scholarly journals Oleic acid protects Caenorhabditis mothers from mating-induced death

2020 ◽  
Author(s):  
Leo S. Choi ◽  
Cheng Shi ◽  
Coleen T. Murphy
Keyword(s):  
Oleic Acid ◽  
Fat Metabolism ◽  
Dietary Supplementation ◽  
Cost Of Reproduction ◽  
Short Term ◽  
C Elegans ◽  
Δ9 Desaturase ◽  
The Cost ◽  
Lifespan Regulation

AbstractReproduction comes at a cost, including death. Previous studies of the interconnections between reproduction, lifespan, and fat metabolism in C. elegans were predominantly performed in low-reproduction conditions. To understand how increased reproduction affects lifespan and fat metabolism, we examined mated worms; we find that a Δ9 desaturase, FAT-7, is significantly up-regulated. Dietary supplementation of oleic acid (OA), the immediate downstream product of FAT-7 activity, restores fat storage and completely rescues mating-induced death, while other fatty acids cannot. OA-mediated lifespan restoration is also observed in C. elegans mutants suffering increased death from short-term mating, and in mated C. remanei females, indicating a conserved role of oleic acid in post-mating lifespan regulation. Because OA supplementation does not further increase the reproductive span or the brood size of mated C. elegans mothers, our results suggest that altering specific fat metabolism uncouples reproduction and somatic lifespan regulation, providing potent targets to ameliorate the cost of reproduction.

scholarly journals Oleic Acid Protects Caenorhabditis Mothers From Mating-Induced Death and the Cost of Reproduction

2021 ◽  
Vol 9 ◽  
Author(s):  
Leo S. Choi ◽  
Cheng Shi ◽  
Jasmine Ashraf ◽  
Salman Sohrabi ◽  
Coleen T. Murphy
Keyword(s):  
Oleic Acid ◽  
Fat Metabolism ◽  
Dietary Supplementation ◽  
Cost Of Reproduction ◽  
Costs Of Reproduction ◽  
Short Term ◽  
C Elegans ◽  
Δ9 Desaturase ◽  
The Cost

Reproduction comes at a cost, including accelerated death. Previous studies of the interconnections between reproduction, lifespan, and fat metabolism in C. elegans were predominantly performed in low-reproduction conditions. To understand how increased reproduction affects lifespan and fat metabolism, we examined mated worms; we find that a Δ9 desaturase, FAT-7, is significantly up-regulated. Dietary supplementation of oleic acid (OA), the immediate downstream product of FAT-7 activity, restores fat storage and completely rescues mating-induced death, while other fatty acids cannot. OA-mediated lifespan restoration is also observed in C. elegans mutants suffering increased death from short-term mating, and in mated C. remanei females, indicating a conserved role of oleic acid in post-mating lifespan regulation. Our results suggest that increased reproduction can be uncoupled from the costs of reproduction from somatic longevity regulation if provided with the limiting lipid, oleic acid.

scholarly journals PENERAPAN INFORMASI AKUNTANSI DIFERENSIAL DALAM PENGAMBILAN KEPUTUSAN MEMBELI ATAU MEMBUAT SENDIRI PRODUK SETENGAH JADI PADA UD. BERKAT ANUGERAH

2013 ◽  
Vol 8 (4) ◽  
Author(s):  
Phamela D Tampubolon ◽  
David Paul Elia Saerang ◽  
Agus Toni Poputra
Keyword(s):  
Research Method ◽  
Accounting Information ◽  
Third Party ◽  
Economic Conditions ◽  
Short Term ◽  
Descriptive Research ◽  
Course Of Action ◽  
Management Measure ◽  
The Cost

Amid competition is so rapid and uncertain economic conditions, every company is required to be more efficient in order tobe more efficient in orderto survive and all of it can not be separated from the role of management.  Management measure which is occupied to measure the success or failure of the company is profit. To produce an efficient profit differential accounting information requires management to select the best course of action among alternatives available. The purpose of this study is to analyze the application of differential accounting information in the decision to buy or make your own semi-finished products on UD. Berkat Anugerah. This study uses a descriptive research method. The result of the analysis of research conducted on UD. Berkat Anugerah seen from the cost accounting showed diferential role in the short-term decision making, where the company should buy semi-finished products from third party cost incurred due to lower than producing its own.

scholarly journals tert-Butyl Hydroperoxide (tBHP)-Induced Lipid Peroxidation and Embryonic Defects Resemble Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency in C. elegans

2020 ◽  
Vol 21 (22) ◽  
pp. 8688
Author(s):  
Hung-Chi Yang ◽  
Hsiang Yu ◽  
Tian-Hsiang Ma ◽  
Wen-Ye Tjong ◽  
Arnold Stern ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
G6pd Deficiency ◽  
Short Term ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
C Elegans ◽  
Tert Butyl Hydroperoxide ◽  
Calcium Independent Phospholipase A2 ◽  
Glucose 6 Phosphate Dehydrogenase

G6PD is required for embryonic development in animals, as severe G6PD deficiency is lethal to mice, zebrafish and nematode. Lipid peroxidation is linked to membrane-associated embryonic defects in Caenorhabditis elegans (C. elegans). However, the direct link between lipid peroxidation and embryonic lethality has not been established. The aim of this study was to delineate the role of lipid peroxidation in gspd-1-knockdown (ortholog of g6pd) C. elegans during reproduction. tert-butyl hydroperoxide (tBHP) was used as an exogenous inducer. Short-term tBHP administration reduced brood size and enhanced germ cell death in C. elegans. The altered phenotypes caused by tBHP resembled GSPD-1 deficiency in C. elegans. Mechanistically, tBHP-induced malondialdehyde (MDA) production and stimulated calcium-independent phospholipase A2 (iPLA) activity, leading to disturbed oogenesis and embryogenesis. The current study provides strong evidence to support the notion that enhanced lipid peroxidation in G6PD deficiency promotes death of germ cells and impairs embryogenesis in C. elegans.

scholarly journals Effect of insulin, and oleic acid on triglyceride secretion by chicken hepatocytes in primary culture. Role of the Δ9 desaturase

1994 ◽  
Vol 34 (6) ◽  
pp. 626-626
Author(s):  
P. Legrand ◽  
E. Le Bihan ◽  
D. Catheline ◽  
MC Fichot ◽  
P. Lemarchal
Keyword(s):  
Oleic Acid ◽  
Primary Culture ◽  
Triglyceride Secretion ◽  
Δ9 Desaturase

scholarly journals The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Caroline Kumsta ◽  
Jessica T. Chang ◽  
Reina Lee ◽  
Ee Phie Tan ◽  
Yongzhi Yang ◽  
...  
Keyword(s):  
Heat Shock ◽  
Stress Responses ◽  
Dependent Manner ◽  
Selective Autophagy ◽  
C Elegans ◽  
Proteotoxic Stress ◽  
Autophagy Induction ◽  
The Impact ◽  
Lifespan Regulation

AbstractAutophagy can degrade cargos with the help of selective autophagy receptors such as p62/SQSTM1, which facilitates the degradation of ubiquitinated cargo. While the process of autophagy has been linked to aging, the impact of selective autophagy in lifespan regulation remains unclear. We have recently shown in Caenorhabditis elegans that transcript levels of sqst-1/p62 increase upon a hormetic heat shock, suggesting a role of SQST-1/p62 in stress response and aging. Here, we find that sqst-1/p62 is required for hormetic benefits of heat shock, including longevity, improved neuronal proteostasis, and autophagy induction. Furthermore, overexpression of SQST-1/p62 is sufficient to induce autophagy in distinct tissues, extend lifespan, and improve the fitness of mutants with defects in proteostasis in an autophagy-dependent manner. Collectively, these findings illustrate that increased expression of a selective autophagy receptor is sufficient to induce autophagy, enhance proteostasis and extend longevity, and demonstrate an important role for sqst-1/p62 in proteotoxic stress responses.

scholarly journals Role of endogenous oleic acid produced by Δ9-desaturase on triacylglycerol secretion in cultured chicken hepatocytes

1996 ◽  
Vol 36 (4) ◽  
pp. 438-438
Author(s):  
P. Legrand ◽  
D. Catheline ◽  
M. Fichot ◽  
P. Lemarchal
Keyword(s):  
Oleic Acid ◽  
Δ9 Desaturase

scholarly journals Integration of heterogeneous functional genomics data in gerontology research identifies genes and pathway underlying aging across species

2018 ◽  
Author(s):  
Jason A Bubier ◽  
George L Sutphin ◽  
Timothy J Reynolds ◽  
Ron Korstanje ◽  
Axis Fuksman-Kumpa ◽  
...  
Keyword(s):  
Functional Genomics ◽  
Model Organism ◽  
Heterogeneous Data ◽  
Related Genome ◽  
C Elegans ◽  
Gene Sets ◽  
Genome Wide ◽  
Analysis System ◽  
The Cost

Understanding the biological mechanisms behind aging, lifespan and healthspan is becoming increasingly important as the proportion of the world's population over the age of 65 grows, along with the cost and complexity of their care. BigData oriented approaches and analysis methods for integrative functional genomics enable current and future bio-gerontologists to synthesize, distill and interpret vast, heterogeneous data. GeneWeaver is an analysis system for integration of data that allows investigators to store, search, and analyze immense amounts of data including user-submitted experimental data, data from primary publications, and data in other databases. Aging related genome-wide gene sets from primary publications were curated into this system in concert with data from other model-organism and aging-specific databases, and used in several application using GeneWeavers analysis tools. For example, we identified Cd63 as a frequently represented gene among aging-related genome-wide results. To evaluate the role of Cd63 in aging, we performed RNAi knockdown of the C. elegans ortholog, tsp-7, demonstrating that this manipulation is capable of extending lifespan. The tools in GeneWeaver enable aging researchers to make new discoveries into the associations between the genes, normal biological processes, and diseases that affect aging, healthspan, and lifespan.

scholarly journals Contratos agrarios y renta de la tierra en Toledo, 1521-1650

2019 ◽  
pp. 7-40
Author(s):  
David González Agudo
Keyword(s):  
Seventeenth Century ◽  
Sixteenth Century ◽  
Economic Performance ◽  
Representative Sample ◽  
Land Rent ◽  
Short Term ◽  
The Cost ◽  
The Ideal

Little is known about the management of secular clerg y assets in modern Spain. The aim of this work is to analyse agrarian contracts and the evolution of land rent in Toledo between 1521 and 1650, from a representative sample of fifty rural properties belonging to the city’s Cathedral. The census was the most frequent contract, although the lease provided the main source of income for the Chapter. Long-term leases were more prevalent during the first half of the sixteenth century, after which short-term leases increased. From 1521-1529 and 1642-1650, farmland rents increased by 28%, while meadow rents fell by 57%. Such a divergence can be explained by the growing profitability of farmland and increases in the cost of livestock activities. In the seventeenth century, agrarian depression in the region and reorientation of Madrid’s grain supplies would have dr iven down the rents of the Cathedral far mlands that were closely located to the seat of the new Crown. However, the takeover of a considerable share of the leases by Chapter canons and civil elites would have altered both rent trends and contractual for mulas. This makes the role of land rent a proxy for economic performance and questions the idea that corporate interests prevailed over the ideal of maximizing income.

scholarly journals Justification of sale terms as a way to minimize the cost of trade credit

2020 ◽  
Vol 17 (3) ◽  
pp. 360-372
Author(s):  
Tetiana Konieva
Keyword(s):  
Food Processing ◽  
Trade Credit ◽  
Negative Influence ◽  
Bank Loans ◽  
Short Term ◽  
Cheap Alternative ◽  
Rate Method ◽  
The Individual ◽  
The Cost

The individual and implicit nature of the trade credit cost can provoke its increase, and, as a result, violate payment discipline and negative influence on the business price.This research is dedicated to improving the sale terms definition to minimize the cost of trade credit. The methods for determining the cost of trade credit of a particular company are proposed to apply, considering the results of the comparative analysis of other enterprises from the same industry. Based on the example of Ukrainian food processing enterprises, it was revealed that 66% of them for the period 2013–2018 had an aggressive policy, and in 44% of the cases, it was connected with the growing role of trade credit. Minimum (23 days) and average (79 days) days payable outstanding, defined in the industry, were equated, respectively, to discount period and payment delay. Considering and comparing the cost of trade credit with alternative financial resources, the marginal level of the discount was determined. Considering the rate of short-term credit, according to the failed discount method, this level is 2.7% for 2018; toward the effective annual rate method – 2.48%. In the case of the overdraft, the marginal discount is 2.9% and 2.66%, respectively.When the actual discount is equal or below this level, the buyer attracts trade credit instead of bank loans. Discount higher than marginal, longer discount period, and cheap alternative financing sources provide early payments, positive financial results, and make trade credit free of charge.

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