ASSESSMENT OF PHYSIOLOGICAL PARAMETERS OF THE TRIGEMINAL AND COCHLEOVESTIBULAR SYSTEMS IN TEMPOROMANDIBULAR JOINT PAIN DYSFUNCTION

2020 ◽  
Vol 17 (2) ◽  
pp. 110-120
Author(s):  
N.D. Sorokina ◽  
◽  
L.R. Shahalieva ◽  
S.S. Pertsov ◽  
L.V. Polma ◽  
...  
Keyword(s):  
Nervous System ◽  
Evoked Potentials ◽  
Temporomandibular Joint ◽  
Differential Diagnostics ◽  
Autonomous Nervous System ◽  
Dental Diseases ◽  
Grade Ii ◽  
The Right ◽  
Distal Occlusion ◽  
The Brain

One of the most common causes of chronic pain in the facial region, including in the trigeminal nerve link, which is not associated with dental diseases, is pain dysfunction of the temporomandibular joint. At the same time, there is evidence in the literature that there are relationships between pain dysfunction of the temporomandibular joint, abnormal occlusion, cervical-muscular tonic phenomena, postural disorders, dysfunction of the Autonomous nervous system and cochleovestibular manifestations. At the same time, neurophysiological indicators of functional disorders in the maxillofacial region and intersystem interactions in pain dysfunction of the temporomandibular joint are insufficiently studied.Goal. The aim of the work is to evaluate the neurophysiological features of trigeminal afferentation in terms of trigeminal somatosensory evoked potentials (TSWP) and the auditory conducting system of the brain in terms of acoustic stem evoked potentials (ASVP) in distal occlusion of the dentition with pain dysfunction of the temporomandibular joint (TMJ) in comparison with physiological occlusion in students 18-21 years old. Material and methods. The main study included 41 students with distal occlusion (21 girls and 20 boys), (grade II Engl, symmetrically right and left in 14 people, and grade II Engl on the left and grade I on the right in 12 people, grade I on the left and grade II on the right in 15 people). All respondents with distal occlusion and who were practically healthy signed an informed consent to participate in the study. We used complex orthodontic methods of examination, subjective degree of severity and intensity of pain in the TMJ, assessment of the Autonomous nervous system (samples and tests), and neurophysiological methods for assessing TSVP and ASVP. Results. Significant differences in ASEP parameters were found in the group of respondents with distal occlusion in the form of a decrease in the latency period of peak I, III, and V compared to physiological occlusion, that correlated with the subjective assessment (in points) of cochleovestibular disorders. According to the TSVP study, a decrease in the duration of latent periods was found, which indicates an increased excitability of non-specific brain stem structures at the medullo-ponto-mesencephalic level compared to the control group. Conclusions. The results obtained are supposed to be used for differential diagnostics, including such dental diseases as TMJ pain dysfunction, occlusion abnormalities accompanied by pain syndrome. Additional functional diagnostics of multi-modal VP of the brain (acoustic evoked potentials, trigeminal evoked potentials) can be performed in conjunction with indicators of autonomic nervous system dysfunction, with parameters of severity of clinical symptoms of cochleovestibular disorders, musculoskeletal dysfunction the maxillofacial area, with indicators of pain, which will determine the tactics and effectiveness of subsequent treatment.

The significance of the detection of oxidative and reducing tissue enzymes for questions of localization in the brain

1927 ◽  
Vol 23 (6-7) ◽  
pp. 613-621
Author(s):  
М. Bielschowsky ◽  
М. Rose
Keyword(s):  
Nervous System ◽  
The Right ◽  
The Brain

Histology of the nervous system is served, for the purpose of research, almost exclusively by stained slices from fixed objects. As fixing agents, mainly alcohol, formaldehyde and mixtures of chromium salts are used, which produce more or less fast clotting of tissue colloids, as a result of which the in vivo structure of cells with their processes is very much changed. To what extent our preparations give us the right to conclude about the living structure of cells and especially about the processes running or already running intra vitam is an old and much debated problem.

scholarly journals The relevance of the use of electroencephalography and audiometry for the diagnosis of drug-related nervous system complications in patients with multi-drug resistant pulmonary tuberculosis during the main course of chemotherapy

2018 ◽  
pp. 25-29
Author(s):  
V.I. Ignatieva ◽  
T.M. Martsinyuk ◽  
V.A. Svyatnenko ◽  
G.L. Gumeniuk
Keyword(s):  
Nervous System ◽  
Pulmonary Tuberculosis ◽  
Evoked Potentials ◽  
Differential Diagnostics ◽  
Drug Resistant ◽  
Objective Data ◽  
Treatment Practice ◽  
Tb Treatment ◽  
Timely Treatment

PURPOSE. To analyze the relevance of introduction of modern diagnostics methods for the evaluation of drug-related complications that affect the nervous system in TB treatment practice. MATERIALS AND METHODS. We have analyzed the literature data regarding the problem of diagnosing drug-related complications that affect the nervous system in patients with multi-drug resistant pulmonary tuberculosis during the main course of chemotherapy. RESULTS. According to the results of the analysis, it was revealed that today in the TB practice there is over- or under-diagnosing of drug-related complications from the part of nervous system in patients with multi-drug resistant pulmonary tuberculosis during the main course of chemotherapy, which is due to the lack of technical possibilities of control and the need to get conclusions from specialists with narrow expertise – otolaryngologists, ophthalmologists and neuropathologists. CONCLUSIONS. The lack of data on the prevalence of drug-related nervous system complications is due to the possibility of their detection only with the help of specific technical means of control and on the basis of the conclusions of narrow specialists. The wide introduction of electroencephalography using evoked potentials and audiometry in TB practice will allow obtaining objective data on prevalence, carrying out clear differential diagnostics, monitoring the development of such complications, as well as providing timely treatment within the required amount.

Rapidly progressive vision loss due to fulminant idiopathic intracranial hypertension: a diagnostic and management dilemma

2020 ◽  
Vol 13 (11) ◽  
pp. e236188
Author(s):  
Jagadeesh Sutraye ◽  
Mohan Kannam ◽  
Rajat Kapoor ◽  
Virender Sachdeva
Keyword(s):  
Intracranial Hypertension ◽  
Idiopathic Intracranial Hypertension ◽  
Vision Loss ◽  
Obese Woman ◽  
Visual Fields ◽  
Csf Analysis ◽  
Contrast Enhanced ◽  
Grade Ii ◽  
The Right ◽  
The Brain

A 44-year-old obese woman presented with decrease in vision in the right eye (RE) for 3 days. She reported a simultaneous onset of holocranial headache that worsened on bending forward. She denied eye pain, pain on eye movements, and other ocular or neurological complaints. On examination, her distance best-corrected visual acuity was counting fingers at 1 m in the RE and 20/20 in the left eye (LE). Colour vision was subnormal in both eyes (BE). There was grade II relative afferent pupillary defect in the RE. Fundus examination showed disc oedema in BE . Visual fields in the LE showed central scotoma extending nasally. A provisional diagnosis of papillitis was considered. However, contrast-enhanced MRI of the brain and orbits showed evidence of elevated intracranial pressure. Cerebrospinal fluid (CSF) opening pressure was 42 cm H2O while rest of the CSF analysis was normal. Diagnosis was revised to fulminant idiopathic intracranial hypertension. Management with medical therapy and urgent thecoperiteoneal shunt improved visual function in BE.

scholarly journals Differential Diagnostics of Vertebrogenic and Nonvertebrogenic Vascular Pathologies

Biomeditsina ◽  
2020 ◽  
pp. 47-59
Author(s):  
N. N. Karkischenko ◽  
A. A. Nikolaev ◽  
Yu. A. Chudina ◽  
D. B. Chaivanov ◽  
A. A. Vartanov
Keyword(s):  
Spinal Cord ◽  
Nervous System ◽  
Cervical Spine ◽  
Autonomic Nervous System ◽  
Vertebral Artery ◽  
Cardiovascular System ◽  
Blood Vessels ◽  
Vascular Diseases ◽  
Differential Diagnostics ◽  
The Brain

This article investigates consistency in the work of the heart and blood vessels in vascular diseases of a vertebrogenic and non-vertebrogenic nature, which are characterized by disorders of the cardiovascular system leading to an insuffi cient blood supply to the spinal cord and the brain. Vertebrogenic vascular pathologies were studied by the example of vertebral artery disorders in osteochondrosis of the cervical spine, while non-vertebrogenic pathologies were considered in the syndrome of somatoform dysfunction of the autonomic nervous system. It is shown that, compared to the norm, the degree of consistence in the work of the heart and blood vessels is lower in vertebrogenic and non-vertebrogenic vascular pathologies.

scholarly journals MORPHOLOGY AND FUNCTION OF THE AUTONOMOUS NERVOUS SYSTEM

2020 ◽  
Vol 20 (1) ◽  
pp. 212-217
Author(s):  
A.P. Stepanchuk
Keyword(s):  
Spinal Cord ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Abdominal Cavity ◽  
Nerve Cells ◽  
Autonomous Nervous System ◽  
Autonomic Nervous ◽  
Lumbar Spinal ◽  
The Brain ◽  
Lateral Nuclei

The autonomic nervous system consists of the sympathetic and parasympathetic divisions. The central part is represented by supra-segmental and segmental centres. Parasympathetic segmental centres in the brain are accessory nucleus of the oculomotor nerves, superior salivary nucleus of the facial nerve, inferior salivary nucleus of the glossopharyngeal nerve and dorsal nucleus of the vagus nerve. In the spinal cord, these are the intermediate lateral nuclei. Sympathetic segmental centres in the brain are absent, and in the spinal cord, intermediate-lateral nuclei are located in the lateral horns in the eighth cervical, all thoracic and 1-2 lumbar spinal segments. The peripheral part of the autonomic nervous system is represented by pre-nodal and post-nodal branches, paravertebral, prevertebral and terminal nodes and plexuses. The intramural part of the autonomic nervous system lies in the larger part of a wide and narrow-loop net and represented with a large number of nerve cells different by their shapes and sizes and clustered as intramural nodes, or individual nerve cells included along the net loops. The autonomic plexuses of the abdominal cavity are topographically divided into celiac, superior and inferior mesenteric, abdominal aortic, mesenteric, superior and inferior hypogastric region.

The Thirty-Sixth Maudsley Lecture: Memory Mechanisms of the Brain

1962 ◽  
Vol 108 (453) ◽  
pp. 119-133 ◽  
Author(s):  
J. Z. Young
Keyword(s):  
Nervous System ◽  
Dynamic System ◽  
Memory Systems ◽  
Static Picture ◽  
The Right ◽  
The Brain

The invitation to give a commemorative lecture of such importance evokes feelings of gratitude and pleasure that a body as distinguished as your own should show interest in the work of one's collaborators. This is especially so for us because the field in which we work might seem, to superficial observation, to be remote from practical interests. It has long been our hope that by study of a relatively simple animal we might be able to discover some of the fundamental features of living memory systems, which have not yielded to investigation in mammals or man. Your interest encourages us to think that we may be on the right lines and I hope that in return it may be possible to tell you at least something of the principles that underlie the coding and storing of information in the nervous system. But the brain is a very complicated instrument and the problem is far from solution. The account that I shall give will be grossly over-simplified and will probably seem to present an absurdly static picture of what we all know to be a continually active and dynamic system.

scholarly journals Caffeine Components Empower the Brain Potentiality

2020 ◽  
Vol 1 (1) ◽  
pp. 16-17
Author(s):  
Seyedeh Nasim Habibzadeh
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Standard Dose ◽  
Inhibitory Neurotransmitter ◽  
Nutritional Components ◽  
Dietary Component ◽  
The Central Nervous System ◽  
The Right ◽  
High Level ◽  
The Brain

The brain requires certain fuels to function in high level. Literally, nutritional components can modulate the brain productivity. One of the right nutrition to enhance the brain power is dietary component of caffeine. Caffeine as a component of coffee, tea and chocolate is very popular. Although, depending on the dietary demands or conventional habits some people do not consume caffeine-containing substances (i.e. foods or beverage). Nonetheless, caffeine constituents maximize the brain potential via promoting the central nervous system (CNS) through blocking an inhibitory neurotransmitter (adenosine) and releasing some other specific neurotransmitters (noradrenaline, dopamine and serotonin) in brain. The chemistry of caffeine in a standard dose in fact can affect the brain intelligence.

Piccolo male in due gemelle monozigotiche. L'apporto dell'EEG allo studio dell'ereditarietà nell'epilessia

1955 ◽  
Vol 4 (3) ◽  
pp. 342-357
Author(s):  
V. Pelliccioli ◽  
F. Garioni
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Low Voltage ◽  
Functional Differentiation ◽  
The Other ◽  
Allo Studio ◽  
Left Handed ◽  
The Central Nervous System ◽  
The Right ◽  
The Brain

SUMMARYMonozigotic twin-girls 6 8/12 years old, one right-handed girl and the other left-handed, present petit mal seizures, appeared contemporaneusly when the twin-girls were 5 years old. The Eleccal tracing of petit mal with these troencephalogram shows a typicaracteristics: in the left hemisphere of the right-handed girl and in the right of the left-handed girl there is a preponderance of attivity.One sister of the twis-girls, 8 years old, has a tracing with epilectical activity spike-wawe 3 per second of high voltage; she never had clinical seizures.The mother's, 34 years old, present a tracing on activation, with teta activity 7 per second of low voltage.The tracing of the father, 33 years old, is negative.The tracing of the maternal-grand mother, 67 years old, present on activation, a light dysrithmia in the Pa O. right seat.The AA take from these dates some considerations about the question of the heredity in the Epilepsy and conclude on the base of their researches that they could favour the conception that existe in the epilepsy a functional miopragie of the brain, on hereditary base. These miopragies are, probably, connected with one functional differentiation deficiency of determined structures of the central-nervous-system.

Treatment of a B-Cell, Primary Central Nervous System Lymphoma Patient with Radioimmunotherapy Using Zevalin®: A Proof-of-Principal Case.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 4639-4639
Author(s):  
Ruby Meredith ◽  
Louis Nabors ◽  
Sui Shen ◽  
John Fiveash ◽  
Sthepen Besh ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
B Cell ◽  
Frontal Lobe ◽  
Systemic Disease ◽  
Pet Scan ◽  
Whole Body ◽  
High Dose ◽  
The Right ◽  
The Brain

Abstract Primary Central Nervous System NHL (PCNSL) has increased in incidence across all age groups over the past decades. 90% are B-cell NHL. Resection has not been shown to improve survival and standard chemotherapy is not effective. While radiation therapy (RT) was formerly the standard therapy, high-dose methotrexate (Mtx) is the single most active agent. High-dose Mtx alone or in combination with RT has resulted in response rates of 100% and median survival ranging between 30–60 months, although the risk of relapse is 50%. The prognosis at relapse is poor; clearly, new strategies are needed for these patients. There are no previous cases or clinical trials to evaluate the efficacy of Zevalin in PCNSL. We report a single patient with PCNSL treated with Zevalin. A 26YO male with a CD20+/CD19+ PCNSL was diagnosed in 05/01 when he presented with a left frontal mass. The patient underwent surgical resection (pathology: pleomorphic xanthoastrocytoma). By 09/01 local progression was documented and a second excision was done. Pathology showed a CD20+/CD19+, PCNSL (previous pathology was reviewed and the diagnosis was confirmed). No systemic disease was found and the patient was HIV negative. While the patient was waiting to start RT, the lesion progressed and a third resection was done, followed by RT. By 01/03 progression was documented by imaging studies but the lesion was found in the right frontal lobe, just across the previous lesion in the left side; diagnosis was confirmed with a stereotactic biopsy. Systemic disease was not documented. PET scan showed area of increased uptake in the right frontal lobe of the brain consistent with active lymphoma with no areas of abnormally increased F-18 uptake in the rest of the body. It was decided to treat the patient with Zevalin RIT. The study utilized the standard Zevalin kit and the preparation, administration and storage were followed in the drug labeling directions. On day 1 he received Rituxan 250 mg/m2 followed by 5.0 mCi of 111In-2B8 for biodistribution evaluation. Whole body scintogram planar images were obtained 24 and 48 hours after the infusion of the 111In-2B8 and they showed increased activity in the right frontal lobe consistent with the patients known lymphoma. Otherwise, there was normal blood pool and organ distribution of the radiolabeled antibody. On day 8 the patient received Rituxan 250 mg/m2 followed by 29.1 mCi of Zevalin (0.4 mCi/Kg). Tumor localization of radioactivity was evident at 24 hours. The estimated localization per gram of tumor at 24 hours was 0.21% of the injected dose (marrow 0.0042%, liver 0.0069%, kidney 0.0065%, spleen 0.015%). The anticipated hematologic toxicity nadired on week 5 and recovered by week 7. MRI was performed on weeks 6, 14, 20 indicating stable disease with an interval decrease in the right frontal abnormal T2 hyperintensity. PET scan performed on week 20 indicating interval decrease in the right frontal lobe uptake. On week 32, an MRI of the brain and a PET scan showed progression. This report is the first description in humans using Zevalin in PCNSL, and serves as a proof-of-principle. We have proposed a hypothesis-driven pilot study to confirm our observation that Zevalin binds to the PCNSL and it is able to deliver local radiation. If positive, a more definitive design would be pursued. Images (MRI, PET, Indium Scans) will be presented in the meeting.

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