scholarly journals Dynamic Expression of m6A Regulators During Multiple Human Tissue Development and Cancers

2021 ◽  
Vol 8 ◽  
Author(s):  
Ya Zhang ◽  
Sicong Xu ◽  
Gang Xu ◽  
Yueying Gao ◽  
Si Li ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cancer Progression ◽  
Human Tissue ◽  
Copy Number ◽  
Tissue Development ◽  
Dynamic Expression ◽  
Mrna Binding Protein ◽  
Cancer Types ◽  
Mrna Binding ◽  
Copy Number Amplification

N6-methyladenosine (m6A) plays critical roles in human development and cancer progression. However, our knowledge regarding the dynamic expression of m6A regulators during human tissue development is still lacking. Here, we comprehensively analyzed the dynamic expression alterations of m6A regulators during seven tissue development and eight cancer types. We found that m6A regulators globally exhibited decreased expression during development. In addition, IGF2BP1/2/3 (insulinlike growth factor 2 MRNA-binding protein 1/2/3) exhibited reverse expression pattern in cancer progression, suggesting an oncofetal reprogramming in cancer. The expressions of IGF2BP1/2/3 were regulated by genome alterations, particularly copy number amplification in cancer. Clinical association analysis revealed that higher expressions of IGF2BP1/2/3 were associated with worse survival of cancer patients. Finally, we found that genes significantly correlated with IGF2BP1/2/3 were significantly enriched in cancer hallmark-related pathways. In summary, dynamic expression analysis will guide both mechanistic and therapeutic roles of m6A regulators during tissue development and cancer progression.

scholarly journals Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?

2012 ◽  
Vol 70 (15) ◽  
pp. 2657-2675 ◽  
Author(s):  
Jessica L. Bell ◽  
Kristin Wächter ◽  
Britta Mühleck ◽  
Nikolaos Pazaitis ◽  
Marcel Köhn ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cancer Progression ◽  
Binding Proteins ◽  
Insulin Like Growth Factor ◽  
Mrna Binding Proteins ◽  
Mrna Binding

scholarly journals Human Insulin Growth Factor 2 mRNA Binding Protein 2 Increases MicroRNA 33a/b Inhibition of Liver ABCA1 Expression and Alters Low-Density Apolipoprotein Levels in Mice

2020 ◽  
Vol 40 (16) ◽  
Author(s):  
Muhua Yang ◽  
Christina Gallo-Ebert ◽  
Michael Hayward ◽  
Weidong Liu ◽  
Virginia McDonough ◽  
...  
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Association Studies ◽  
Blood Levels ◽  
Genome Wide Association Studies ◽  
Low Density ◽  
Nucleotide Polymorphisms ◽  
Insulin Growth Factor ◽  
Mrna Binding Protein ◽  
Mrna Binding

ABSTRACT Genome-wide association studies (GWAS) have linked IGF2BP2 single-nucleotide polymorphisms (SNPs) with type 2 diabetes (T2D). Mice overexpressing mIGF2BP2 have elevated cholesterol levels when fed a diet that induces hepatic steatosis. These and other studies suggest an important role for insulin growth factor 2 mRNA binding protein 2 (IGF2BP2) in the initiation and progression of several metabolic disorders. The ATPase binding cassette protein ABCA1 initiates nascent high-density apolipoprotein (HDL) biogenesis by transferring phospholipid and cholesterol to delipidated apolipoprotein AI (ApoAI). Individuals with mutational ablation of ABCA1 have Tangier disease, which is characterized by a complete loss of HDL. MicroRNA 33a and 33b (miR-33a/b) bind to the 3′ untranslated region (UTR) of ABCA1 and repress its posttranscriptional gene expression. Here, we show that IGF2BP2 works together with miR-33a/b in repressing ABCA1 expression. Our data suggest that IGF2BP2 is an accessory protein of the argonaute (AGO2)–miR-33a/b–RISC complex, as it directly binds to miR-33a/b, AGO2, and the 3′ UTR of ABCA1. Finally, we show that mice overexpressing human IGF2BP2 have decreased ABCA1 expression, increased low-density lipoprotein-cholesterol (LDL-C) and cholesterol blood levels, and elevated SREBP-dependent signaling. Our data support the hypothesis that IGF2BP2 has an important role in maintaining lipid homeostasis through its modulation of ABCA1 expression, as its overexpression or loss leads to dyslipidemia.

scholarly journals Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in cancer

2018 ◽  
Vol 11 (1) ◽  
Author(s):  
Xinwei Huang ◽  
Hong Zhang ◽  
Xiaoran Guo ◽  
Zongxin Zhu ◽  
Haibo Cai ◽  
...  
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Mrna Binding Protein ◽  
Mrna Binding

The roles of Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3) in melanoma progression

2013 ◽  
Vol 69 (2) ◽  
pp. e20-e21
Author(s):  
Chia-Yu Chu ◽  
Yi-Shuan Sheen ◽  
Kuanyin K. Lin ◽  
Meng-Chen Hsieh ◽  
Hsien-Ching Chiu ◽  
...  
Keyword(s):  
Growth Factor ◽  
Messenger Rna ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Melanoma Progression ◽  
Factor Ii ◽  
Mrna Binding Protein ◽  
Mrna Binding

scholarly journals Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 Modulates Aggressiveness of Ewing Sarcoma by Regulating the CD164-CXCR4 Axis

2020 ◽  
Vol 10 ◽  
Author(s):  
Caterina Mancarella ◽  
Giulia Caldoni ◽  
Irene Ribolsi ◽  
Alessandro Parra ◽  
Maria Cristina Manara ◽  
...  
Keyword(s):  
Growth Factor ◽  
Ewing Sarcoma ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Mrna Binding Protein ◽  
Mrna Binding ◽  
Cxcr4 Axis

scholarly journals Expression and prognostic analyses of the insulin-like growth factor 2 mRNA binding protein family in human pancreatic cancer

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Xiao-Han Cui ◽  
Shu-Yi Hu ◽  
Chun-Fu Zhu ◽  
Xi-Hu Qin
Keyword(s):  
Pancreatic Cancer ◽  
Overall Survival ◽  
Growth Factor ◽  
Binding Protein ◽  
Gene Set Enrichment Analysis ◽  
Human Pancreatic Cancer ◽  
Insulin Like Growth Factor ◽  
Expression Levels ◽  
Mrna Binding Protein ◽  
Mrna Binding

Abstract Background Despite advances in early diagnosis and treatment, cancer remains the leading cause of mortality worldwide. The insulin-like growth factor 2 mRNA binding protein (IGF2BP) family has been reported to be involved in a variety of human malignant tumours. However, little is known about their expression and prognostic value in human pancreatic cancer. Therefore, we performed a detailed cancer versus normal differential analysis. Methods The Cancer Genome Atlas (TCGA) and Gene Expression Profiling Interactive Analysis (GEPIA) databases were used to analyse the mRNA expression levels of the IGF2BP family in various cancers, including pancreatic cancer. Then, the LinkedOmics and GEPIA databases were used to assess the relation between the expression levels of IGF2BPs and overall survival (OS). Then, univariate and multivariate Cox regression analyses were performed, and subgroups based on grade and stage were analysed. The signalling pathways associated with IGF2BP2 and IGF2BP3 were then investigated via gene set enrichment analysis (GSEA). Results IGF2BP2 and IGF2BP3 were associated with each subset of OS based on grade and stage. Further clinical correlation analysis of IGF2BP2 and IGF2BP3 confirmed that IGF2BP2 and IGF2BP3 are fundamental factors in promoting pancreatic cancer progression. Conclusion IGF2BP2 and IGF2BP3 are key factors in promoting the progression of pancreatic cancer and are closely related to overall survival.

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