scholarly journals Injectable Hydrogel Based on Modified Gelatin and Sodium Alginate for Soft-Tissue Adhesive

2021 ◽  
Vol 9 ◽  
Author(s):  
Yuhang Xing ◽  
Xueqin Qing ◽  
Hao Xia ◽  
Shiqi Hao ◽  
Haofang Zhu ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Sodium Alginate ◽  
Biomedical Applications ◽  
Wound Closure ◽  
Tissue Adhesive ◽  
Uniform Structure ◽  
Tissue Adhesives ◽  
Promising Candidate ◽  
Injectable Hydrogel ◽  
Excellent Adhesion

To assist or replace the traditional suture techniques for wound closure, soft-tissue adhesives with excellent adhesion strength and favorable biocompatibility are of great significance in biomedical applications. In this study, an injectable hydrogel tissue adhesive containing adipic acid dihydrazide–modified gelatin (Gel-ADH) and oxidized sodium alginate (OSA) was developed. It was found that this tissue adhesive possessed a uniform structure, appropriate swelling ratio, good injectability, and excellent hemocompatibility and cytocompatibility. The adhesion capacity of the developed adhesive with optimized component and concentration was stronger than that of the commercial adhesive Porcine Fibrin Sealant Kit. All these results suggested that the developed hydrogel was a promising candidate for a soft-tissue adhesive.

scholarly journals Adhesive Cements That Bond Soft Tissue Ex Vivo

Materials ◽  
2019 ◽  
Vol 12 (15) ◽  
pp. 2473 ◽  
Author(s):  
Xiuwen Liu ◽  
Michael Pujari-Palmer ◽  
David Wenner ◽  
Philip Procter ◽  
Gerard Insley ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissues ◽  
Ex Vivo ◽  
Tissue Adhesive ◽  
Wet Milling ◽  
Tissue Adhesives ◽  
Porcine Skin ◽  
Lap Shear ◽  
Bond Strengths ◽  
Calcified Tissues

The aim of the present study was to evaluate the soft tissue bond strength of a newly developed, monomeric, biomimetic, tissue adhesive called phosphoserine modified cement (PMC). Two types of PMCs were evaluated using lap shear strength (LSS) testing, on porcine skin: a calcium metasilicate (CS1), and alpha tricalcium phosphate (αTCP) PMC. CS1 PCM bonded strongly to skin, reaching a peak LSS of 84, 132, and 154 KPa after curing for 0.5, 1.5, and 4 h, respectively. Cyanoacrylate and fibrin glues reached an LSS of 207 kPa and 33 kPa, respectively. αTCP PMCs reached a final LSS of ≈110 kPa. In soft tissues, stronger bond strengths were obtained with αTCP PMCs containing large amounts of amino acid (70–90 mol%), in contrast to prior studies in calcified tissues (30–50 mol%). When αTCP particle size was reduced by wet milling, and for CS1 PMCs, the strongest bonding was obtained with mole ratios of 30–50% phosphoserine. While PM-CPCs behave like stiff ceramics after setting, they bond to soft tissues, and warrant further investigation as tissue adhesives, particularly at the interface between hard and soft tissues.

scholarly journals Advances in Photoreactive Tissue Adhesives Derived from Natural Polymers

2020 ◽  
Vol 4 (2) ◽  
pp. 32
Author(s):  
Amal Narayanan ◽  
Ying Xu ◽  
Ali Dhinojwala ◽  
Abraham Joy
Keyword(s):  
Wound Closure ◽  
Photochemical Reactions ◽  
Cohesive Strength ◽  
Tissue Adhesive ◽  
Natural Polymers ◽  
Tissue Adhesives ◽  
Wound Closure Techniques ◽  
Accelerate Wound Healing ◽  
Tissue Surfaces ◽  
Crosslinking Reactions

To stop blood loss and accelerate wound healing, conventional wound closure techniques such as sutures and staples are currently used in the clinic. These tissue-piercing wound closure techniques have several disadvantages such as the potential for causing inflammation, infections, and scar formation. Surgical sealants and tissue adhesives can address some of the disadvantages of current sutures and staples. An ideal tissue adhesive will demonstrate strong interfacial adhesion and cohesive strength to wet tissue surfaces. Most reported studies rely on the liquid-to-solid transition of organic molecules by taking advantage of polymerization and crosslinking reactions for improving the cohesive strength of the adhesives. Crosslinking reactions triggered using light are commonly used for increasing tissue adhesive strength since the reactions can be controlled spatially and temporally, providing the on-demand curing of the adhesives with minimum misplacements. In this review, we describe the recent advances in the field of naturally derived tissue adhesives and sealants in which the adhesive and cohesive strengths are modulated using photochemical reactions.

scholarly journals Evaluation of antibacterial efficacy and healing with cyanoacrylate tissue adhesive after periodontal flap surgery

2019 ◽  
pp. 12-17
Author(s):  
Aditi Mahajani ◽  
Menaka K.B ◽  
Sayed Asem Ahmed Jagirdar ◽  
Manjula Vagrali ◽  
Renuka Metgud ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Closure ◽  
Antibacterial Properties ◽  
Tissue Adhesive ◽  
Antibacterial Efficacy ◽  
Flap Surgery ◽  
Tissue Adhesives ◽  
Bacterial Colony ◽  
Post Surgery ◽  
Periodontal Flap Surgery

Surgical pocket therapy entails raising a mucoperiosteal flap in order to carry out effective debridement so as to eliminate periodontal pockets and result in a healthy periodontium. Braided silk is the most commonly used suture material following periodontal flap surgery. Cyanoacrylate tissue adhesives are slowly gaining popularity as wound closure agents. OBJECTIVES: To evaluate the antibacterial and healing properties of cyanoacrylate tissue adhesives following periodontal flap surgery. METHODS: Patients undergoing full mouth periodontal flap surgery were randomly selected for placement of cyanoacrylates or silk sutures using split mouth study design. Wound healing was evaluated at 1 week using Early Wound Healing Index. Supragingival pooled plaque samples were collected for analysis of total bacterial count at 1week follow up using lawn cultures in blood agar. Pain and burning sensation with cyanoacrylates during and post surgery was recorded using a questionnaire. RESULTS: Silk sutures showed improved wound healing when compared with cyanoacrylates. However, use of cyanoacrylates resulted in reduced bacterial colony counts thereby exhibiting antibacterial properties. Enhanced patient compliance was noted with cyanoacrylate tissue adhesives. SIGNIFICANCE: Cyanoacrylates can be used as an alternative to silk sutures for periodontal wound closure. KEY WORDS: Cyanoacrylate tissue adhesive, silk sutures, antibacterial efficacy, wound healing

Study of a novel injectable hydrogel of human-like collagen and carboxymethylcellulose for soft tissue augmentation

e-Polymers ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Bowen Liu ◽  
Xiaoxuan Ma ◽  
Chenhui Zhu ◽  
Yu Mi ◽  
Daidi Fan ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Biomedical Applications ◽  
Soft Tissue Augmentation ◽  
Injectable Hydrogel ◽  
Amide Bonds ◽  
Tissue Augmentation ◽  
Biocompatibility Test ◽  
Good Biocompatibility ◽  
Equilibrium Swelling Ratio

Abstract A novel injectable hydrogel was fabricated by human-like collagen (HLC) and carboxymethylcellulose (CMC) with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and adipic acid dihydrazide (ADH) as cross-linkers. The morphology and structure of the hydrogels were characterized by scanning electron microscope and Fourier transform infrared spectroscopy. The results showed that the HLC and CMC were successfully cross-linked through amide bonds and HLC could enhance the pore size of the composite, whereas CMC could be a strong backbone in the hydrogel to keep its appearance. The results of thermogravimetric analysis showed that the thermostability of HLC/CMC was strengthened significantly as compared with that of CMC. The tests of the equilibrium swelling ratio and in vitro degradability indicated that the HLC/CMC hydrogel possesses good water absorbing ability and slow degradability in vitro. Finally, biocompatibility test provided the possibility that HLC/CMC hydrogels are suitable for biomedical applications such as soft tissue augmentation for their good biocompatibility.

A soft tissue adhesive based on aldehyde-sodium alginate and amino-carboxymethyl chitosan preparation through the Schiff reaction

2017 ◽  
Vol 11 (3) ◽  
pp. 215-222 ◽  
Author(s):  
Yu Wu ◽  
Liu Yuan ◽  
Nai-an Sheng ◽  
Zi-qi Gu ◽  
Wen-hao Feng ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Sodium Alginate ◽  
Carboxymethyl Chitosan ◽  
Tissue Adhesive ◽  
Schiff Reaction

Fabrication of gelatin/sodium alginate-poly (3-hydroxybutyric acid) bilayer electrospun biosheet as wound healing material in nursing care on pediatric fracture surgery

2020 ◽  
pp. 152808372097634
Author(s):  
Daiqi Jiang ◽  
Zaiju Tong ◽  
Lingjun Peng ◽  
Lingzhi Zhang ◽  
Qianzi Ruan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Sodium Alginate ◽  
Wound Closure ◽  
Skin Wound ◽  
Tissue Formation ◽  
Hydroxybutyric Acid ◽  
Physiochemical Properties ◽  
Pediatric Fracture ◽  
Fracture Surgery

Novel the bilayered electrospun biosheet with rapid cell mimiciking and proliferative efficacy will be suitable for wound healing application. The optimized concentration of gelatin (G) and sodium alginate (A) biosheet with nanofibrous Poly (3-hydroxybutyric acid) (P) as a bilayered elctrospun matrix through electrospinning. The engineered GAP bilayered biosheet involves tissue formation at extra cellular matrix (ECM) which further characterized its function in vitro and invivo. Here we fabricated GAP which exhibit better physiochemical properties, biological and mechanical properties with superior prosomes it enhance air passable at skin wounds. The Bilayered biosheet matrix possess better biocompatibility, cell adherence, fructuous and cell to cell interactions evaluated using cell lines. Furthermore, GAP bilayered matrix regulates growth factors to attain maximum wound closure efficiency during invivo. Thus, the fabricated GAP electrospun biosheet would be a possible wound dressing for skin wound applications.

scholarly journals Skin stretch suturing with Nice knots in the treatment of small- or medium-sized wounds

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Jianmin Xu ◽  
Rui Chang ◽  
Wei Zhang ◽  
Chengcheng Zhang ◽  
Dezhi Zhu ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Hair Growth ◽  
Wound Closure ◽  
Skin Wound ◽  
Soft Tissue Defects ◽  
Cutaneous Sensation ◽  
The Mean ◽  
Skin Stretch ◽  
Mean Time ◽  
Tissue Defects

Abstract Background To investigate the clinical efficacy and outcomes of skin stretch suturing with self-locking sliding Nice knots in the treatment of small- or medium-sized wounds. Methods From June 2015 to May 2018, 26 patients with small- or medium-sized wounds were included in the present study. Skin stretch suturing with self-locking slide Nice knots was performed to gradually close the soft-tissue defects in these patients. The time of wound closure and healing was recorded. The color and blood supply of the skin, cutaneous sensation, the stretch of skin, and the hair growth situation of the skin wound were observed and recorded. Results There were 17 males and 9 females with an average age of 30.65 years (range, 15–48 years). The areas of the soft-tissue defects were between 3.2 × 7.1 cm and 8.0 × 15.2 cm. All patients underwent stretch suturing with self-locking slide Nice knots to close the soft-tissue defects. All wounds were successfully closed and healed. The mean time of wound closure was 10.69 days (range, 5–20 days), and the mean time of wound healing was 16.85 days (range, 10–24 days). The cutaneous sensation of skin wound recovered normally, and the color of the skin wounds was the same as that of normal skin at the last follow-up. The hair growth situation of the skin wounds also returned to normal. Conclusions This study revealed that Nice knots yielded an accepted clinical result as a new method to close small- or medium-sized wounds that was simple and less minimally invasive, resulted in progressive tension, did not return to previous results, and partially replace flaps or free skin grafts.

scholarly journals A mussel-inspired film for adhesion to wet buccal tissue and efficient buccal drug delivery

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Shanshan Hu ◽  
Xibo Pei ◽  
Lunliang Duan ◽  
Zhou Zhu ◽  
Yanhua Liu ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Wound Closure ◽  
Ex Vivo ◽  
Covalent Bonding ◽  
Mucosal Barrier ◽  
Buccal Delivery ◽  
Tissue Adhesives ◽  
Drug Bioavailability ◽  
Buccal Drug Delivery ◽  
Strong Adhesion

AbstractAdministration of drugs via the buccal route has attracted much attention in recent years. However, developing systems with satisfactory adhesion under wet conditions and adequate drug bioavailability still remains a challenge. Here, we propose a mussel-inspired mucoadhesive film. Ex vivo models show that this film can achieve strong adhesion to wet buccal tissues (up to 38.72 ± 10.94 kPa). We also demonstrate that the adhesion mechanism of this film relies on both physical association and covalent bonding between the film and mucus. Additionally, the film with incorporated polydopamine nanoparticles shows superior advantages for transport across the mucosal barrier, with improved drug bioavailability (~3.5-fold greater than observed with oral delivery) and therapeutic efficacy in oral mucositis models (~6.0-fold improvement in wound closure at day 5 compared with that observed with no treatment). We anticipate that this platform might aid the development of tissue adhesives and inspire the design of nanoparticle-based buccal delivery systems.

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