A Clinical Case of Fitting Scleral Lens for Correction of Pellucid Marginal Degeneration

The Eye ◽  
2021 ◽  
Vol 23 (4) ◽  
pp. 17-20
Author(s):  
N. Yu. Pyltsina ◽  
E. A. Bezbabnova ◽  
A. A. Selezneva ◽  
M. S. Shmelkova
Keyword(s):  
Corneal Stroma ◽  
Corneal Dystrophy ◽  
Good Choice ◽  
Corneal Ectasia ◽  
Narrow Angle ◽  
Social Rehabilitation ◽  
The Right ◽  
Corneal Leukoma ◽  
Peripheral Cornea ◽  
Corneal Thinning

Background. Pellucid Marginal Degeneration (PMD) is a rare bilateral degenerative corneal disease. It causes corneal ectasia with bilateral, clear, inferior (typically 4 o’clock to 8 o’clock), peripheral corneal thinning. It usually affects about 80% of corneal stroma, which leads to the corneal ectasia above the thinning area as well as provokes the irregular astigmatism and visual impairment that are difficult to correct. Purpose. To study the possibilities of correction and social rehabilitation in a patient with PMD wearing scleral lenses. Materials and methods. The study included a patient with PMD, signs of corneal dysfunction and narrow-angle subcompensated glaucoma in the right eye, and PMD of the cornea resulted in a corneal leukoma – terminal glaucoma in the left eye. In addition to standard ophthalmic methods, we performed corneal topography and optical coherence tomography (OCT). For intraocular pressure measurement, ICARE IOP tonometer was used in several areas of the intact peripheral cornea. Results. Prior to lens fitting, UCVA in the right eye amounted to 0.06. Scleral lens helped achieve a high visual acuity of 0.9–1.0. The lens was well-tolerated by the patient. Conclusion. Scleral lenses may be a good choice for patients with irregular cornea caused by corneal dystrophy. Not only they are easy to use and have a good visual effect, but they also help patients with social rehabilitation.

scholarly journals Histopathological Features in a Case of Peters' Anomaly with Acquired Corneal Staphyloma

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Kumi Shirai ◽  
Yuka Okada ◽  
Yasushi Nakamura ◽  
Shizuya Saika
Keyword(s):  
Collagen Type ◽  
Corneal Stroma ◽  
Posterior Part ◽  
Collagen Type I ◽  
Type I ◽  
Peters Anomaly ◽  
Hematoxylin And Eosin ◽  
Corneal Staphyloma ◽  
The Right ◽  
Peripheral Cornea

We report a case of corneal staphyloma histologically diagnosed as caused by Peters' anomaly. A 62-year-old male had a protruding opaque vascularized cornea that began to bulge from six months ago in the right eye. Since his right eye was blind and he wanted us to remove the eyeball for cosmetic improvement, we enucleated the affected eye. The enucleated tissue was fixed in formalin and embedded in paraffin for histological examination. Hematoxylin and eosin staining showed that the cornea lacked the posterior part of the corneal stroma and Descemet's membrane in the central region and the entire corneal endothelium. The corneal epithelium was keratinized. Collagen type I was strongly positive in peripheral cornea and weakly in protruding stroma. The cells labeled by antibodies againstαSMA were scattered in the entire corneal stroma. As judged by the histological findings, the eye with the central corneal staphyloma was diagnosed as Peters' anomaly.

Artificial Odour Classification System

2018 ◽  
pp. 25-37
Author(s):  
Nor Idayu Mahat ◽  
Maz Jamilah Masnan ◽  
Ali Yeon Md Shakaff ◽  
Ammar Zakaria ◽  
Muhd Khairulzaman Abdul Kadir
Keyword(s):  
Feature Selection ◽  
Mahalanobis Distance ◽  
Feature Selection Method ◽  
Classification Performance ◽  
Good Choice ◽  
Classification Rule ◽  
Good Classification Performance ◽  
The Right ◽  
The Cost

This chapter overviews the issue of multicollinearity in electronic nose (e-nose) classification and investigates some analytical solutions to deal with the problem. Multicollinearity effect may harm classification analysis from producing good parameters estimate during the construction of the classification rule. The common approach to deal with multicollinearity is feature extraction. However, the criterion used in extracting the raw features based on variances may not be appropriate for the ultimate goal of classification accuracy. Alternatively, feature selection method would be advisable as it chooses only valuable features. Two distance-based criteria in determining the right features for classification purposes, Wilk's Lambda and bounded Mahalanobis distance, are applied. Classification with features determined by bounded Mahalanobis distance statistically performs better than Wilk's Lambda. This chapter suggests that classification of e-nose with feature selection is a good choice to limit the cost of experiments and maintain good classification performance.

scholarly journals Visually Evoked Potentials in a Patient with a Fyodorov-Zuev Keratoprosthesis

2015 ◽  
Vol 6 (1) ◽  
pp. 12-17
Author(s):  
Roy Schwartz ◽  
Adiel Barak ◽  
Hadas Newman
Keyword(s):  
Evoked Potential ◽  
Corneal Dystrophy ◽  
Visually Evoked Potentials ◽  
Past Medical History ◽  
Visual Status ◽  
Ahmed Valve ◽  
Pars Plana ◽  
The Right ◽  
Valve Implantation ◽  
Normal Latency

Purpose: To describe a visually evoked potential (VEP) examination performed on a patient with a keratoprosthesis. Methods: We report the case of a 60-year-old patient with a Fyodorov-Zuev keratoprosthesis in the right eye complained of gradual visual deterioration in that eye. His past medical history consisted of failed corneal graft procedures due to corneal dystrophy and an Ahmed valve implantation due to secondary glaucoma. A clinical examination and an ultrasound demonstrated vitreal opacities. In order to assess the visual status, a flash VEP test was conducted. Results: VEP recorded from the right eye consisted of a broadened and poorly formed positive P1 wave, with a subnormal amplitude, but a normal latency. Consequently, the patient underwent a pars plana vitrectomy. Conclusion: This case demonstrates the viability of VEP exams in patients with keratoprostheses.

scholarly journals Tectonic DSAEK for the Management of Impending Corneal Perforation

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
Enrique O. Graue-Hernandez ◽  
Isaac Zuñiga-Gonzalez ◽  
Julio C. Hernandez-Camarena ◽  
Martha Jaimes ◽  
Patricia Chirinos-Saldaña ◽  
...  
Keyword(s):  
Dry Eye ◽  
Amniotic Membrane ◽  
Ocular Surface ◽  
Autologous Serum ◽  
Lamellar Keratoplasty ◽  
Corneal Perforation ◽  
Structural Support ◽  
History Of ◽  
The Right ◽  
Corneal Thinning

Purpose. To report a case of severe corneal thinning secondary to dry eye treated with a tectonic Descemet stripping automated lamellar keratoplasty (DSAEK) and amniotic membrane graft.Methods. A 72-year-old man with a history of long standing diabetes mellitus type 2 and dry eye presented with 80% corneal thinning and edema on the right eye and no signs of infectious disease, initially managed with topical unpreserved lubrication and 20% autologous serum drops. Eight weeks after, the defect advanced in size and depth until Descemetocele was formed. Thereafter, he underwent DSAEK for tectonic purposes. One month after the procedure, the posterior lamellar graft was well adhered but a 4 mm epithelial defect was still present. A multilayered amniotic membrane graft was then performed.Results. Ocular surface healed quickly and reepithelization occurred over a 2-week period. Eight months after, the ocular surface remained stable and structurally adequate.Conclusion. Tectonic DSAEK in conjunction with multilayered amniotic graft may not only provide structural support and avoid corneal perforation, but may also promote reepithelization and ocular surface healing and decrease concomitant inflammation.

scholarly journals Performance Evaluation and Comparison of Scheduling Algorithms on 5G Networks using Network Simulator

2019 ◽  
Vol 14 (4) ◽  
pp. 530-539
Author(s):  
Doan Perdana ◽  
Aji Nur Sanyoto ◽  
Yoseph Gustommy Bisono
Keyword(s):  
Round Robin ◽  
Good Choice ◽  
Network Simulator ◽  
5G Networks ◽  
Video Traffic ◽  
Fairness Index ◽  
Voice Traffic ◽  
Performance Evaluation And Comparison ◽  
The Right ◽  
Better Than

In this research, we compared the Round Robin (RR) and the Proportional Fair (PF) algorithms for different user equipment density scenarios using voice and video traffic, to evaluate the key impact on performance of 5G mmwave network. This research simulated on NS3.27 with an integrated mmwave module. Based on the result, we found that the RR is a good choice for voice traffic. It has a throughput of 3.65% better than PF with similar fairness index. On the other hand, we found that the PF is the right choice for video traffic due to has better result for throughput. It has a throughput of 1.24% better than RR. For fairness index round robin has better result for voice and video traffic.

scholarly journals Clinical and Ultrastructural Studies of Gelatinous Drop-Like Corneal Dystrophy (GDLD) of a Patient with TACSTD2 Gene Mutation

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Ali Masmali ◽  
Aljoharah Alkanaan ◽  
Hind M. Alkatan ◽  
Omar Kirat ◽  
Abdullah Ayidh Almutairi ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amyloid Fibrils ◽  
Polarized Light ◽  
Corneal Dystrophy ◽  
Corneal Tissue ◽  
Ultrastructural Studies ◽  
Amyloid Deposits ◽  
Exon 1 ◽  
Pas Staining ◽  
The Right

Purpose. To describe clinical, molecular genetics, histopathologic and ultrastructural findings of gelatinous drop-like corneal dystrophy (GDLD) (OMIM #204870) in a Sudanese patient. Method. An ocular examination revealed the onset of GDLD in a Sudanese patient (50 years old) at King Khalid Specialist Hospital, Riyadh. The 333 sequence variants in 13 GDLD genes of a DNA sample were screened by Asper Ophthalmics Ltd. It was further confirmed by sequencing. The patient had undergone a penetrating keratoplasty in the right eye. The corneal tissue was processed for histopathology and ultrastructural studies. Results. Slit-lamp observation showed grayish-white multiple superficial corneal nodules of various sizes in the left and right eye. Both corneas became clear after the surgery. The GDLD deposits in the subepithelial region and in the anterior stroma were confirmed by PAS staining and their apple-green birefringence under polarized light. Ultrastructurally, the amyloid fibrils were very thin and grouped in whorl-like structures, which caused splits between and within the stromal lamellae. Collagen fibrils (CFs) and keratocytes had degenerated. A homozygous c.355T > A mutation in exon 1 of the TACSTD2 (M1S1) gene was detected, and alteration of the amino acid (p.Cysl19Ser in NCBI entry NP_002344.2) was observed. Conclusion. In our patient with GDLD, a “c.355T > A” mutation in exon 1 of TACSTD2 was detected and believed to be responsible for the alteration of the amino acid leading to the formation of the amyloid deposits. The deposits caused the ultrastructural degeneration of epithelium, Bowman’s layer, stroma, and keratocytes of the GDLD cornea.

scholarly journals Impairment of the autophagy-lysosomal pathway and activation of pyroptosis in macular corneal dystrophy

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Tao Zheng ◽  
Chuchu Zhao ◽  
Baowen Zhao ◽  
Hanruo Liu ◽  
Shijian Wang ◽  
...  
Keyword(s):  
Inflammatory Responses ◽  
Periodic Acid ◽  
Corneal Transplantation ◽  
Corneal Stroma ◽  
Keratan Sulfate ◽  
Corneal Dystrophy ◽  
Autophagic Flux ◽  
Periodic Acid Schiff ◽  
Caspase 1 ◽  
Macular Corneal Dystrophy

Abstract Macular corneal dystrophy (MCD) is ascribed to mutations in the carbohydrate sulfotransferase (CHST6) gene affecting keratan sulfate (KS) hydrophilicity and causing non-sulfated KS to precipitate in keratocytes and the corneal stroma. We investigated roles for inflammatory responses in MCD pathogenesis by examining the lysosomal-autophagy pathway and activation of pyroptosis in MCD keratocytes. Normal and lesioned keratocytes were obtained from MCD patients undergoing corneal transplantation. The keratocytes were subjected to gene sequencing, RT-PCR, western blotting, transmission electron microscopy, histological staining, induction and inhibition assays of autophagy and pyroptosis, CCK-8 and LysoTracker Green DND-26 labeling, and flow cytometry. A novel homozygous MCD mutation was identified in a family from Northeast China; the mutation was distinguished by cytoplasmic vacuolation, cell membrane disruption, electron dense deposits, and deposition of a band of Periodic acid-Schiff and Alcian blue-positive material in the keratocytes and stroma layer. KS protein levels were decreased, expression of p62 and LC3-II proteins was enhanced, cathepsin D expression was declined and the LysoTracker Green DND-26 signal was dramatically reduced in MCD keratocytes. Bafilomycin-A1 treatment significantly increased caspase-1 and Pro-IL-1β expression in normal and MCD keratocytes. Nod-like receptors pyrins-3 (NLRP3), caspase-1, Pro-IL-1β, and IL-1β levels were pronouncedly elevated in cells exposed to H2O2. Ac-YVAD-CMK treatment reversed this expression in normal and MCD keratocytes. Suppression of the autophagic degradation of non-sulfated KS by impaired autophagic flux in MCD keratocytes triggers pyroptosis. Amelioration of impaired autophagy and restraint of pyroptosis may, therefore, have therapeutic efficacy in the treatment of MCD.

scholarly journals Visual outcome on Fitting Rose-K2 XL lens in a case with Terrien’s marginal degeneration

2015 ◽  
Vol 4 (4) ◽  
pp. 49-51 ◽  
Author(s):  
S K Mishra ◽  
G S Shrestha ◽  
P Dhungel ◽  
B Aryal
Keyword(s):  
Visual Acuity ◽  
Contact Lens ◽  
Visual Outcome ◽  
Corneal Astigmatism ◽  
Good Visual Acuity ◽  
Uncommon Disease ◽  
Optical Zone ◽  
Peripheral Cornea ◽  
Irregular Astigmatism ◽  
Corneal Thinning

Terrien’s marginal degeneration is an uncommon disease of the peripheral cornea occurring at any age that results in corneal thinning causing corneal irregular astigmatism. RoseK2 XL lens has an aspheric optical zone and employed in the fitting of irregular corneas for vision and comfort while maintaining corneal health. Rose K2 XL lens was fitted in a 17 year female presented to Contact lens clinic of B.P. Koirala Lions Center for Ophthalmic Studies, Kathmandu having RE Terrien’s marginal degeneration. Her presenting visual acuity was 6/60 in right eye and 6/6 in left eye with best subjective refraction OD: +2.00/-3.00X150 and OS: Plano. Her corneal topography revealed irregular corneal astigmatism as indicated by SimK49.85/41.63@137. RoseK2 XL which is a mini-scleral lens, showed an excellent fitting attaining visual acuity 6/6. RoseK2 XL lens provides not only good visual acuity also confirms comfort in patients with corneal marginal degeneration.DOI: http://dx.doi.org/10.3126/jcmc.v4i4.11974

scholarly journals Implementation Of Assessments In Determining Victims Of Narcotics Abuse In Rehabilitation Efforts In Covid-19 Pandemic Conditions In District Of Karawang Indonesia

2021 ◽  
Vol 8 (04) ◽  
pp. 6425-6440
Author(s):  
Oci Senjaya ◽  
Dr.Candra Hayatul Iman ◽  
Rina Marlina
Keyword(s):  
Southeast Asia ◽  
Southeast Asian ◽  
Assessment Process ◽  
Sick Person ◽  
Asian Region ◽  
Social Rehabilitation ◽  
The World ◽  
The Right

The problem of narcotics has become a very serious threat to all countries in the world, including in Southeast Asia. Indonesia as part of the Southeast Asian region sees the phenomenon of abuse and circulation of narcotics in the country as a serious threat that must be fought. The Covid-19 pandemic has not dampened the illicit narcotics business. Narcotics Abusers during the Covid-19 Pandemic have the right to obtain rehabilitation efforts through an assessment process, the Narcotics Law aims to ensure the arrangement of medical and ssocial rehabilitation efforts for abusers and narcotics addicts. An addict and a victim of narcotics abuse is a victim of narcotics so he deserves to be called a sick person. As a result, an addict and a victim of narcotics abuse must undergo treatment by admitting it to a medical and / or social rehabilitation institution.

scholarly journals CASE REPORT Management Cataract Complication and Malignant Glaucoma After Viterectomy Surgery and C3F8 Gas Tamponnade

2020 ◽  
Vol 4 (1) ◽  
pp. 11
Author(s):  
Frisma Sagara Brilliyanto ◽  
Wimbo Sasono
Keyword(s):  
Anterior Segment ◽  
Cataract Extraction ◽  
Gas Tamponade ◽  
Narrow Angle ◽  
Malignant Glaucoma ◽  
Blurry Vision ◽  
Intravitreal Gas ◽  
The Right ◽  
Gas Expansion ◽  
Aqueous Misdirection

Report a clinical presentation of patient with rhematogenous retinal detachment by viterectomy and high myopia with C3F8 gas tamponade. A 20-year-old female came into the outpatient clinic with blurry vision on the right eye as her chief complaint. It had been happening since 1 month ago. In examination, we found result of visual acuity RE 1/300 and LE 1/60 correction Sferis-16.00 5/7.5, anterior segment in a normal range. In posterior segment evaluation, there were RE detachment on 3-11 o’clock position and hole on 6 and 8 o’clock position. Then we performed vitrectomy and  C3F8 gas tamponade. The first day after surgery, we found IOP 19,6 mmHg and Von Herrick III. Then after the second day, we found a pain on the right eye, TIO 47.3 mmHg, Von Herrick 0 and opaque lens. Then we performed iridectomy and intravitreal gas aspiration. After it were done, we found IOP 17.3 mmHg and Von Herrick 0. In anterior segment OCT evaluation, we found a narrow angle anterior segment. Then we planned to do a cataract extraction with using viscoelastic to perform the anterior chamber.Malignant glaucoma can occur in cases after vitrectomy action due to aqueous misdirection and emphasis on gas expansion on tamponade. Cataract extraction and gas aspiration can help open the anterior chamber and the intraocular pressure returns to normal

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