorideascholinergicstimulants,but,unfortunately,ithasbeenfoundthatitdoesnothavealastingeffectbecauseofitstoo short action duration due to its rapid hydrolysis by acetylcholinesterase (AChE) enzymes and the lack ofspecificity.

scholarly journals MORPHOLOGY AND FUNCTION OF THE AUTONOMOUS NERVOUS SYSTEM

2020 ◽  
Vol 20 (1) ◽  
pp. 212-217
Author(s):  
A.P. Stepanchuk
Keyword(s):  
Spinal Cord ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Abdominal Cavity ◽  
Nerve Cells ◽  
Autonomous Nervous System ◽  
Autonomic Nervous ◽  
Lumbar Spinal ◽  
The Brain ◽  
Lateral Nuclei

The autonomic nervous system consists of the sympathetic and parasympathetic divisions. The central part is represented by supra-segmental and segmental centres. Parasympathetic segmental centres in the brain are accessory nucleus of the oculomotor nerves, superior salivary nucleus of the facial nerve, inferior salivary nucleus of the glossopharyngeal nerve and dorsal nucleus of the vagus nerve. In the spinal cord, these are the intermediate lateral nuclei. Sympathetic segmental centres in the brain are absent, and in the spinal cord, intermediate-lateral nuclei are located in the lateral horns in the eighth cervical, all thoracic and 1-2 lumbar spinal segments. The peripheral part of the autonomic nervous system is represented by pre-nodal and post-nodal branches, paravertebral, prevertebral and terminal nodes and plexuses. The intramural part of the autonomic nervous system lies in the larger part of a wide and narrow-loop net and represented with a large number of nerve cells different by their shapes and sizes and clustered as intramural nodes, or individual nerve cells included along the net loops. The autonomic plexuses of the abdominal cavity are topographically divided into celiac, superior and inferior mesenteric, abdominal aortic, mesenteric, superior and inferior hypogastric region.

‘Neurologie: the doctrine of the nerves’

2021 ◽  
pp. 614-662
Author(s):  
Alastair Compston
Keyword(s):  
Spinal Cord ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Cranial Nerves ◽  
De Anima ◽  
Autonomic Nervous ◽  
Reflex Movement ◽  
Cerebral Localization ◽  
Brain And Spinal Cord ◽  
The Brain

Chapter 16: ‘Neurologie: the doctrine of the nerves: the brain and nervous stock’ summarizes Willis’s treatises in Cerebri anatome, Nervorumque descriptio et usus (1664), De motu musculari (1670) and De anima brutorum (1672). Willis’s coinage of the term ‘neurologie’, intending this as the doctrine of the nerves based on the anatomy of the cranial nerves rather than the study of diseases affecting the brain and nervous stock, is described. The chapter explains why these treatises are additionally important for assigning function to the cerebrum and cerebellum rather than the ventricles; the concept of cerebral localization; the distinction between voluntary and involuntary, or reflex, movement; Willis’s account of the autonomic nervous system; and his ideas on muscular movement. Apart from these innovative contributions, Willis’s description of the arrangement of blood vessels supplying the brain and spinal cord, for which the book is celebrated, is described. The fifteen engraved plates are included. {148 words}

Central Nerve System Impairment, AMA Guides, Sixth Edition: An Overview

2018 ◽  
Vol 23 (1) ◽  
pp. 10-13
Author(s):  
James B. Talmage ◽  
Jay Blaisdell
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Neurological Impairment ◽  
Sixth Edition ◽  
Central Nerve System ◽  
The Central Nervous System ◽  
The One ◽  
Nerve System ◽  
The Brain

Abstract Injuries that affect the central nervous system (CNS) can be catastrophic because they involve the brain or spinal cord, and determining the underlying clinical cause of impairment is essential in using the AMA Guides to the Evaluation of Permanent Impairment (AMA Guides), in part because the AMA Guides addresses neurological impairment in several chapters. Unlike the musculoskeletal chapters, Chapter 13, The Central and Peripheral Nervous System, does not use grades, grade modifiers, and a net adjustment formula; rather the chapter uses an approach that is similar to that in prior editions of the AMA Guides. The following steps can be used to perform a CNS rating: 1) evaluate all four major categories of cerebral impairment, and choose the one that is most severe; 2) rate the single most severe cerebral impairment of the four major categories; 3) rate all other impairments that are due to neurogenic problems; and 4) combine the rating of the single most severe category of cerebral impairment with the ratings of all other impairments. Because some neurological dysfunctions are rated elsewhere in the AMA Guides, Sixth Edition, the evaluator may consult Table 13-1 to verify the appropriate chapter to use.

ASSESSMENT OF PHYSIOLOGICAL PARAMETERS OF THE TRIGEMINAL AND COCHLEOVESTIBULAR SYSTEMS IN TEMPOROMANDIBULAR JOINT PAIN DYSFUNCTION

2020 ◽  
Vol 17 (2) ◽  
pp. 110-120
Author(s):  
N.D. Sorokina ◽  
◽  
L.R. Shahalieva ◽  
S.S. Pertsov ◽  
L.V. Polma ◽  
...  
Keyword(s):  
Nervous System ◽  
Evoked Potentials ◽  
Temporomandibular Joint ◽  
Differential Diagnostics ◽  
Autonomous Nervous System ◽  
Dental Diseases ◽  
Grade Ii ◽  
The Right ◽  
Distal Occlusion ◽  
The Brain

One of the most common causes of chronic pain in the facial region, including in the trigeminal nerve link, which is not associated with dental diseases, is pain dysfunction of the temporomandibular joint. At the same time, there is evidence in the literature that there are relationships between pain dysfunction of the temporomandibular joint, abnormal occlusion, cervical-muscular tonic phenomena, postural disorders, dysfunction of the Autonomous nervous system and cochleovestibular manifestations. At the same time, neurophysiological indicators of functional disorders in the maxillofacial region and intersystem interactions in pain dysfunction of the temporomandibular joint are insufficiently studied.Goal. The aim of the work is to evaluate the neurophysiological features of trigeminal afferentation in terms of trigeminal somatosensory evoked potentials (TSWP) and the auditory conducting system of the brain in terms of acoustic stem evoked potentials (ASVP) in distal occlusion of the dentition with pain dysfunction of the temporomandibular joint (TMJ) in comparison with physiological occlusion in students 18-21 years old. Material and methods. The main study included 41 students with distal occlusion (21 girls and 20 boys), (grade II Engl, symmetrically right and left in 14 people, and grade II Engl on the left and grade I on the right in 12 people, grade I on the left and grade II on the right in 15 people). All respondents with distal occlusion and who were practically healthy signed an informed consent to participate in the study. We used complex orthodontic methods of examination, subjective degree of severity and intensity of pain in the TMJ, assessment of the Autonomous nervous system (samples and tests), and neurophysiological methods for assessing TSVP and ASVP. Results. Significant differences in ASEP parameters were found in the group of respondents with distal occlusion in the form of a decrease in the latency period of peak I, III, and V compared to physiological occlusion, that correlated with the subjective assessment (in points) of cochleovestibular disorders. According to the TSVP study, a decrease in the duration of latent periods was found, which indicates an increased excitability of non-specific brain stem structures at the medullo-ponto-mesencephalic level compared to the control group. Conclusions. The results obtained are supposed to be used for differential diagnostics, including such dental diseases as TMJ pain dysfunction, occlusion abnormalities accompanied by pain syndrome. Additional functional diagnostics of multi-modal VP of the brain (acoustic evoked potentials, trigeminal evoked potentials) can be performed in conjunction with indicators of autonomic nervous system dysfunction, with parameters of severity of clinical symptoms of cochleovestibular disorders, musculoskeletal dysfunction the maxillofacial area, with indicators of pain, which will determine the tactics and effectiveness of subsequent treatment.

scholarly journals Bladder and bowel responses to lumbosacral epidural stimulation in uninjured and transected anesthetized rats

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Robert F. Hoey ◽  
Daniel Medina-Aguiñaga ◽  
Fahmi Khalifa ◽  
Beatrice Ugiliweneza ◽  
Sharon Zdunowski ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Surface Area ◽  
Electrode Array ◽  
Frequency Dependent ◽  
Epidural Stimulation ◽  
Sphincter Electromyography ◽  
Neurologic Disorders ◽  
Movement Threshold

AbstractSpinal cord epidural stimulation (scES) mapping at L5-S1 was performed to identify parameters for bladder and bowel inhibition and/or contraction. Using spinally intact and chronic transected rats of both sexes in acute urethane-anesthetized terminal preparations, scES was systematically applied using a modified Specify 5–6–5 (Medtronic) electrode during bladder filling/emptying cycles while recording bladder and colorectal pressures and external urethral and anal sphincter electromyography activity. The results indicate frequency-dependent effects on void volume, micturition, bowel peristalsis, and sphincter activity just above visualized movement threshold intensities that differed depending upon neurological intactness, with some sex-dependent differences. Thereafter, a custom-designed miniature 15-electrode array designed for greater selectivity was tested and exhibited the same frequency-dependent urinary effects over a much smaller surface area without any concurrent movements. Thus, select activation of autonomic nervous system circuitries with scES is a promising neuromodulation approach for expedient translation to individuals with SCI and potentially other neurologic disorders.

Some Points in the Histology of Lymphogenous and Hæmatogenous Toxic Lesions of the Spinal Cord

1908 ◽  
Vol 54 (226) ◽  
pp. 560-561
Author(s):  
David Orr ◽  
R. G. Rows
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Sciatic Nerve ◽  
Morphological Type ◽  
Broth Culture ◽  
Anatomical Distribution ◽  
Tabes Dorsalis ◽  
The Central Nervous System ◽  
The Brain

At a quarterly meeting of this Association held last year at Nottingham, we showed the results of our experiments with toxins upon the spinal cord and brain of rabbits. Our main conclusion was, that the central nervous system could be infected by toxins passing up along the lymph channels of the perineural sheath. The method we employed in our experiments consisted in placing a celloidin capsule filled with a broth culture of an organism under the sciatic nerve or under the skin of the cheek; and we invariably found a resulting degeneration in the spinal cord or brain, according to the situation of the capsule. These lesions we found to be identical in morphological type and anatomical distribution with those found in the cord of early tabes dorsalis and in the brain and cord of general paralysis of the insane. The conclusion suggested by our work was that these two diseases, if toxic, were most probably infections of lymphogenous origin.

Vital staining of cells of the brain vegetative centers

1926 ◽  
Vol 22 (5-6) ◽  
pp. 730-731
Author(s):  
G. P.
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Vital Staining ◽  
Frozen Sections ◽  
Autonomic Nervous ◽  
The Brain ◽  
Dark Blue

V. Rakhmanov (Zhurn. Neurop. And Psych., 1925, No. 3-4) proposes to inject them with 1% Trypanblau solution in the amount of 1 cubic meter to study the vegetative centers in mice. with. weekly for 6-8 weeks. The brain is fixed in 10% formalin, frozen sections are stained with alum carmine or cochineal. In this case, dark blue dust-like grains appear in the plasma and nuclei of cells - selectively for the cells of the autonomic nervous system.

Ten Million and One—Neurological Disability as a National Problem

PEDIATRICS ◽  
1958 ◽  
Vol 21 (5) ◽  
pp. 871-872
Author(s):  
ERIC DENHOFF
Keyword(s):  
Spinal Cord ◽  
New York ◽  
Nervous System ◽  
Highly Qualified ◽  
Neurological Disability ◽  
The Brain

This monograph summarizes the results of the Conference on Neurological Disability as a National Problem held at Arden House, Harriman, New York, in December, 1955. It was attended by more than 50 highly qualified specialists with various interests in the field who met to explore the realistic possibilities of meeting the problems posed by more than 10 million patients suffering from more than 300 clinical entities loosely grouped together as "neurologic disabilities." Neurologic disabilities are defined as those disorders which are associated demonstrably with dysfunction, disease, or injury of the nervous system, the brain, the spinal cord, and the peripheral neuromuscular connections.

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