Lichen sclerosus in men: improving diagnostic and treatment methods

2020 ◽  
pp. 64-69
Author(s):  
A. V. Ignatovskiy
Keyword(s):  
Topical Corticosteroid ◽  
Interferon Alpha ◽  
Comparison Group ◽  
Activity Index ◽  
Lichen Sclerosus ◽  
Main Group ◽  
Complex Treatment ◽  
External Application ◽  
Area Index ◽  
Interferon Alpha 2B

Objective of the study. To evaluate the effectiveness of systemic interferon alpha‑2b in the complex therapy of lichen scleroatrophic of the penis.Material and methods. The study involved 26 male patients with a verified diagnosis: lichen scleroatrophic of the penis. The main group was 19 people, the comparison group was 7 men. The duration of the disease in men was from 9 to 12 months. To estimate the area of lesion as well as to estimate their dynamic changes were developed: Scleroatrophic Lichen Area Index (LS-S in men) and Scleroatrophic Lichen Activity Index (LS-A). Treatment in the main group: topical corticosteroid momentasone cream two times a day for 21 days, as well as interferon alpha‑2b suppositories in a dose of 3 million ME two times a day, daily for 10 days, then three times a week for 2 months with subsequent external application of 1–2 times a day for 2 months of ointment with interferon alpha‑2b. In patients with balanopostitis the cream was used in combination with momentazone, economazole, gentamycin and dexpanthenol. Patients from the comparison group received momentazone cream for 21 days, and in case of recurrence of symptoms – the prescription of topical calcineurin inhibitors. Patients of both groups received vitamin E of 200 mg per day for 2 months. The end point of observation for patients of both groups was 3 months after the end of therapy.Results. Against the background of treatment, improvement was achieved in all patients in the main group within 21 days. Subsequent cancellation of topical corticosteroid and continuation of therapy with suppositories and ointment of the interferon alpha‑2b allowed to maintain positive dynamics of the skin process during the whole period of observation. The control group also achieved a positive effect from therapy with topical corticosteroids (cream with momentazone), but after its cancellation, in the period from 4 to 6 weeks, symptoms were recurrent, which required the continuation of therapy with topical calcinerin inhibitors – tacrolimus ointment 0.1% 1–2 times a day for 4 weeks. The use of the LS-A Index showed that the indices of skin manifestations were the fastest to regress than those of the LS-S index assessing the area of lesion.Conclusions. 1. The use of system therapy with interferon alpha‑2b, along with topical GCSs, in the complex treatment can reduce the severity of clinical manifestations of GSAL without resorting to prolonged use of topical GCSs. 2. The use of interferon alpha‑2b in the complex treatment of the genital lichen sclerosus has demonstrated its effectiveness in a small group of patients. 3. Application of the developed Lesion Area Index and Lichen Sclerosus Activity Index in men allow to objectively assess the effectiveness of treatment. 4. Lichen sclerosus assessment indices allow to develop an individual plan of rehabilitation measures. 5. It is expedient to continue studies on pathogenetic mechanisms of influence of alpha‑2b interferon in genital lichen sclerosus. 

scholarly journals Endobronchial valve in complex treatment of patients with drug resistant fibrous cavernous pulmonary tuberculosis

2020 ◽  
Vol 98 (1) ◽  
pp. 35-40
Author(s):  
O. Yu. Askalonova ◽  
E. A. Tseymakh ◽  
A. V. Levin ◽  
P. E. Zimonin
Keyword(s):  
Pulmonary Tuberculosis ◽  
Comparison Group ◽  
Main Group ◽  
Drug Resistant ◽  
Complex Treatment ◽  
X Ray ◽  
Endobronchial Valve ◽  
Sputum Conversion ◽  
Valve Implantation ◽  
Valve Block

The objective of the study: to assess the efficacy of complex treatment with endobronchial valve implantation in the patients suffering from drug resistant fibrous cavernous pulmonary tuberculosis.Subjects and methods. Treatment outcomes in 97 patients with limited fibrous cavernous pulmonary tuberculosis were analyzed. Main Group included 42 patients who had bronchial valve block implanted. Comparison Group included 55 patients. Artificial pneumoperitoneum was used in both groups.Results. In Main Group, sputum conversion was achieved in 12 months in 40 (95.2%) patients, and in 32 patients (58.2%) in Comparison Group (p < 0.01). In 12 months after treatment start, positive X-ray changes were observed in 42 (100%) patients of Main Group and 40 (72.7%) patients of Comparison Group. Healing of cavities in 12 months was observed only in the patients from Main Group (26 (61.9%) patients). Upon completion of the study, surgery was still indicated to 4 (9.5%) of patients from Main Group and to 35 (63.6%) patients from Comparison Group.

scholarly journals CLINICAL ASSESSMENT OF THE EFFECTIVENESS APPLICATION "BIOCERULIN" IN THE COMPLEX TREATMENT OF THE PATIENTS WITH ONTOGENIC FLAGMONS OF THE MAXILLOFACIAL AREA

2019 ◽  
pp. 29-32
Author(s):  
D.V. Steblovskyi ◽  
V.V. Bondarenko ◽  
O.S. Ivanytska ◽  
V.M. Skrypnyk ◽  
I.O. Ivanytskyi
Keyword(s):  
General Condition ◽  
Inflammatory Process ◽  
New Technologies ◽  
Comparison Group ◽  
Main Group ◽  
The Body ◽  
Steady Increase ◽  
Complex Treatment ◽  
Maxillofacial Region ◽  
Traditional Therapy

Treatment of odontogenic phlegmon of the maxillofacial region remains an urgent problem of surgical dentistry due to the steady increase in their frequency, tendency to generalize the process and adverse effects. In this regard, there is a constant search for ways to improve the effectiveness of treatment of patients with odontogenic phlegmons of maxillofacial region. New technologies of drug treatment of this pathology are developed and put into practice. In recent years the attention of researchers in various conditions accompanied by the development of oxidative stress began to attract drugs that have antioxidant action, as it became known that the excess of reactive oxygen species in the regenerating wounds in the hearth of purulent inflammation affects the course of the course, wound healing. Interest in the treatment of various pathological conditions of the body is caused by the domestic antioxidant multifunctional enzyme "Bioceruline" which is composed of copper. In this regard, the purpose of our study was to evaluate the effectiveness of the use of "Biocerulin" in the complex treatment of patients with odontogenic phlegmon of maxillofacial region. The object of the clinical study was 45 patients with odontogenic phlegmons of the maxillofacial region from 18 to 55 years old, who were treated in the maxillofacial department of PU "Poltava M.V. Sklifosovskyi regional clinical hospital PRC». All patients were without somatic pathology in compensated clinical condition. Immediately after hospitalization, patients underwent an emergency opening of purulent lesion, revision and adequate drainage of the affected cellular spaces, removal of the "causal" tooth. The extent of surgery and the choice of optimal access depended on the location and prevalence of phlegmon. Depending on the treatment, patients were divided into comparison groups (22 patients) and the main group (23 patients). The traditional therapy was used in the comparison group. "Biocerulin"was prescribed for the patients of the main group in addition to the traditional therapy. Analysis of obtained data in the treatment of patients with phlegmon revealed that both groups of patients had clear differences in the clinical course of purulent-inflammatory process. On the 2nd day after the opening of the phlegmon theweakness, headache, and sleep disorders were noted in the most of the patients of the comparison group who received traditional therapy. Pain with varying degrees of intensity was present in all patients. Improvement of the general condition of patients of this group was noted not earlier than 3-5 days after surgery. The improvement of the general condition and reduction of pain, normalization or decrease in body temperature, the beginning of restoration of function of the jaw apparatuswere notedin patients of the main group on the background of the introduction of "Bioceruline" already on the 2-3rd day after surgery. Thus, on the basis of the conducted researches it is possible to conclude that the basic (traditional) conservative therapeutic measures used for patients of the comparison group are not effective enough for the relief of the local and general inflammatory process, which caused the prolonged nature of organ-specific and functional rehabilitation of patients as a whole. The use of "Bioceruline" in complex therapy of patients with odontogenicphlegmons of the maxillofacial regionprovides rapid and intensive recovery of the general condition of patients and accelerates reparative processes in the wound and shortens the treatment time via 1.4 bed-days.

Experience of using a CO₂ laser in the stage treatment of vulvar lichen sclerosus

2020 ◽  
pp. 58-65
Author(s):  
A. V. Ignatovskiy ◽  
M. A. Nezabudkina
Keyword(s):  
Activity Index ◽  
Calcineurin Inhibitors ◽  
Lichen Sclerosus ◽  
Autologous Plasma ◽  
Area Index ◽  
Co Laser ◽  
Topical Calcineurin Inhibitors ◽  
Positive Therapeutic Effect ◽  
Vulvar Lichen Sclerosus

Vulvar lichen sclerosus is a chronic dermatosis in which first-line drugs are topical glucocorticosteroids, and alternative drugs are topical calcineurin inhibitors. To date, there is insufficient data on the effectiveness of using CO₂ lasers in the treatment of VLS, although the authors of the published works note a positive therapeutic effect. The results of step-by-step application of the Lutronic CO₂ fractional laser were studied. The efficiency of the treatment was evaluated using the skin activity index and the lesion area index developed by the author. The study included 8 women diagnosed with VLS. The obtained results demonstrated a positive effect of step-by-step treatment of VLS with sequential use of topical glucocorticosteroid and autologous plasma injections, followed by CO₂ laser fractional exposure. The positive dynamics of the treatment was confirmed by the dermatological index of quality of life, as well as the indices of assessment of the area and activity of the skin process of VLS.

scholarly journals Фітопрепарат «Ресверазин» у комплексному лікуванні генералізованого пародонтиту

2018 ◽  
Author(s):  
N. O. Hevkaliuk
Keyword(s):  
Oral Cavity ◽  
Comparison Group ◽  
Clinical Signs ◽  
Main Group ◽  
Complex Treatment ◽  
Average Value ◽  
Periodontal Condition ◽  
Periodontal Infection ◽  
Periodontal Index ◽  
High Prevalence

Summary. High prevalence, unfavorable effects of periodontal infection centers on the oral cavity condition determine the relevance of the problem of the use of phytopreparations in the treatment of generalized periodontitis.The aim of the study – to evaluate the clinical efficacy of the drug Resverazin in the complex treatment of generalized periodontitis.Materials and Methods. The study was attended by 43 patients, patients with chronic generalized periodontitis of primary and stage I. The main group was 25 people, the comparison group was 18. To assess the hygienic state of the cavity, the indices Green-Wermillion, ONI-S, Silness-Loe, Stallard were used. The assessment of the periodontal condition was conducted according to clinical signs; the severity of gingivitis was determined by the PMA index, the state is clear – according to the index of bleeding Muhlleman, the stages of destructive changes in the periodontium – according to the periodontal index (PI). For the treatment of periodontitis in both groups, traditional therapy was used. The patients in the main group were prescribed Resverazin for 1 capsule 2 times a day after eating. The course of treatment was 2 months.Results and Discussion. In an objective survey conducted before treatment, the average value of the index of hygiene in the main group was (1.64±0.31), in the comparison group – (1.59±0.23) points. The PMA index in the main group was (63.12±1.17), in the comparison group – (62.39±1.13) points. The ONI-S, Silness-Loe and Stallard indexes in the patients in the main group were (2.36±0.13), (1.54±0.08), (1.200±0.062) points, in the comparison group – (2.30±0.12), (1.51±0.06) and (0.890±0.032) points, respectively. The values of PI and the Muhlleman index in the groups were (1.22±0.09) and (2.21±0.13) and (1.24±0.13) and (2.18±0.11) points, respectively. During the treatment, a positive dynamics of the studied parameters was observed. The values of the PMA index (%) and PI were (10.23±1.11) and (0.63±0.11) in the main group and (11.22±1.19) and (0.84±0.12) in the comparison group.Conclusions. The obtained results confirm the high clinical efficiency of the natural complex Resverazin, the inclusion of which in the scheme of basic therapy of generalized periodontitis contributes to positive dynamics and stable changes in the tissues of periodontal disease.

scholarly journals ALGORITHM OF COMPLEX TREATMENT OF DESTRUCTIVE FORMS OF PULMONARY TUBERCULOSIS AND ITS RATIONALE

2021 ◽  
Vol 19 (1) ◽  
pp. 36-39
Author(s):  
Yu. A. Sheifer ◽  
◽  
I. S. Gelberg ◽  
Keyword(s):  
Drug Resistance ◽  
Pulmonary Tuberculosis ◽  
Comparison Group ◽  
Main Group ◽  
Long Term Results ◽  
Complex Treatment ◽  
Results Of Treatment ◽  
Artificial Pneumothorax ◽  
Cavity Closure

Background. In destructive forms of pulmonary tuberculosis, especially in the presence of drug resistance of mycobacteria, one of the ways to increase the effectiveness of therapy is the use of collapse therapeutic techniques in various modifications. Purpose of the study: to develop and substantiate an algorithm for complex treatment of destructive forms of pulmonary tuberculosis, using artificial pneumothorax (AP). Material and methods: A cohort of 84 people with destructive pulmonary tuberculosis was formed. It was divided into two groups: 42 patients in the main group (chemotherapy (ChT) + AP) and 42 in the comparison group (ChT). Results: an algorithm for the treatment of patients with destructive forms of pulmonary tuberculosis was formulated. Within a period of up to 6 months, abacillation was achieved in 61.9% of cases in the main group (MG), and in 18.9% (p <0.05) in the comparison group (CG). By the 10th month of treatment, the closure of decay cavities was achieved in 78.7% of cases in the MG and in 42.8% (p <0.05) in the CG. By 12 months the closure of decay cavities was observed in 92.1 and 52.4% of cases respectively (p <0.05). Conclusions: The use of the algorithm for the complex treatment of destructive forms of pulmonary tuberculosis makes it possible to achieve abacillation at an earlier time (up to 6 months - in 61.9%). It also allows to increase the frequency of cavity closure by 39.6% as well as achieve an increase in clinical cure (according to long-term results of treatment) by 23.8% and a decrease in the amplification of drug resistance and mortality by 14.3% and 11.9% correspondingly.

scholarly journals Evaluation of effectiveness of complex treatment of chronic generalized periodontitis using original splinting design

2021 ◽  
Vol 38 (6) ◽  
pp. 83-93
Author(s):  
N. B. Astashina ◽  
E. P. Rogozhnikova ◽  
A. S. Arutyunov ◽  
N. N. Malginov ◽  
S. V. Kazakov
Keyword(s):  
Quality Of Life ◽  
Comparison Group ◽  
Negative Impact ◽  
Young Patients ◽  
Pathological Process ◽  
Main Group ◽  
Complex Treatment ◽  
Periodontal Tissues

Relevance. The relevance of the study is dictated by the high prevalence of periodontal disease among young people and by the need to search for new approaches to periodontitis treatment in order to increase the effectiveness of treatment at early stages of pathological process. Objective. To evaluate the effectiveness of complex treatment of chronic generalized periodontitis (CGP) of mild severity using a removable splinting construction made according to the author's technique. Materials and methods. At the orthopedic stage of the complex treatment of mild CGP, splinting constructions were used for 47 young patients: in the main group (n = 16) the authors treatment and preventive splint, in the first comparison group (n = 15) a removable metal splint, in the second comparison group (n = 16) a fixed adhesive fiber splint. Periodontal hemodynamics was assessed using ultrasound Doppler analysis 1, 6 and 12 months after the therapeutic measures and tooth immobilization. To identify the possible negative impact of the treatment on the quality of life (QOL) in patients with splint constructions, we used the OHIP-14-Ru questionnaire; the follow-up period was 1.3, 6, and 12 months. Results. Dental immobilization contributed to the improvement of blood flow in the periodontal tissues in the short and long term follow-up, so after 12 months: Vam in the main group increased by 39,8 % and amounted to 0,397 0,004 cm / s, in patients of the comparison groups Vam was 0,329 0,006 cm / s and 0,335 0,003 cm / s, respectively, that is 15,4 % and 18,4 % higher compared with the figures before treatment. The quality of life index for patients using splinting constructions made according to the author's technique, by the OHIP-14-Ru questionnaire was assessed as good 1 year after (3.46 0.59). Conclusions. The use of the proposed original orthopedic design in a complex plan for mild periodontitis treatment helps to improve regional blood circulation and stabilize the pathological process.

scholarly journals JUSTIFICATION OF THE EFFECTIVENESS OF THE USE OF DALMAXIN RECTAL SUPPOSITORIES (THIOTRIAZOLIN) IN THE COMPLEX TREATMENT OF ACUTE PARAPROCTITIS

2020 ◽  
pp. 54-62
Author(s):  
O. A. Viltsaniuk ◽  
M. V. Mazur
Keyword(s):  
Postoperative Period ◽  
Microbial Contamination ◽  
Comparison Group ◽  
Main Group ◽  
Symptomatic Therapy ◽  
Complex Treatment ◽  
Study Objective ◽  
Endogenous Intoxication ◽  
Hospitalization Period ◽  
Rectal Suppositories

Summary. The problem of treatment of acute purulent paraproctitis is one of the most urgent problems of modern coloproctology. Study objective. To evaluate the effectiveness of the use of Dalmaxin rectal suppositories in the complex treatment of acute paraproctitis. Materials and methods. The effectiveness of use of Dalmaxin rectal suppositories was conducted in 62 patients with acute subcutaneous paraproctitis, assigned to two groups, a main group of 30 patients and a comparison group of 32 patients. All patients underwent radical surgery. Antimicrobial, detoxification and symptomatic therapy was prescribed postoperatively. Local treatment of purulent wounds was carried out using hydrophilic ointments depending on the phase of the wound process; the patients of the main group were additionally administered Dalmaxin rectal suppositories twice a day. The effectiveness of the treatment was evaluated by the severity of the swelling, the nature of the discharge from the wound, the level of microbial contamination, the wound cleansing period, the appearance of granulation tissue and epithelialization, and by cytological examination. Furthermore, general laboratory and biochemical studies were performed. Endogenous intoxication (EI) and its changes in the course of treatment were evaluated by the level of average-mass molecules, leukocyte intoxication index and hematological intoxication index. Statistical processing and comparison of the obtained data was performed using the STATISTICA® 5.5 integrated system (STATSOFT® Inc., USA), license A XX 910A374605FA. Results. The study showed that in patients with acute paraproctitis, the severity of the postoperative period is due to the severe intoxication and the development of a systemic inflammatory response syndrome that were observed in patients at the time of hospitalization. After surgical intervention, clinical and laboratory parameters did not normalize in the first five days of the postoperative period, and only starting from the fifth day, there was a gradual decrease in the level of EI and laboratory indicators, reaching the normal ones only at the time of discharge from the hospital. EI complicates the course of the postoperative period, primarily by weakening the level of humoral immunity and inhibiting the processes of reparative regeneration. When comparing the results of treatment of acute paraproctitis in patients using Dalmaxin rectal suppositories with traditional methods. The hospitalization period of the patients of the main group was also shorter than in the comparison group, and was (9.2 ± 0.5) and (11.9 ± 0.9) bed days, respectively. Conclusions. A comparative evaluation of the use of Dalmaxin in the complex treatment of acute purulent paraproctitis showed that the drug, due to its properties, significantly improves the course of the postoperative period, as evidenced by faster reduction of endogenous intoxication, reduction of microbial contamination and wound cleansing from necrotic tissues, faster granulation and epithelialization, as well as wound healing, thus helping to reduce the time of hospitalization.

scholarly journals The effectiveness of the use of anti-dysbiotic hepatoprotector in the complex treatment of patients with periodontal inflammatory diseases on the background of chronic non-calculous cholecystitis

2018 ◽  
Author(s):  
A. I. Furdychko ◽  
A. Yu. Buchkovska ◽  
M. A. Pasichnyk
Keyword(s):  
Periodontal Disease ◽  
Comparison Group ◽  
Inflammatory Diseases ◽  
Periodontal Diseases ◽  
Main Group ◽  
Control Group ◽  
Complex Treatment ◽  
Hepatobiliary System ◽  
The Difference ◽  
Calculous Cholecystitis

Summary. Inflammatory periodontal diseases continue to be one of the pressing problems of modern dentistry [1]. It is known that there is a close relationship between general-somatic pathology and diseases of the oral cavity [2]. The aim of the study – to learn the effectiveness of the use of anti-dysbiotic hepatoprotector in the complex treatment of patients with periodontal inflammatory diseases on the background of chronic non-calculous cholecystitis. Materials and Methods. The main (group 1) group consisted of 106 people who suffered from inflammatory periodontal disease (IPD) with concomitant chronic non-calculous cholecystitis (CNC). The comparison group included 92 patients with IPD without concomitant pathology (group 2). To compare the research results of the patients with IPD, 30 healthy teethed individuals without periodontal pathology and without somatic diseases (group 3 or the control group) were involved. The state of the hepatobiliary system in patients of the main group was assessed by the doctors of the Gastroenterology Department of Zolochiv District Hospital of Lviv region. Results and Discussion. The symptomatic HCG and the presence of solid and soft dental deposits were diagnosed in all patients. The Green-Vermillion’s index was the highest in patients from the main group (1.67±0.01); it was probably (p <0.05) higher than that in the comparison group (1.54±0.04), as well as in the control group (0.44±0.07). The PMA index in the subgroup 1A immediately after treatment decreased by 9.7 (p <0.001) times. The index of bleeding in the subgroup 1A decreased by 10.7 (p <0.001) times. The PMA index in the subgroup 1A immediately after treatment decreased by 10.4 (p <0.001) times. The index of bleeding in the subgroup 1A under the influence of the proposed therapy decreased by 6.5 (p <0.001) times.The difference regarding the data before treatment remained lower by 2.2 times and 2.0 (p <0.001) times, however, the difference between the subgroups 1A and 1B in 3 months and 6 months was already 2.1 times in both cases. Conclusions. It was found that the clinical course of inflammatory periodontal diseases was much more difficult in these patients. The presence of pathology in the hepatobiliary system in patients increases the risk of periodontal disease. Therefore, in order to improve the efficacy of treatment, it is advisable to use this antidysbiotic drug in the complex treatment, and the results obtained in 3 and 6 months after treatment indicate a long-lasting positive effect.

Sign in / Sign up

Export Citation Format

Share Document