scholarly journals Oleic Acid Protects Caenorhabditis Mothers From Mating-Induced Death and the Cost of Reproduction

2021 ◽  
Vol 9 ◽  
Author(s):  
Leo S. Choi ◽  
Cheng Shi ◽  
Jasmine Ashraf ◽  
Salman Sohrabi ◽  
Coleen T. Murphy
Keyword(s):  
Oleic Acid ◽  
Fat Metabolism ◽  
Dietary Supplementation ◽  
Cost Of Reproduction ◽  
Costs Of Reproduction ◽  
Short Term ◽  
C Elegans ◽  
Δ9 Desaturase ◽  
The Cost

Reproduction comes at a cost, including accelerated death. Previous studies of the interconnections between reproduction, lifespan, and fat metabolism in C. elegans were predominantly performed in low-reproduction conditions. To understand how increased reproduction affects lifespan and fat metabolism, we examined mated worms; we find that a Δ9 desaturase, FAT-7, is significantly up-regulated. Dietary supplementation of oleic acid (OA), the immediate downstream product of FAT-7 activity, restores fat storage and completely rescues mating-induced death, while other fatty acids cannot. OA-mediated lifespan restoration is also observed in C. elegans mutants suffering increased death from short-term mating, and in mated C. remanei females, indicating a conserved role of oleic acid in post-mating lifespan regulation. Our results suggest that increased reproduction can be uncoupled from the costs of reproduction from somatic longevity regulation if provided with the limiting lipid, oleic acid.

scholarly journals Oleic acid protects Caenorhabditis mothers from mating-induced death

2020 ◽  
Author(s):  
Leo S. Choi ◽  
Cheng Shi ◽  
Coleen T. Murphy
Keyword(s):  
Oleic Acid ◽  
Fat Metabolism ◽  
Dietary Supplementation ◽  
Cost Of Reproduction ◽  
Short Term ◽  
C Elegans ◽  
Δ9 Desaturase ◽  
The Cost ◽  
Lifespan Regulation

AbstractReproduction comes at a cost, including death. Previous studies of the interconnections between reproduction, lifespan, and fat metabolism in C. elegans were predominantly performed in low-reproduction conditions. To understand how increased reproduction affects lifespan and fat metabolism, we examined mated worms; we find that a Δ9 desaturase, FAT-7, is significantly up-regulated. Dietary supplementation of oleic acid (OA), the immediate downstream product of FAT-7 activity, restores fat storage and completely rescues mating-induced death, while other fatty acids cannot. OA-mediated lifespan restoration is also observed in C. elegans mutants suffering increased death from short-term mating, and in mated C. remanei females, indicating a conserved role of oleic acid in post-mating lifespan regulation. Because OA supplementation does not further increase the reproductive span or the brood size of mated C. elegans mothers, our results suggest that altering specific fat metabolism uncouples reproduction and somatic lifespan regulation, providing potent targets to ameliorate the cost of reproduction.

scholarly journals PENERAPAN INFORMASI AKUNTANSI DIFERENSIAL DALAM PENGAMBILAN KEPUTUSAN MEMBELI ATAU MEMBUAT SENDIRI PRODUK SETENGAH JADI PADA UD. BERKAT ANUGERAH

2013 ◽  
Vol 8 (4) ◽  
Author(s):  
Phamela D Tampubolon ◽  
David Paul Elia Saerang ◽  
Agus Toni Poputra
Keyword(s):  
Research Method ◽  
Accounting Information ◽  
Third Party ◽  
Economic Conditions ◽  
Short Term ◽  
Descriptive Research ◽  
Course Of Action ◽  
Management Measure ◽  
The Cost

Amid competition is so rapid and uncertain economic conditions, every company is required to be more efficient in order tobe more efficient in orderto survive and all of it can not be separated from the role of management.  Management measure which is occupied to measure the success or failure of the company is profit. To produce an efficient profit differential accounting information requires management to select the best course of action among alternatives available. The purpose of this study is to analyze the application of differential accounting information in the decision to buy or make your own semi-finished products on UD. Berkat Anugerah. This study uses a descriptive research method. The result of the analysis of research conducted on UD. Berkat Anugerah seen from the cost accounting showed diferential role in the short-term decision making, where the company should buy semi-finished products from third party cost incurred due to lower than producing its own.

scholarly journals tert-Butyl Hydroperoxide (tBHP)-Induced Lipid Peroxidation and Embryonic Defects Resemble Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency in C. elegans

2020 ◽  
Vol 21 (22) ◽  
pp. 8688
Author(s):  
Hung-Chi Yang ◽  
Hsiang Yu ◽  
Tian-Hsiang Ma ◽  
Wen-Ye Tjong ◽  
Arnold Stern ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
G6pd Deficiency ◽  
Short Term ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
C Elegans ◽  
Tert Butyl Hydroperoxide ◽  
Calcium Independent Phospholipase A2 ◽  
Glucose 6 Phosphate Dehydrogenase

G6PD is required for embryonic development in animals, as severe G6PD deficiency is lethal to mice, zebrafish and nematode. Lipid peroxidation is linked to membrane-associated embryonic defects in Caenorhabditis elegans (C. elegans). However, the direct link between lipid peroxidation and embryonic lethality has not been established. The aim of this study was to delineate the role of lipid peroxidation in gspd-1-knockdown (ortholog of g6pd) C. elegans during reproduction. tert-butyl hydroperoxide (tBHP) was used as an exogenous inducer. Short-term tBHP administration reduced brood size and enhanced germ cell death in C. elegans. The altered phenotypes caused by tBHP resembled GSPD-1 deficiency in C. elegans. Mechanistically, tBHP-induced malondialdehyde (MDA) production and stimulated calcium-independent phospholipase A2 (iPLA) activity, leading to disturbed oogenesis and embryogenesis. The current study provides strong evidence to support the notion that enhanced lipid peroxidation in G6PD deficiency promotes death of germ cells and impairs embryogenesis in C. elegans.

scholarly journals Age-related shapes of the cost of reproduction in vertebrates

2007 ◽  
Vol 3 (6) ◽  
pp. 674-677 ◽  
Author(s):  
G Proaktor ◽  
E.J Milner-Gulland ◽  
T Coulson
Keyword(s):  
Life History ◽  
Exponential Decay ◽  
Theoretical Method ◽  
Cost Of Reproduction ◽  
Frequent Pattern ◽  
Costs Of Reproduction ◽  
Age Related ◽  
Cost Curves ◽  
The Cost ◽  
Related Survival

The shape of the association between age and the cost of reproduction varies across species. However, it is unclear whether there are any general patterns in the way the cost of reproduction varies with life history, taxon or ecological function. Using a simple theoretical method, we identified three characteristic patterns to describe the age-related survival cost of reproduction. The most frequent pattern is an approximately exponential decay (ED) with increasing age. Two additional u-shaped patterns were identified, where the cost of reproduction was higher for young and old individuals compared with intermediate-aged individuals. The majority of these u-shaped curves suggested higher costs of reproduction at older ages (RQ), with the rest suggesting a higher cost at young ages (LQ). While predators were most likely to exhibit ED-shaped cost curves, herbivores were equally likely to exhibit ED and RQ curves; birds were likely to exhibit ED-shaped curves and mammals were split equally between ED and RQ curves. These findings suggest that there may be predictable differences in the age-related shape of the cost of reproduction between species, but further research is required to identify the mechanisms generating such differences.

scholarly journals Effect of insulin, and oleic acid on triglyceride secretion by chicken hepatocytes in primary culture. Role of the Δ9 desaturase

1994 ◽  
Vol 34 (6) ◽  
pp. 626-626
Author(s):  
P. Legrand ◽  
E. Le Bihan ◽  
D. Catheline ◽  
MC Fichot ◽  
P. Lemarchal
Keyword(s):  
Oleic Acid ◽  
Primary Culture ◽  
Triglyceride Secretion ◽  
Δ9 Desaturase

scholarly journals Role of endogenous oleic acid produced by Δ9-desaturase on triacylglycerol secretion in cultured chicken hepatocytes

1996 ◽  
Vol 36 (4) ◽  
pp. 438-438
Author(s):  
P. Legrand ◽  
D. Catheline ◽  
M. Fichot ◽  
P. Lemarchal
Keyword(s):  
Oleic Acid ◽  
Δ9 Desaturase

scholarly journals Integration of heterogeneous functional genomics data in gerontology research identifies genes and pathway underlying aging across species

2018 ◽  
Author(s):  
Jason A Bubier ◽  
George L Sutphin ◽  
Timothy J Reynolds ◽  
Ron Korstanje ◽  
Axis Fuksman-Kumpa ◽  
...  
Keyword(s):  
Functional Genomics ◽  
Model Organism ◽  
Heterogeneous Data ◽  
Related Genome ◽  
C Elegans ◽  
Gene Sets ◽  
Genome Wide ◽  
Analysis System ◽  
The Cost

Understanding the biological mechanisms behind aging, lifespan and healthspan is becoming increasingly important as the proportion of the world's population over the age of 65 grows, along with the cost and complexity of their care. BigData oriented approaches and analysis methods for integrative functional genomics enable current and future bio-gerontologists to synthesize, distill and interpret vast, heterogeneous data. GeneWeaver is an analysis system for integration of data that allows investigators to store, search, and analyze immense amounts of data including user-submitted experimental data, data from primary publications, and data in other databases. Aging related genome-wide gene sets from primary publications were curated into this system in concert with data from other model-organism and aging-specific databases, and used in several application using GeneWeavers analysis tools. For example, we identified Cd63 as a frequently represented gene among aging-related genome-wide results. To evaluate the role of Cd63 in aging, we performed RNAi knockdown of the C. elegans ortholog, tsp-7, demonstrating that this manipulation is capable of extending lifespan. The tools in GeneWeaver enable aging researchers to make new discoveries into the associations between the genes, normal biological processes, and diseases that affect aging, healthspan, and lifespan.

scholarly journals Contratos agrarios y renta de la tierra en Toledo, 1521-1650

2019 ◽  
pp. 7-40
Author(s):  
David González Agudo
Keyword(s):  
Seventeenth Century ◽  
Sixteenth Century ◽  
Economic Performance ◽  
Representative Sample ◽  
Land Rent ◽  
Short Term ◽  
The Cost ◽  
The Ideal

Little is known about the management of secular clerg y assets in modern Spain. The aim of this work is to analyse agrarian contracts and the evolution of land rent in Toledo between 1521 and 1650, from a representative sample of fifty rural properties belonging to the city’s Cathedral. The census was the most frequent contract, although the lease provided the main source of income for the Chapter. Long-term leases were more prevalent during the first half of the sixteenth century, after which short-term leases increased. From 1521-1529 and 1642-1650, farmland rents increased by 28%, while meadow rents fell by 57%. Such a divergence can be explained by the growing profitability of farmland and increases in the cost of livestock activities. In the seventeenth century, agrarian depression in the region and reorientation of Madrid’s grain supplies would have dr iven down the rents of the Cathedral far mlands that were closely located to the seat of the new Crown. However, the takeover of a considerable share of the leases by Chapter canons and civil elites would have altered both rent trends and contractual for mulas. This makes the role of land rent a proxy for economic performance and questions the idea that corporate interests prevailed over the ideal of maximizing income.

scholarly journals Flowering sex ratios and costs of reproduction in gynodioecious Ocotea oblonga (Lauraceae)

2020 ◽  
Vol 131 (2) ◽  
pp. 344-355
Author(s):  
Juan C Penagos Zuluaga ◽  
Simon A Queenborough ◽  
Liza S Comita
Keyword(s):  
Reproductive Investment ◽  
Cost Of Reproduction ◽  
Costs Of Reproduction ◽  
Growth Data ◽  
Seed Fertility ◽  
Moist Forest ◽  
Biased Sex Ratio ◽  
The Cost ◽  
Ecological Differences

Abstract In gynodioecious plant species, both female and hermaphrodite individuals produce fruit, but only hermaphrodites produce pollen. Such sex-specific differences in reproductive investment may contribute to dimorphism, but the magnitude and ecological effects are still unclear, especially for gynodioecious tropical trees where collecting flowers and determining the sex is complex. We documented flowering and fruiting over three years in a natural population of Ocotea oblonga (Lauraceae) trees in a tropical moist forest, Panama. We determined sex from freshly collected flowers, counted and measured fruit, and used long-term growth data for each individual. We confirmed that O. oblonga is gynodioecious. No tree switched sex or had flowers of both sexes. The population was hermaphrodite-biased. We found no ecological differences in reproductive investment (seed, fruit, or tree size, or growth rate) between the sexes, indicating that the sex differential in the cost of reproduction is much smaller in woody gynodioecious taxa than in dioecious taxa. Females produced more fruit than hermaphrodites, which may contribute to their persistence in the population. Accordingly, and contrary to most studies of temperate gynodioecious populations, our study of a tropical tree shows no differential cost of reproduction in a hermaphrodite-biased population. Consequently, other factors such as seed fertility or herbivory could drive the biased sex ratio in this population.

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