scholarly journals Editorial: Biotechnological Production and Conversion of Aromatic Compounds and Natural Products

2020 ◽  
Vol 8 ◽  
Author(s):  
Nils J. H. Averesch ◽  
Oliver Kayser
Keyword(s):  
Natural Products ◽  
Aromatic Compounds ◽  
Biotechnological Production

scholarly journals Natural products isolated from Casimiroa

2020 ◽  
Vol 18 (1) ◽  
pp. 778-797
Author(s):  
Khun Nay Win Tun ◽  
Nanik Siti Aminah ◽  
Alfinda Novi Kristanti ◽  
Hnin Thanda Aung ◽  
Yoshiaki Takaya
Keyword(s):  
Natural Products ◽  
Spectral Data ◽  
Aromatic Compounds ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Quinoline Alkaloids

AbstractAbout 140 genera and more than 1,600 species belong to the Rutaceae family. They grow in temperate and tropical zones on both hemispheres, as trees, shrubs, and herbs. Casimiroa is one of the genera constituting 13 species, most of which are found in tropical and subtropical regions. Many chemical constituents have been derived from this genus, including quinoline alkaloids, flavonoids, coumarins, and N-benzoyltyramide derivatives. This article reviews different studies carried out on aromatic compounds of genus Casimiroa; their biological activities; the different skeletons of coumarins, alkaloids, flavonoids, and others; and their characteristic NMR spectral data.

scholarly journals POTENCIAL BIOTECNOLÓGICO DE LAS ESPONJAS EN LA PRODUCCIÓN DE NUEVOS FÁRMACOS: PERSPECTIVAS Y LIMITACIONES

2011 ◽  
Vol 26 (2) ◽  
pp. 31
Author(s):  
R. N. Águila-Ramírez ◽  
C. J. Hernández-Guerrero ◽  
B. González-Acosta
Keyword(s):  
Clinical Trials ◽  
Natural Products ◽  
Pharmacological Activity ◽  
Natural Environment ◽  
Marine Sponges ◽  
Biotechnological Production ◽  
Antiviral Compounds ◽  
Genetic Modifications ◽  
New Compounds

La búsqueda de productos naturales con actividad farmacológica a partir de esponjas marinas tiene un gran potencial debido a las interesantes actividades que algunos compuestos presentan en ensayos clínicos, principalmente en la búsqueda de compuestos anticancerígenos y antivirales. Sin embargo, también existen diversas problemáticas que pueden frenar el desarrollo de un nuevo compuesto. Por lo que en esta revisión se pretende dar un panorama general de las perspectivas y limitantes que se presentan en la búsqueda de nuevos compuestos a partir de esponjas en el medio natural, en el establecimiento de cultivos de esponjas, de primorfos y células madre como una alternativa o el aislamiento de bacterias asociadas a ellas que produzcan dichos metabolitos con la finalidad de realizar modificaciones genéticas que permitan una producción biotecnológica. Biotechnical potential of sponges in new pharmaceutics production: perspectives and limits The search for natural products with pharmacological activity of marine sponges has great potential due to the interesting activities that some compounds have in clinical trials, mainly in the search of anticancer and antiviral compounds. However, there are various problems that may limit the development of a new compound. In this review we intended to give an overview of the perspectives and limitations that occur in the search of new compounds from sponges of the natural environment, in the establishment of culture of sponges, primorph and steam cells as an alternative, or isolated bacteria from sponges which are the metabolites producers to development genetic modifications for a biotechnological production.

scholarly journals Arthur John Birch. 3 August 1915 — 8 December 1995

2007 ◽  
Vol 53 ◽  
pp. 21-44 ◽  
Author(s):  
Rodney W. Rickards ◽  
John Cornforth
Keyword(s):  
Organic Chemistry ◽  
Twentieth Century ◽  
Natural Products ◽  
Organometallic Chemistry ◽  
Oral Contraceptives ◽  
Aromatic Compounds ◽  
Liquid Ammonia ◽  
Wide Range ◽  
National Science ◽  
The Subject

Arthur John Birch AC CMG FAA FRS was one of the great masters of organic chemistry of the twentieth century. His extraordinary creativity left its imprint across the breadth of the subject in its broadest sense, from synthesis to biochemistry to organometallic chemistry. He remains best known for the reaction that bears his name, the Birch reduction of aromatic compounds by solutions of sodium and ethanol in liquid ammonia. This process has wide application, most notably in the commercial synthesis of oral contraceptives, giving rise to his being called ‘the father of the pill’, although he himself preferred the more remote ‘grandfather’ relationship. His polyketide theory, which accounts for the biosynthetic origins of a wide range of natural products, is less widely acknowledged today simply because it has become absorbed into the accepted knowledge base of the subject. His final researches on the use of diene iron tricarbonyl derivatives in synthesis are equally distinguished and have prompted others to extend their application. During his career he was involved in the design of three new university chemistry buildings, one of which now bears his name, and contributed influential advice to governments on national science policies.

scholarly journals Vibrational Circular Dichroism: Recent Advances for the Assignment of the Absolute Configuration of Natural Products

2015 ◽  
Vol 10 (10) ◽  
pp. 1934578X1501001 ◽  
Author(s):  
Eleuterio Burgueño-Tapia ◽  
Pedro Joseph-Nathan
Keyword(s):  
Natural Products ◽  
Circular Dichroism ◽  
Absolute Configuration ◽  
Aromatic Compounds ◽  
Vibrational Circular Dichroism ◽  
Exciton Coupling ◽  
Coupling Approach ◽  
The Absolute ◽  
Circular Dichroïsm

Vibrational circular dichroism (VCD) emerged during the last decade as a reliable tool for the absolute configuration (AC) determination of organic compounds. The principles, instrumentation, and methodology applied prior to early 2013 were recently reviewed by us. Since VCD is a very dynamic field, the aim of this review is to update VCD advances for the AC assignment of terpenoids, aromatic compounds, alkaloids, and other natural products for the 2013-2014 period, when VCD was applied to the AC assignment of some 70 natural products. In addition, although discovered in 2012, a brief introduction to the VCD exciton coupling approach and its applications in natural products AC assignment is presented.

scholarly journals Arenophile-Mediated Photochemical Dearomatization of Nonactivated Arenes

2020 ◽  
Vol 74 (7) ◽  
pp. 577-583 ◽  
Author(s):  
Mikiko Okumura ◽  
David Sarlah
Keyword(s):  
Natural Products ◽  
Transition Metal ◽  
Visible Light ◽  
Bioactive Compounds ◽  
Aromatic Compounds ◽  
Ring Opening ◽  
Organic Molecules ◽  
Building Blocks ◽  
Metal Catalyzed

Aromatic compounds are one of the most abundant classes of organic molecules and find utility as precursors for alicyclic hydrocarbon building blocks. While many established dearomatization reactions are exceptionally powerful, dearomatization with concurrent introduction of functionality, i.e. dearomative functionalization, is still a largely underdeveloped field. This review aims to provide an overview of our recent efforts and progress in the development of dearomative functionalization of simple and nonactivated arenes using arenophile-arene cycloaddition platform. These cycloadducts, formed via a visible-light-mediated [4+2]-photocycloaddition, can be elaborated in situ through olefin chemistry or transition-metal-catalyzed ring-opening with carbon-, nitrogen-, and oxygen-based nucleophiles, providing access to diverse structures with functional and stereochemical complexity. Moreover, the dearomatized products are amenable to further elaborations, which effectively install other functionalities onto the resulting alicyclic carbocycles. The utility of the arenophile-mediated dearomatization methods are also highlighted by the facile syntheses of natural products and bioactive compounds through novel disconnections.

scholarly journals Terpene Bioconversion – How does its Future Look?

2010 ◽  
Vol 5 (9) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Ulrich Krings ◽  
Ralf Guenter Berger
Keyword(s):  
Natural Products ◽  
Genetic Engineering ◽  
Pharmaceutical Products ◽  
Cosmetic Products ◽  
Future Perspectives ◽  
Biotechnological Production ◽  
High Quality ◽  
Plant Materials ◽  
Convenience Food ◽  
Natural Flavors

The usage of essential oils as such or of volatile fractions thereof is widespread in the flavor and fragrance industry to aromatize perfumery and cosmetic products, foodstuffs, and many household and pharmaceutical products. The increased market share of convenience food together with consumers’ request for constant high quality and natural products have established a lasting increase in the demand for natural flavorings that cannot be satisfied by the traditional plant materials. This review summarizes selected work on terpene bioconversion / transformation and focuses on recently published papers dealing with novel strains and products, high product yields, intriguing genetic engineering approaches, and integrated bioprocesses. The future perspectives of an industrial realization of a biotechnological production of terpene-derived natural flavors are critically evaluated.

scholarly journals Antitumor astins originate from the fungal endophyteCyanodermella asterisliving within the medicinal plantAster tataricus

2019 ◽  
Vol 116 (52) ◽  
pp. 26909-26917 ◽  
Author(s):  
Thomas Schafhauser ◽  
Linda Jahn ◽  
Norbert Kirchner ◽  
Andreas Kulik ◽  
Liane Flor ◽  
...  
Keyword(s):  
Natural Products ◽  
Medicinal Plants ◽  
Biosynthetic Gene Cluster ◽  
Biological Properties ◽  
Fungal Endophyte ◽  
Antitumor Activities ◽  
Biotechnological Production ◽  
Peptide Synthetase ◽  
Plant Enzymes ◽  
Macrocyclic Peptides

Medicinal plants are a prolific source of natural products with remarkable chemical and biological properties, many of which have considerable remedial benefits. Numerous medicinal plants are suffering from wildcrafting, and thus biotechnological production processes of their natural products are urgently needed. The plantAster tataricusis widely used in traditional Chinese medicine and contains unique active ingredients named astins. These are macrocyclic peptides showing promising antitumor activities and usually containing the highly unusual moiety 3,4-dichloroproline. The biosynthetic origins of astins are unknown despite being studied for decades. Here we show that astins are produced by the recently discovered fungal endophyteCyanodermella asteris. We were able to produce astins in reasonable and reproducible amounts using axenic cultures of the endophyte. We identified the biosynthetic gene cluster responsible for astin biosynthesis in the genome ofC. asterisand propose a production pathway that is based on a nonribosomal peptide synthetase. Striking differences in the production profiles of endophyte and host plant imply a symbiotic cross-species biosynthesis pathway for astin C derivatives, in which plant enzymes or plant signals are required to trigger the synthesis of plant-exclusive variants such as astin A. Our findings lay the foundation for the sustainable biotechnological production of astins independent from aster plants.

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