scholarly journals The p53 Family: A Role in Lipid and Iron Metabolism

2021 ◽  
Vol 9 ◽  
Author(s):  
Kyra Laubach ◽  
Jin Zhang ◽  
Xinbin Chen
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Iron Metabolism ◽  
Tumor Suppressors ◽  
Tumor Suppression ◽  
Critical Role ◽  
Biological Processes ◽  
P53 Family ◽  
Cycle Arrest

The p53 family of tumor suppressors, which includes p53, p63, and p73, has a critical role in many biological processes, such as cell cycle arrest, apoptosis, and differentiation. In addition to tumor suppression, the p53 family proteins also participate in development, multiciliogenesis, and fertility, indicating these proteins have diverse roles. In this review, we strive to cover the relevant studies that demonstrate the roles of p53, p63, and p73 in lipid and iron metabolism.

scholarly journals Estrogen-induced disruption of intracellular iron metabolism leads to oxidative stress, membrane damage, and cell cycle arrest in MCF-7 cells

Tumor Biology ◽  
2017 ◽  
Vol 39 (10) ◽  
pp. 101042831772618 ◽  
Author(s):  
Khuloud Bajbouj ◽  
Jasmin Shafarin ◽  
Maher Y Abdalla ◽  
Iman M Ahmad ◽  
Mawieh Hamad
Keyword(s):  
Oxidative Stress ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Iron Metabolism ◽  
Membrane Damage ◽  
Intracellular Iron ◽  
Cycle Arrest ◽  
Mcf 7

scholarly journals Tumor Suppressor Inactivation in the Pathogenesis of Adult T-Cell Leukemia

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Christophe Nicot
Keyword(s):  
Cell Cycle ◽  
T Cell ◽  
Tumor Suppressor ◽  
Cell Cycle Arrest ◽  
Tumor Suppressors ◽  
Epigenetic Mechanisms ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Cycle Arrest

Tumor suppressor functions are essential to control cellular proliferation, to activate the apoptosis or senescence pathway to eliminate unwanted cells, to link DNA damage signals to cell cycle arrest checkpoints, to activate appropriate DNA repair pathways, and to prevent the loss of adhesion to inhibit initiation of metastases. Therefore, tumor suppressor genes are indispensable to maintaining genetic and genomic integrity. Consequently, inactivation of tumor suppressors by somatic mutations or epigenetic mechanisms is frequently associated with tumor initiation and development. In contrast, reactivation of tumor suppressor functions can effectively reverse the transformed phenotype and lead to cell cycle arrest or death of cancerous cells and be used as a therapeutic strategy. Adult T-cell leukemia/lymphoma (ATLL) is an aggressive lymphoproliferative disease associated with infection of CD4 T cells by the Human T-cell Leukemia Virus Type 1 (HTLV-I). HTLV-I-associated T-cell transformation is the result of a multistep oncogenic process in which the virus initially induces chronic T-cell proliferation and alters cellular pathways resulting in the accumulation of genetic defects and the deregulated growth of virally infected cells. This review will focus on the current knowledge of the genetic and epigenetic mechanisms regulating the inactivation of tumor suppressors in the pathogenesis of HTLV-I.

Abstract SY02-02: Tumor suppression in the absence of p53-mediated cell cycle arrest, apoptosis, and senescence.

2013 ◽  
Author(s):  
Tongyuan Li ◽  
Ning Kon ◽  
Le Jiang ◽  
Ying Zhao ◽  
Richard Baer ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Tumor Suppression ◽  
Cycle Arrest

scholarly journals Critical role of PP2A-B56 family protein degradation in HIV-1 Vif mediated G2 cell cycle arrest

2020 ◽  
Vol 527 (1) ◽  
pp. 257-263
Author(s):  
Kayoko Nagata ◽  
Keisuke Shindo ◽  
Yusuke Matsui ◽  
Kotaro Shirakawa ◽  
Akifumi Takaori-Kondo
Keyword(s):  
Cell Cycle ◽  
Protein Degradation ◽  
Cell Cycle Arrest ◽  
Critical Role ◽  
Cycle Arrest ◽  
Family Protein ◽  
G2 Cell Cycle Arrest ◽  
Hiv 1

Critical Role of AMPK/FoxO3A Axis in Globular Adiponectin-Induced Cell Cycle Arrest and Apoptosis in Cancer Cells

2015 ◽  
Vol 231 (2) ◽  
pp. 357-369 ◽  
Author(s):  
Anup Shrestha ◽  
Saroj Nepal ◽  
Mi Jin Kim ◽  
Jae Hoon Chang ◽  
Sang-Hyun Kim ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Critical Role ◽  
Cycle Arrest ◽  
Globular Adiponectin ◽  
Apoptosis In Cancer Cells

scholarly journals Re-expression of p16INK4a in mesothelioma cells results in cell cycle arrest, cell death, tumor suppression and tumor regression

Oncogene ◽  
1998 ◽  
Vol 16 (24) ◽  
pp. 3087-3095 ◽  
Author(s):  
Sandra P Frizelle ◽  
Jon Grim ◽  
Joan Zhou ◽  
Pankaj Gupta ◽  
David T Curiel ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Death ◽  
Cell Cycle Arrest ◽  
Tumor Suppression ◽  
Tumor Regression ◽  
Cycle Arrest

scholarly journals Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

Cell ◽  
2012 ◽  
Vol 149 (6) ◽  
pp. 1269-1283 ◽  
Author(s):  
Tongyuan Li ◽  
Ning Kon ◽  
Le Jiang ◽  
Minjia Tan ◽  
Thomas Ludwig ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Tumor Suppression ◽  
Cycle Arrest

scholarly journals Critical role for p27Kip1 in cell cycle arrest after androgen depletion in mouse mammary carcinoma cells (SC-3)

Oncogene ◽  
1998 ◽  
Vol 17 (20) ◽  
pp. 2619-2627 ◽  
Author(s):  
Masafumi Menjo ◽  
Yoko Kaneko ◽  
Etsuro Ogata ◽  
Kyoji Ikeda ◽  
Makoto Nakanishi
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Mammary Carcinoma ◽  
Critical Role ◽  
Carcinoma Cells ◽  
Mouse Mammary Carcinoma ◽  
Cycle Arrest ◽  
Mammary Carcinoma Cells ◽  
Androgen Depletion

scholarly journals Cellular Senescence: Mechanisms and Therapeutic Potential

Biomedicines ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1769
Author(s):  
Zehuan Liao ◽  
Han Lin Yeo ◽  
Siaw Wen Wong ◽  
Yan Zhao
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cellular Senescence ◽  
Biological Process ◽  
Therapeutic Potential ◽  
Biological Processes ◽  
Limb Patterning ◽  
Cycle Arrest ◽  
Major Interest ◽  
Secretory Phenotype

Cellular senescence is a complex and multistep biological process which cells can undergo in response to different stresses. Referring to a highly stable cell cycle arrest, cellular senescence can influence a multitude of biological processes—both physiologically and pathologically. While phenotypically diverse, characteristics of senescence include the expression of the senescence-associated secretory phenotype, cell cycle arrest factors, senescence-associated β-galactosidase, morphogenesis, and chromatin remodelling. Persistent senescence is associated with pathologies such as aging, while transient senescence is associated with beneficial programmes, such as limb patterning. With these implications, senescence-based translational studies, namely senotherapy and pro-senescence therapy, are well underway to find the cure to complicated diseases such as cancer and atherosclerosis. Being a subject of major interest only in the recent decades, much remains to be studied, such as regarding the identification of unique biomarkers of senescent cells. This review attempts to provide a comprehensive understanding of the diverse literature on senescence, and discuss the knowledge we have on senescence thus far.

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