Rebamipid in real clinical practice: quality of life and safety of use

2021 ◽  
pp. 7-11
Author(s):  
A. E. Babich ◽  
E. V. Luchinina ◽  
O. G. Kompaniets ◽  
N. A. Zubareva
Keyword(s):  
Quality Of Life ◽  
Gastric Ulcer ◽  
Evidence Base ◽  
Role Functioning ◽  
Erosive Gastritis ◽  
Vital Activity ◽  
Good Tolerance ◽  
Literary Sources ◽  
Sf 36

The aim of the study was to assess the tolerability and impact on the quality of life of pharmacotherapy for gastric ulcer, erosive gastritis using regimens including rebamipide. The quality of life of patients was assessed using the SF-36 questionnaire. Pharmacotherapy of gastric ulcer with the inclusion of rebamipide as part of the conventional treatment regimen provides data comparable to the healthy group on the scales of physical functioning, role functioning due to physical condition, pain intensity, general health, and vital activity. The results of our own research and data from literary sources indicate that rebamipide is a drug with a confident evidence base, good tolerance and safety of use.

scholarly journals Quality of life in patients, suffering localized reno-cellular cancer after operative treatment

2019 ◽  
Vol 86 (11-12) ◽  
pp. 56-62
Author(s):  
O. A. Voylenko ◽  
O. A. Kononenko ◽  
S. L. Semko ◽  
M. V. Pikul ◽  
O. E. Stakhovskyi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Operative Treatment ◽  
Psychological Health ◽  
State Of Health ◽  
Role Functioning ◽  
Vital Activity ◽  
Physical Role ◽  
Sf 36

Objective. To rise the efficacy of treatment in patients, suffering localized reno-cellular cancer (LRCC), studying quality of life in patients and determination of optimal procedure of operative treatment. Materials and methods. Of 511 patients, suffering LRCC (T1-T2 N0M0), in whom quality of life was estimated in accordance to the SF-36 questionnaire, renal resection  was performed in 422 (82.6%), nephrectomy - 89 (17.4%). The observation duration median have constituted 28.9 mo (from 3 to 131 mo). Results. A patient’s cognition of the oncological disease missing have raised the quality of life self-estimation, predominantly in accordance to indices of psychological component of health after nephrectomy and after renal resection. Comparing the quality of life between the patients’ groups, there was obtained a statistically significant advantage of renal resection over nephrectomy in accordance to five indices of quality of life, including: physical functioning - 75 [65; 85] points after nephrectomy and 80 [70; 90] points after renal resection (p < 0.005); general state of health - 65 [57; 72] and 70 [65; 80] (p < 0.001); vital activity - 65 [55; 70] and 70 [60; 75] (p < 0.005); psychological health - 76 [60; 80] and 80 [68; 88] (p < 0.005); the emotionally-role functioning - 66.7 [66.7; 100] and 100 [66,7; 100] (p < 0.05) points, accordingly. Conclusion. Renal resection has a statistically proven advantage over nephrectomy in accordance to patients’ quality of life, determined, basing on data from the SF-36 questionnaire, predominantly due to better psychological self estimation of the patient’s state of health (p < 0.01). Difference between the investigated groups in accordance to indices of pain intensity, social and physical-role functioning was not established.

scholarly journals Adult long-term health-related quality of life of congenital hydrocephalus patients

2015 ◽  
Vol 16 (6) ◽  
pp. 621-625 ◽  
Author(s):  
Anja Kutscher ◽  
Ulf Nestler ◽  
Matthias K. Bernhard ◽  
Andreas Merkenschlager ◽  
Ulrich Thome ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Summary Score ◽  
Congenital Hydrocephalus ◽  
Role Functioning ◽  
Sf 36 ◽  
Related Quality ◽  
Health Related ◽  
The Mean

OBJECT Congenital hydrocephalus has a major impact on the lives of patients and their relatives, as well as their long-term neurological development and social integration. The aim of this study was to assess the self-reported health-related quality of life (HRQOL) of patients after reaching adulthood. METHODS A total of 31 patients who required CSF shunt treatment for congenital hydrocephalus within the 1st year of life (between 1963 and 1987) agreed to undergo a structured SF-36 self-assessment. An age-matched German standard cohort was used as control. Additional parameters of surgical, social, and global neurological outcome were analyzed. The mean patient age was 35 years (range 26–51 years, 13 females and 18 males). Hydrocephalus etiologies were posthemorrhagic hydrocephalus (n = 9), postinfectious hydrocephalus (n = 5), aqueductal stenosis (n = 10), myelomeningocele (n = 2), and unknown cause (n = 5). RESULTS The mean modified Rankin Scale score was 1.6 (range 0–4). Hydrocephalic patients achieved lower scores for the SF-36 items physical functioning (70.5 vs 93.5, p < 0.05), physical role functioning (74.2 vs 88.3, p < 0.05), and general health perceptions (64.5 vs 72.3, p < 0.05). Emotional, social role functioning, and mental health items did not differ between the groups. Assessment of vitality and pain resulted in a trend to worse values. Whereas the Physical Component Summary score was lower (46.1 vs 54.3, p < 0.05), the Mental Component Summary score was not significantly different (50.2 vs 48.7, p = 0.3). There was neither a statistically significant difference between subgroups of different etiologies nor an association with the number of subsequent hydrocephalus-related surgeries. CONCLUSIONS Adult HRQOL for patients with congenital hydrocephalus appears to be similar to that for healthy con with regard to mental health and social functioning aspects. Physical impairment is a predominant factor of compro quality of life.

scholarly journals Health related quality of life in children with migraine. A controlled study

2013 ◽  
pp. 54-58
Author(s):  
Mateus Lage Martins ◽  
Rafael Corrêa Valério ◽  
Tales José Corrêa de Almeida ◽  
Vitor Rodrigues Laender ◽  
Dilermando Fazito de Resende ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Bodily Pain ◽  
Controlled Study ◽  
Health Related Quality ◽  
Role Functioning ◽  
Sf 36 ◽  
Related Quality ◽  
Health Related ◽  
The Impact

Background: Headaches are prevalent in the pediatric population. Migraine significantly impacts the health-related quality of life (HRQoL) of sufferers. Objective: To measure the impact of migraine on the HRQoL of children, by applying the Brazilian version of the SF-36 in children with migraine and in controls. Methods: In this cross-sectional study, HRQoL was measured with the SF-36, and scores for the 8 domains of the test were contrasted comparing children (5 to 14 years) with and without migraine. Results: Sample consisted of 66 children (30 with migraine and 36 controls). Mean age was 10.9 years for migraine (Standard Deviation - SD = 3 years) and 10.4 for controls (SD = 3.1 years). Proportion of children with low HRQoL scores was significantly higher in the migraine group, relative to controls, for the 8 domains of the test: vitality, physical functioning, bodily pain, general health perceptions, physical role functioning, emotional role functioning, social role functioning, and mental health. Conclusion: Children with migraine are significantly impacted in their HRQoL, relative to children without migraine.

scholarly journals TL 18166 - Evaluation of quality of life and radiological parameters after hallux valgus correction

2019 ◽  
Vol 13 (Supl 1) ◽  
pp. 97S
Author(s):  
Henrique Mansur ◽  
Vinicius Trindade Cardoso ◽  
Isnar Moreira de Castro Júnior
Keyword(s):  
Quality Of Life ◽  
Hallux Valgus ◽  
Social Role ◽  
Short Form ◽  
Role Functioning ◽  
Significance Level ◽  
Radiological Parameters ◽  
Sf 36 ◽  
Correction Surgery

Introduction: The outcome of hallux valgus correction surgery is usually evaluated based on parameters of interest to the surgeon; however, the outcomes considered important by patients differ from those analyzed by physicians. Our objective is to evaluate the quality of life of patients undergoing hallux valgus correction and to assess the maintenance of radiographic parameters over time. Methods: The study included 38 patients who underwent hallux valgus correction surgery using different osteotomy techniques (scarf, chevron, arciform, proximal chevron and chevron-Akin) from January 2010 to December 2012. The patients were evaluated radiographically at 3 different times (preoperatively and 1 and 5 years postoperatively) and filled out the 36-Item Short Form Survey (SF-36) for the assessment of quality of life. Statistical analysis was performed using the paired Student’s t-test and the nonparametric Wilcoxon signed-rank and Friedman tests, with a maximum significance level of 5%. Results: Among the main findings of the SF-36 questionnaire, the sections on which the patients reported the best results were emotional role functioning, physical functioning and social role functioning, and the final mean score was 74.9. The metatarsophalangeal and intermetatarsal angles and medial eminence showed significant decreases during the postoperative period (p<0.05), and only 1 patient presented loss of joint congruence. Conclusion: Different surgical osteotomy techniques used to correct moderate and severe hallux valgus improved the patients’ radiological parameters and quality of life.

scholarly journals COCHLEAR IMPLANTATION PREVALENCE IN ELDERLY

2014 ◽  
Vol 13 (1) ◽  
pp. 122-128
Author(s):  
A. V. Starokha ◽  
A. V. Balakina ◽  
M. M. Litvak ◽  
A. E. Knipenberg ◽  
N. V. Shcherbik ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Cochlear Implantation ◽  
Sensorineural Hearing ◽  
Weighted Sums ◽  
Equal Weight ◽  
Role Functioning ◽  
Sf 36

Current paper describes an experience of cochlear implantation in elderly. Cochlear implantation has become a widely accepted intervention in the treatment of individuals with severe-to-profound sensorineural hearing loss. Cochlear implants are now accepted as a standard of care to optimize hearing and subsequent speech development in children and adults with deafness. But cochlear implantation affects not only hearing abilities, speech perception and speech production; it also has an outstanding impact on the social life, activities and self-esteem of each patient. The aim of this study was to evaluate the cochlear implantation efficacy in elderly with severe to profound sensorineural hearing loss. There were 5 patients under our observation. Surgery was performed according to traditional posterior tympanotomy and cochleostomy for cochlear implant electrode insertion for all observed patients. The study was conducted in two stages: before speech processor’s activation and 3 months later. Pure tone free field audiometry was performed to each patient to assess the efficiency of cochlear implantation in dynamics. The aim of the study was also to evaluate quality of life in elderly with severe to profound sensorineural hearing loss after unilateral cochlear implantation. Each patient underwent questioning with 36 Item Short Form Health Survey (SF-36). SF-36 is a set of generic, coherent, and easily administered quality-of-life measures. The SF-36 consists of eight scaled scores, which are the weighted sums of the questions in their section. Each scale is directly transformed into a 0-100 scale on the assumption that each question carries equal weight. The eight sections are: physical functioning; physical role functioning; emotional role functioning; vitality; emotional well-being; social role functioning; bodily pain; general health perceptions. Our results demonstrate that cochlear implantation in elderly consistently improved quality of life and enhance the efficiency of audiologic rehabilitation.

Improvement of the quality of life concerning the health of patients with peripheral arterial disease (PAD) after successful bypass surgery

VASA ◽  
2008 ◽  
Vol 37 (4) ◽  
pp. 338-344 ◽  
Author(s):  
Wohlgemuth ◽  
Safonova ◽  
Engelhardt ◽  
Freitag ◽  
Wölfle ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Bypass Surgery ◽  
Bodily Pain ◽  
Arterial Disease ◽  
Health Perceptions ◽  
Role Functioning ◽  
General Activity ◽  
Sf 36 ◽  
Peripheral Arterial

Background: To test whether quality of life depends on the psyche of patients after successful bypass surgery for peripheral arterial disease (PAD). Patients and methods: A total of 74 consecutive patients aged 36–69 years (57.7 ± 8.8 years) with symptomatic PAD in the stages Fontaine IIb–IV were enrolled in a prospective study after successful bypass surgery. Because of bypass failure and one death during the study period, 11 of these patients were excluded from evaluation. Prior to surgery, Doppler sonography and digital subtraction angiography were carried out in all patients. Before and after revascularization, the ankle / brachial index (ABI) was determined in all study objects and the pain free walking distance (PFWD) in those with PAD stage Fontaine IIb. Health-related quality of life was measured by using the "Medical Outcomes Study Group Short Form 36" (SF-36), and personality was determined by employing the Psycho-Diagnostic-Test (PDT). Results: After surgery, there was an increase in ABI from 0.32 ± 0.13 to 0.79 ± 0.19 (p < .01), in PFWD from 42.6 m ± 38.6 m to 419.7 m ± 152.3 m (p < .01), and in the SF-36 scales "Physical functioning", "Bodily pain", "General health perceptions", and "Role-functioning physical" (p < .05). ABI correlated positively with "Bodily pain" (p < .01), "General health perceptions" (p < .01) and "Mental health" (p < .05). Among SF-36 and PDT-scales, "Role-functioning physical" correlated negatively with "Moodiness" / "Neuroticism" (p < .05), and "Social functioning" correlated positively with "General activity" (p < .01). Conclusions: Whether objective clinical improvement increases quality of life mainly depends on the psyche of patients: A high level of general activity favors an improved quality of life and neurotic characteristics are more likely to be a hindrance.

scholarly journals Comparative Evaluation of the Quality Of Life Of Patients after the Pressible-Transparent Cholecismostomy аnd "Traditional" Cholecismostomy with Thermal Mucoclasion of the Gold Bubble

2017 ◽  
Vol 10 (3) ◽  
pp. 236-240
Author(s):  
Maxim Borisovich Polyansky ◽  
Dmitry Petrovich Nazarenko ◽  
Tatjana Aleksandrovna Ishunina ◽  
Dmitrii Igorevich Kolmykov
Keyword(s):  
Quality Of Life ◽  
Acute Cholecystitis ◽  
Psychological Health ◽  
Statistical Processing ◽  
Role Functioning ◽  
Group I ◽  
Sf 36 ◽  
Group Ii ◽  
Microsoft Office

Relevance. The number of elderly patients with acute cholecystitis is constantly increasing, in spite of the success achieved in the diagnosis and treatment of this pathology. The possibilities for radical treatment of patients with high operational anesthesia risk are substantially limited. The aim of the study was to conduct comparative analysis of the quality of life of patients after transcutaneous-transhepaticmicrocholecystostomy and traditional cholecystostomy with thermal mucoclasia of the gallbladder. Materials and methods. The quality of life of 31 patients with high operational anesthesia risk following transcutaneous-transhepaticmicrocholecystostomy (TTMC) and traditional cholecystostomy with thermal mucoclasia of the gallbladder (TCTMG), was studied. All patients were divided into two groups: the first group consisted of 20 (64.5%) patients who underwent TTMC, the second one included 11 (35.5%) patients who underwent TCTMG. Quality of life of patients was studied with the help of the questionnaire using the SF-36 Health Status Survey 4 months after TTMC or TCTMG. Statistical processing of the results was carried out using the program Microsoft Office Excel -2013. Results and its discussion. The physical component of health (physical functioning, role functioning due to physical condition, pain intensity, general health) was 64.25% higher in patients of Group II than in patients of Group I (p = 0.001), and the psychological Health component (mental health, role functioning due to emotional state, social functioning, vital activity) was also (68.05%) higher in Group II (p = 0.004).   Conclusions. The use of the method of thermal mucoclasia of the gallbladder in patients with high operational anesthesia risk allows to achieve higher quality indices compared to patients who underwent TTMC, since after demucotization of the gallbladder cavity it is obliterated due to hyperplasia of the connective tissue of the lamina propria or submucosa, thereby finally solving the problem of acute cholecystitis in this category of patients.

scholarly journals PO 18194 - Functional and quality of life assessment of patients with ankle ulcers treated with complete Achilles tendon resection

2019 ◽  
Vol 13 (Supl 1) ◽  
pp. 40S
Author(s):  
Wrgelles Godinho Bordone Pires ◽  
Roberto Zambelli De Almeida Pinto ◽  
Philipe Eduardo Carvalho Maia ◽  
Rodrigo Simões Castilho ◽  
Felipe Daniel Vasconcelos de Carvalho ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Achilles Tendon ◽  
Physical Functioning ◽  
Life Assessment ◽  
Posterior Region ◽  
Role Functioning ◽  
Quality Of Life Assessment ◽  
Sf 36 ◽  
The Mean

Objective: The objective of this study is to perform a functional and quality of life assessment of patients subjected to debridement of ulcers in the posterior region of the ankle, which progressed to complete Achilles tendon resection without any type of tendon reconstruction or transfer. Methods: This is a case series of 4 patients, mostly diabetic, who underwent complete resection of an exposed and degenerated Achilles tendon due to ulcer in the posterior region of the ankle that precluded preservation given the need to control the infectious process considering the diagnosis of calcaneal osteomyelitis. This diagnosis was compatible with changes observed in the magnetic resonance imaging evaluation and was confirmed in cultures of bone tissue removed during debridement. The patients filled out the Brazilian Portuguese version of the Achilles Tendon Total Rupture Score (ATRS-BR) and 36-Item Short Form Survey (SF-36) during the postoperative period, and follow-up ranged from 6 to 24 months. The ATRS score ranges from 0 to 100, and the higher the scores are, the fewer symptoms and limitations the patients have. The SF-36 consists of 36 questions covering 8 domains: physical role functioning, physical functioning, bodily pain, general health perceptions, social role functioning, vitality, mental health and emotional role functioning. The items are independently assessed, and the total possible score is 100 points, which is indicative of the best health status. Results: All 4 Achilles tendons were approached. The mean age of the patients was 69.8 years. The mean score on the physical functioning section of the SF-36 was 63.8 points. When comparing the outcome with literature data, we observed that when patients with ulcers were compared with individuals of a similar age group, our study showed better results than previous studies. The mean score of the ATRS-BR was 46.3 points, which suggests a poor outcome. However, the patients had few complaints about their physical functioning, as shown in the SF-36 analysis. The decision not to perform Achilles tendon reconstruction was made jointly by the medical team and the patients and their families. Conclusion: Not reconstructing the Achilles tendon in patients, mostly elderly diabetic patients with posterior ankle ulcers, led to encouraging functional scores. The present study suggests that this type of ulcer treatment is a viable option for such populations.

scholarly journals Quality of life measures (EORTC QLQ-C30 and SF-36) as predictors of survival in palliative colorectal and lung cancer patients

2009 ◽  
Vol 7 (3) ◽  
pp. 289-297 ◽  
Author(s):  
Gunn E. Grande ◽  
Morag C. Farquhar ◽  
Stephen I.G. Barclay ◽  
Christopher J. Todd
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Summary Score ◽  
Role Functioning ◽  
Appetite Loss ◽  
Sf 36 ◽  
Mental Health Summary ◽  
Eortc Qlq C30 ◽  
Eortc Qlq

AbstractObjective:Self-reported health-related quality of life (HRQoL) is an important predictor of survival alongside clinical variables and physicians' prediction. This study assessed whether better prediction is achieved using generic (SF-36) HRQoL measures or cancer-specific (EORTC QLQ-C30) measures that include symptoms.Method:Fifty-four lung and 46 colorectal patients comprised the sample. Ninety-four died before study conclusion. EORTC QLQ-C30 and SF-36 scores and demographic and clinical information were collected at baseline. Follow-up was 5 years. Deaths were flagged by the Office of National Statistics. Cox regression survival analyses were conducted. Surviving cases were censored in the analysis.Results:Univariate analyses showed that survival was significantly associated with better EORTC QLQ-C30 physical functioning, role functioning, and global health and less dyspnea and appetite loss. For the SF-36, survival was significantly associated with better emotional role functioning, general health, energy/vitality, and social functioning. The SF-36 summary score for mental health was significantly related to better survival, whereas the SF-36 summary score for physical health was not. In the multivariate analysis, only the SF-36 mental health summary score remained an independent, significant predictor, mainly due to considerable intercorrelations between HRQoL scales. However, models combining the SF-36 mental health summary score with diagnosis explained a similar amount of variance (12%–13%) as models combining diagnosis with single scale SF-36 Energy/Vitality or EORTC QLQ-C30 Appetite Loss.Significance of results:HRQoL contributes significantly to prediction of survival. Generic measures are at least as useful as disease-specific measures including symptoms. Intercorrelations between HRQoL variables and between HRQoL and clinical variables makes it difficult to identify prime predictors. We need to identify variables that are as independent of each other as possible to maximize predictive power and produce more consistent results.

scholarly journals Influence of morbid obesity on physical capacity, knee-related symptoms and overall quality of life: A cross-sectional study

2017 ◽  
Vol 63 (2) ◽  
pp. 142-147 ◽  
Author(s):  
Lilian Sarli Tamura ◽  
Everton Cazzo ◽  
Elinton Adami Chaim ◽  
Sérgio Rocha Piedade
Keyword(s):  
Quality Of Life ◽  
Morbid Obesity ◽  
Cross Sectional Study ◽  
Physical Capacity ◽  
Role Functioning ◽  
Sectional Study ◽  
Cross Sectional ◽  
Sf 36 ◽  
The Mean

Summary Objective: To evaluate the impact of morbid obesity on physical capacity, joint-related symptoms, and on the overall quality of life. Method: Cross-sectional study carried out at a university hospital, enrolling 39 individuals admitted to a bariatric surgery service. Physical capacity was assessed by Six-Minute Walk Test (SMWT) and the Borg rating of perceived exertion (RPE). Knee-related symptoms were evaluated by Knee Injury and Osteoarthritis Outcome Score (KOOS) and the Lysholm Score. Quality of life was evaluated by Short Form 36 Health Questionnaire (SF-36). Results: On SMWT, the mean distance walked was 374.1±107.5 m. The mean Borg score was 12.9±2.4. KOOS questionnaire found the following scores: pain (64.3±24), other symptoms (67.2±25.5), function in daily living (60.4±26.8), function in sport and recreation (28.5±32.2), knee-related quality of life (35.9±33.5), mean Lysholm scale score (55.3±25.4). SF-36 provided the following scores: physical functioning (41±27.4), physical role functioning (34.6±39.2), bodily pain (45.7±23.6), general health perceptions (63.1±26.2), vitality (53.5±12.1), social role functioning (52.6±29.3), emotional role functioning (41±44.9), mental health (55±27.7). Conclusion: Obesity led to significant loss of physical capacity, gait impairment, knee-related symptoms, and a negative impact on the overall quality of life.

Sign in / Sign up

Export Citation Format

Share Document